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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.


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amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G C5AR1 complement C5a receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:44,293,612...44,310,430
Ensembl chr19:52,950,317...52,966,146 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G IDE insulin degrading enzyme involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chr10:89,196,295...89,320,223
Ensembl chr10:92,716,540...92,833,353 		JBrowse link
G IGF1R insulin like growth factor 1 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974 		JBrowse link
G INSR insulin receptor involved_in ISO PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chr19:6,393,407...6,578,234
Ensembl chr19:7,260,246...7,414,889 		JBrowse link
G ITGAM integrin subunit alpha M involved_in ISO (PMID:20199584)
(PMID:22438044)		 ARUK-UCL PMID:20199584 PMID:22438044 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406 		JBrowse link
G ITGB2 integrin subunit beta 2 involved_in ISO (PMID:20199584) ARUK-UCL PMID:20199584 NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:10,640,225...10,683,728
Ensembl chr19:11,357,311...11,396,791 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chr12:31,713,938...31,799,287
Ensembl chr12:31,966,149...32,051,979 		JBrowse link
G LRP2 LDL receptor related protein 2 involved_in ISO PMID:16306401 ARUK-UCL PMID:16306401 RGD:14697713 NCBI chr2B:56,407,871...56,640,471
Ensembl chr2B:173,873,767...174,103,697 		JBrowse link
G MARCO macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chr2B:5,896,433...5,940,284
Ensembl chr2B:119,475,677...119,520,385 		JBrowse link
G MME membrane metalloendopeptidase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:152,085,694...152,240,148
Ensembl chr 3:160,197,566...160,292,119 		JBrowse link
G MSR1 macrophage scavenger receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:15,335,795...15,421,472
Ensembl chr 8:12,088,873...12,175,927 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:32,821,279...32,825,488
Ensembl chr19:41,570,683...41,575,226 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:27472885) UniProt PMID:27472885 NCBI chr19:62,811...77,897
Ensembl chr19:1,018,095...1,042,104 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865 		JBrowse link
G IDE insulin degrading enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:89,196,295...89,320,223
Ensembl chr10:92,716,540...92,833,353 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:10,640,225...10,683,728
Ensembl chr19:11,357,311...11,396,791 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:31,713,938...31,799,287
Ensembl chr12:31,966,149...32,051,979 		JBrowse link
G LRP4 LDL receptor related protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:46,808,090...46,868,649
Ensembl chr11:47,366,321...47,411,105 		JBrowse link
G MME membrane metalloendopeptidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:152,085,694...152,240,148
Ensembl chr 3:160,197,566...160,292,119 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578 		JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLTC clathrin heavy chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:53,685,865...53,761,008
Ensembl chr17:58,529,750...58,603,636 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:31,713,938...31,799,287
Ensembl chr12:31,966,149...32,051,979 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:3,663,649...3,683,450
Ensembl chr 4:3,646,179...3,666,098 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:81,011,324...81,122,352
Ensembl chr11:84,619,241...84,730,684 		JBrowse link
G RAB11A RAB11A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:44,810,880...44,833,438
Ensembl chr15:63,088,084...63,108,077 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr19:7,676,095...7,690,177 JBrowse link
G RAB5A RAB5A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:19,866,110...19,903,701
Ensembl chr 3:20,197,067...20,234,579 		JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 involved_in ISO (PMID:20876579) ARUK-UCL PMID:20876579 NCBI chr 7:84,110,130...84,132,870
Ensembl chr 7:97,708,806...97,729,824 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G IFNG interferon gamma involved_in ISO (PMID:29061364)
(PMID:17255335)		 ARUK-UCL PMID:17255335 PMID:29061364 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IFNGR1 interferon gamma receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:134,958,270...134,980,560
Ensembl chr 6:139,045,821...139,068,053 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:3,663,649...3,683,450
Ensembl chr 4:3,646,179...3,666,098 		JBrowse link
G MYOCD myocardin involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:38,880,120...38,983,246
Ensembl chr17:43,584,259...43,681,659 		JBrowse link
G PLA2G3 phospholipase A2 group III involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chr22:12,158,589...12,164,441
Ensembl chr22:29,995,364...30,001,160 		JBrowse link
G SRF serum response factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,763,099...42,773,332
Ensembl chr 6:44,057,192...44,066,768 		JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:23467355) Alzheimers_University_of_Toronto PMID:23467355 NCBI chr19:62,811...77,897
Ensembl chr19:1,018,095...1,042,104 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G IL4 interleukin 4 involved_in ISO (PMID:18941241) ARUK-UCL PMID:18941241 RGD:13825436 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISO (PMID:26619118) ARUK-UCL PMID:26619118 NCBI chr12:31,713,938...31,799,287
Ensembl chr12:31,966,149...32,051,979 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:14,192,293...14,352,357
Ensembl chr18:17,833,047...17,990,086 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578 		JBrowse link
G TTPA alpha tocopherol transfer protein acts_upstream_of_or_within ISO (PMID:26637123) MGI PMID:26637123 NCBI chr 8:59,591,592...59,619,658
Ensembl chr 8:61,266,954...61,293,699 		JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G APP amyloid beta precursor protein acts_upstream_of ISO (PMID:19057576) ARUK-UCL PMID:19057576 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
Term paths to the root