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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.


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amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G C5AR1 complement C5a receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:53,097,162...53,111,563
Ensembl chr 6:53,097,142...53,111,565 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,595...11,349,764 		JBrowse link
G IDE insulin degrading enzyme involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chr14:103,992,035...104,106,571
Ensembl chr14:103,992,039...104,106,576 		JBrowse link
G IGF1R insulin like growth factor 1 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058 		JBrowse link
G INSR insulin receptor involved_in ISO PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chr 2:71,797,209...71,939,923
Ensembl chr 2:71,797,204...71,936,104 		JBrowse link
G ITGB2 integrin subunit beta 2 involved_in ISO (PMID:20199584) ARUK-UCL PMID:20199584 NCBI chr13:207,514,281...207,544,108
Ensembl chr13:207,512,950...207,544,107 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,827 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chr 5:22,435,636...22,519,276 JBrowse link
G LRP2 LDL receptor related protein 2 involved_in ISO PMID:16306401 ARUK-UCL PMID:16306401 RGD:14697713 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694 		JBrowse link
G MARCO macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chr15:24,502,935...24,541,286
Ensembl chr15:24,503,108...24,541,283 		JBrowse link
G MME membrane metalloendopeptidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:95,018,395...95,122,977
Ensembl chr13:95,019,081...95,126,045 		JBrowse link
G MSR1 macrophage scavenger receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:3,859,903...3,939,612
Ensembl chr17:3,859,692...3,939,726 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,670...2,161,171 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:45,309,199...45,312,562
Ensembl chr 6:45,309,201...45,312,539 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:27472885) UniProt PMID:27472885 NCBI chr 2:77,357,161...77,375,349
Ensembl chr 2:77,357,218...77,375,180 		JBrowse link
G CD36 CD36 molecule involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105 		JBrowse link
G IDE insulin degrading enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:103,992,035...104,106,571
Ensembl chr14:103,992,039...104,106,576 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,827 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISO (PMID:23152628), (PMID:24305823)
(PMID:24305823)
(PMID:21289173)		 ARUK-UCL PMID:21289173 PMID:23152628 PMID:24305823 NCBI chr 5:22,435,636...22,519,276 JBrowse link
G LRP4 LDL receptor related protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:15,616,137...15,672,876
Ensembl chr 2:15,616,131...15,672,874 		JBrowse link
G MME membrane metalloendopeptidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:95,018,395...95,122,977
Ensembl chr13:95,019,081...95,126,045 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLTC clathrin heavy chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:35,848,894...35,926,028
Ensembl chr12:35,848,540...35,926,015 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISO (PMID:26005850)
(PMID:20630619)		 ARUK-UCL PMID:20630619 PMID:26005850 NCBI chr 5:22,435,636...22,519,276 JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:2,129,492...2,145,632
Ensembl chr 8:2,125,405...2,145,647 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:19,835,934...19,947,239
Ensembl chr 9:19,835,938...20,123,566 		JBrowse link
G RAB11A RAB11A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:163,858,254...163,887,741
Ensembl chr 1:163,858,123...163,891,527 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr 2:70,884,457...70,896,169
Ensembl chr 2:70,884,462...70,896,172 		JBrowse link
G RAB5A RAB5A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:6,905,302...6,940,165
Ensembl chr13:6,905,390...6,941,423 		JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 involved_in ISO (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chr 9:72,057,506...72,079,587
Ensembl chr 9:72,057,511...72,079,444 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,224...84,402,957 		JBrowse link
G IFNG interferon gamma involved_in ISO (PMID:29061364)
(PMID:17255335)		 ARUK-UCL PMID:17255335 PMID:29061364 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IFNGR1 interferon gamma receptor 1 involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chr 1:27,037,151...27,061,095
Ensembl chr 1:27,037,165...27,061,093 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:2,129,492...2,145,632
Ensembl chr 8:2,125,405...2,145,647 		JBrowse link
G MYOCD myocardin involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:56,931,628...57,029,258
Ensembl chr12:56,931,317...57,029,258 		JBrowse link
G PLA2G3 phospholipase A2 group III involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chr14:47,923,005...47,928,762
Ensembl chr14:47,923,954...47,928,810 		JBrowse link
G SRF serum response factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:38,213,300...38,223,686
Ensembl chr 7:38,213,487...38,222,144 		JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:23467355) Alzheimers_University_of_Toronto PMID:23467355 NCBI chr 2:77,357,161...77,375,349
Ensembl chr 2:77,357,218...77,375,180 		JBrowse link
G APOE apolipoprotein E involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G IL4 interleukin 4 involved_in ISO PMID:18941241
(PMID:18941241)		 ARUK-UCL PMID:18941241 RGD:13825436 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISO (PMID:26619118) ARUK-UCL PMID:26619118 NCBI chr 5:22,435,636...22,519,276 JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:106,163,899...106,314,998
Ensembl chr 6:106,163,989...106,314,944 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
G TTPA alpha tocopherol transfer protein acts_upstream_of_or_within ISO (PMID:26637123) MGI PMID:26637123 NCBI chr 4:70,960,580...70,980,883
Ensembl chr 4:70,961,465...70,980,876 		JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G APP amyloid beta precursor protein acts_upstream_of ISO (PMID:19057576) ARUK-UCL PMID:19057576 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,435,094...189,716,056 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,595...11,349,764 		JBrowse link
Term paths to the root