Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta clearance
go back to main search page
Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.


show annotations for term's descendants           Sort by:
amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement component 3 involved_in IMP
IGI		 (PMID:22438044)
(PMID:20199584)		 ARUK-UCL PMID:20199584 PMID:22438044 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G C5ar1 complement component 5a receptor 1 involved_in IGI (PMID:19561098) ARUK-UCL PMID:19561098 NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465 		JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Ide insulin degrading enzyme acts_upstream_of_or_within
involved_in		 IDA
IMP
ISO		 (PMID:26637123)
(PMID:20876579)		 MGI
ARUK-UCL
GO_Central		 PMID:20876579 PMID:26637123 GO_REF:0000096 GO_REF:0000119 NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010 		JBrowse link
G Igf1r insulin-like growth factor I receptor involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Insr insulin receptor involved_in ISO GO_Central GO_REF:0000096 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Itgam integrin alpha M involved_in IGI
IMP		 (PMID:20199584)
(PMID:22438044)		 ARUK-UCL PMID:20199584 PMID:22438044 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Itgb2 integrin beta 2 involved_in IMP (PMID:20199584) ARUK-UCL PMID:20199584 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IGI (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 involved_in IMP (PMID:19098903) BHF-UCL PMID:19098903 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017 		JBrowse link
G Lrp2 low density lipoprotein receptor-related protein 2 involved_in ISO GO_Central GO_REF:0000096 NCBI chr 2:69,254,679...69,416,373
Ensembl chr 2:69,254,684...69,416,409 		JBrowse link
G Marco macrophage receptor with collagenous structure involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000096 GO_REF:0000107 NCBI chr 1:120,402,267...120,432,753
Ensembl chr 1:120,402,267...120,432,753 		JBrowse link
G Mme membrane metallo endopeptidase involved_in IGI
IBA
ISO		 (PMID:16636059) ARUK-UCL
GO_Central		 PMID:16636059 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451 		JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in IBA
IMP
IGI		 (PMID:11240025)
(PMID:22438044)		 GO_Central
ARUK-UCL		 PMID:11240025 PMID:22438044 GO_REF:0000033 NCBI chr 8:39,996,284...40,095,790
Ensembl chr 8:40,034,726...40,095,714 		JBrowse link
G Syk spleen tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IMP (PMID:29859094) UniProt PMID:29859094 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175 		JBrowse link
G Tyrobp TYRO protein tyrosine kinase binding protein involved_in ISO (PMID:27477018) UniProt PMID:27477018 NCBI chr 7:30,113,207...30,117,007
Ensembl chr 7:30,113,185...30,117,010 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP-binding cassette, sub-family A member 7 involved_in IMP (PMID:27472885) UniProt PMID:27472885 NCBI chr10:79,832,328...79,851,406
Ensembl chr10:79,832,328...79,851,406 		JBrowse link
G Cd36 CD36 molecule involved_in IBA
IEA
ISO		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Ide insulin degrading enzyme involved_in ISO GO_Central GO_REF:0000096 GO_REF:0000119 NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IDA (PMID:22383525) ARUK-UCL PMID:22383525 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 involved_in IBA
ISO
IGI
IDA
IEA
IMP		 (PMID:24305823)
(PMID:21289173)
(PMID:23152628)		 GO_Central
ARUK-UCL
Ensembl		 PMID:21289173 PMID:23152628 PMID:24305823 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017 		JBrowse link
G Lrp4 low density lipoprotein receptor-related protein 4 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:91,287,794...91,344,246
Ensembl chr 2:91,287,856...91,344,124 		JBrowse link
G Mme membrane metallo endopeptidase involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000096 GO_REF:0000107 GO_REF:0000119 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISS
ISO
IMP		 (PMID:30617257), (PMID:31134514), (PMID:31980586) ARUK-UCL
GO_Central		 PMID:30617257 PMID:31134514 PMID:31980586 GO_REF:0000024 GO_REF:0000119 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175 		JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cltc clathrin heavy chain involved_in ISO GO_Central GO_REF:0000119 NCBI chr11:86,585,178...86,648,637
Ensembl chr11:86,585,177...86,648,391 		JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 involved_in ISO
IBA
IDA
IEA		 (PMID:20630619) GO_Central
ARUK-UCL
Ensembl		 PMID:20630619 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017 		JBrowse link
G Lrpap1 low density lipoprotein receptor-related protein associated protein 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 5:35,248,834...35,263,043
Ensembl chr 5:35,248,845...35,263,110 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
IGI
IMP		 (PMID:26005850) GO_Central
ARUK-UCL		 PMID:26005850 GO_REF:0000119 NCBI chr 7:89,778,711...89,858,655
Ensembl chr 7:89,779,421...89,862,673 		JBrowse link
G Rab11a RAB11A, member RAS oncogene family involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 9:64,622,582...64,645,038
Ensembl chr 9:64,622,581...64,645,040 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr17:33,961,458...33,979,460
Ensembl chr17:33,961,458...33,979,504 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr17:53,786,262...53,814,706
Ensembl chr17:53,786,262...53,814,708 		JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 involved_in IMP (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase involved_in IMP (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Ifng interferon gamma involved_in IDA
IGI		 (PMID:29061364)
(PMID:17255335)		 ARUK-UCL PMID:17255335 PMID:29061364 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in IGI (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977 		JBrowse link
G Lrpap1 low density lipoprotein receptor-related protein associated protein 1 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 5:35,248,834...35,263,043
Ensembl chr 5:35,248,845...35,263,110 		JBrowse link
G Myocd myocardin involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr11:65,064,434...65,160,821
Ensembl chr11:65,067,387...65,160,815 		JBrowse link
G Pla2g3 phospholipase A2, group III acts_upstream_of_or_within IDA (PMID:26637123) MGI PMID:26637123 NCBI chr11:3,438,158...3,449,346
Ensembl chr11:3,438,284...3,449,350 		JBrowse link
G Srf serum response factor involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr17:46,857,764...46,869,194
Ensembl chr17:46,859,255...46,867,101 		JBrowse link
G Tnf tumor necrosis factor involved_in IGI (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP-binding cassette, sub-family A member 7 involved_in IMP (PMID:23467355) Alzheimers_University_of_Toronto PMID:23467355 NCBI chr10:79,832,328...79,851,406
Ensembl chr10:79,832,328...79,851,406 		JBrowse link
G Apoe apolipoprotein E involved_in IMP (PMID:14741101) UniProt PMID:14741101 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Il4 interleukin 4 involved_in IDA
ISO		 (PMID:18941241) ARUK-UCL
GO_Central		 PMID:18941241 GO_REF:0000096 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 involved_in IMP (PMID:26619118) ARUK-UCL PMID:26619118 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO
IMP		 (PMID:26949937), (PMID:28802038), (PMID:30617257), (PMID:31235932) GO_Central
ARUK-UCL		 PMID:26949937 PMID:28802038 PMID:30617257 PMID:31235932 GO_REF:0000119 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175 		JBrowse link
G Ttpa tocopherol (alpha) transfer protein acts_upstream_of_or_within IMP (PMID:26637123) MGI PMID:26637123 NCBI chr 4:20,007,889...20,030,823
Ensembl chr 4:20,007,938...20,030,785 		JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G App amyloid beta precursor protein acts_upstream_of ISO GO_Central GO_REF:0000119 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Clu clusterin involved_in ISS
ISO		 Alzheimers_University_of_Toronto
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
Term paths to the root