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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.


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amyloid-beta clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 IEA
ISO
GO_REF:0000107
UniProtKB:P05555 (MGI:5319446|PMID:22438044), (MGI:5905548|PMID:20199584)
Ensembl
RGD
PMID:20199584, PMID:22438044 GO_REF:0000107, MGI:5319446, MGI:5905548 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C5ar1 complement C5a receptor 1 ISO UniProtKB:P05067 (MGI:4354701|PMID:19561098) RGD PMID:19561098 MGI:4354701 NCBI chr 1:78,186,777...78,195,132
Ensembl chr 1:78,186,776...78,195,328
JBrowse link
G Ide insulin degrading enzyme IGI
ISO
IMP
PMID:19406747
(MGI:5912601|PMID:26637123), (MGI:6270905|PMID:20876579)
(PMID:10684867), (PMID:16511862)
RGD PMID:10684867, PMID:16511862, PMID:20876579, PMID:26637123, PMID:19406747, PMID:10684867 MGI:5912601, MGI:6270905, RGD:13210538, RGD:1627576 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
JBrowse link
G Igf1r insulin-like growth factor 1 receptor ISO
IEA
(PMID:19406747)
GO_REF:0000107
RGD
Ensembl
PMID:19406747 GO_REF:0000107 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Insr insulin receptor IMP PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Itgam integrin subunit alpha M ISO UniProtKB:P01027 (MGI:5319446|PMID:22438044), (MGI:5905548|PMID:20199584) RGD PMID:20199584, PMID:22438044 MGI:5319446, MGI:5905548 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb2 integrin subunit beta 2 ISO (MGI:5905548|PMID:20199584) RGD PMID:20199584 MGI:5905548 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Ldlr low density lipoprotein receptor ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821) RGD PMID:20005821 MGI:4415751 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lrp1 LDL receptor related protein 1 ISO (MGI:5437434|PMID:19098903) RGD PMID:19098903 MGI:5437434 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Lrp2 LDL receptor related protein 2 IMP PMID:16306401 ARUK-UCL PMID:16306401 RGD:14697713 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Marco macrophage receptor with collagenous structure IMP PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chr16:85,115,199...85,147,683
Ensembl chr16:85,115,201...85,135,859
JBrowse link
G Mme membrane metallo-endopeptidase IDA
ISO
PMID:19406747
UniProtKB:P05067 (MGI:3689460|PMID:16636059)
UniProtKB:Q61391 (PMID:12657655), (PMID:14749444), (PMID:15100223)
RGD PMID:12657655, PMID:14749444, PMID:15100223, PMID:16636059, PMID:19406747 MGI:3689460, RGD:13210538 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Msr1 macrophage scavenger receptor 1 ISO
IBA
UniProtKB:P01027|UniProtKB:P05555 (MGI:5319446|PMID:22438044), (MGI:5902691|PMID:11240025)
PMID:21873635
RGD PMID:11240025, PMID:22438044, PMID:21873635 MGI:5319446, MGI:5902691, RGD:13792537 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO (MGI:6193432|PMID:29859094) RGD PMID:29859094 MGI:6193432 NCBI chr 9:14,611,541...14,618,076
Ensembl chr 9:14,611,561...14,618,013
JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 ISS
ISO
GO_REF:0000024
(MGI:6271506|PMID:27472885)
UniProt
RGD
PMID:27472885 GO_REF:0000024, MGI:6271506 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Cd36 CD36 molecule IMP
ISO
PMID:18941241
(PMID:18941241)
RGD PMID:18941241, PMID:18941241 RGD:13825436 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Ide insulin degrading enzyme IMP
ISO
PMID:18941241
(PMID:23525105)
RGD PMID:23525105, PMID:18941241 RGD:13825436 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
JBrowse link
G Ldlr low density lipoprotein receptor IEA
ISO
GO_REF:0000107
(MGI:5902678|PMID:22383525)
Ensembl
RGD
PMID:22383525 GO_REF:0000107, MGI:5902678 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lrp1 LDL receptor related protein 1 ISO (PMID:23152628), (PMID:24305823)
UniProtKB:P05067|UniProtKB:P49768 (MGI:5465209|PMID:23152628), (MGI:5529723|PMID:24305823), (MGI:5897551|PMID:21289173)
RGD PMID:21289173, PMID:23152628, PMID:24305823 MGI:5465209, MGI:5529723, MGI:5897551 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Lrp4 LDL receptor related protein 4 ISO (PMID:18289866) RGD PMID:18289866 NCBI chr 3:80,362,643...80,416,684
Ensembl chr 3:80,362,858...80,416,679
JBrowse link
G Mme membrane metallo-endopeptidase IMP
ISO
PMID:18941241
UniProtKB:P05067 (PMID:15100223), (PMID:24825898)
RGD PMID:15100223, PMID:24825898, PMID:18941241 RGD:13825436 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cltc clathrin heavy chain ISO (PMID:26005850) RGD PMID:26005850 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Lrp1 LDL receptor related protein 1 ISO UniProtKB:Q13492 (PMID:26005850)
(MGI:5439721|PMID:20630619)
RGD PMID:20630619, PMID:26005850 MGI:5439721 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 ISO (PMID:26005850) RGD PMID:26005850 NCBI chr14:80,911,281...80,923,290
Ensembl chr14:80,911,270...80,924,831
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein IEA
ISO
GO_REF:0000107
UniProtKB:P05067:PRO_0000000092 (MGI:5637941|PMID:26005850)
UniProtKB:Q07954 (PMID:26005850)
Ensembl
RGD
PMID:26005850 GO_REF:0000107, MGI:5637941 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO UniProtKB:Q07954|UniProtKB:Q15907 (PMID:26005850) RGD PMID:26005850 NCBI chr 8:70,192,975...70,215,719
Ensembl chr 8:70,192,975...70,215,719
JBrowse link
G Rab11b RAB11B, member RAS oncogene family ISO UniProtKB:P62491|UniProtKB:Q07954 (PMID:26005850) RGD PMID:26005850 NCBI chr 7:18,598,991...18,612,132
Ensembl chr 7:18,598,880...18,612,147
JBrowse link
G Rab5a RAB5A, member RAS oncogene family ISO UniProtKB:Q07954 (PMID:26005850) RGD PMID:26005850 NCBI chr 9:5,910...6,065 JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 ISO (MGI:6270905|PMID:20876579) RGD PMID:20876579 MGI:6270905 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO (MGI:6270905|PMID:20876579) RGD PMID:20876579 MGI:6270905 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Ifng interferon gamma ISO UniProtKB:P06804|UniProtKB:P15261 (MGI:3697769|PMID:17255335), (MGI:6304699|PMID:29061364) RGD PMID:17255335, PMID:29061364 MGI:3697769, MGI:6304699 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 ISO UniProtKB:P01580|UniProtKB:P06804 (MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:3697769 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 ISO UniProtKB:Q07954 (PMID:19098903) RGD PMID:19098903 NCBI chr14:80,911,281...80,923,290
Ensembl chr14:80,911,270...80,924,831
JBrowse link
G Myocd myocardin ISO
IEA
(PMID:19098903)
GO_REF:0000107
RGD
Ensembl
PMID:19098903 GO_REF:0000107 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
G Pla2g3 phospholipase A2, group III ISO (MGI:5912601|PMID:26637123) RGD PMID:26637123 MGI:5912601 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Srf serum response factor ISO (PMID:19098903) RGD PMID:19098903 NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
JBrowse link
G Tnf tumor necrosis factor ISO UniProtKB:P01580|UniProtKB:P15261 (MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:3697769 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 ISS
ISO
GO_REF:0000024
(MGI:5487687|PMID:23467355)
Alzheimers_University_of_Toronto
RGD
PMID:23467355 GO_REF:0000024, MGI:5487687 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Apoe apolipoprotein E ISS
ISO
GO_REF:0000024
(MGI:3621689|PMID:14741101)
UniProt
RGD
PMID:14741101 GO_REF:0000024, MGI:3621689 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Il4 interleukin 4 IDA
IBA
ISO
PMID:18941241
PMID:21873635
(MGI:6272248|PMID:18941241)
RGD PMID:18941241, PMID:18941241, PMID:21873635 MGI:6272248, RGD:13825436, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Lrp1 LDL receptor related protein 1 ISO (MGI:5754651|PMID:26619118) RGD PMID:26619118 MGI:5754651 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 ISO
IEA
UniProtKB:Q14457 (PMID:27853422)
GO_REF:0000107
RGD
Ensembl
PMID:27853422 GO_REF:0000107 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO (MGI:5906931|PMID:28802038), (MGI:6254954|PMID:26949937) RGD PMID:26949937, PMID:28802038 MGI:5906931, MGI:6254954 NCBI chr 9:14,611,541...14,618,076
Ensembl chr 9:14,611,561...14,618,013
JBrowse link
G Ttpa alpha tocopherol transfer protein ISO MGI:2386172 (MGI:5912601|PMID:26637123) RGD PMID:26637123 MGI:5912601 NCBI chr 5:34,007,926...34,029,315
Ensembl chr 5:34,007,920...34,028,452
JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO
IBA
IEA
(PMID:24446231)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:24446231, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Clu clusterin ISO
ISS
IEA
(PMID:24446231)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:24446231 GO_REF:0000024, GO_REF:0000107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.