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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.


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amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G C5AR1 complement C5a receptor 1 involved_in IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:47,307,477...47,322,066
Ensembl chr19:47,290,023...47,322,066 		JBrowse link
G CLU clusterin involved_in IDA (PMID:27477018) UniProt PMID:27477018 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700 		JBrowse link
G IDE insulin degrading enzyme involved_in
acts_upstream_of_or_within		 IMP
ISO
ISS		 (PMID:10684867), (PMID:16511862)
(PMID:26637123)		 ARUK-UCL
MGI		 PMID:10684867 PMID:16511862 PMID:26637123 GO_REF:0000024 NCBI chr10:92,451,684...92,574,093
Ensembl chr10:92,451,684...92,574,096 		JBrowse link
G IGF1R insulin like growth factor 1 receptor involved_in IMP (PMID:19406747) ARUK-UCL PMID:19406747 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G INSR insulin receptor involved_in ISS (PMID:19406747) ARUK-UCL PMID:19406747 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G ITGAM integrin subunit alpha M involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G ITGB2 integrin subunit beta 2 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989 		JBrowse link
G LDLR low density lipoprotein receptor involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in NAS
TAS		 (PMID:20199584)
(PMID:19098903)		 ARUK-UCL
BHF-UCL		 PMID:19098903 PMID:20199584 NCBI chr12:57,128,483...57,213,361
Ensembl chr12:57,128,483...57,213,361 		JBrowse link
G LRP2 LDL receptor related protein 2 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 2:169,127,109...169,362,534
Ensembl chr 2:169,127,109...169,362,534 		JBrowse link
G MARCO macrophage receptor with collagenous structure involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:118,942,194...118,994,660
Ensembl chr 2:118,942,194...118,994,660 		JBrowse link
G MME membrane metalloendopeptidase involved_in IGI
IBA
IDA
IEA
ISS		 (PMID:14749444)
(PMID:12657655), (PMID:15100223), (PMID:19057576)		 ARUK-UCL
GO_Central
Ensembl		 PMID:12657655 PMID:14749444 PMID:15100223 PMID:19057576 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704 		JBrowse link
G MSR1 macrophage scavenger receptor 1 involved_in IEA
IBA
ISS		 Ensembl
GO_Central
ARUK-UCL		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in IDA (PMID:27477018) UniProt PMID:27477018 NCBI chr 9:90,801,600...90,898,549
Ensembl chr 9:90,801,787...90,898,549 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA
IDA		 (PMID:27477018) Ensembl
UniProt		 PMID:27477018 GO_REF:0000107 NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IDA (PMID:27477018) UniProt PMID:27477018 NCBI chr19:35,904,403...35,908,295
Ensembl chr19:35,904,401...35,908,295 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISS UniProt GO_REF:0000024 NCBI chr19:1,040,107...1,065,572
Ensembl chr19:1,039,997...1,065,572 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in IMP
IBA		 (PMID:18941241) ARUK-UCL
GO_Central		 PMID:18941241 GO_REF:0000033 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277 		JBrowse link
G IDE insulin degrading enzyme involved_in ISS
IMP		 (PMID:23525105) ARUK-UCL PMID:23525105 GO_REF:0000024 NCBI chr10:92,451,684...92,574,093
Ensembl chr10:92,451,684...92,574,096 		JBrowse link
G LDLR low density lipoprotein receptor involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISS
IBA
IMP		 (PMID:23152628), (PMID:24305823) ARUK-UCL
GO_Central		 PMID:23152628 PMID:24305823 GO_REF:0000024 GO_REF:0000033 NCBI chr12:57,128,483...57,213,361
Ensembl chr12:57,128,483...57,213,361 		JBrowse link
G LRP4 LDL receptor related protein 4 involved_in IMP (PMID:18289866) ARUK-UCL PMID:18289866 NCBI chr11:46,856,717...46,918,550
Ensembl chr11:46,856,717...46,918,642 		JBrowse link
G MME membrane metalloendopeptidase involved_in ISS
IGI
IDA
IEA		 (PMID:24825898)
(PMID:15100223)		 ARUK-UCL
Ensembl		 PMID:15100223 PMID:24825898 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISS
IMP
IEA		 (PMID:33097708) ARUK-UCL
Ensembl		 PMID:33097708 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186 		JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLTC clathrin heavy chain involved_in IMP (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr17:59,619,895...59,696,956
Ensembl chr17:59,619,680...59,696,956 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISS
IBA
IGI		 (PMID:26005850) ARUK-UCL
GO_Central		 PMID:26005850 GO_REF:0000024 GO_REF:0000033 NCBI chr12:57,128,483...57,213,361
Ensembl chr12:57,128,483...57,213,361 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IMP (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr 4:3,503,612...3,532,422
Ensembl chr 4:3,503,612...3,532,446 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IGI
IEA
ISS		 (PMID:26005850) ARUK-UCL
Ensembl		 PMID:26005850 GO_REF:0000107 NCBI chr11:85,957,175...86,069,860
Ensembl chr11:85,957,175...86,069,882 		JBrowse link
G RAB11A RAB11A, member RAS oncogene family involved_in IGI (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr15:65,869,491...65,891,989
Ensembl chr15:65,726,054...65,891,989 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in IGI (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr19:8,390,360...8,404,434
Ensembl chr19:8,389,981...8,404,434 		JBrowse link
G RAB5A RAB5A, member RAS oncogene family involved_in IGI (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr 3:19,947,097...19,985,175
Ensembl chr 3:19,947,097...19,985,175 		JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G IFNG interferon gamma involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IFNGR1 interferon gamma receptor 1 involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:137,197,484...137,219,385
Ensembl chr 6:137,197,483...137,219,449 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IGI (PMID:19098903) BHF-UCL PMID:19098903 NCBI chr 4:3,503,612...3,532,422
Ensembl chr 4:3,503,612...3,532,446 		JBrowse link
G MIR1908 microRNA 1908 acts_upstream_of IDA (PMID:29635818) ARUK-UCL PMID:29635818 NCBI chr11:61,815,161...61,815,240
Ensembl chr11:61,815,161...61,815,240 		JBrowse link
G MIR34A microRNA 34a involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 1:9,151,668...9,151,777
Ensembl chr 1:9,151,668...9,151,777 		JBrowse link
G MYOCD myocardin involved_in IMP (PMID:19098903) BHF-UCL PMID:19098903 NCBI chr17:12,665,890...12,768,949
Ensembl chr17:12,665,890...12,768,949 		JBrowse link
G PLA2G3 phospholipase A2 group III involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chr22:31,134,807...31,140,508
Ensembl chr22:31,134,807...31,140,508 		JBrowse link
G SRF serum response factor involved_in IMP (PMID:19098903) BHF-UCL PMID:19098903 NCBI chr 6:43,171,269...43,181,506
Ensembl chr 6:43,171,269...43,181,506 		JBrowse link
G TNF tumor necrosis factor involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISS Alzheimers_University_of_Toronto GO_REF:0000024 NCBI chr19:1,040,107...1,065,572
Ensembl chr19:1,039,997...1,065,572 		JBrowse link
G APOE apolipoprotein E involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G IL4 interleukin 4 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in TAS
ISS		 (PMID:22383525) ARUK-UCL PMID:22383525 GO_REF:0000024 NCBI chr12:57,128,483...57,213,361
Ensembl chr12:57,128,483...57,213,361 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in TAS (PMID:22383525) ARUK-UCL PMID:22383525 NCBI chr 4:3,503,612...3,532,422
Ensembl chr 4:3,503,612...3,532,446 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IGI (PMID:27853422) ARUK-UCL PMID:27853422 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISS
IMP
IEA		 (PMID:31235932) ARUK-UCL
Ensembl		 PMID:31235932 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186 		JBrowse link
G TTPA alpha tocopherol transfer protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chr 8:63,058,409...63,086,053
Ensembl chr 8:63,048,553...63,086,053 		JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in IDA (PMID:24446231) Alzheimers_University_of_Toronto PMID:24446231 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G APP amyloid beta precursor protein acts_upstream_of IMP (PMID:19057576) ARUK-UCL PMID:19057576 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G CLU clusterin involved_in IDA (PMID:24446231) Alzheimers_University_of_Toronto PMID:24446231 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700 		JBrowse link
Term paths to the root