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ONTOLOGY REPORT - ANNOTATIONS

Term:cysteine-type endopeptidase activity involved in execution phase of apoptosis
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Accession:GO:0097200 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis.
Comment:Examples of gene products that may be annotated to this term include CASP3, CASP6 and CASP7, also called effector (or executioner) caspases.
Synonyms:narrow_synonym: effector caspase activity;   executioner caspase activity


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cysteine-type endopeptidase activity involved in execution phase of apoptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:16374543), (PMID:17559062), (PMID:18723680), (PMID:20566630), (PMID:22253444)
GO_REF:0000033
(PMID:12124386)		 UniProt
RGD
GO_Central		 PMID:12124386 PMID:16374543 PMID:17559062 PMID:18723680 PMID:20566630 More... GO_REF:0000024 GO_REF:0000033 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 enables ISO
IEA
IBA		 (PMID:22253444)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:22253444 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 enables ISO
IBA		 (PMID:16123041), (PMID:16352606), (PMID:16374543), (PMID:16916640), (PMID:18723680), (PMID:20566630), (PMID:22184066), (PMID:22253444), (PMID:22451931), (PMID:27889207), (PMID:28863261)
GO_REF:0000033		 RGD
GO_Central		 PMID:16123041 PMID:16352606 PMID:16374543 PMID:16916640 PMID:18723680 More... GO_REF:0000033 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      hydrolase activity 2639
        peptidase activity 704
          endopeptidase activity 475
            cysteine-type endopeptidase activity 90
              cysteine-type endopeptidase activity involved in apoptotic process 10
                cysteine-type endopeptidase activity involved in execution phase of apoptosis 5
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