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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.


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amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P05555 (MGI:5319446|PMID:22438044), (MGI:5905548|PMID:20199584)		 Ensembl
RGD		 PMID:20199584 PMID:22438044 GO_REF:0000107 MGI:5319446 MGI:5905548 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C5ar1 complement C5a receptor 1 involved_in ISO UniProtKB:P05067 (MGI:4354701|PMID:19561098) RGD PMID:19561098 MGI:4354701 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G Ide insulin degrading enzyme involved_in
acts_upstream_of_or_within		 IMP
ISO
IGI		 PMID:10684867
(MGI:6270905|PMID:20876579)
(MGI:5912601|PMID:26637123)
(PMID:10684867), (PMID:16511862)
PMID:19406747		 RGD PMID:10684867 PMID:16511862 PMID:20876579 PMID:26637123 PMID:10684867 More... MGI:5912601 MGI:6270905, RGD:1627576, RGD:13210538 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor involved_in ISO
IEA		 (PMID:19406747)
GO_REF:0000107		 RGD
Ensembl		 PMID:19406747 GO_REF:0000107 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Insr insulin receptor involved_in IMP PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO UniProtKB:P01027 (MGI:5319446|PMID:22438044), (MGI:5905548|PMID:20199584) RGD PMID:20199584 PMID:22438044 MGI:5319446 MGI:5905548 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (MGI:5905548|PMID:20199584) RGD PMID:20199584 MGI:5905548 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821) RGD PMID:20005821 MGI:4415751 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (MGI:5437434|PMID:19098903) RGD PMID:19098903 MGI:5437434 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in IMP PMID:16306401 ARUK-UCL PMID:16306401 RGD:14697713 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708 		JBrowse link
G Marco macrophage receptor with collagenous structure involved_in IMP PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chr13:31,616,278...31,648,521
Ensembl chr13:31,616,278...31,648,521 		JBrowse link
G Mme membrane metallo-endopeptidase involved_in IDA
ISO
IBA		 PMID:19406747
UniProtKB:P05067 (MGI:3689460|PMID:16636059)
PMID:21873635
UniProtKB:Q61391 (PMID:12657655), (PMID:14749444), (PMID:15100223)		 RGD PMID:12657655 PMID:14749444 PMID:15100223 PMID:16636059 PMID:19406747 More... MGI:3689460, RGD:13210538, RGD:13792537 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in IBA
ISO		 PMID:21873635
UniProtKB:P01027|UniProtKB:P05555 (MGI:5319446|PMID:22438044), (MGI:5902691|PMID:11240025)		 RGD PMID:11240025 PMID:22438044 PMID:21873635 MGI:5319446 MGI:5902691, RGD:13792537 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6193432|PMID:29859094) RGD PMID:29859094 MGI:6193432 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6271506|PMID:27472885)		 UniProt
RGD		 PMID:27472885 GO_REF:0000024 MGI:6271506 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Cd36 CD36 molecule involved_in IBA
IEA
IMP
ISO		 PMID:21873635
GO_REF:0000107
PMID:18941241
(PMID:18941241)		 Ensembl
RGD		 PMID:18941241 PMID:21873635 PMID:18941241 GO_REF:0000107, RGD:13792537, RGD:13825436 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd36l1 CD36 molecule like 1 involved_in IBA
IMP		 PMID:21873635
PMID:18941241		 GO_Central
ARUK-UCL		 PMID:21873635 PMID:18941241 RGD:13792537, RGD:13825436 NCBI chr 4:17,424,749...17,465,808
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Ide insulin degrading enzyme involved_in IMP
IEA
ISO		 PMID:18941241
GO_REF:0000107
(PMID:23525105)		 Ensembl
RGD		 PMID:23525105 PMID:18941241 GO_REF:0000107, RGD:13825436 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO
IEA		 (MGI:5902678|PMID:22383525)
GO_REF:0000107		 RGD
Ensembl		 PMID:22383525 GO_REF:0000107 MGI:5902678 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO
IBA
IEA		 (PMID:23152628), (PMID:24305823)
PMID:21873635
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (MGI:5465209|PMID:23152628), (MGI:5529723|PMID:24305823), (MGI:5897551|PMID:21289173)		 RGD
Ensembl		 PMID:21289173 PMID:23152628 PMID:24305823 PMID:21873635 GO_REF:0000107 MGI:5465209 MGI:5529723 MGI:5897551, RGD:13792537 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Lrp4 LDL receptor related protein 4 involved_in ISO (PMID:18289866) RGD PMID:18289866 NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593 		JBrowse link
G Mme membrane metallo-endopeptidase involved_in ISO
IEA
IMP		 UniProtKB:P05067 (PMID:15100223), (PMID:24825898)
GO_REF:0000107
PMID:18941241		 RGD
Ensembl		 PMID:15100223 PMID:24825898 PMID:18941241 GO_REF:0000107, RGD:13825436 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:33097708)
(MGI:6313424|PMID:30617257), (MGI:6393391|PMID:31980586), (MGI:6695864|PMID:31134514)		 RGD PMID:30617257 PMID:31134514 PMID:31980586 PMID:33097708 MGI:6313424 MGI:6393391 MGI:6695864 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cltc clathrin heavy chain involved_in ISO
IEA		 (PMID:26005850)
GO_REF:0000107		 RGD
Ensembl		 PMID:26005850 GO_REF:0000107 NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO
IBA
IEA		 UniProtKB:Q13492 (PMID:26005850)
PMID:21873635
GO_REF:0000107
(MGI:5439721|PMID:20630619)		 RGD
Ensembl		 PMID:20630619 PMID:26005850 PMID:21873635 GO_REF:0000107 MGI:5439721, RGD:13792537 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO (PMID:26005850) RGD PMID:26005850 NCBI chr14:75,651,371...75,663,380
Ensembl chr14:75,651,376...75,665,414 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
IEA		 UniProtKB:Q07954 (PMID:26005850)
GO_REF:0000107
UniProtKB:P05067-PRO_0000000092 (MGI:5637941|PMID:26005850)		 RGD
Ensembl		 PMID:26005850 GO_REF:0000107 MGI:5637941 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family involved_in ISO
IEA		 UniProtKB:Q07954|UniProtKB:Q15907 (PMID:26005850)
GO_REF:0000107		 RGD
Ensembl		 PMID:26005850 GO_REF:0000107 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO UniProtKB:P62491|UniProtKB:Q07954 (PMID:26005850) RGD PMID:26005850 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family involved_in ISO UniProtKB:Q07954 (PMID:26005850) RGD PMID:26005850 NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873 		JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 involved_in ISO (MGI:6270905|PMID:20876579) RGD PMID:20876579 MGI:6270905 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in ISO
IEA		 (MGI:6270905|PMID:20876579)
GO_REF:0000107		 RGD
Ensembl		 PMID:20876579 GO_REF:0000107 MGI:6270905 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Ifng interferon gamma involved_in ISO UniProtKB:P06804|UniProtKB:P15261 (MGI:3697769|PMID:17255335), (MGI:6304699|PMID:29061364) RGD PMID:17255335 PMID:29061364 MGI:3697769 MGI:6304699 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P01580|UniProtKB:P06804 (MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:3697769 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO UniProtKB:Q07954 (PMID:19098903) RGD PMID:19098903 NCBI chr14:75,651,371...75,663,380
Ensembl chr14:75,651,376...75,665,414 		JBrowse link
G Myocd myocardin involved_in IEA
ISO		 GO_REF:0000107
(PMID:19098903)		 Ensembl
RGD		 PMID:19098903 GO_REF:0000107 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
G Pla2g3 phospholipase A2, group III acts_upstream_of_or_within ISO (MGI:5912601|PMID:26637123) RGD PMID:26637123 MGI:5912601 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
G Srf serum response factor involved_in ISO (PMID:19098903) RGD PMID:19098903 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO UniProtKB:P01580|UniProtKB:P15261 (MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:3697769 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5487687|PMID:23467355)		 Alzheimers_University_of_Toronto
RGD		 PMID:23467355 GO_REF:0000024 MGI:5487687 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Apoe apolipoprotein E involved_in ISS
ISO		 GO_REF:0000024
(MGI:3621689|PMID:14741101)		 UniProt
RGD		 PMID:14741101 GO_REF:0000024 MGI:3621689 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Il4 interleukin 4 involved_in IDA
IBA
ISO		 PMID:18941241
PMID:21873635
(MGI:6272248|PMID:18941241)		 RGD PMID:18941241 PMID:18941241 PMID:21873635 MGI:6272248, RGD:13825436, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (MGI:5754651|PMID:26619118) RGD PMID:26619118 MGI:5754651 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA		 UniProtKB:Q14457 (PMID:27853422)
GO_REF:0000107		 RGD
Ensembl		 PMID:27853422 GO_REF:0000107 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:31235932)
(MGI:5906931|PMID:28802038), (MGI:6254954|PMID:26949937), (MGI:6313424|PMID:30617257), (MGI:6378367|PMID:31235932)		 RGD PMID:26949937 PMID:28802038 PMID:30617257 PMID:31235932 MGI:5906931 MGI:6254954 MGI:6313424 MGI:6378367 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Ttpa alpha tocopherol transfer protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:2386172 (MGI:5912601|PMID:26637123)
GO_REF:0000107		 RGD
Ensembl		 PMID:26637123 GO_REF:0000107 MGI:5912601 NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073 		JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO
IEA
IBA		 (PMID:24446231)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:24446231 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein acts_upstream_of ISO (PMID:19057576) RGD PMID:19057576 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Clu clusterin involved_in ISO
ISS
IEA		 (PMID:24446231)
GO_REF:0000024
GO_REF:0000107		 RGD
Alzheimers_University_of_Toronto
Ensembl		 PMID:24446231 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
Term paths to the root