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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.



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amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement component 3 involved_in IMP
IGI
(PMID:22438044)
(PMID:20199584)
ARUK-UCL PMID:20199584 PMID:22438044 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G C5ar1 complement component 5a receptor 1 involved_in IGI (PMID:19561098) ARUK-UCL PMID:19561098 NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465
JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996
JBrowse link
G Ide insulin degrading enzyme acts_upstream_of_or_within
involved_in
IDA
IMP
ISO
(PMID:26637123)
(PMID:20876579)
MGI
ARUK-UCL
GO_Central
PMID:20876579 PMID:26637123 GO_REF:0000096 GO_REF:0000119 NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010
JBrowse link
G Igf1r insulin-like growth factor I receptor involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
JBrowse link
G Insr insulin receptor involved_in ISO GO_Central GO_REF:0000096 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
JBrowse link
G Itgam integrin alpha M involved_in IGI
IMP
(PMID:20199584)
(PMID:22438044)
ARUK-UCL PMID:20199584 PMID:22438044 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Itgb2 integrin beta 2 involved_in IMP (PMID:20199584) ARUK-UCL PMID:20199584 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542
JBrowse link
G Ldlr low density lipoprotein receptor involved_in IGI (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 involved_in IMP (PMID:19098903) BHF-UCL PMID:19098903 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
JBrowse link
G Lrp2 low density lipoprotein receptor-related protein 2 involved_in ISO GO_Central GO_REF:0000096 NCBI chr 2:69,254,679...69,416,373
Ensembl chr 2:69,254,684...69,416,409
JBrowse link
G Marco macrophage receptor with collagenous structure involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000096 GO_REF:0000107 NCBI chr 1:120,402,267...120,432,753
Ensembl chr 1:120,402,267...120,432,753
JBrowse link
G Mme membrane metallo endopeptidase involved_in IGI
IBA
ISO
(PMID:16636059) ARUK-UCL
GO_Central
PMID:16636059 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451
JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in IBA
IMP
IGI
(PMID:11240025)
(PMID:22438044)
GO_Central
ARUK-UCL
PMID:11240025 PMID:22438044 GO_REF:0000033 NCBI chr 8:39,996,284...40,095,790
Ensembl chr 8:40,034,726...40,095,714
JBrowse link
G Syk spleen tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IMP (PMID:29859094) UniProt PMID:29859094 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175
JBrowse link
G Tyrobp TYRO protein tyrosine kinase binding protein involved_in ISO (PMID:27477018) UniProt PMID:27477018 NCBI chr 7:30,113,207...30,117,007
Ensembl chr 7:30,113,185...30,117,010
JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP-binding cassette, sub-family A member 7 involved_in IMP (PMID:27472885) UniProt PMID:27472885 NCBI chr10:79,832,328...79,851,406
Ensembl chr10:79,832,328...79,851,406
JBrowse link
G Cd36 CD36 molecule involved_in IBA
IEA
ISO
GO_Central
Ensembl
GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Ide insulin degrading enzyme involved_in ISO GO_Central GO_REF:0000096 GO_REF:0000119 NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010
JBrowse link
G Ldlr low density lipoprotein receptor involved_in IDA (PMID:22383525) ARUK-UCL PMID:22383525 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 involved_in IBA
ISO
IGI
IDA
IEA
IMP
(PMID:24305823)
(PMID:21289173)
(PMID:23152628)
GO_Central
ARUK-UCL
Ensembl
PMID:21289173 PMID:23152628 PMID:24305823 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
JBrowse link
G Lrp4 low density lipoprotein receptor-related protein 4 involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr 2:91,287,794...91,344,246
Ensembl chr 2:91,287,856...91,344,124
JBrowse link
G Mme membrane metallo endopeptidase involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000096 GO_REF:0000107 GO_REF:0000119 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISS
ISO
IMP
(PMID:30617257), (PMID:31134514), (PMID:31980586) ARUK-UCL
GO_Central
PMID:30617257 PMID:31134514 PMID:31980586 GO_REF:0000024 GO_REF:0000119 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175
JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cltc clathrin heavy chain involved_in ISO GO_Central GO_REF:0000119 NCBI chr11:86,585,178...86,648,637
Ensembl chr11:86,585,177...86,648,391
JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 involved_in ISO
IBA
IDA
IEA
(PMID:20630619) GO_Central
ARUK-UCL
Ensembl
PMID:20630619 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
JBrowse link
G Lrpap1 low density lipoprotein receptor-related protein associated protein 1 involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr 5:35,248,834...35,263,043
Ensembl chr 5:35,248,845...35,263,110
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
IGI
IMP
(PMID:26005850) GO_Central
ARUK-UCL
PMID:26005850 GO_REF:0000119 NCBI chr 7:89,778,711...89,858,655
Ensembl chr 7:89,779,421...89,862,673
JBrowse link
G Rab11a RAB11A, member RAS oncogene family involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr 9:64,622,582...64,645,038
Ensembl chr 9:64,622,581...64,645,040
JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr17:33,961,458...33,979,460
Ensembl chr17:33,961,458...33,979,504
JBrowse link
G Rab5a RAB5A, member RAS oncogene family involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr17:53,786,262...53,814,706
Ensembl chr17:53,786,262...53,814,708
JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 involved_in IMP (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase involved_in IMP (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Ifng interferon gamma involved_in IDA
IGI
(PMID:29061364)
(PMID:17255335)
ARUK-UCL PMID:17255335 PMID:29061364 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in IGI (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977
JBrowse link
G Lrpap1 low density lipoprotein receptor-related protein associated protein 1 involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr 5:35,248,834...35,263,043
Ensembl chr 5:35,248,845...35,263,110
JBrowse link
G Myocd myocardin involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr11:65,064,434...65,160,821
Ensembl chr11:65,067,387...65,160,815
JBrowse link
G Pla2g3 phospholipase A2, group III acts_upstream_of_or_within IDA (PMID:26637123) MGI PMID:26637123 NCBI chr11:3,438,158...3,449,346
Ensembl chr11:3,438,284...3,449,350
JBrowse link
G Srf serum response factor involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr17:46,857,764...46,869,194
Ensembl chr17:46,859,255...46,867,101
JBrowse link
G Tnf tumor necrosis factor involved_in IGI (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP-binding cassette, sub-family A member 7 involved_in IMP (PMID:23467355) Alzheimers_University_of_Toronto PMID:23467355 NCBI chr10:79,832,328...79,851,406
Ensembl chr10:79,832,328...79,851,406
JBrowse link
G Apoe apolipoprotein E involved_in IMP (PMID:14741101) UniProt PMID:14741101 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
JBrowse link
G Il4 interleukin 4 involved_in IDA
ISO
(PMID:18941241) ARUK-UCL
GO_Central
PMID:18941241 GO_REF:0000096 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 involved_in IMP (PMID:26619118) ARUK-UCL PMID:26619118 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO
IMP
(PMID:26949937), (PMID:28802038), (PMID:30617257), (PMID:31235932) GO_Central
ARUK-UCL
PMID:26949937 PMID:28802038 PMID:30617257 PMID:31235932 GO_REF:0000119 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175
JBrowse link
G Ttpa tocopherol (alpha) transfer protein acts_upstream_of_or_within IMP (PMID:26637123) MGI PMID:26637123 NCBI chr 4:20,007,889...20,030,823
Ensembl chr 4:20,007,938...20,030,785
JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
JBrowse link
G App amyloid beta precursor protein acts_upstream_of ISO GO_Central GO_REF:0000119 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Clu clusterin involved_in ISS
ISO
Alzheimers_University_of_Toronto
GO_Central
GO_REF:0000024 GO_REF:0000119 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996
JBrowse link

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