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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.

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amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:6,250,422...6,289,264 JBrowse link
G C5AR1 complement C5a receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:40,633,540...40,651,839
Ensembl chr 6:40,633,448...40,652,845 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:25,704,441...25,721,789
Ensembl chr 8:25,703,257...25,721,789 		JBrowse link
G IDE insulin degrading enzyme involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chr 9:85,722,728...85,843,247
Ensembl chr 9:85,721,886...85,843,117 		JBrowse link
G IGF1R insulin like growth factor 1 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:17,212,206...17,534,036
Ensembl chr29:17,459,404...17,526,930 		JBrowse link
G INSR insulin receptor involved_in ISO PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chr 6:6,625,951...6,803,610
Ensembl chr 6:6,630,777...6,803,592 		JBrowse link
G ITGAM integrin subunit alpha M involved_in ISO (PMID:20199584)
(PMID:22438044)		 ARUK-UCL PMID:20199584 PMID:22438044 NCBI chr 5:27,957,162...28,042,697
Ensembl chr 5:27,957,324...28,042,691 		JBrowse link
G ITGB2 integrin subunit beta 2 involved_in ISO (PMID:20199584) ARUK-UCL PMID:20199584 NCBI chr 2:88,597,554...88,644,890
Ensembl chr 2:88,597,556...88,624,025 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:10,062,204...10,091,780
Ensembl chr 6:10,062,790...10,091,377 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chr11:53,039,147...53,125,041
Ensembl chr11:53,039,364...53,125,776 		JBrowse link
G LRP2 LDL receptor related protein 2 involved_in ISO PMID:16306401 ARUK-UCL PMID:16306401 RGD:14697713 NCBI chr10:54,672,876...54,889,374
Ensembl chr10:54,711,517...54,889,208 		JBrowse link
G MARCO macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chr10:11,329,036...11,389,428
Ensembl chr10:11,329,026...11,388,999 		JBrowse link
G MME membrane metalloendopeptidase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:35,577,460...35,681,730
Ensembl chr15:35,580,714...35,633,914 		JBrowse link
G MSR1 macrophage scavenger receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:14,221,389...14,305,059
Ensembl chr 8:14,220,529...14,304,946 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:101,254,085...101,374,724
Ensembl chr12:101,260,061...101,349,856 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:30,816,675...30,820,816
Ensembl chr 6:30,816,678...30,820,597 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr21:68,214,875...68,309,336
Ensembl chr21:68,216,201...68,268,669 		JBrowse link
G IDE insulin degrading enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:85,722,728...85,843,247
Ensembl chr 9:85,721,886...85,843,117 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:10,062,204...10,091,780
Ensembl chr 6:10,062,790...10,091,377 		JBrowse link
G LOC103233590 phospholipid-transporting ATPase ABCA7 involved_in ISO (PMID:27472885) UniProt PMID:27472885 NCBI chr 6:792,684...821,522
Ensembl chr 6:792,783...821,375 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:53,039,147...53,125,041
Ensembl chr11:53,039,364...53,125,776 		JBrowse link
G LRP4 LDL receptor related protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:18,393,489...18,474,514
Ensembl chr 1:18,413,513...18,471,444 		JBrowse link
G MME membrane metalloendopeptidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:35,577,460...35,681,730
Ensembl chr15:35,580,714...35,633,914 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLTC clathrin heavy chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:33,751,641...33,826,415
Ensembl chr16:33,752,556...33,799,102 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:53,039,147...53,125,041
Ensembl chr11:53,039,364...53,125,776 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:45,206,455...45,225,766
Ensembl chr27:45,206,618...45,225,767 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:77,214,391...77,325,626
Ensembl chr 1:77,213,836...77,324,875 		JBrowse link
G RAB11A RAB11A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:17,682,629...17,702,325
Ensembl chr26:17,682,874...17,702,309 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:7,743,130...7,757,237
Ensembl chr 6:7,743,361...7,757,305 		JBrowse link
G RAB5A RAB5A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:64,678,910...64,715,228
Ensembl chr15:64,682,723...64,713,928 		JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 involved_in ISO (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chr21:56,865,498...56,888,196
Ensembl chr21:56,865,312...56,886,698 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:69,664,784...69,690,343
Ensembl chr 4:69,665,417...69,688,686 		JBrowse link
G IFNG interferon gamma involved_in ISO (PMID:29061364)
(PMID:17255335)		 ARUK-UCL PMID:17255335 PMID:29061364 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IFNGR1 interferon gamma receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:36,203,038...36,224,039
Ensembl chr13:36,203,004...36,222,542 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:45,206,455...45,225,766
Ensembl chr27:45,206,618...45,225,767 		JBrowse link
G MYOCD myocardin involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:11,923,464...12,100,897
Ensembl chr16:12,000,197...12,095,552 		JBrowse link
G PLA2G3 phospholipase A2 group III involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chr19:14,025,373...14,033,214
Ensembl chr19:14,025,742...14,030,643 		JBrowse link
G SRF serum response factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:28,983,161...28,993,465
Ensembl chr17:28,983,002...28,992,995 		JBrowse link
G TNF tumor necrosis factor involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G IL4 interleukin 4 involved_in ISO (PMID:18941241) ARUK-UCL PMID:18941241 RGD:13825436 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G LOC103233590 phospholipid-transporting ATPase ABCA7 involved_in ISO (PMID:23467355) Alzheimers_University_of_Toronto PMID:23467355 NCBI chr 6:792,684...821,522
Ensembl chr 6:792,783...821,375 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISO (PMID:26619118) ARUK-UCL PMID:26619118 NCBI chr11:53,039,147...53,125,041
Ensembl chr11:53,039,364...53,125,776 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:59,384,822...59,538,780
Ensembl chr18:59,384,944...59,540,070 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
G TTPA alpha tocopherol transfer protein acts_upstream_of_or_within ISO (PMID:26637123) MGI PMID:26637123 NCBI chr 8:58,952,685...58,979,083
Ensembl chr 8:58,950,626...58,978,258 		JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G APP amyloid beta precursor protein acts_upstream_of ISO (PMID:19057576) ARUK-UCL PMID:19057576 NCBI chr 2:66,037,224...66,320,860
Ensembl chr 2:66,037,261...66,321,306 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:25,704,441...25,721,789
Ensembl chr 8:25,703,257...25,721,789 		JBrowse link
Term paths to the root