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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.

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amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (PMID:22438044)
(PMID:20199584)		 ARUK-UCL PMID:20199584 PMID:22438044 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697 		JBrowse link
G C5ar1 complement C5a receptor 1 involved_in ISO (PMID:19561098) ARUK-UCL PMID:19561098 NCBI chrNW_004955574:1,221,942...1,229,634
Ensembl chrNW_004955574:1,221,187...1,231,655 		JBrowse link
G Clu clusterin involved_in ISO (PMID:27477018) UniProt PMID:27477018 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876 		JBrowse link
G Ide insulin degrading enzyme involved_in
acts_upstream_of_or_within		 ISO (PMID:10684867), (PMID:16511862)
(PMID:20876579)
(PMID:26637123)
PMID:19406747		 ARUK-UCL
MGI		 PMID:10684867 PMID:16511862 PMID:19406747 PMID:20876579 PMID:26637123 RGD:13210538 RGD:1627576 NCBI chrNW_004955425:819,461...926,440
Ensembl chrNW_004955425:847,615...926,318 		JBrowse link
G Igf1r insulin like growth factor 1 receptor involved_in ISO (PMID:19406747) ARUK-UCL PMID:19406747 NCBI chrNW_004955416:26,101,090...26,382,660
Ensembl chrNW_004955416:26,102,628...26,382,666 		JBrowse link
G Insr insulin receptor involved_in ISO PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chrNW_004955563:1,867,400...2,011,845
Ensembl chrNW_004955563:1,867,400...2,009,149 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (PMID:20199584)
(PMID:22438044)		 ARUK-UCL PMID:20199584 PMID:22438044 NCBI chrNW_004955493:8,116,886...8,160,806
Ensembl chrNW_004955493:8,116,834...8,260,759 		JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (PMID:20199584) ARUK-UCL PMID:20199584 NCBI chrNW_004955407:41,779,849...41,805,637
Ensembl chrNW_004955407:41,777,777...41,800,201 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chrNW_004955458:4,861,431...4,941,939
Ensembl chrNW_004955458:4,861,431...4,941,146 		JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in ISO PMID:16306401 ARUK-UCL PMID:16306401 RGD:14697713 NCBI chrNW_004955449:5,155,109...5,314,886
Ensembl chrNW_004955449:5,160,946...5,314,948 		JBrowse link
G Marco macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chrNW_004955459:10,700,645...10,739,222
Ensembl chrNW_004955459:10,698,294...10,739,131 		JBrowse link
G Mme membrane metalloendopeptidase involved_in ISO PMID:19406747
(PMID:16636059)
(PMID:12657655), (PMID:15100223), (PMID:19057576)
(PMID:14749444)		 ARUK-UCL PMID:12657655 PMID:14749444 PMID:15100223 PMID:16636059 PMID:19057576 More... RGD:13210538 NCBI chrNW_004955448:6,193,113...6,311,666
Ensembl chrNW_004955448:6,226,059...6,314,949 		JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in ISO (PMID:22438044)
(PMID:11240025)		 ARUK-UCL PMID:11240025 PMID:22438044 NCBI chrNW_004955463:1,197,086...1,263,943
Ensembl chrNW_004955463:1,197,022...1,264,765 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO (PMID:27477018) UniProt PMID:27477018 NCBI chrNW_004955515:1,328,793...1,400,206
Ensembl chrNW_004955515:1,328,630...1,380,581 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:27477018)
(PMID:29859094)		 UniProt PMID:27477018 PMID:29859094 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP involved_in ISO (PMID:27477018) UniProt PMID:27477018 NCBI chrNW_004955468:2,673,657...2,677,633
Ensembl chrNW_004955468:2,673,980...2,677,321 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:27472885) UniProt PMID:27472885 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in ISO (PMID:18941241) ARUK-UCL PMID:18941241 RGD:13825436 NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313 		JBrowse link
G Ide insulin degrading enzyme involved_in ISO (PMID:23525105)
PMID:18941241		 ARUK-UCL PMID:18941241 PMID:23525105 RGD:13825436 NCBI chrNW_004955425:819,461...926,440
Ensembl chrNW_004955425:847,615...926,318 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO (PMID:22383525) ARUK-UCL PMID:22383525 NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:23152628), (PMID:24305823)
(PMID:21289173)
(PMID:24305823)		 ARUK-UCL PMID:21289173 PMID:23152628 PMID:24305823 NCBI chrNW_004955458:4,861,431...4,941,939
Ensembl chrNW_004955458:4,861,431...4,941,146 		JBrowse link
G Lrp4 LDL receptor related protein 4 involved_in ISO (PMID:18289866) ARUK-UCL PMID:18289866 NCBI chrNW_004955422:1,191,338...1,238,227
Ensembl chrNW_004955422:1,191,338...1,238,227 		JBrowse link
G Mme membrane metalloendopeptidase involved_in ISO (PMID:15100223)
PMID:18941241
(PMID:24825898)		 ARUK-UCL PMID:15100223 PMID:18941241 PMID:24825898 RGD:13825436 NCBI chrNW_004955448:6,193,113...6,311,666
Ensembl chrNW_004955448:6,226,059...6,314,949 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:33097708)
(PMID:30617257), (PMID:31134514), (PMID:31980586)		 ARUK-UCL PMID:30617257 PMID:31134514 PMID:31980586 PMID:33097708 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697 		JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cltc clathrin heavy chain involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004955451:3,380,304...3,445,973
Ensembl chrNW_004955451:3,380,304...3,445,973 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:26005850)
(PMID:20630619)		 ARUK-UCL PMID:20630619 PMID:26005850 NCBI chrNW_004955458:4,861,431...4,941,939
Ensembl chrNW_004955458:4,861,431...4,941,146 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004955514:2,195,228...2,208,258
Ensembl chrNW_004955514:2,195,228...2,208,688 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208 		JBrowse link
G Rab11a RAB11A, member RAS oncogene family involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004955450:9,638,761...9,656,291
Ensembl chrNW_004955450:9,638,761...9,656,603 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004955563:1,008,267...1,017,315
Ensembl chrNW_004955563:1,008,769...1,017,315 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004955430:11,991,548...12,040,003 JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in ISO (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chrNW_004955425:25,362,165...25,380,611
Ensembl chrNW_004955425:25,359,884...25,380,745 		JBrowse link
G Ifng interferon gamma involved_in ISO (PMID:29061364)
(PMID:17255335)		 ARUK-UCL PMID:17255335 PMID:29061364 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004955436:22,183,318...22,199,013 JBrowse link
G LOC102027002 lanosterol 14-alpha demethylase involved_in ISO (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chrNW_004955432:9,092,923...9,112,615
Ensembl chrNW_004955432:9,092,933...9,112,615 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chrNW_004955514:2,195,228...2,208,258
Ensembl chrNW_004955514:2,195,228...2,208,688 		JBrowse link
G Myocd myocardin involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chrNW_004955467:4,653,065...4,743,438
Ensembl chrNW_004955467:4,656,380...4,743,110 		JBrowse link
G Pla2g3 phospholipase A2 group III acts_upstream_of_or_within ISO (PMID:26637123) MGI PMID:26637123 NCBI chrNW_004955455:5,314,520...5,320,151
Ensembl chrNW_004955455:5,315,450...5,320,053 		JBrowse link
G Srf serum response factor involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chrNW_004955437:9,100,546...9,109,305
Ensembl chrNW_004955437:9,098,968...9,107,057 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:23467355) Alzheimers_University_of_Toronto PMID:23467355 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:14741101) UniProt PMID:14741101 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G Il4 interleukin 4 involved_in ISO PMID:18941241
(PMID:18941241)		 ARUK-UCL PMID:18941241 RGD:13825436 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:26619118) ARUK-UCL PMID:26619118 NCBI chrNW_004955458:4,861,431...4,941,939
Ensembl chrNW_004955458:4,861,431...4,941,146 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:27853422) ARUK-UCL PMID:27853422 NCBI chrNW_004955402:9,752,101...9,864,317
Ensembl chrNW_004955402:9,750,730...9,864,317 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:31235932)
(PMID:26949937), (PMID:28802038), (PMID:30617257), (PMID:31235932)		 ARUK-UCL PMID:26949937 PMID:28802038 PMID:30617257 PMID:31235932 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697 		JBrowse link
G Ttpa alpha tocopherol transfer protein acts_upstream_of_or_within ISO (PMID:26637123) MGI PMID:26637123 NCBI chrNW_004955444:15,877,972...15,891,949
Ensembl chrNW_004955444:15,869,940...15,894,544 		JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO (PMID:24446231) Alzheimers_University_of_Toronto PMID:24446231 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G App amyloid beta precursor protein acts_upstream_of ISO (PMID:19057576) ARUK-UCL PMID:19057576 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268 		JBrowse link
G Clu clusterin involved_in ISO (PMID:24446231) Alzheimers_University_of_Toronto PMID:24446231 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876 		JBrowse link
Term paths to the root