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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.

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amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (PMID:22438044)
(PMID:20199584)		 ARUK-UCL PMID:20199584 PMID:22438044 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
G C5ar1 complement C5a receptor 1 involved_in ISO (PMID:19561098) ARUK-UCL PMID:19561098 NCBI chrNW_004624832:6,413,169...6,423,394
Ensembl chrNW_004624832:6,414,587...6,423,394 		JBrowse link
G Clu clusterin involved_in ISO (PMID:27477018) UniProt PMID:27477018 NCBI chrNW_004624758:22,431,331...22,444,185
Ensembl chrNW_004624758:22,426,918...22,444,357 		JBrowse link
G Ide insulin degrading enzyme involved_in
acts_upstream_of_or_within		 ISO PMID:19406747
(PMID:20876579)
(PMID:26637123)
(PMID:10684867), (PMID:16511862)		 ARUK-UCL
MGI		 PMID:10684867 PMID:16511862 PMID:19406747 PMID:20876579 PMID:26637123 RGD:13210538 RGD:1627576 NCBI chrNW_004624737:3,708,309...3,822,390
Ensembl chrNW_004624737:3,702,985...3,835,776 		JBrowse link
G Igf1r insulin like growth factor 1 receptor involved_in ISO (PMID:19406747) ARUK-UCL PMID:19406747 NCBI chrNW_004624768:5,396,027...5,688,435
Ensembl chrNW_004624768:5,396,156...5,681,809 		JBrowse link
G Insr insulin receptor involved_in ISO PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chrNW_004624828:345,135...485,856
Ensembl chrNW_004624828:345,135...486,184 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (PMID:20199584)
(PMID:22438044)		 ARUK-UCL PMID:20199584 PMID:22438044 NCBI chrNW_004624782:14,316,505...14,367,841
Ensembl chrNW_004624782:14,318,499...14,367,922 		JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (PMID:20199584) ARUK-UCL PMID:20199584 NCBI chrNW_004624745:30,452,576...30,479,036
Ensembl chrNW_004624745:30,452,576...30,470,611 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chrNW_004624828:2,999,122...3,021,893
Ensembl chrNW_004624828:2,999,169...3,021,987 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chrNW_004624802:10,734,907...10,812,888
Ensembl chrNW_004624802:10,734,263...10,812,763 		JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in ISO PMID:16306401 ARUK-UCL PMID:16306401 RGD:14697713 NCBI chrNW_004624787:6,797,462...6,998,859
Ensembl chrNW_004624787:6,798,938...6,998,697 		JBrowse link
G Marco macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chrNW_004624732:26,203,345...26,236,001
Ensembl chrNW_004624732:26,203,219...26,236,057 		JBrowse link
G Mme membrane metalloendopeptidase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:32,601,835...32,691,368
Ensembl chrNW_004624730:32,601,488...32,689,080 		JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in ISO (PMID:22438044)
(PMID:11240025)		 ARUK-UCL PMID:11240025 PMID:22438044 NCBI chrNW_004624839:694,149...769,322
Ensembl chrNW_004624839:694,032...770,254 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO (PMID:27477018) UniProt PMID:27477018 NCBI chrNW_004624868:1,654,079...1,738,648
Ensembl chrNW_004624868:1,653,997...1,701,391 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:27477018)
(PMID:29859094)		 UniProt PMID:27477018 PMID:29859094 NCBI chrNW_004624754:17,643,397...17,649,255
Ensembl chrNW_004624754:17,643,363...17,648,231 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP involved_in ISO (PMID:27477018) UniProt PMID:27477018 NCBI chrNW_004624794:10,183,934...10,187,180
Ensembl chrNW_004624794:10,183,515...10,187,244 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:27472885) UniProt PMID:27472885 NCBI chrNW_004624828:7,572,821...7,592,428
Ensembl chrNW_004624828:7,573,130...7,591,038 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624739:29,341,620...29,441,232
Ensembl chrNW_004624739:29,407,568...29,441,333 		JBrowse link
G Ide insulin degrading enzyme involved_in ISO PMID:18941241
(PMID:23525105)		 ARUK-UCL PMID:18941241 PMID:23525105 RGD:13825436 NCBI chrNW_004624737:3,708,309...3,822,390
Ensembl chrNW_004624737:3,702,985...3,835,776 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO (PMID:22383525) ARUK-UCL PMID:22383525 NCBI chrNW_004624828:2,999,122...3,021,893
Ensembl chrNW_004624828:2,999,169...3,021,987 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:23152628), (PMID:24305823)
(PMID:24305823)
(PMID:21289173)		 ARUK-UCL PMID:21289173 PMID:23152628 PMID:24305823 NCBI chrNW_004624802:10,734,907...10,812,888
Ensembl chrNW_004624802:10,734,263...10,812,763 		JBrowse link
G Lrp4 LDL receptor related protein 4 involved_in ISO (PMID:18289866) ARUK-UCL PMID:18289866 NCBI chrNW_004624767:1,708,866...1,757,629 JBrowse link
G Mme membrane metalloendopeptidase involved_in ISO PMID:18941241
(PMID:15100223)
(PMID:24825898)		 ARUK-UCL PMID:15100223 PMID:18941241 PMID:24825898 RGD:13825436 NCBI chrNW_004624730:32,601,835...32,691,368
Ensembl chrNW_004624730:32,601,488...32,689,080 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:33097708)
(PMID:30617257), (PMID:31134514), (PMID:31980586)		 ARUK-UCL PMID:30617257 PMID:31134514 PMID:31980586 PMID:33097708 NCBI chrNW_004624754:17,643,397...17,649,255
Ensembl chrNW_004624754:17,643,363...17,648,231 		JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cltc clathrin heavy chain involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004624871:1,439,975...1,507,514
Ensembl chrNW_004624871:1,439,838...1,510,911 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:26005850)
(PMID:20630619)		 ARUK-UCL PMID:20630619 PMID:26005850 NCBI chrNW_004624802:10,734,907...10,812,888
Ensembl chrNW_004624802:10,734,263...10,812,763 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004624755:24,436,128...24,447,923
Ensembl chrNW_004624755:24,436,208...24,449,147 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004624845:3,875,601...3,990,347
Ensembl chrNW_004624845:3,891,061...3,990,342 		JBrowse link
G Rab11a RAB11A, member RAS oncogene family involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004624781:6,699,926...6,718,020
Ensembl chrNW_004624781:6,699,926...6,718,545 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004624828:1,165,877...1,174,306
Ensembl chrNW_004624828:1,165,327...1,174,417 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004624821:5,271,246...5,311,469 JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in ISO (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chrNW_004624951:681,559...711,476
Ensembl chrNW_004624951:682,178...711,474 		JBrowse link
G Ifng interferon gamma involved_in ISO (PMID:29061364)
(PMID:17255335)		 ARUK-UCL PMID:17255335 PMID:29061364 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004624886:618,372...640,954
Ensembl chrNW_004624886:618,289...642,928 		JBrowse link
G LOC101724157 lanosterol 14-alpha demethylase involved_in ISO (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chrNW_004624809:1,080,427...1,110,802
Ensembl chrNW_004624809:1,080,656...1,100,254 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chrNW_004624755:24,436,128...24,447,923
Ensembl chrNW_004624755:24,436,208...24,449,147 		JBrowse link
G Myocd myocardin involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chrNW_004624877:618,789...647,471 JBrowse link
G Pla2g3 phospholipase A2 group III acts_upstream_of_or_within ISO (PMID:26637123) MGI PMID:26637123 NCBI chrNW_004624747:7,602,848...7,607,872
Ensembl chrNW_004624747:7,603,277...7,607,753 		JBrowse link
G Srf serum response factor involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chrNW_004624754:16,371,995...16,381,287 JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:23467355) Alzheimers_University_of_Toronto PMID:23467355 NCBI chrNW_004624828:7,572,821...7,592,428
Ensembl chrNW_004624828:7,573,130...7,591,038 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:14741101) UniProt PMID:14741101 NCBI chrNW_004624907:1,752,322...1,755,308 JBrowse link
G Il4 interleukin 4 involved_in ISO PMID:18941241
(PMID:18941241)		 ARUK-UCL PMID:18941241 RGD:13825436 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:26619118) ARUK-UCL PMID:26619118 NCBI chrNW_004624802:10,734,907...10,812,888
Ensembl chrNW_004624802:10,734,263...10,812,763 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:27853422) ARUK-UCL PMID:27853422 NCBI chrNW_004624770:10,592,304...10,731,640 JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:31235932)
(PMID:26949937), (PMID:28802038), (PMID:30617257), (PMID:31235932)		 ARUK-UCL PMID:26949937 PMID:28802038 PMID:30617257 PMID:31235932 NCBI chrNW_004624754:17,643,397...17,649,255
Ensembl chrNW_004624754:17,643,363...17,648,231 		JBrowse link
G Ttpa alpha tocopherol transfer protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chrNW_004624744:28,713,596...28,738,435
Ensembl chrNW_004624744:28,713,320...28,739,539 		JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO (PMID:24446231) Alzheimers_University_of_Toronto PMID:24446231 NCBI chrNW_004624907:1,752,322...1,755,308 JBrowse link
G App amyloid beta precursor protein acts_upstream_of ISO (PMID:19057576) ARUK-UCL PMID:19057576 NCBI chrNW_004624745:13,904,912...14,159,374
Ensembl chrNW_004624745:13,902,577...14,159,372 		JBrowse link
G Clu clusterin involved_in ISO (PMID:24446231) Alzheimers_University_of_Toronto PMID:24446231 NCBI chrNW_004624758:22,431,331...22,444,185
Ensembl chrNW_004624758:22,426,918...22,444,357 		JBrowse link
Term paths to the root