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ONTOLOGY REPORT - ANNOTATIONS


Term:apoptotic signaling pathway
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Accession:GO:0097190 term browser browse the term
Definition:The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
Comment:This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
Synonyms:exact_synonym: apoptotic signalling pathway;   induction of apoptosis by extracellular signals
 alt_id: GO:0008624



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apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor acts_upstream_of
involved_in
ISO
IEA
(MGI:1860411|PMID:10845921) MGI
Ensembl
PMID:10845921 GO_REF:0000107 MGI:1860411 NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598
JBrowse link
G ANXA6 annexin A6 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 4:58,091,186...58,140,102
Ensembl chr 4:58,091,251...58,139,372
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr15:38,026,893...38,160,842
Ensembl chr15:38,028,132...38,114,987
JBrowse link
G BAD BCL2 associated agonist of cell death acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2158953|PMID:11717309), (MGI:3057092|PMID:15231831)
(MGI:2671672|PMID:12931191)
MGI
Ensembl
PMID:11717309 PMID:12931191 PMID:15231831 GO_REF:0000107 MGI:2158953 MGI:2671672 MGI:3057092 NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405
JBrowse link
G BAK1 BCL2 antagonist/killer 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,950,359...2,957,604
Ensembl chr12:2,948,364...2,957,018
JBrowse link
G BAX BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
ISS
(MGI:2676517|PMID:14507967), (MGI:2677915|PMID:12925707)
(MGI:3796786|PMID:18436203)
MGI
Ensembl
HGNC-UCL
PMID:12925707 PMID:14507967 PMID:18436203 GO_REF:0000024 GO_REF:0000107 MGI:2676517 MGI:2677915 MGI:3796786 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BBC3 BCL2 binding component 3 involved_in ISO (PMID:11463392) UniProt PMID:11463392 NCBI chr 1:108,742,793...108,750,832
Ensembl chr 1:108,741,713...108,749,946
JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger acts_upstream_of ISO (MGI:1932296|PMID:11290297) MGI PMID:11290297 MGI:1932296 NCBI chr 2:10,818,232...10,828,473
Ensembl chr 2:10,818,232...10,833,613
JBrowse link
G CASP10 caspase 10 involved_in IEA GOC GO_REF:0000108 NCBI chr37:10,315,867...10,350,585 JBrowse link
G CASP12 caspase 12 involved_in IEA GOC
GOC
GO_REF:0000108 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
JBrowse link
G CASP2 caspase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2450211|PMID:12477715), (MGI:3603971|PMID:16183742) MGI
Ensembl
PMID:12477715 PMID:16183742 GO_REF:0000107 MGI:2450211 MGI:3603971 NCBI chr16:6,378,447...6,396,251
Ensembl chr16:6,379,913...6,396,646
JBrowse link
G CASP4 caspase 4, apoptosis-related cysteine peptidase involved_in IEA GOC
GOC
GO_REF:0000108 NCBI chr 5:27,133,778...27,147,954
Ensembl chr 5:27,132,565...27,149,736
JBrowse link
G CASP8 caspase 8 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3603971|PMID:16183742) MGI
Ensembl
PMID:16183742 GO_REF:0000107 MGI:3603971 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G CASP8AP2 caspase 8 associated protein 2 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr12:49,040,069...49,077,418
Ensembl chr12:49,039,411...49,077,688
JBrowse link
G CAV1 caveolin 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr14:55,458,934...55,494,563
Ensembl chr14:55,461,048...55,492,935
JBrowse link
G CD24 CD24 molecule acts_upstream_of_or_within ISO (MGI:2686748|PMID:14707049), (MGI:3757615|PMID:8920854), (MGI:3757616|PMID:8943715) MGI PMID:8920854 PMID:8943715 PMID:14707049 MGI:2686748 MGI:3757615 MGI:3757616 NCBI chr12:64,239,957...64,245,114 JBrowse link
G CD28 CD28 molecule acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1340173|PMID:10429671) MGI
Ensembl
PMID:10429671 GO_REF:0000107 MGI:1340173 NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854
JBrowse link
G CD3E CD3 epsilon subunit of T-cell receptor complex involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:80946|PMID:8666928) Ensembl
Ensembl
MGI
PMID:8666928 GO_REF:0000107 MGI:80946 NCBI chr 5:15,403,724...15,415,259
Ensembl chr 5:15,403,710...15,415,260
JBrowse link
G CD5 CD5 molecule acts_upstream_of_or_within ISO (MGI:1340173|PMID:10429671) MGI PMID:10429671 MGI:1340173 NCBI chr18:55,216,415...55,235,567
Ensembl chr18:55,217,276...55,235,405
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator involved_in IEA GOC GO_REF:0000108 NCBI chr37:10,268,407...10,307,803
Ensembl chr37:10,268,582...10,345,095
JBrowse link
G COMMD3 COMM domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:10,829,693...10,833,643
Ensembl chr 2:10,818,232...10,833,613
JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:33,873,600...34,052,498
Ensembl chr15:33,878,467...34,092,094
JBrowse link
G CTNNB1 catenin beta 1 acts_upstream_of ISO (MGI:4454604|PMID:20454446)
(MGI:3051737|PMID:15131783)
MGI PMID:15131783 PMID:20454446 MGI:3051737 MGI:4454604 NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927
JBrowse link
G DAPK1 death associated protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:72,278,939...72,448,907
Ensembl chr 1:72,280,103...72,447,822
JBrowse link
G DAPK3 death associated protein kinase 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1196722|PMID:9488481)
(MGI:3687891|PMID:12917339)
MGI
Ensembl
PMID:9488481 PMID:12917339 GO_REF:0000107 MGI:1196722 MGI:3687891 NCBI chr20:55,590,199...55,603,883
Ensembl chr20:55,590,223...55,602,682
JBrowse link
G DAPL1 death associated protein like 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr36:4,678,544...4,698,711
Ensembl chr36:4,678,563...4,698,710
JBrowse link
G DAXX death domain associated protein acts_upstream_of_or_within ISO (MGI:3687891|PMID:12917339) MGI PMID:12917339 MGI:3687891 NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340
JBrowse link
G DIDO1 death inducer-obliterator 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1340704|PMID:10393935) MGI
InterPro
InterPro
PMID:10393935 GO_REF:0000002 MGI:1340704 NCBI chr24:46,691,117...46,735,117
Ensembl chr24:46,692,605...46,724,505
JBrowse link
G FADD Fas associated via death domain involved_in ISO (PMID:11101870) BHF-UCL PMID:11101870 NCBI chr18:48,087,447...48,094,497 JBrowse link
G FAIM2 Fas apoptotic inhibitory molecule 2 acts_upstream_of ISO (MGI:4880811|PMID:21209208) MGI PMID:21209208 MGI:4880811 NCBI chr27:4,802,711...4,831,230
Ensembl chr27:4,798,235...4,827,917
JBrowse link
G FAS Fas cell surface death receptor acts_upstream_of_or_within ISO (MGI:65483|PMID:7511063), (MGI:80946|PMID:8666928) RGD
MGI
PMID:7511063 PMID:8666928 PMID:16953119 MGI:65483 MGI:80946 RGD:1600313 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
JBrowse link
G FASLG Fas ligand acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3525895|PMID:15629131), (MGI:65483|PMID:7511063) MGI
Ensembl
PMID:7511063 PMID:15629131 GO_REF:0000107 MGI:3525895 MGI:65483 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224
JBrowse link
G HIP1 huntingtin interacting protein 1 involved_in ISO (PMID:11007801) UniProt PMID:11007801 NCBI chr 6:6,957,760...7,115,676
Ensembl chr 6:6,961,053...7,115,618
JBrowse link
G IFI6 interferon alpha inducible protein 6 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:72,638,657...72,642,648
Ensembl chr 2:72,638,705...72,642,648
JBrowse link
G INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 acts_upstream_of ISO (MGI:5287344|PMID:21750715) MGI PMID:21750715 MGI:5287344 NCBI chr 5:31,639,263...31,642,663
Ensembl chr 5:31,639,189...31,642,914
JBrowse link
G ING5 inhibitor of growth family member 5 acts_upstream_of
involved_in
ISO
IEA
(MGI:5287344|PMID:21750715) MGI
Ensembl
PMID:21750715 GO_REF:0000107 MGI:5287344 NCBI chr25:51,535,521...51,556,264
Ensembl chr25:51,534,753...51,554,644
JBrowse link
G INHBB inhibin subunit beta B acts_upstream_of ISO (MGI:4454604|PMID:20454446) MGI PMID:20454446 MGI:4454604 NCBI chr19:29,765,697...29,768,485
Ensembl chr19:29,767,682...29,768,077
JBrowse link
G ITGAM integrin subunit alpha M involved_in ISO (MGI:3812233|PMID:18685038) ARUK-UCL PMID:18685038 MGI:3812233 NCBI chr 6:16,944,062...16,996,525
Ensembl chr 6:16,808,971...16,996,286
JBrowse link
G LOC607300 death associated protein involved_in ISO (PMID:1087798), (PMID:7828849) UniProt PMID:1087798 PMID:7828849 NCBI chr34:3,616,960...3,682,424
Ensembl chr34:3,617,000...3,680,793
JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 acts_upstream_of ISO (MGI:3607973|PMID:16260493) MGI PMID:16260493 MGI:3607973 NCBI chr12:49,669,849...49,740,039
Ensembl chr12:49,672,389...49,739,850
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 acts_upstream_of ISO (MGI:3619752|PMID:16458303) MGI PMID:16458303 MGI:3619752 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 acts_upstream_of
involved_in
ISO
IEA
(MGI:3619752|PMID:16458303) MGI
Ensembl
PMID:16458303 GO_REF:0000107 MGI:3619752 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
G MLLT11 MLLT11 transcription factor 7 cofactor involved_in IEA InterPro GO_REF:0000002 NCBI chr17:60,142,411...60,153,650
Ensembl chr17:60,152,378...60,152,650
JBrowse link
G MOAP1 modulator of apoptosis 1 involved_in ISO (PMID:11060313) BHF-UCL PMID:11060313
G NANOS3 nanos C2HC-type zinc finger 3 acts_upstream_of ISO (MGI:3796786|PMID:18436203) MGI PMID:18436203 MGI:3796786
G NDUFA13 NADH:ubiquinone oxidoreductase subunit A13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:43,721,568...43,730,607
Ensembl chr20:43,721,640...43,730,295
JBrowse link
G P2RX4 purinergic receptor P2X 4 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr26:7,897,528...7,914,279
Ensembl chr26:7,898,015...7,914,234
JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in ISO PMID:12857854 BHF-UCL PMID:12857854 RGD:8554350 NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740
JBrowse link
G PAWR pro-apoptotic WT1 regulator acts_upstream_of_or_within ISO (MGI:3687891|PMID:12917339) MGI PMID:12917339 MGI:3687891 NCBI chr15:22,114,014...22,159,287 JBrowse link
G PCGF2 polycomb group ring finger 2 acts_upstream_of
involved_in
ISO
IEA
(MGI:1932296|PMID:11290297) MGI
Ensembl
PMID:11290297 GO_REF:0000107 MGI:1932296 NCBI chr 9:23,488,862...23,499,769
Ensembl chr 9:23,488,857...23,499,549
JBrowse link
G PDE3A phosphodiesterase 3A involved_in ISO (PMID:31420216) UniProt PMID:31420216 NCBI chr27:26,555,558...26,878,624
Ensembl chr27:26,560,547...26,878,913
JBrowse link
G PIDD1 p53-induced death domain protein 1 acts_upstream_of_or_within ISO (MGI:3603971|PMID:16183742) MGI PMID:16183742 MGI:3603971 NCBI chr18:45,168,244...45,174,085
Ensembl chr18:45,168,245...45,173,107
JBrowse link
G PPARD peroxisome proliferator activated receptor delta involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:4,492,867...4,579,340
Ensembl chr12:4,492,672...4,579,340
JBrowse link
G PSEN1 presenilin 1 acts_upstream_of
involved_in
ISO
IEA
(MGI:3044464|PMID:15148382) MGI
Ensembl
PMID:15148382 GO_REF:0000107 MGI:3044464 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532
JBrowse link
G PSEN2 presenilin 2 acts_upstream_of ISO (MGI:3044464|PMID:15148382) MGI PMID:15148382 MGI:3044464 NCBI chr 7:38,147,157...38,163,023
Ensembl chr 7:38,147,173...38,166,722
JBrowse link
G PTGIS prostaglandin I2 synthase involved_in ISO (PMID:11551955) UniProt PMID:11551955 NCBI chr24:36,129,091...36,162,525
Ensembl chr24:36,132,173...36,162,509
JBrowse link
G SENP1 SUMO specific peptidase 1 involved_in ISO (PMID:1087798) UniProt PMID:1087798 NCBI chr27:6,664,750...6,719,257
Ensembl chr27:6,664,818...6,714,479
JBrowse link
G SGPL1 sphingosine-1-phosphate lyase 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 4:21,666,264...21,717,476
Ensembl chr 4:21,660,939...21,715,155
JBrowse link
G SHH sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:18,650,553...18,663,571
Ensembl chr16:18,484,809...18,662,903
JBrowse link
G SLFN12 schlafen family member 12 involved_in ISO (PMID:31420216) UniProt PMID:31420216 NCBI chr 9:38,140,071...38,146,347 JBrowse link
G SPN sialophorin acts_upstream_of_or_within ISO (MGI:1340173|PMID:10429671) MGI PMID:10429671 MGI:1340173 NCBI chr 6:17,770,303...17,774,946 JBrowse link
G TFPT TCF3 fusion partner involved_in IBA
ISS
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000024 NCBI chr 1:103,090,723...103,098,601
Ensembl chr 1:102,989,360...103,098,573
JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 acts_upstream_of_or_within ISO (MGI:2670551|PMID:12872135) MGI PMID:12872135 MGI:2670551 NCBI chr20:54,948,237...54,961,996
Ensembl chr20:54,959,525...54,961,780
JBrowse link
G TM2D1 TM2 domain containing 1 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:2135414|PMID:11278849)
(PMID:21873635)
MGI
GO_Central
PMID:11278849 PMID:21873635 MGI:2135414 NCBI chr 5:48,274,876...48,315,480
Ensembl chr 5:48,268,186...48,313,634
JBrowse link
G TNF tumor necrosis factor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3525895|PMID:15629131), (MGI:67096|PMID:8208546) MGI
Ensembl
PMID:8208546 PMID:15629131 GO_REF:0000107 MGI:3525895 MGI:67096 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:116,757,271...116,760,453
Ensembl chr 1:116,757,289...116,772,325
JBrowse link
G UACA uveal autoantigen with coiled-coil domains and ankyrin repeats involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr30:34,376,072...34,467,278
Ensembl chr30:34,376,077...34,467,206
JBrowse link
G UMOD uromodulin involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:6107740|PMID:28990932) Ensembl
Ensembl
MGI
PMID:28990932 GO_REF:0000107 MGI:6107740 NCBI chr 6:24,991,459...25,006,735
Ensembl chr 6:24,991,459...25,006,735
JBrowse link
G VDR vitamin D receptor ISO RGD PMID:9579411 RGD:70308 NCBI chr27:6,852,915...6,909,466
Ensembl chr27:6,852,723...6,909,470
JBrowse link
G WNT4 Wnt family member 4 acts_upstream_of ISO (MGI:4454604|PMID:20454446) MGI PMID:20454446 MGI:4454604 NCBI chr 2:77,112,045...77,129,702
Ensembl chr 2:77,101,300...77,127,111
JBrowse link
B cell receptor apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
death-inducing signaling complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FADD Fas associated via death domain involved_in ISO (PMID:24025841) UniProt PMID:24025841 NCBI chr18:48,087,447...48,094,497 JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3612236|PMID:16365167) Ensembl
Ensembl
MGI
PMID:16365167 GO_REF:0000107 MGI:3612236 NCBI chr20:5,892,839...5,972,672
Ensembl chr20:5,892,834...5,972,090
JBrowse link
extrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1B activin A receptor type 1B involved_in ISO (PMID:9884026) BHF-UCL PMID:9884026 NCBI chr27:3,009,710...3,029,726
Ensembl chr27:2,994,857...3,042,396
JBrowse link
G B9D2 B9 domain containing 2 involved_in ISS AgBase GO_REF:0000024 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
G BAD BCL2 associated agonist of cell death involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405
JBrowse link
G BAX BCL2 associated X, apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BID BH3 interacting domain death agonist acts_upstream_of_or_within ISO (MGI:1343652|PMID:10476969) MGI PMID:10476969 MGI:1343652 NCBI chr27:45,344,304...45,355,735
Ensembl chr27:45,337,145...45,384,059
JBrowse link
G CASP3 caspase 3 involved_in ISO (MGI:4355273|PMID:19626005) ComplexPortal PMID:19626005 MGI:4355273 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G CASP8 caspase 8 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2386520|PMID:12065591), (MGI:3687663|PMID:10588860)
(MGI:5486419|PMID:22675671)
(MGI:5521568|PMID:22089168)
MGI
Ensembl
PMID:10588860 PMID:12065591 PMID:22089168 PMID:22675671 GO_REF:0000107 MGI:2386520 MGI:3687663 MGI:5486419 MGI:5521568 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G CD27 CD27 molecule involved_in ISO (PMID:9177220) BHF-UCL PMID:9177220 NCBI chr27:38,534,704...38,537,806
Ensembl chr27:38,534,707...38,537,604
JBrowse link
G CD70 CD70 molecule involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr20:53,639,315...53,642,687
Ensembl chr20:53,639,436...53,642,319
JBrowse link
G CTTN cortactin acts_upstream_of ISO (MGI:5437589|PMID:22660580) MGI PMID:22660580 MGI:5437589 NCBI chr18:47,932,367...47,960,732
Ensembl chr18:47,916,632...47,960,674
JBrowse link
G DAB2 DAB adaptor protein 2 acts_upstream_of ISO (MGI:5442513|PMID:15734730) MGI PMID:15734730 MGI:5442513 NCBI chr 4:69,625,874...69,648,349
Ensembl chr 4:69,625,527...69,648,321
JBrowse link
G FADD Fas associated via death domain involved_in
acts_upstream_of_or_within
ISO (PMID:16611992)
(MGI:3603971|PMID:16183742)
(MGI:3687663|PMID:10588860)
(PMID:21785459)
UniProt
MGI
PMID:10588860 PMID:16183742 PMID:16611992 PMID:21785459 MGI:3603971 MGI:3687663 NCBI chr18:48,087,447...48,094,497 JBrowse link
G FAS Fas cell surface death receptor involved_in
acts_upstream_of_or_within
ISO (PMID:22891283)
(MGI:3818355|PMID:17980593)
(MGI:2183141|PMID:12011074)
UniProt
MGI
PMID:12011074 PMID:17980593 PMID:22891283 MGI:2183141 MGI:3818355 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
JBrowse link
G FASLG Fas ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224
JBrowse link
G G0S2 G0/G1 switch 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 7:8,335,699...8,336,615
Ensembl chr 7:8,336,015...8,336,302
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:112,129,116...112,138,714
Ensembl chr 1:112,103,825...112,138,559
JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in ISO (MGI:4818524|PMID:20371704) ARUK-UCL PMID:20371704 MGI:4818524 NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666
JBrowse link
G HIPK1 homeodomain interacting protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:51,732,079...51,783,534
Ensembl chr17:51,732,016...51,781,063
JBrowse link
G IFNG interferon gamma involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698
JBrowse link
G IL12A interleukin 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:26,125,529...26,133,546
Ensembl chr34:26,124,770...26,133,550
JBrowse link
G IL33 interleukin 33 acts_upstream_of_or_within ISO (MGI:5437589|PMID:22660580) MGI PMID:22660580 MGI:5437589 NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721
JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (MGI:1340173|PMID:10429671) MGI PMID:10429671 MGI:1340173 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
JBrowse link
G IL7 interleukin 7 acts_upstream_of
involved_in
ISO
IEA
(MGI:1340173|PMID:10429671) MGI
Ensembl
PMID:10429671 GO_REF:0000107 MGI:1340173 NCBI chr29:26,384,493...26,422,586
Ensembl chr29:26,384,493...26,422,737
JBrowse link
G INHBA inhibin subunit beta A involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr18:8,272,978...8,288,432
Ensembl chr18:8,272,872...8,283,794
JBrowse link
G JAK2 Janus kinase 2 acts_upstream_of_or_within ISO (MGI:5009182|PMID:12426001) MGI PMID:12426001 MGI:5009182 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997
JBrowse link
G KRT18 keratin 18 acts_upstream_of_or_within ISO (MGI:3711847|PMID:10747083) MGI PMID:10747083 MGI:3711847 NCBI chr27:2,189,269...2,193,368
Ensembl chr27:2,189,269...2,193,368
JBrowse link
G KRT8 keratin 8 acts_upstream_of_or_within ISO (MGI:3711847|PMID:10747083) MGI PMID:10747083 MGI:3711847 NCBI chr27:2,221,608...2,229,343 JBrowse link
G MLLT11 MLLT11 transcription factor 7 cofactor involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr17:60,142,411...60,153,650
Ensembl chr17:60,152,378...60,152,650
JBrowse link
G NDUFA13 NADH:ubiquinone oxidoreductase subunit A13 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1930995|PMID:10924506) MGI
Ensembl
Ensembl
PMID:10924506 GO_REF:0000107 MGI:1930995 NCBI chr20:43,721,568...43,730,607
Ensembl chr20:43,721,640...43,730,295
JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3700102|PMID:17286969) MGI
Ensembl
PMID:17286969 GO_REF:0000107 MGI:3700102 NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740
JBrowse link
G PARP2 poly(ADP-ribose) polymerase 2 acts_upstream_of_or_within ISO (MGI:2386520|PMID:12065591) MGI PMID:12065591 MGI:2386520 NCBI chr15:17,705,966...17,716,743
Ensembl chr15:17,705,975...17,716,094
JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 acts_upstream_of
involved_in
ISO
IEA
(MGI:3578073|PMID:15858817) MGI
Ensembl
PMID:15858817 GO_REF:0000107 MGI:3578073 NCBI chr30:10,487,926...10,513,437
Ensembl chr30:10,487,921...10,513,397
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 involved_in ISO (PMID:16207722) UniProt PMID:16207722 NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295
JBrowse link
G PIDD1 p53-induced death domain protein 1 acts_upstream_of_or_within ISO (MGI:3603971|PMID:16183742) MGI PMID:16183742 MGI:3603971 NCBI chr18:45,168,244...45,174,085
Ensembl chr18:45,168,245...45,173,107
JBrowse link
G PML PML nuclear body scaffold acts_upstream_of_or_within ISO (MGI:1306978|PMID:9806545) MGI PMID:9806545 MGI:1306978 NCBI chr30:37,232,337...37,278,434
Ensembl chr30:37,232,306...37,277,741
JBrowse link
G PRDX2 peroxiredoxin 2 acts_upstream_of
involved_in
ISO
IEA
(MGI:3050700|PMID:15259009) MGI
Ensembl
PMID:15259009 GO_REF:0000107 MGI:3050700 NCBI chr20:49,352,271...49,356,755
Ensembl chr20:49,352,266...49,356,682
JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C acts_upstream_of ISO (MGI:80946|PMID:8666928) MGI PMID:8666928 MGI:80946 NCBI chr 7:4,155,876...4,282,151
Ensembl chr 7:4,137,728...4,282,124
JBrowse link
G RB1CC1 RB1 inducible coiled-coil 1 acts_upstream_of
involved_in
ISO
IEA
(MGI:3689241|PMID:17015619) MGI
Ensembl
PMID:17015619 GO_REF:0000107 MGI:3689241 NCBI chr29:4,445,668...4,544,223
Ensembl chr29:4,375,785...4,517,168
JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in ISO (PMID:10521396), (PMID:8612133)
(PMID:7538908)
BHF-UCL PMID:7538908 PMID:8612133 PMID:10521396 NCBI chr35:3,367,796...3,407,631
Ensembl chr35:3,263,226...3,405,883
JBrowse link
G RNF41 ring finger protein 41 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr10:512,650...521,293
Ensembl chr10:514,635...542,395
JBrowse link
G SFRP1 secreted frizzled related protein 1 acts_upstream_of ISO (MGI:3040721|PMID:14976225) MGI PMID:14976225 MGI:3040721 NCBI chr16:24,262,451...24,306,162
Ensembl chr16:24,261,946...24,302,964
JBrowse link
G SGPP1 sphingosine-1-phosphate phosphatase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2386810|PMID:12235122) Ensembl
MGI
PMID:12235122 GO_REF:0000107 MGI:2386810 NCBI chr 8:38,195,649...38,228,299
Ensembl chr 8:38,197,532...38,228,406
JBrowse link
G SIVA1 SIVA1 apoptosis inducing factor involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 8:72,309,400...72,313,726
Ensembl chr 8:72,309,447...72,313,640
JBrowse link
G SMAD3 SMAD family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:31,246,313...31,360,098
Ensembl chr30:31,245,657...31,363,337
JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in ISS BHF-UCL
AgBase
GO_REF:0000024 NCBI chr 1:112,629,476...112,643,885
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS
IEA
AgBase
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242
JBrowse link
G TLR3 toll like receptor 3 involved_in ISO (PMID:21737330) UniProt PMID:21737330 NCBI chr16:44,617,012...44,633,591
Ensembl chr16:44,550,846...44,653,247
JBrowse link
G TNF tumor necrosis factor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5521568|PMID:22089168)
(MGI:5510543|PMID:19498109)
MGI
Ensembl
PMID:19498109 PMID:22089168 GO_REF:0000107 MGI:5510543 MGI:5521568 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF12A TNF receptor superfamily member 12A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2667292|PMID:12821115) Ensembl
MGI
PMID:12821115 GO_REF:0000107 MGI:2667292 NCBI chr 6:38,166,160...38,168,189
Ensembl chr 6:38,166,160...38,168,189
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:69721|PMID:7990930)
(PMID:21873635)
MGI
Ensembl
GO_Central
PMID:7990930 PMID:21873635 GO_REF:0000107 MGI:69721 NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191
JBrowse link
G TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 acts_upstream_of_or_within ISO (MGI:2667292|PMID:12821115) MGI PMID:12821115 MGI:2667292 NCBI chr 5:32,473,543...32,481,596
Ensembl chr 5:32,473,083...32,481,121
JBrowse link
G TRADD TNFRSF1A associated via death domain involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:5521568|PMID:22089168)
GO_Central
MGI
PMID:21873635 PMID:22089168 MGI:5521568 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963
JBrowse link
G WWOX WW domain containing oxidoreductase acts_upstream_of_or_within ISO (MGI:3851310|PMID:19366691) MGI PMID:19366691 MGI:3851310 NCBI chr 5:72,298,254...73,243,667
Ensembl chr 5:72,299,157...73,261,406
JBrowse link
G YAP1 Yes1 associated transcriptional regulator acts_upstream_of ISO (MGI:3818355|PMID:17980593) MGI PMID:17980593 MGI:3818355 NCBI chr 5:29,394,760...29,495,977
Ensembl chr 5:29,394,541...29,496,251
JBrowse link
G ZNF274 zinc finger protein 274 acts_upstream_of_or_within ISO (MGI:1929440|PMID:10545116) MGI PMID:10545116 MGI:1929440 NCBI chr 1:99,696,295...99,719,559
Ensembl chr 1:99,697,185...99,719,455
JBrowse link
extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAD BCL2 associated agonist of cell death involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3032484|PMID:14967141)
(MGI:3029504|PMID:12431371)
(MGI:2183839|PMID:12115603), (MGI:2675215|PMID:12944463)
Ensembl
Ensembl
MGI
PMID:12115603 PMID:12431371 PMID:12944463 PMID:14967141 GO_REF:0000107 MGI:2183839 MGI:2675215 MGI:3029504 MGI:3032484 NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405
JBrowse link
G BAG3 BAG cochaperone 3 acts_upstream_of_or_within ISO (MGI:3513163|PMID:11527400) MGI PMID:11527400 MGI:3513163 NCBI chr28:29,792,612...29,815,466
Ensembl chr28:29,792,777...29,815,138
JBrowse link
G BAK1 BCL2 antagonist/killer 1 acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:3581932|PMID:15967824)
(PMID:21873635)
(MGI:3575206|PMID:15680329)
MGI
Ensembl
GO_Central
PMID:15680329 PMID:15967824 PMID:21873635 GO_REF:0000107 MGI:3575206 MGI:3581932 NCBI chr12:2,950,359...2,957,604
Ensembl chr12:2,948,364...2,957,018
JBrowse link
G BAX BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3581932|PMID:15967824)
(MGI:3575206|PMID:15680329)
MGI
Ensembl
PMID:15680329 PMID:15967824 GO_REF:0000107 MGI:3575206 MGI:3581932 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BCL2 BCL2 apoptosis regulator involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:2179928|PMID:12082633)
GO_Central
Ensembl
GO_Central
MGI
PMID:12082633 PMID:21873635 GO_REF:0000107 MGI:2179928 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G BCL2A1 BCL2 related protein A1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:57,451,512...57,463,692
Ensembl chr 3:57,424,555...57,463,692
JBrowse link
G BCL2L1 BCL2 like 1 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:2183839|PMID:12115603)
GO_Central
Ensembl
GO_Central
MGI
PMID:12115603 PMID:21873635 GO_REF:0000107 MGI:2183839 NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355
JBrowse link
G BCL2L11 BCL2 like 11 acts_upstream_of_or_within ISO (MGI:3581932|PMID:15967824) MGI PMID:15967824 MGI:3581932 NCBI chr17:35,619,804...35,665,782
Ensembl chr17:35,619,582...35,664,587
JBrowse link
G BCL2L2 BCL2 like 2 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2183839|PMID:12115603)
GO_Central
GO_Central
MGI
PMID:12115603 PMID:21873635 MGI:2183839 NCBI chr 8:3,569,335...3,573,922
Ensembl chr 8:3,569,399...3,586,070
JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr25:51,449,700...51,450,967 JBrowse link
G CASP2 caspase 2 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:3691999|PMID:11536012)
GO_Central
Ensembl
MGI
PMID:11536012 PMID:21873635 GO_REF:0000107 MGI:3691999 NCBI chr16:6,378,447...6,396,251
Ensembl chr16:6,379,913...6,396,646
JBrowse link
G COL2A1 collagen type II alpha 1 chain acts_upstream_of
involved_in
ISO
IEA
(MGI:1097047|PMID:9299161) MGI
Ensembl
PMID:9299161 GO_REF:0000107 MGI:1097047 NCBI chr27:6,756,994...6,787,733
Ensembl chr27:6,756,994...6,787,733
JBrowse link
G CTNNA1 catenin alpha 1 acts_upstream_of
involved_in
ISO
IEA
(MGI:5315030|PMID:22411810) MGI
Ensembl
PMID:22411810 GO_REF:0000107 MGI:5315030 NCBI chr11:26,273,322...26,459,497
Ensembl chr11:26,143,013...26,459,091
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 acts_upstream_of
involved_in
ISO
IEA
(MGI:3777228|PMID:18322241), (MGI:3833195|PMID:18971423) MGI
Ensembl
PMID:18322241 PMID:18971423 GO_REF:0000107 MGI:3777228 MGI:3833195 NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 involved_in ISO (PMID:17701904) BHF-UCL PMID:17701904 NCBI chr10:406,856...424,746
Ensembl chr10:406,633...424,264
JBrowse link
G EYA1 EYA transcriptional coactivator and phosphatase 1 acts_upstream_of ISO (MGI:3577160|PMID:15817220) MGI PMID:15817220 MGI:3577160 NCBI chr29:20,176,306...20,595,131
Ensembl chr29:20,177,014...20,525,653
JBrowse link
G EYA2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (MGI:2158099|PMID:11700312) MGI PMID:11700312 MGI:2158099 NCBI chr24:34,126,086...34,308,412
Ensembl chr24:34,082,197...34,308,423
JBrowse link
G FADD Fas associated via death domain acts_upstream_of_or_within ISO (MGI:2675560|PMID:13679421) MGI PMID:13679421 MGI:2675560 NCBI chr18:48,087,447...48,094,497 JBrowse link
G FAS Fas cell surface death receptor involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2675560|PMID:13679421)
GO_Central
MGI
PMID:13679421 PMID:21873635 MGI:2675560 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
JBrowse link
G FGF10 fibroblast growth factor 10 acts_upstream_of
involved_in
ISO
IEA
(MGI:3690587|PMID:16956603) MGI
Ensembl
PMID:16956603 GO_REF:0000107 MGI:3690587 NCBI chr 4:65,851,130...65,930,944
Ensembl chr 4:65,851,069...65,928,192
JBrowse link
G FOXO3 forkhead box O3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3029504|PMID:12431371) Ensembl
Ensembl
MGI
PMID:12431371 GO_REF:0000107 MGI:3029504 NCBI chr12:65,552,455...65,673,467
Ensembl chr12:65,552,310...65,670,198
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 1:112,129,116...112,138,714
Ensembl chr 1:112,103,825...112,138,559
JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666
JBrowse link
G IGF1 insulin like growth factor 1 acts_upstream_of_or_within ISO (MGI:3029504|PMID:12431371) MGI PMID:12431371 MGI:3029504 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794
JBrowse link
G IL1A interleukin 1 alpha involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3691999|PMID:11536012) Ensembl
MGI
PMID:11536012 GO_REF:0000107 MGI:3691999 NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435
JBrowse link
G IL1B interleukin 1 beta acts_upstream_of_or_within ISO (MGI:3691999|PMID:11536012) MGI PMID:11536012 MGI:3691999 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
JBrowse link
G IL2 interleukin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2179928|PMID:12082633) Ensembl
Ensembl
MGI
PMID:12082633 GO_REF:0000107 MGI:2179928 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394
JBrowse link
G IL3 interleukin 3 acts_upstream_of_or_within ISO (MGI:2387238|PMID:12124386), (MGI:2675215|PMID:12944463), (MGI:3032484|PMID:14967141), (MGI:3057092|PMID:15231831), (MGI:3513163|PMID:11527400), (MGI:3575206|PMID:15680329) MGI PMID:11527400 PMID:12124386 PMID:12944463 PMID:14967141 PMID:15231831 More... MGI:2387238 MGI:2675215 MGI:3032484 MGI:3057092 MGI:3513163 MGI:3575206 NCBI chr11:20,330,480...20,332,668
Ensembl chr11:20,330,480...20,332,668
JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2183839|PMID:12115603)
GO_Central
GO_Central
MGI
PMID:12115603 PMID:21873635 MGI:2183839 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
JBrowse link
G ITGAV integrin subunit alpha V involved_in ISO (MGI:3530680|PMID:15591537) BHF-UCL PMID:15591537 MGI:3530680 NCBI chr36:28,815,215...28,890,569
Ensembl chr36:28,804,013...28,887,430
JBrowse link
G ITM2B integral membrane protein 2B acts_upstream_of_or_within ISO (MGI:2179928|PMID:12082633) MGI PMID:12082633 MGI:2179928 NCBI chr22:3,255,139...3,261,440
Ensembl chr22:3,255,631...3,261,433
JBrowse link
G KITLG KIT ligand acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3038547|PMID:15039234) MGI
Ensembl
Ensembl
PMID:15039234 GO_REF:0000107 MGI:3038547 NCBI chr15:29,591,068...29,671,985
Ensembl chr15:29,591,170...29,671,974
JBrowse link
G LCN2 lipocalin 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4821076|PMID:16377569) MGI
Ensembl
PMID:16377569 GO_REF:0000107 MGI:4821076 NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member involved_in IEA
IBA
ISS
(PMID:21873635) Ensembl
GO_Central
Ensembl
UniProt
UniProt
GO_Central
PMID:21873635 GO_REF:0000024 GO_REF:0000107 NCBI chr17:59,759,605...59,763,111
Ensembl chr17:59,759,605...59,763,111
JBrowse link
G MKNK1 MAPK interacting serine/threonine kinase 1 acts_upstream_of_or_within ISO (MGI:3793518|PMID:17903173) MGI PMID:17903173 MGI:3793518 NCBI chr15:13,857,495...13,898,709
Ensembl chr15:13,857,553...13,898,723
JBrowse link
G MKNK2 MAPK interacting serine/threonine kinase 2 acts_upstream_of_or_within ISO (MGI:3793518|PMID:17903173) MGI PMID:17903173 MGI:3793518 NCBI chr20:56,966,656...56,978,414
Ensembl chr20:56,965,800...56,974,073
JBrowse link
G MOAP1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) BHF-UCL PMID:16199525
G NF1 neurofibromin 1 acts_upstream_of ISO (MGI:3038547|PMID:15039234) MGI PMID:15039234 MGI:3038547 NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382
JBrowse link
G NGF nerve growth factor acts_upstream_of_or_within ISO (MGI:2681362|PMID:14623868) MGI PMID:14623868 MGI:2681362 NCBI chr17:52,900,647...52,901,607
Ensembl chr17:52,900,647...52,901,607
JBrowse link
G TGFB2 transforming growth factor beta 2 acts_upstream_of ISO (MGI:67124|PMID:8206089) MGI PMID:8206089 MGI:67124 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242
JBrowse link
extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAD BCL2 associated agonist of cell death involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3029504|PMID:12431371) Ensembl
Ensembl
MGI
PMID:12431371 GO_REF:0000107 MGI:3029504 NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405
JBrowse link
G BAG3 BAG cochaperone 3 acts_upstream_of_or_within ISO (PMID:10597216) MGI PMID:10597216 NCBI chr28:29,792,612...29,815,466
Ensembl chr28:29,792,777...29,815,138
JBrowse link
G BAX BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1349210|PMID:10597216) MGI
Ensembl
PMID:10597216 GO_REF:0000107 MGI:1349210 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BCL2 BCL2 apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:10597216) MGI
Ensembl
PMID:10597216 GO_REF:0000107 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G BEX3 brain expressed X-linked 3 acts_upstream_of_or_within ISO (MGI:1859527|PMID:10764727) MGI PMID:10764727 MGI:1859527 NCBI chr  X:76,754,209...76,755,843
Ensembl chr  X:76,755,256...76,755,594
JBrowse link
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr28:13,040,016...13,044,364
Ensembl chr28:13,040,573...13,044,323
JBrowse link
G CASP8 caspase 8 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3054336|PMID:15322156)
GO_Central
MGI
GO_Central
PMID:15322156 PMID:21873635 MGI:3054336 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G CASP8AP2 caspase 8 associated protein 2 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:1347587|PMID:10235259)
(PMID:21873635)
MGI
GO_Central
PMID:10235259 PMID:21873635 MGI:1347587 NCBI chr12:49,040,069...49,077,418
Ensembl chr12:49,039,411...49,077,688
JBrowse link
G DAB2IP DAB2 interacting protein involved_in ISO (PMID:19903888) BHF-UCL PMID:19903888 NCBI chr 9:60,725,887...60,918,242
Ensembl chr 9:60,726,809...60,918,139
JBrowse link
G DAPK1 death associated protein kinase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4431305|PMID:20053891)
(MGI:3051747|PMID:15010850)
MGI
Ensembl
Ensembl
PMID:15010850 PMID:20053891 GO_REF:0000107 MGI:3051747 MGI:4431305 NCBI chr 1:72,278,939...72,448,907
Ensembl chr 1:72,280,103...72,447,822
JBrowse link
G DAXX death domain associated protein involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in ISO (PMID:18846110) UniProt PMID:18846110 NCBI chr  X:35,759,367...35,789,759
Ensembl chr  X:35,759,416...35,789,774
JBrowse link
G DDX47 DEAD-box helicase 47 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:33,509,959...33,525,496
Ensembl chr27:33,509,958...33,525,516
JBrowse link
G DEDD death effector domain containing acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:1306907|PMID:9774341)
(PMID:21873635)
MGI
Ensembl
GO_Central
PMID:9774341 PMID:21873635 GO_REF:0000107 MGI:1306907 NCBI chr38:21,341,101...21,351,665
Ensembl chr38:21,342,534...21,351,972
JBrowse link
G DEDD2 death effector domain containing 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:112,148,146...112,164,473
Ensembl chr 1:112,148,925...112,163,770
JBrowse link
G DELE1 DAP3 binding cell death enhancer 1 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 2:36,865,275...36,880,304
Ensembl chr 2:36,865,289...36,879,840
JBrowse link
G FADD Fas associated via death domain involved_in ISO (PMID:24025841) UniProt PMID:24025841 NCBI chr18:48,087,447...48,094,497 JBrowse link
G FAS Fas cell surface death receptor involved_in
acts_upstream_of_or_within
ISO (MGI:5009197|PMID:10950869)
(MGI:2687085|PMID:12801066), (MGI:3029504|PMID:12431371), (MGI:77677|PMID:8524870)
(MGI:3029504|PMID:12431371)
(MGI:1340173|PMID:10429671)
(MGI:2687085|PMID:12801066), (MGI:3038547|PMID:15039234), (MGI:3576402|PMID:15632112), (MGI:3687663|PMID:10588860), (MGI:3819026|PMID:18363966), (MGI:77677|PMID:8524870)
BHF-UCL
MGI
PMID:8524870 PMID:10429671 PMID:10588860 PMID:10950869 PMID:12431371 More... MGI:1340173 MGI:2687085 MGI:3029504 MGI:3038547 MGI:3576402 MGI:3687663 MGI:3819026 MGI:5009197 MGI:77677 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
JBrowse link
G FASLG Fas ligand involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(PMID:26582200)
(MGI:3038547|PMID:15039234), (MGI:3687663|PMID:10588860)
GO_Central
Ensembl
GO_Central
MGI
RGD
PMID:10588860 PMID:15039234 PMID:16689665 PMID:21873635 PMID:26582200 GO_REF:0000107 MGI:3038547 MGI:3687663 RGD:1582444 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224
JBrowse link
G GABARAP GABA type A receptor-associated protein involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 5:32,207,879...32,209,976
Ensembl chr 5:32,207,887...32,209,908
JBrowse link
G HMGB2 high mobility group box 2 acts_upstream_of
involved_in
ISO
IEA
(MGI:3831045|PMID:19139395) MGI
Ensembl
PMID:19139395 GO_REF:0000107 MGI:3831045 NCBI chr25:23,939,024...23,941,720
Ensembl chr25:23,939,027...23,941,606
JBrowse link
G IL18 interleukin 18 involved_in IEP (PMID:11131641) UniProt
UniProt
PMID:11131641 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
JBrowse link
G ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein acts_upstream_of ISO (MGI:4431305|PMID:20053891) MGI PMID:20053891 MGI:4431305 NCBI chr28:16,613,934...16,638,058 JBrowse link
G MOAP1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) BHF-UCL PMID:16199525
G NF1 neurofibromin 1 acts_upstream_of_or_within ISO (MGI:3038547|PMID:15039234) MGI PMID:15039234 MGI:3038547 NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382
JBrowse link
G NGF nerve growth factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:52,900,647...52,901,607
Ensembl chr17:52,900,647...52,901,607
JBrowse link
G PIDD1 p53-induced death domain protein 1 acts_upstream_of_or_within ISO (MGI:3603971|PMID:16183742) MGI PMID:16183742 MGI:3603971 NCBI chr18:45,168,244...45,174,085
Ensembl chr18:45,168,245...45,173,107
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3038547|PMID:15039234) Ensembl
Ensembl
MGI
PMID:15039234 GO_REF:0000107 MGI:3038547 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase acts_upstream_of
involved_in
ISO
IEA
(MGI:3612236|PMID:16365167) MGI
Ensembl
PMID:16365167 GO_REF:0000107 MGI:3612236 NCBI chr20:5,892,839...5,972,672
Ensembl chr20:5,892,834...5,972,090
JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 acts_upstream_of_or_within ISO (MGI:3612236|PMID:16365167) MGI PMID:16365167 MGI:3612236 NCBI chr17:7,931,786...8,012,484
Ensembl chr17:7,934,739...8,178,707
JBrowse link
G SKIL SKI like proto-oncogene acts_upstream_of
involved_in
ISO
IEA
(MGI:1858539|PMID:10811619) MGI
Ensembl
PMID:10811619 GO_REF:0000107 MGI:1858539 NCBI chr34:34,871,770...34,898,681
Ensembl chr34:34,871,574...34,894,854
JBrowse link
G SORT1 sortilin 1 involved_in ISO (PMID:14985763) BHF-UCL PMID:14985763 NCBI chr 6:42,454,091...42,521,251
Ensembl chr 6:42,453,942...42,516,740
JBrowse link
G STK3 serine/threonine kinase 3 acts_upstream_of
involved_in
ISO
IEA
(MGI:4420852|PMID:20080598) MGI
Ensembl
PMID:20080598 GO_REF:0000107 MGI:4420852 NCBI chr13:647,363...920,887
Ensembl chr13:648,216...920,847
JBrowse link
G STK4 serine/threonine kinase 4 acts_upstream_of
involved_in
ISO
IEA
(MGI:4420852|PMID:20080598) MGI
Ensembl
PMID:20080598 GO_REF:0000107 MGI:4420852 NCBI chr24:32,375,630...32,463,848
Ensembl chr24:32,375,189...32,521,042
JBrowse link
G TNF tumor necrosis factor involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
(PMID:21873635)
(MGI:4420852|PMID:20080598)
(MGI:3029504|PMID:12431371)
GO_Central
MGI
GO_Central
Ensembl
PMID:12431371 PMID:20080598 PMID:21873635 GO_REF:0000107 MGI:3029504 MGI:4420852 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
fibroblast growth factor receptor apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGFR3 fibroblast growth factor receptor 3 involved_in ISO (PMID:17561467) UniProt PMID:17561467 NCBI chr 3:62,309,128...62,318,932
Ensembl chr 3:62,303,756...62,323,896
JBrowse link
granzyme-mediated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UBE4B ubiquitination factor E4B involved_in ISO (PMID:11802788) UniProt PMID:11802788 NCBI chr 5:63,214,846...63,339,218
Ensembl chr 5:63,215,470...63,338,215
JBrowse link
hormone-mediated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone ISO RGD PMID:11790788 RGD:1358682 NCBI chr29:15,831,944...15,840,560
Ensembl chr29:15,831,944...15,834,384
JBrowse link
G ESR2 estrogen receptor 2 acts_upstream_of_or_within ISO (MGI:3047056|PMID:15187231) MGI PMID:15187231 MGI:3047056 NCBI chr 8:38,645,917...38,715,347
Ensembl chr 8:38,645,430...38,702,691
JBrowse link
G METTL21C methyltransferase 21C, AARS1 lysine acts_upstream_of_or_within ISO (MGI:5781029|PMID:24677265) MGI PMID:24677265 MGI:5781029 NCBI chr22:52,181,222...52,194,859
Ensembl chr22:52,182,115...52,190,163
JBrowse link
intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAD BCL2 associated agonist of cell death involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405
JBrowse link
G BAX BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of
ISS
IEA
ISO
(MGI:3692043|PMID:14502238) HGNC-UCL
Ensembl
MGI
PMID:14502238 GO_REF:0000024 GO_REF:0000107 MGI:3692043 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BBC3 BCL2 binding component 3 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 1:108,742,793...108,750,832
Ensembl chr 1:108,741,713...108,749,946
JBrowse link
G BNIP3 BCL2 interacting protein 3 acts_upstream_of_or_within ISO (MGI:3696331|PMID:16954213) MGI PMID:16954213 MGI:3696331 NCBI chr28:40,037,681...40,050,499
Ensembl chr28:40,038,643...40,049,797
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase acts_upstream_of ISO (MGI:3790365|PMID:17938250) MGI PMID:17938250 MGI:3790365 NCBI chr17:35,208,989...35,252,296
Ensembl chr17:35,208,991...35,252,975
JBrowse link
G CASP12 caspase 12 involved_in ISO PMID:10638761 ParkinsonsUK-UCL PMID:10638761 RGD:10047306 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
JBrowse link
G CASP4 caspase 4, apoptosis-related cysteine peptidase involved_in ISO (PMID:15123740) ParkinsonsUK-UCL PMID:15123740 NCBI chr 5:27,133,778...27,147,954
Ensembl chr 5:27,132,565...27,149,736
JBrowse link
G CLU clusterin involved_in ISS UniProt
UniProt
GO_REF:0000024 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563
JBrowse link
G COA8 cytochrome c oxidase assembly factor 8 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3694393|PMID:16782708) MGI
InterPro
InterPro
PMID:16782708 GO_REF:0000002 MGI:3694393 NCBI chr 8:71,324,271...71,357,468
Ensembl chr 8:71,318,244...71,357,466
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in ISO (PMID:16301996) UniProt PMID:16301996 NCBI chr  X:35,759,367...35,789,759
Ensembl chr  X:35,759,416...35,789,774
JBrowse link
G FLCN folliculin acts_upstream_of ISO (MGI:5050037|PMID:21258407) MGI PMID:21258407 MGI:5050037 NCBI chr 5:42,176,093...42,195,718
Ensembl chr 5:42,176,291...42,195,711
JBrowse link
G HRAS HRas proto-oncogene, GTPase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3696331|PMID:16954213) MGI
Ensembl
PMID:16954213 GO_REF:0000107 MGI:3696331 NCBI chr18:25,642,844...25,644,717
Ensembl chr18:25,642,844...25,644,717
JBrowse link
G HSF4 heat shock transcription factor 4 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 5:82,190,996...82,201,224
Ensembl chr 5:82,196,500...82,201,151
Ensembl chr 5:82,196,500...82,201,151
JBrowse link
G HTRA2 HtrA serine peptidase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3511636|PMID:15509788) MGI
Ensembl
PMID:15509788 GO_REF:0000107 MGI:3511636 NCBI chr17:48,610,408...48,613,399
Ensembl chr17:48,610,408...48,613,399
JBrowse link
G IFI6 interferon alpha inducible protein 6 involved_in ISO (PMID:26244642) UniProt PMID:26244642 NCBI chr 2:72,638,657...72,642,648
Ensembl chr 2:72,638,705...72,642,648
JBrowse link
G LGALS12 galectin 12 acts_upstream_of_or_within
involved_in
ISO
IBA
(PMID:11435439)
(PMID:21873635)
MGI
GO_Central
PMID:11435439 PMID:21873635 NCBI chr18:53,428,894...53,446,767
Ensembl chr18:53,437,562...53,447,013
JBrowse link
G LOC480043 influenza virus NS1A binding protein acts_upstream_of ISO (MGI:4819697|PMID:15485691) MGI PMID:15485691 MGI:4819697 NCBI chr 7:18,430,970...18,444,573
Ensembl chr 7:18,431,553...18,444,573
JBrowse link
G MLLT11 MLLT11 transcription factor 7 cofactor involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr17:60,142,411...60,153,650
Ensembl chr17:60,152,378...60,152,650
JBrowse link
G MSH6 mutS homolog 6 acts_upstream_of_or_within ISO (MGI:2677657|PMID:14632208) MGI PMID:14632208 MGI:2677657 NCBI chr10:49,825,330...49,838,036
Ensembl chr10:49,803,898...49,838,028
JBrowse link
G NBN nibrin acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3805397|PMID:18614044) MGI
Ensembl
PMID:18614044 GO_REF:0000107 MGI:3805397 NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563
JBrowse link
G PLSCR1 phospholipid scramblase 1 involved_in ISO (MGI:5315351|PMID:15863367) UniProt PMID:15863367 MGI:5315351 NCBI chr23:41,639,938...41,668,972
Ensembl chr23:41,599,843...41,669,112
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:16,469,793...16,472,910
Ensembl chr 1:16,469,793...16,472,910
JBrowse link
G PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F involved_in ISS UniProt GO_REF:0000024 NCBI chr26:31,162,810...31,193,586
Ensembl chr26:31,166,593...31,193,587
JBrowse link
G PRKCA protein kinase C alpha acts_upstream_of_or_within ISO (MGI:2671671|PMID:12928424) MGI PMID:12928424 MGI:2671671 NCBI chr 9:13,638,106...13,879,571
Ensembl chr 9:13,644,010...13,967,630
JBrowse link
G SGPP1 sphingosine-1-phosphate phosphatase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1932564|PMID:10859351) Ensembl
MGI
PMID:10859351 GO_REF:0000107 MGI:1932564 NCBI chr 8:38,195,649...38,228,299
Ensembl chr 8:38,197,532...38,228,406
JBrowse link
G SIRT1 sirtuin 1 involved_in ISO (PMID:23313858) AgBase PMID:23313858 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
G SIVA1 SIVA1 apoptosis inducing factor NOT|involved_in ISO (PMID:12011449) BHF-UCL PMID:12011449 NCBI chr 8:72,309,400...72,313,726
Ensembl chr 8:72,309,447...72,313,640
JBrowse link
intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1344924|PMID:10479688) MGI
Ensembl
PMID:10479688 GO_REF:0000107 MGI:1344924 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in ISO (PMID:15102863) UniProt PMID:15102863 NCBI chr25:51,449,700...51,450,967 JBrowse link
G CASP6 caspase 6 involved_in ISO (PMID:22858542) UniProt PMID:22858542 NCBI chr32:29,897,706...29,910,522
Ensembl chr32:29,897,823...29,911,469
JBrowse link
G CEP63 centrosomal protein 63 acts_upstream_of ISO (MGI:5662131|PMID:26158450) MGI PMID:26158450 MGI:5662131 NCBI chr23:31,249,517...31,303,145
Ensembl chr23:31,249,673...31,303,142
JBrowse link
G DDX5 DEAD-box helicase 5 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:12,300,706...12,307,931
Ensembl chr 9:12,300,708...12,307,663
JBrowse link
G E2F2 E2F transcription factor 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1927703|PMID:11095619) MGI
Ensembl
PMID:11095619 GO_REF:0000107 MGI:1927703 NCBI chr 2:75,901,009...75,923,406
Ensembl chr 2:75,901,058...75,923,255
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr20:29,735,380...31,113,859
Ensembl chr20:30,356,572...31,113,859
JBrowse link
G HINT1 histidine triad nucleotide binding protein 1 involved_in ISO (PMID:16835243) UniProt PMID:16835243 NCBI chr11:19,551,057...19,555,390 JBrowse link
G JMY junction mediating and regulatory protein, p53 cofactor acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:1891484|PMID:10518217)
(PMID:21873635)
MGI
GO_Central
PMID:10518217 PMID:21873635 MGI:1891484 NCBI chr 3:27,545,682...27,646,449
Ensembl chr 3:27,544,132...27,646,814
JBrowse link
G LOC488622 myeloid cell nuclear differentiation antigen involved_in ISO (PMID:21573174) UniProt PMID:21573174 NCBI chr38:22,874,345...22,892,362 JBrowse link
G MYBBP1A MYB binding protein 1a involved_in ISO (PMID:21471221) UniProt PMID:21471221 NCBI chr 5:30,528,141...30,538,815
Ensembl chr 5:30,526,720...30,539,483
JBrowse link
G NECAB3 N-terminal EF-hand calcium binding protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1927703|PMID:11095619) Ensembl
MGI
PMID:11095619 GO_REF:0000107 MGI:1927703 NCBI chr24:22,895,149...22,904,689
Ensembl chr24:22,878,402...22,904,656
JBrowse link
G PDK2 pyruvate dehydrogenase kinase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:26,099,457...26,116,094
Ensembl chr 9:26,100,343...26,115,423
JBrowse link
G PERP p53 apoptosis effector related to PMP22 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1929912|PMID:10733530) Ensembl
Ensembl
MGI
PMID:10733530 GO_REF:0000107 MGI:1929912 NCBI chr 1:30,418,847...30,435,287
Ensembl chr 1:30,419,963...30,435,859
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:16,469,793...16,472,910
Ensembl chr 1:16,469,793...16,472,910
JBrowse link
G PML PML nuclear body scaffold acts_upstream_of_or_within ISO (MGI:3034149|PMID:14992722) MGI PMID:14992722 MGI:3034149 NCBI chr30:37,232,337...37,278,434
Ensembl chr30:37,232,306...37,277,741
JBrowse link
G POU4F1 POU class 4 homeobox 1 involved_in ISO (MGI:5825431|PMID:17145718) UniProt PMID:17145718 MGI:5825431 NCBI chr22:31,992,657...31,997,066 JBrowse link
G POU4F2 POU class 4 homeobox 2 involved_in ISO (MGI:5825431|PMID:17145718) UniProt PMID:17145718 MGI:5825431 NCBI chr15:45,030,818...45,034,446
Ensembl chr15:45,031,094...45,032,784
JBrowse link
G PPP1R13B protein phosphatase 1 regulatory subunit 13B involved_in ISO (PMID:11684014) UniProt PMID:11684014 NCBI chr 8:71,462,338...71,518,918
Ensembl chr 8:71,463,270...71,553,692
JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240
JBrowse link
G RRN3 RRN3 homolog, RNA polymerase I transcription factor acts_upstream_of
involved_in
ISO
IEA
(MGI:3583493|PMID:15989966) MGI
Ensembl
PMID:15989966 GO_REF:0000107 MGI:3583493 NCBI chr 6:28,478,770...28,507,722
Ensembl chr 6:28,478,829...28,507,696
JBrowse link
G RRP8 ribosomal RNA processing 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:29,907,555...29,917,142
Ensembl chr21:29,907,361...29,918,408
JBrowse link
G SHISA5 shisa family member 5 acts_upstream_of_or_within ISO (MGI:2183272|PMID:12135983) MGI PMID:12135983 MGI:2183272 NCBI chr20:40,604,183...40,624,607
Ensembl chr20:40,601,626...40,623,601
JBrowse link
G STK11 serine/threonine kinase 11 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr20:57,558,966...57,579,163
Ensembl chr20:57,559,424...57,579,118
JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4454200|PMID:20434500)
(MGI:2183272|PMID:12135983), (MGI:3589512|PMID:16107883)
MGI
Ensembl
PMID:12135983 PMID:16107883 PMID:20434500 GO_REF:0000107 MGI:2183272 MGI:3589512 MGI:4454200 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
G TP53BP2 tumor protein p53 binding protein 2 involved_in ISO (PMID:11684014) UniProt PMID:11684014 NCBI chr 7:40,296,278...40,329,818
Ensembl chr 7:40,252,697...40,329,828
JBrowse link
G WWOX WW domain containing oxidoreductase acts_upstream_of_or_within ISO (MGI:1930321|PMID:11058590) MGI PMID:11058590 MGI:1930321 NCBI chr 5:72,298,254...73,243,667
Ensembl chr 5:72,299,157...73,261,406
JBrowse link
G ZNF385B zinc finger protein 385B involved_in ISO (PMID:22945289) UniProt PMID:22945289 NCBI chr36:22,900,669...23,248,779
Ensembl chr36:22,918,832...23,203,215
JBrowse link
intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 acts_upstream_of_or_within ISO (MGI:3584078|PMID:15983387) MGI PMID:15983387 MGI:3584078 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629
JBrowse link
G ATM ATM serine/threonine kinase acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:3714678|PMID:17476307)
(PMID:21873635)
(MGI:1926715|PMID:11040211), (MGI:3652689|PMID:16777961)
MGI
GO_Central
PMID:11040211 PMID:16777961 PMID:17476307 PMID:21873635 MGI:1926715 MGI:3652689 MGI:3714678 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207
JBrowse link
G BAD BCL2 associated agonist of cell death involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3057092|PMID:15231831)
(MGI:3029504|PMID:12431371)
Ensembl
Ensembl
MGI
PMID:12431371 PMID:15231831 GO_REF:0000107 MGI:3029504 MGI:3057092 NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405
JBrowse link
G BAK1 BCL2 antagonist/killer 1 acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:3689797|PMID:15901672)
(PMID:21873635)
(MGI:3581932|PMID:15967824)
MGI
Ensembl
GO_Central
PMID:15901672 PMID:15967824 PMID:21873635 GO_REF:0000107 MGI:3581932 MGI:3689797 NCBI chr12:2,950,359...2,957,604
Ensembl chr12:2,948,364...2,957,018
JBrowse link
G BAX BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3689797|PMID:15901672)
(MGI:2675761|PMID:12952892)
(MGI:3581932|PMID:15967824)
MGI
Ensembl
PMID:12952892 PMID:15901672 PMID:15967824 GO_REF:0000107 MGI:2675761 MGI:3581932 MGI:3689797 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BCL2 BCL2 apoptosis regulator involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:3584078|PMID:15983387)
GO_Central
Ensembl
GO_Central
MGI
PMID:15983387 PMID:21873635 GO_REF:0000107 MGI:3584078 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G BCL2A1 BCL2 related protein A1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:57,451,512...57,463,692
Ensembl chr 3:57,424,555...57,463,692
JBrowse link
G BCL2L1 BCL2 like 1 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:2677658|PMID:14517295)
GO_Central
Ensembl
GO_Central
MGI
PMID:14517295 PMID:21873635 GO_REF:0000107 MGI:2677658 NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355
JBrowse link
G BCL2L11 BCL2 like 11 acts_upstream_of_or_within ISO (PMID:11546872)
(MGI:3581932|PMID:15967824)
MGI PMID:11546872 PMID:15967824 MGI:3581932 NCBI chr17:35,619,804...35,665,782
Ensembl chr17:35,619,582...35,664,587
JBrowse link
G BCL2L2 BCL2 like 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 8:3,569,335...3,573,922
Ensembl chr 8:3,569,399...3,586,070
JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr25:51,449,700...51,450,967 JBrowse link
G BRCA1 BRCA1 DNA repair associated acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:14654789) MGI
Ensembl
Ensembl
PMID:14654789 GO_REF:0000107 NCBI chr 9:19,958,941...20,025,494
Ensembl chr 9:19,958,391...20,025,494
JBrowse link
G BRCA2 BRCA2 DNA repair associated acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3714678|PMID:17476307) MGI
Ensembl
PMID:17476307 GO_REF:0000107 MGI:3714678 NCBI chr25:7,734,450...7,797,851
Ensembl chr25:7,734,453...7,797,815
JBrowse link
G CASP2 caspase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:6,378,447...6,396,251
Ensembl chr16:6,379,913...6,396,646
JBrowse link
G CASP9 caspase 9 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484
JBrowse link
G CHEK2 checkpoint kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:22,052,256...22,145,675
Ensembl chr26:21,427,961...22,240,624
JBrowse link
G CRIP1 cysteine rich protein 1 involved_in ISS
IEA
IBA
(PMID:21873635) UniProt
Ensembl
GO_Central
PMID:21873635 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:72,784,726...72,786,108
Ensembl chr 8:72,784,788...72,786,108
JBrowse link
G EI24 EI24 autophagy associated transmembrane protein acts_upstream_of_or_within ISO (MGI:1350723|PMID:10594026) MGI PMID:10594026 MGI:1350723 NCBI chr 5:8,949,886...8,963,967
Ensembl chr 5:8,950,883...8,963,967
JBrowse link
G EPHA2 EPH receptor A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:81,534,130...81,561,722
Ensembl chr 2:81,534,125...81,561,725
JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1913261|PMID:11005836) Ensembl
Ensembl
MGI
PMID:11005836 GO_REF:0000107 MGI:1913261 NCBI chr28:1,358,383...1,432,276
Ensembl chr28:1,361,107...1,427,162
JBrowse link
G FNIP2 folliculin interacting protein 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr15:55,871,782...55,962,676
Ensembl chr15:55,830,806...55,959,052
JBrowse link
G HIC1 HIC ZBTB transcriptional repressor 1 involved_in IEA Ensembl
Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 NCBI chr 9:46,156,909...46,162,849
Ensembl chr 9:46,159,136...46,162,004
JBrowse link
G HMOX1 heme oxygenase 1 ISO RGD PMID:11854317 RGD:625692 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773
JBrowse link
G HTRA2 HtrA serine peptidase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr17:48,610,408...48,613,399
Ensembl chr17:48,610,408...48,613,399
JBrowse link
G IER3 immediate early response 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3775338|PMID:11753682) MGI
Ensembl
PMID:11753682 GO_REF:0000107 MGI:3775338 NCBI chr12:529,002...530,328
Ensembl chr12:529,339...530,232
JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:2,747,303...2,772,574
Ensembl chr38:2,747,297...2,772,587
JBrowse link
G MAEL maelstrom spermatogenic transposon silencer involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3813746|PMID:18694567) Ensembl
Ensembl
MGI
PMID:18694567 GO_REF:0000107 MGI:3813746 NCBI chr 7:31,364,111...31,394,675
Ensembl chr 7:31,364,293...31,409,435
JBrowse link
G MBD4 methyl-CpG binding domain 4, DNA glycosylase acts_upstream_of_or_within ISO (MGI:2678630|PMID:14562041) MGI PMID:14562041 MGI:2678630 NCBI chr20:5,716,162...5,725,068
Ensembl chr20:5,716,239...5,724,881
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:3689797|PMID:15901672)
GO_Central
GO_Central
Ensembl
MGI
Ensembl
PMID:15901672 PMID:21873635 GO_REF:0000107 MGI:3689797 NCBI chr17:59,759,605...59,763,111
Ensembl chr17:59,759,605...59,763,111
JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2678630|PMID:14562041) Ensembl
Ensembl
MGI
PMID:14562041 GO_REF:0000107 MGI:2678630 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116
JBrowse link
G MOAP1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) BHF-UCL PMID:16199525
G MSH2 mutS homolog 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3029112|PMID:14744764)
(MGI:1334080|PMID:10097137)
MGI
Ensembl
PMID:10097137 PMID:14744764 GO_REF:0000107 MGI:1334080 MGI:3029112 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
JBrowse link
G MSH6 mutS homolog 6 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:3053495|PMID:15324697)
(PMID:21873635)
MGI
GO_Central
PMID:15324697 PMID:21873635 MGI:3053495 NCBI chr10:49,825,330...49,838,036
Ensembl chr10:49,803,898...49,838,028
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor acts_upstream_of_or_within ISO (MGI:2677658|PMID:14517295) MGI PMID:14517295 MGI:2677658 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309
JBrowse link
G NECAB3 N-terminal EF-hand calcium binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:22,895,149...22,904,689
Ensembl chr24:22,878,402...22,904,656
JBrowse link
G NFATC4 nuclear factor of activated T cells 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3709926|PMID:17242187) MGI
Ensembl
PMID:17242187 GO_REF:0000107 MGI:3709926 NCBI chr 8:4,337,098...4,346,409
Ensembl chr 8:4,336,450...4,346,100
JBrowse link
G PCBP4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) UniProt PMID:10891498 NCBI chr20:37,748,854...37,759,072
Ensembl chr20:37,748,938...37,759,073
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3709926|PMID:17242187) Ensembl
Ensembl
MGI
PMID:17242187 GO_REF:0000107 MGI:3709926 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO (MGI:2675761|PMID:12952892) MGI PMID:12952892 MGI:2675761 NCBI chr 1:16,469,793...16,472,910
Ensembl chr 1:16,469,793...16,472,910
JBrowse link
G PML PML nuclear body scaffold acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:3580934|PMID:15626733)
(PMID:21873635)
(MGI:1306978|PMID:9806545)
MGI
GO_Central
PMID:9806545 PMID:15626733 PMID:21873635 MGI:1306978 MGI:3580934 NCBI chr30:37,232,337...37,278,434
Ensembl chr30:37,232,306...37,277,741
JBrowse link
G POLB DNA polymerase beta involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1334987|PMID:10197627) Ensembl
Ensembl
MGI
PMID:10197627 GO_REF:0000107 MGI:1334987 NCBI chr16:23,306,359...23,335,352
Ensembl chr16:23,306,367...23,335,322
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2450507|PMID:12604618)
GO_Central
GO_Central
MGI
PMID:12604618 PMID:21873635 MGI:2450507 NCBI chr29:24,904...243,926
Ensembl chr29:35,007...243,895
JBrowse link
G RAD9A RAD9 checkpoint clamp component A acts_upstream_of ISO (MGI:3584078|PMID:15983387) MGI PMID:15983387 MGI:3584078 NCBI chr18:50,065,154...50,070,582
Ensembl chr18:50,065,685...50,070,710
JBrowse link
G SFN stratifin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:73,268,289...73,269,663
Ensembl chr 2:73,268,791...73,269,537
JBrowse link
G SIRT1 sirtuin 1 involved_in ISO (MGI:5297787|PMID:16269335) UniProt PMID:16269335 MGI:5297787 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
G SKIL SKI like proto-oncogene acts_upstream_of
involved_in
ISO
IEA
(MGI:1858539|PMID:10811619) MGI
Ensembl
PMID:10811619 GO_REF:0000107 MGI:1858539 NCBI chr34:34,871,770...34,898,681
Ensembl chr34:34,871,574...34,894,854
JBrowse link
G SOD2 superoxide dismutase 2 acts_upstream_of_or_within ISO (MGI:3691744|PMID:15642323) MGI PMID:15642323 MGI:3691744 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
G TNF tumor necrosis factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3709926|PMID:17242187) Ensembl
Ensembl
MGI
PMID:17242187 GO_REF:0000107 MGI:3709926 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A acts_upstream_of_or_within ISO (MGI:3709926|PMID:17242187) MGI PMID:17242187 MGI:3709926 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:3709926|PMID:17242187)
(PMID:21873635)
MGI
Ensembl
GO_Central
PMID:17242187 PMID:21873635 GO_REF:0000107 MGI:3709926 NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191
JBrowse link
G TOPORS TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:49,809,156...49,821,224
Ensembl chr11:49,809,465...49,821,075
JBrowse link
G UACA uveal autoantigen with coiled-coil domains and ankyrin repeats acts_upstream_of_or_within ISO (MGI:3056865|PMID:15271982) MGI PMID:15271982 MGI:3056865 NCBI chr30:34,376,072...34,467,278
Ensembl chr30:34,376,077...34,467,206
JBrowse link
G USP47 ubiquitin specific peptidase 47 acts_upstream_of ISO (MGI:4839431|PMID:19966869) MGI PMID:19966869 MGI:4839431 NCBI chr21:34,917,664...35,027,969
Ensembl chr21:34,911,269...35,026,790
JBrowse link
G XPA XPA, DNA damage recognition and repair factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1913261|PMID:11005836) Ensembl
MGI
PMID:11005836 GO_REF:0000107 MGI:1913261 NCBI chr11:54,976,978...54,996,140
Ensembl chr11:54,976,976...54,996,065
JBrowse link
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AEN apoptosis enhancing nuclease involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:51,797,251...51,819,385
Ensembl chr 3:51,809,975...51,819,394
JBrowse link
G ATAD5 ATPase family AAA domain containing 5 acts_upstream_of_or_within ISO (MGI:3584078|PMID:15983387) MGI PMID:15983387 MGI:3584078 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629
JBrowse link
G BAG6 BAG cochaperone 6 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:1,126,730...1,141,978
Ensembl chr12:1,126,732...1,137,896
JBrowse link
G BBC3 BCL2 binding component 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3603103|PMID:16151013) Ensembl
Ensembl
MGI
PMID:16151013 GO_REF:0000107 MGI:3603103 NCBI chr 1:108,742,793...108,750,832
Ensembl chr 1:108,741,713...108,749,946
JBrowse link
G BCL3 BCL3 transcription coactivator acts_upstream_of_or_within ISO (PMID:16384933) MGI PMID:16384933 NCBI chr 1:110,620,850...110,628,830
Ensembl chr 1:110,620,827...110,654,771
JBrowse link
G BRCA2 BRCA2 DNA repair associated acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3579926|PMID:15735671)
(MGI:3714678|PMID:17476307)
MGI
Ensembl
PMID:15735671 PMID:17476307 GO_REF:0000107 MGI:3579926 MGI:3714678 NCBI chr25:7,734,450...7,797,851
Ensembl chr25:7,734,453...7,797,815
JBrowse link
G CDIP1 cell death inducing p53 target 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17599062) MGI
Ensembl
Ensembl
PMID:17599062 GO_REF:0000107 NCBI chr 6:36,854,124...36,880,231
Ensembl chr 6:36,854,141...36,880,230
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A acts_upstream_of_or_within ISO (MGI:2675761|PMID:12952892) MGI PMID:12952892 MGI:2675761 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281
JBrowse link
G CHEK2 checkpoint kinase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1354114|PMID:10710310) MGI
Ensembl
PMID:10710310 GO_REF:0000107 MGI:1354114 NCBI chr26:22,052,256...22,145,675
Ensembl chr26:21,427,961...22,240,624
JBrowse link
G DDIT4 DNA damage inducible transcript 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:22,916,718...22,918,893
Ensembl chr 4:22,916,096...22,964,035
JBrowse link
G DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr10:9,982,245...9,994,327
Ensembl chr10:9,980,080...9,991,934
JBrowse link
G ELL3 elongation factor for RNA polymerase II 3 acts_upstream_of ISO (MGI:5438719|PMID:22768269) MGI PMID:22768269 MGI:5438719 NCBI chr30:10,514,633...10,517,963
Ensembl chr30:10,515,045...10,517,880
JBrowse link
G EP300 E1A binding protein p300 involved_in ISO (PMID:17403783) UniProt PMID:17403783 NCBI chr10:24,076,538...24,156,708
Ensembl chr10:24,077,971...24,156,396
JBrowse link
G HIPK1 homeodomain interacting protein kinase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:3619785|PMID:16537918)
(PMID:21873635)
MGI
Ensembl
GO_Central
PMID:16537918 PMID:21873635 GO_REF:0000107 MGI:3619785 NCBI chr17:51,732,079...51,783,534
Ensembl chr17:51,732,016...51,781,063
JBrowse link
G HIPK2 homeodomain interacting protein kinase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:3619785|PMID:16537918)
(PMID:21873635)
MGI
Ensembl
GO_Central
PMID:16537918 PMID:21873635 GO_REF:0000107 MGI:3619785 NCBI chr16:9,066,957...9,256,916
Ensembl chr16:9,066,970...9,244,526
JBrowse link
G LOC102152733 RNA exonuclease 1 homolog involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:45,378,285...45,414,679 JBrowse link
G LOC488622 myeloid cell nuclear differentiation antigen acts_upstream_of_or_within ISO (PMID:14654789) MGI PMID:14654789 NCBI chr38:22,874,345...22,892,362 JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:1334080|PMID:10097137)
GO_Central
Ensembl
MGI
PMID:10097137 PMID:21873635 GO_REF:0000107 MGI:1334080 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3784021|PMID:11896600) MGI
Ensembl
Ensembl
PMID:11896600 GO_REF:0000107 MGI:3784021 NCBI chr 6:18,222,367...18,224,015
Ensembl chr 6:18,222,515...18,224,014
JBrowse link
G PHLDA3 pleckstrin homology like domain family A member 3 involved_in ISO (PMID:19203586) UniProt PMID:19203586 NCBI chr 7:1,438,539...1,440,701 JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO (MGI:1858284|PMID:10807576) MGI PMID:10807576 MGI:1858284 NCBI chr 1:16,469,793...16,472,910
Ensembl chr 1:16,469,793...16,472,910
JBrowse link
G PML PML nuclear body scaffold involved_in ISO (MGI:3580934|PMID:15626733) UniProt PMID:15626733 MGI:3580934 NCBI chr30:37,232,337...37,278,434
Ensembl chr30:37,232,306...37,277,741
JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma involved_in ISO (PMID:17245430) UniProt PMID:17245430 NCBI chr 8:69,846,311...69,969,409
Ensembl chr 8:69,846,446...69,967,578
JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240
JBrowse link
G RPS27L ribosomal protein S27 like involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr30:27,749,297...27,753,226 JBrowse link
G SHISA5 shisa family member 5 acts_upstream_of_or_within ISO (MGI:2183272|PMID:12135983) MGI PMID:12135983 MGI:2183272 NCBI chr20:40,604,183...40,624,607
Ensembl chr20:40,601,626...40,623,601
JBrowse link
G SIRT1 sirtuin 1 involved_in ISO (PMID:20100829) UniProt PMID:20100829 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
G SNW1 SNW domain containing 1 involved_in ISO (PMID:21460037) UniProt PMID:21460037 NCBI chr 8:50,478,924...50,512,360
Ensembl chr 8:50,479,338...50,512,243
JBrowse link
G TMEM109 transmembrane protein 109 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:4437179|PMID:20060811)
GO_Central
MGI
PMID:20060811 PMID:21873635 MGI:4437179 NCBI chr18:55,377,331...55,389,810
Ensembl chr18:55,363,698...55,385,587
JBrowse link
G TOPORS TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3578084|PMID:15735665) Ensembl
Ensembl
MGI
PMID:15735665 GO_REF:0000107 MGI:3578084 NCBI chr11:49,809,156...49,821,224
Ensembl chr11:49,809,465...49,821,075
JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2675761|PMID:12952892)
(MGI:3584078|PMID:15983387)
(PMID:14654789), (PMID:14744935)
(MGI:3690827|PMID:16286009)
(MGI:3714678|PMID:17476307)
(MGI:3652689|PMID:16777961)
(MGI:2183272|PMID:12135983)
MGI
Ensembl
Ensembl
PMID:12135983 PMID:12952892 PMID:14654789 PMID:14744935 PMID:15983387 More... GO_REF:0000107 MGI:2183272 MGI:2675761 MGI:3584078 MGI:3652689 MGI:3690827 MGI:3714678 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
G TP63 tumor protein p63 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3693137|PMID:17122775) MGI
Ensembl
Ensembl
PMID:17122775 GO_REF:0000107 MGI:3693137 NCBI chr34:21,766,861...21,985,095
Ensembl chr34:21,766,496...21,983,046
JBrowse link
G TP73 tumor protein p73 involved_in
acts_upstream_of
ISO (PMID:18174154), (PMID:19490146)
(MGI:3584078|PMID:15983387)
UniProt
MGI
PMID:15983387 PMID:18174154 PMID:19490146 MGI:3584078 NCBI chr 5:58,194,385...58,241,159
Ensembl chr 5:58,187,826...58,240,839
JBrowse link
G TTC28 tetratricopeptide repeat domain 28 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:21,424,249...22,049,579
Ensembl chr26:21,427,961...22,240,624
JBrowse link
G USP28 ubiquitin specific peptidase 28 involved_in ISO (PMID:16901786) UniProt PMID:16901786 NCBI chr 5:19,431,313...19,480,709
Ensembl chr 5:19,435,451...19,479,640
JBrowse link
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr  X:101,275,027...101,307,551
Ensembl chr  X:101,275,017...101,307,367
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr15:38,026,893...38,160,842
Ensembl chr15:38,028,132...38,114,987
JBrowse link
G ATF4 activating transcription factor 4 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr10:25,528,880...25,531,018
Ensembl chr10:25,528,874...25,530,993
JBrowse link
G ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 involved_in ISO (PMID:19061639) BHF-UCL PMID:19061639 NCBI chr 6:18,384,981...18,400,038
Ensembl chr 6:18,385,007...18,400,036
JBrowse link
G ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 involved_in ISO (PMID:16725111) ARUK-UCL PMID:16725111 NCBI chr 9:47,694,494...47,727,017
Ensembl chr 9:47,695,809...47,727,778
JBrowse link
G BAG6 BAG cochaperone 6 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:1,126,730...1,141,978
Ensembl chr12:1,126,732...1,137,896
JBrowse link
G BAK1 BCL2 antagonist/killer 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2667259|PMID:12847083)
(MGI:3575207|PMID:15776018)
MGI
Ensembl
Ensembl
PMID:12847083 PMID:15776018 GO_REF:0000107 MGI:2667259 MGI:3575207 NCBI chr12:2,950,359...2,957,604
Ensembl chr12:2,948,364...2,957,018
JBrowse link
G BAX BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
ISS
(MGI:2667259|PMID:12847083)
(MGI:3575207|PMID:15776018)
MGI
Ensembl
UniProt
PMID:12847083 PMID:15776018 GO_REF:0000024 GO_REF:0000107 MGI:2667259 MGI:3575207 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BBC3 BCL2 binding component 3 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 1:108,742,793...108,750,832
Ensembl chr 1:108,741,713...108,749,946
JBrowse link
G BCL2 BCL2 apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:15776018) MGI
Ensembl
PMID:15776018 GO_REF:0000107 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G BRSK2 BR serine/threonine kinase 2 involved_in ISO (PMID:22713462) UniProt PMID:22713462 NCBI chr18:45,666,489...45,688,950
Ensembl chr18:45,628,970...45,689,494
JBrowse link
G CASP12 caspase 12 involved_in
acts_upstream_of_or_within
ISO (MGI:5634893|PMID:12097332)
(MGI:2667259|PMID:12847083)
(MGI:1351404|PMID:10638761)
ParkinsonsUK-UCL
MGI
PMID:10638761 PMID:12097332 PMID:12847083 MGI:1351404 MGI:2667259 MGI:5634893 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
JBrowse link
G CASP4 caspase 4, apoptosis-related cysteine peptidase involved_in ISO (PMID:15123740) ParkinsonsUK-UCL PMID:15123740 NCBI chr 5:27,133,778...27,147,954
Ensembl chr 5:27,132,565...27,149,736
JBrowse link
G CEBPB CCAAT enhancer binding protein beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:36,661,294...36,663,162
Ensembl chr24:36,661,616...36,662,656
JBrowse link
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 involved_in ISO (PMID:19109178) UniProt PMID:19109178
G DAB2IP DAB2 interacting protein involved_in ISO (MGI:3796479|PMID:18281285) BHF-UCL PMID:18281285 MGI:3796479 NCBI chr 9:60,725,887...60,918,242
Ensembl chr 9:60,726,809...60,918,139
JBrowse link
G DDIT3 DNA damage inducible transcript 3 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:2158984|PMID:11854325)
GO_Central
Ensembl
MGI
PMID:11854325 PMID:21873635 GO_REF:0000107 MGI:2158984 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 involved_in ISS UniProt GO_REF:0000024 NCBI chr36:25,749,855...25,822,117
Ensembl chr36:25,767,718...25,820,393
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (MGI:2136067|PMID:11430819) MGI PMID:11430819 MGI:2136067 NCBI chr17:37,886,397...37,950,671
Ensembl chr17:37,886,601...37,949,812
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:1929557|PMID:11146108)
(PMID:21873635)
MGI
GO_Central
PMID:11146108 PMID:21873635 MGI:1929557 NCBI chr 9:11,930,614...12,006,724
Ensembl chr 9:11,934,965...12,006,814
JBrowse link
G ERN2 endoplasmic reticulum to nucleus signaling 2 acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:1346198|PMID:9755171)
(PMID:21873635)
MGI
Ensembl
GO_Central
PMID:9755171 PMID:21873635 GO_REF:0000107 MGI:1346198 NCBI chr 6:22,150,275...22,165,382
Ensembl chr 6:22,150,307...22,165,614
JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha involved_in ISO (MGI:4366390|PMID:19752026) UniProt PMID:19752026 MGI:4366390 NCBI chr 8:28,864,642...28,913,864
Ensembl chr 8:28,864,925...28,914,368
JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in ISO (MGI:5619738|PMID:23028846) CACAO PMID:23028846 MGI:5619738 NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666
JBrowse link
G INS insulin acts_upstream_of_or_within ISO (MGI:2158984|PMID:11854325) MGI PMID:11854325 MGI:2158984 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 involved_in ISO (MGI:4366390|PMID:19752026) UniProt PMID:19752026 MGI:4366390 NCBI chr20:12,746,171...13,065,256
Ensembl chr20:12,747,315...13,064,198
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:29,107,813...29,306,437
Ensembl chr 1:29,108,591...29,306,503
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 acts_upstream_of
involved_in
ISO
IEA
(MGI:4836774|PMID:20811152) MGI
Ensembl
PMID:20811152 GO_REF:0000107 MGI:4836774 NCBI chr25:11,741,863...11,746,885
Ensembl chr25:11,741,863...11,746,885
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (MGI:5621265|PMID:16407291) ParkinsonsUK-UCL PMID:16407291 MGI:5621265 NCBI chr 1:16,469,793...16,472,910
Ensembl chr 1:16,469,793...16,472,910
JBrowse link
G PML PML nuclear body scaffold acts_upstream_of_or_within ISO (MGI:4849347|PMID:21030605) MGI PMID:21030605 MGI:4849347 NCBI chr30:37,232,337...37,278,434
Ensembl chr30:37,232,306...37,277,741
JBrowse link
G QRICH1 glutamine rich 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr20:40,086,141...40,135,810
Ensembl chr20:40,097,149...40,135,140
JBrowse link
G RNF186 ring finger protein 186 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:78,915,131...78,916,909
Ensembl chr 2:78,915,339...78,916,037
JBrowse link
G SELENOK selenoprotein K involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr20:36,109,095...36,115,792
Ensembl chr20:36,109,148...36,115,856
JBrowse link
G SPOP speckle type BTB/POZ protein acts_upstream_of ISO (MGI:4836774|PMID:20811152) MGI PMID:20811152 MGI:4836774 NCBI chr 9:25,685,723...25,752,953
Ensembl chr 9:25,686,439...25,752,900
JBrowse link
G SYVN1 synoviolin 1 acts_upstream_of ISO (MGI:3575050|PMID:15611074) MGI PMID:15611074 MGI:3575050 NCBI chr18:52,061,284...52,068,672
Ensembl chr18:52,060,347...52,067,582
JBrowse link
G TMBIM6 transmembrane BAX inhibitor motif containing 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3050914|PMID:15304216) Ensembl
MGI
PMID:15304216 GO_REF:0000107 MGI:3050914 NCBI chr27:4,921,606...4,944,830
Ensembl chr27:4,921,606...4,944,783
JBrowse link
G TMEM117 transmembrane protein 117 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr27:9,782,805...10,246,635
Ensembl chr27:9,782,805...10,235,028
JBrowse link
G TP53 tumor protein p53 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
G TRIB3 tribbles pseudokinase 3 involved_in ISO (PMID:15775988) UniProt PMID:15775988 NCBI chr24:20,450,281...20,461,141
Ensembl chr24:20,451,001...20,457,510
JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K acts_upstream_of_or_within ISO PMID:18710920 MGI PMID:18710920 RGD:8554156 NCBI chr 3:72,713,035...72,780,199
Ensembl chr 3:72,717,236...72,780,210
JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (MGI:3840374|PMID:19328063) ParkinsonsUK-UCL PMID:19328063 MGI:3840374 NCBI chr26:22,162,675...22,168,149
Ensembl chr26:22,163,222...22,168,105
JBrowse link
intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDCD10 programmed cell death 10 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr34:32,512,109...32,553,524
Ensembl chr34:32,512,112...32,553,445
JBrowse link
G STK25 serine/threonine kinase 25 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr25:51,425,597...51,434,479
Ensembl chr25:51,425,597...51,434,479
JBrowse link
intrinsic apoptotic signaling pathway in response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr36:19,032,376...19,103,382
Ensembl chr36:19,010,717...19,103,292
JBrowse link
G BNIP3 BCL2 interacting protein 3 involved_in ISO (PMID:20436456) BHF-UCL PMID:20436456 NCBI chr28:40,037,681...40,050,499
Ensembl chr28:40,038,643...40,049,797
JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4867601|PMID:20935145) MGI
Ensembl
Ensembl
PMID:20935145 GO_REF:0000107 MGI:4867601 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
intrinsic apoptotic signaling pathway in response to nitrosative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDIT3 DNA damage inducible transcript 3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 involved_in IDA
IEA
(PMID:21716255) CAFA
CAFA
Ensembl
Ensembl
PMID:21716255 GO_REF:0000107 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G SCN2A sodium voltage-gated channel alpha subunit 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2179539|PMID:10827969) Ensembl
Ensembl
MGI
PMID:10827969 GO_REF:0000107 MGI:2179539 NCBI chr36:10,472,496...10,605,055
Ensembl chr36:10,472,361...10,602,685
JBrowse link
intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDKRB2 bradykinin receptor B2 acts_upstream_of
involved_in
ISO
IEA
(MGI:3654719|PMID:16571598) MGI
Ensembl
PMID:16571598 GO_REF:0000107 MGI:3654719 NCBI chr 8:64,974,588...65,005,682
Ensembl chr 8:64,974,997...65,003,407
JBrowse link
intrinsic apoptotic signaling pathway in response to oxidative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member ISO protein:altered expression:liver (rat) RGD PMID:29589772 RGD:14975297 NCBI chr26:9,319,109...9,361,021 JBrowse link
G ARL6IP5 ADP ribosylation factor like GTPase 6 interacting protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:22,632,613...22,653,894
Ensembl chr20:22,633,808...22,653,870
JBrowse link
G BCL2 BCL2 apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2679141|PMID:12855558) MGI
Ensembl
PMID:12855558 GO_REF:0000107 MGI:2679141 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:30,273,281...30,278,554
Ensembl chr17:30,272,749...30,278,554
JBrowse link
G DIABLO diablo IAP-binding mitochondrial protein involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:3587135|PMID:16085184)
GO_Central
GO_Central
Ensembl
MGI
PMID:16085184 PMID:21873635 GO_REF:0000107 MGI:3587135 NCBI chr26:7,125,320...7,144,884
Ensembl chr26:7,125,405...7,144,308
JBrowse link
G GPX1 glutathione peroxidase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2153292|PMID:11562367), (MGI:3613414|PMID:15663476)
(MGI:3698597|PMID:16373599)
MGI
Ensembl
Ensembl
PMID:11562367 PMID:15663476 PMID:16373599 GO_REF:0000107 MGI:2153292 MGI:3613414 MGI:3698597 NCBI chr20:39,889,165...39,890,253
Ensembl chr20:39,889,174...39,890,260
JBrowse link
G GSKIP GSK3B interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:65,110,659...65,131,205
Ensembl chr 8:65,111,414...65,129,622
JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:15659221 RGD:1641883 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:3829088|PMID:18948261)
GO_Central
Ensembl
MGI
PMID:18948261 PMID:21873635 GO_REF:0000107 MGI:3829088 NCBI chr 1:29,107,813...29,306,437
Ensembl chr 1:29,108,591...29,306,503
JBrowse link
G MAPT microtubule associated protein tau ISO RGD PMID:12420308 RGD:8158111 NCBI chr 9:9,572,174...9,674,082
Ensembl chr 9:9,570,557...9,674,349
JBrowse link
G MELK maternal embryonic leucine zipper kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3829088|PMID:18948261) Ensembl
Ensembl
MGI
PMID:18948261 GO_REF:0000107 MGI:3829088 NCBI chr11:52,970,699...53,067,169
Ensembl chr11:52,977,260...53,067,172
JBrowse link
G NOX1 NADPH oxidase 1 acts_upstream_of
involved_in
ISO
IEA
(MGI:4881403|PMID:19661248) MGI
Ensembl
PMID:19661248 GO_REF:0000107 MGI:4881403 NCBI chr  X:74,784,627...74,811,796
Ensembl chr  X:74,785,168...74,811,698
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 involved_in ISO (PMID:18541534) UniProt PMID:18541534 NCBI chr36:16,918,329...16,944,532
Ensembl chr36:16,918,058...16,944,620
JBrowse link
G PML PML nuclear body scaffold acts_upstream_of_or_within ISO (MGI:4849347|PMID:21030605) MGI PMID:21030605 MGI:4849347 NCBI chr30:37,232,337...37,278,434
Ensembl chr30:37,232,306...37,277,741
JBrowse link
G RNF7 ring finger protein 7 acts_upstream_of_or_within ISO (MGI:1333612|PMID:10082581) MGI PMID:10082581 MGI:1333612 NCBI chr23:37,578,222...37,584,862
Ensembl chr23:37,578,273...37,584,523
JBrowse link
G SOD2 superoxide dismutase 2 acts_upstream_of_or_within ISO (MGI:3691744|PMID:15642323) MGI PMID:15642323 MGI:3691744 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
G STK24 serine/threonine kinase 24 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:48,578,037...48,651,028
Ensembl chr22:48,578,858...48,663,329
JBrowse link
G UACA uveal autoantigen with coiled-coil domains and ankyrin repeats acts_upstream_of_or_within ISO (MGI:3056865|PMID:15271982) MGI PMID:15271982 MGI:3056865 NCBI chr30:34,376,072...34,467,278
Ensembl chr30:34,376,077...34,467,206
JBrowse link
G ZNF622 zinc finger protein 622 involved_in ISO (PMID:21771788) UniProt PMID:21771788 NCBI chr 4:86,929,947...86,943,711
Ensembl chr 4:86,826,892...86,951,542
JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BID BH3 interacting domain death agonist acts_upstream_of_or_within ISO (MGI:5566519|PMID:20436477) MGI PMID:20436477 MGI:5566519 NCBI chr27:45,344,304...45,355,735
Ensembl chr27:45,337,145...45,384,059
JBrowse link
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr28:13,040,016...13,044,364
Ensembl chr28:13,040,573...13,044,323
JBrowse link
G BNIP3 BCL2 interacting protein 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr28:40,037,681...40,050,499
Ensembl chr28:40,038,643...40,049,797
JBrowse link
G BNIP3L BCL2 interacting protein 3 like involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr25:31,133,512...31,149,750
Ensembl chr25:31,136,168...31,148,905
JBrowse link
G EYA2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (MGI:2158099|PMID:11700312) MGI PMID:11700312 MGI:2158099 NCBI chr24:34,126,086...34,308,412
Ensembl chr24:34,082,197...34,308,423
JBrowse link
G RHOT1 ras homolog family member T1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:40,715,713...40,779,551
Ensembl chr 9:40,715,941...40,779,400
JBrowse link
G RHOT2 ras homolog family member T2 involved_in ISO (PMID:12482879) UniProt PMID:12482879 NCBI chr 6:39,900,889...39,905,624
Ensembl chr 6:39,901,062...39,922,320
JBrowse link
G VDAC2 voltage dependent anion channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:25,449,926...25,462,147
Ensembl chr 4:25,449,442...25,462,335
JBrowse link
negative regulation of apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AATF apoptosis antagonizing transcription factor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4359364|PMID:17488777) MGI
Ensembl
Ensembl
PMID:17488777 GO_REF:0000107 MGI:4359364 NCBI chr 9:36,773,313...36,878,752
Ensembl chr 9:36,773,312...36,878,745
JBrowse link
G ASAH2 N-acylsphingosine amidohydrolase 2 involved_in ISO (PMID:15946935) UniProt PMID:15946935 NCBI chr26:37,136,601...37,228,215
Ensembl chr26:37,136,897...37,218,783
JBrowse link
G BAX BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3796786|PMID:18436203) MGI
Ensembl
PMID:18436203 GO_REF:0000107 MGI:3796786 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BCL2 BCL2 apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2158578|PMID:11546872) MGI
Ensembl
PMID:11546872 GO_REF:0000107 MGI:2158578 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G BDNF brain derived neurotrophic factor involved_in ISO (MGI:6295053|PMID:26708520) ARUK-UCL PMID:26708520 MGI:6295053 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480
JBrowse link
G BMF Bcl2 modifying factor acts_upstream_of_or_within ISO (MGI:2158578|PMID:11546872) MGI PMID:11546872 MGI:2158578 NCBI chr30:7,301,000...7,321,949
Ensembl chr30:7,274,174...7,322,034
JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1932296|PMID:11290297) MGI
Ensembl
PMID:11290297 GO_REF:0000107 MGI:1932296 NCBI chr 2:10,818,232...10,828,473
Ensembl chr 2:10,818,232...10,833,613
JBrowse link
G COMMD3 COMM domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:10,829,693...10,833,643
Ensembl chr 2:10,818,232...10,833,613
JBrowse link
G CTH cystathionine gamma-lyase acts_upstream_of_or_within ISO (MGI:5304595|PMID:22244329) MGI PMID:22244329 MGI:5304595 NCBI chr 6:75,324,328...75,348,476
Ensembl chr 6:75,324,787...75,349,451
JBrowse link
G CTNNB1 catenin beta 1 acts_upstream_of_or_within ISO (MGI:4454604|PMID:20454446)
(MGI:3051737|PMID:15131783)
MGI PMID:15131783 PMID:20454446 MGI:3051737 MGI:4454604 NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 involved_in ISO PMID:10869418 ARUK-UCL PMID:10869418 RGD:4892026 NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808
JBrowse link
G FAIM2 Fas apoptotic inhibitory molecule 2 acts_upstream_of_or_within ISO (MGI:4880811|PMID:21209208) MGI PMID:21209208 MGI:4880811 NCBI chr27:4,802,711...4,831,230
Ensembl chr27:4,798,235...4,827,917
JBrowse link
G GATA4 GATA binding protein 4 involved_in ISO (MGI:5780531|PMID:25590961) BHF-UCL PMID:25590961 MGI:5780531 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989
JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:25633408 RGD:13507311 NCBI chr20:39,075,085...39,094,697
Ensembl chr20:39,075,085...39,094,697
JBrowse link
G GNAI3 G protein subunit alpha i3 ISO RGD PMID:25633408 RGD:13507311 NCBI chr 6:42,275,060...42,315,545
Ensembl chr 6:42,276,998...42,315,533
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3581090|PMID:15731106) MGI
Ensembl
PMID:15731106 GO_REF:0000107 MGI:3581090 NCBI chr 6:7,487,164...7,488,576
Ensembl chr 6:7,487,250...7,488,576
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 acts_upstream_of_or_within ISO (MGI:3688933|PMID:16857185) MGI PMID:16857185 MGI:3688933 NCBI chr25:8,972,942...8,998,404
Ensembl chr25:8,972,724...8,997,893
JBrowse link
G IGBP1 immunoglobulin binding protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3056248|PMID:15499020) Ensembl
MGI
Ensembl
PMID:15499020 GO_REF:0000107 MGI:3056248 NCBI chr  X:54,558,515...54,612,029
Ensembl chr  X:54,547,446...54,613,171
JBrowse link
G ING2 inhibitor of growth family member 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4867787|PMID:21124965) MGI
Ensembl
Ensembl
PMID:21124965 GO_REF:0000107 MGI:4867787 NCBI chr16:46,843,478...46,850,856
Ensembl chr16:46,845,289...46,850,637
JBrowse link
G LOC489591 cyclin-dependent kinase 11B acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3041915|PMID:15060143) MGI
Ensembl
Ensembl
PMID:15060143 GO_REF:0000107 MGI:3041915 NCBI chr 5:56,698,267...56,714,075 JBrowse link
G MADD MAP kinase activating death domain acts_upstream_of_or_within ISO (MGI:3700423|PMID:14735464) MGI PMID:14735464 MGI:3700423 NCBI chr18:42,290,226...42,332,237
Ensembl chr18:42,290,754...42,328,586
JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 acts_upstream_of_or_within ISO (MGI:3607973|PMID:16260493) MGI PMID:16260493 MGI:3607973 NCBI chr12:49,669,849...49,740,039
Ensembl chr12:49,672,389...49,739,850
JBrowse link
G MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:16,702,623...16,712,426
Ensembl chr10:16,702,621...16,712,278
JBrowse link
G MAZ MYC associated zinc finger protein involved_in ISO (PMID:25487955) ARUK-UCL PMID:25487955 NCBI chr 6:17,867,491...17,870,108
Ensembl chr 6:17,867,488...17,870,197
JBrowse link
G MEIS3 Meis homeobox 3 acts_upstream_of_or_within ISO (MGI:4848231|PMID:21059917) MGI PMID:21059917 MGI:4848231 NCBI chr 1:108,591,759...108,602,635
Ensembl chr 1:108,591,589...108,604,040
JBrowse link
G MNT MAX network transcriptional repressor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2675510|PMID:12970171) MGI
Ensembl
PMID:12970171 GO_REF:0000107 MGI:2675510 NCBI chr 9:46,466,879...46,482,467
Ensembl chr 9:46,469,426...46,482,705
JBrowse link
G MRTFA myocardin related transcription factor A acts_upstream_of_or_within ISO (MGI:2183867|PMID:12019265) MGI PMID:12019265 MGI:2183867 NCBI chr10:24,561,161...24,759,586
Ensembl chr10:24,561,161...24,759,081
JBrowse link
G NANOS3 nanos C2HC-type zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr20:48,591,081...48,591,755 JBrowse link
G NANOS3 nanos C2HC-type zinc finger 3 acts_upstream_of_or_within ISO (MGI:3796786|PMID:18436203) MGI PMID:18436203 MGI:3796786
G NOG noggin acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3640733|PMID:16712836) MGI
Ensembl
PMID:16712836 GO_REF:0000107 MGI:3640733 NCBI chr 9:31,453,604...31,456,060 JBrowse link
G NOG noggin involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 9:31,455,389...31,456,057 JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr36:2,546,237...2,554,559
Ensembl chr36:2,547,421...2,552,780
JBrowse link
G PAM16 presequence translocase associated motor 16 acts_upstream_of_or_within ISO (MGI:4837988|PMID:20719856) MGI PMID:20719856 MGI:4837988 NCBI chr 6:37,040,484...37,047,708 JBrowse link
G PCGF2 polycomb group ring finger 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1932296|PMID:11290297) MGI
Ensembl
Ensembl
PMID:11290297 GO_REF:0000107 MGI:1932296 NCBI chr 9:23,488,862...23,499,769
Ensembl chr 9:23,488,857...23,499,549
JBrowse link
G PSEN1 presenilin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3044464|PMID:15148382) Ensembl
Ensembl
MGI
PMID:15148382 GO_REF:0000107 MGI:3044464 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532
JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (MGI:3044464|PMID:15148382) MGI PMID:15148382 MGI:3044464 NCBI chr 7:38,147,157...38,163,023
Ensembl chr 7:38,147,173...38,166,722
JBrowse link
G QARS1 glutaminyl-tRNA synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:40,077,856...40,085,100
Ensembl chr20:40,078,163...40,085,099
JBrowse link
G RB1 RB transcriptional corepressor 1 involved_in ISO PMID:24027266 ARUK-UCL PMID:24027266 RGD:14397580 NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726
JBrowse link
G TMBIM6 transmembrane BAX inhibitor motif containing 6 involved_in ISO (PMID:21075086) ParkinsonsUK-UCL PMID:21075086 NCBI chr27:4,921,606...4,944,830
Ensembl chr27:4,921,606...4,944,783
JBrowse link
G TNF tumor necrosis factor acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:31124343) ARUK-UCL
Ensembl
PMID:31124343 GO_REF:0000107 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G WNT4 Wnt family member 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4454604|PMID:20454446) MGI
Ensembl
PMID:20454446 GO_REF:0000107 MGI:4454604 NCBI chr 2:77,112,045...77,129,702
Ensembl chr 2:77,101,300...77,127,111
JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAAP1 caspase activity and apoptosis inhibitor 1 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr11:45,063,524...45,112,437
Ensembl chr11:45,064,472...45,109,672
JBrowse link
G IL9 interleukin 9 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4367548|PMID:18551134) MGI
Ensembl
Ensembl
PMID:18551134 GO_REF:0000107 MGI:4367548 NCBI chr11:23,808,919...23,814,085
Ensembl chr11:23,811,117...23,814,079
JBrowse link
G LOC611642 interleukin-9 receptor acts_upstream_of_or_within ISO (MGI:4367548|PMID:18551134) MGI PMID:18551134 MGI:4367548 NCBI chr 6:40,425,072...40,437,917 JBrowse link
G MMP9 matrix metallopeptidase 9 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
JBrowse link
G NLE1 notchless homolog 1 acts_upstream_of_or_within ISO (MGI:5468737|PMID:23231322) MGI PMID:23231322 MGI:5468737 NCBI chr 9:38,222,083...38,230,819
Ensembl chr 9:38,222,051...38,365,621
JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in ISO (PMID:21785459) ParkinsonsUK-UCL PMID:21785459 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303
JBrowse link
G PIH1D1 PIH1 domain containing 1 involved_in ISO (PMID:21078300) UniProt PMID:21078300 NCBI chr 1:107,045,466...107,051,281
Ensembl chr 1:107,045,697...107,051,236
JBrowse link
G PLAUR plasminogen activator, urokinase receptor involved_in ISO (PMID:22984561) CACAO PMID:22984561 NCBI chr 1:111,476,804...111,490,876
Ensembl chr 1:111,476,893...111,490,880
JBrowse link
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2L1 BCL2 like 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355
JBrowse link
G CREB3 cAMP responsive element binding protein 3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr11:52,260,340...52,265,085
Ensembl chr11:52,260,420...52,266,515
JBrowse link
G CREB3L1 cAMP responsive element binding protein 3 like 1 involved_in ISO PMID:15665855
(MGI:5616321|PMID:15665855)
ParkinsonsUK-UCL PMID:15665855 MGI:5616321 RGD:1558627 NCBI chr18:43,138,779...43,173,535
Ensembl chr18:43,139,453...43,173,420
JBrowse link
G GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5525071|PMID:22240901) Ensembl
MGI
PMID:22240901 GO_REF:0000107 MGI:5525071 NCBI chr13:37,512,129...37,514,303
Ensembl chr13:37,512,217...37,514,257
JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 2:59,388,492...59,400,028
Ensembl chr 2:59,388,494...59,400,003
JBrowse link
G HSP70 heat shock protein 70 involved_in ISO (PMID:12150907), (PMID:20625543) ParkinsonsUK-UCL PMID:12150907 PMID:20625543 NCBI chr12:1,285,282...1,287,670 JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in ISO (MGI:5495588|PMID:23453807) ParkinsonsUK-UCL PMID:23453807 MGI:5495588 NCBI chr  X:122,232,052...122,253,499
Ensembl chr  X:122,235,878...122,250,562
JBrowse link
G LRRK2 leucine rich repeat kinase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr27:13,282,824...13,420,917
Ensembl chr27:13,283,756...13,420,870
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr23:52,068,123...52,154,410
Ensembl chr23:52,068,118...52,151,593
JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in ISO (PMID:14652021)
(MGI:5613479|PMID:14652021)
ParkinsonsUK-UCL PMID:14652021 MGI:5613479 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4836774|PMID:20811152) Ensembl
Ensembl
MGI
PMID:20811152 GO_REF:0000107 MGI:4836774 NCBI chr25:11,741,863...11,746,885
Ensembl chr25:11,741,863...11,746,885
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:49,886,887...51,201,930
Ensembl chr 1:49,889,005...51,201,764
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in ISO (MGI:5619464|PMID:21216966) ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chr24:36,936,469...37,010,929
Ensembl chr24:36,936,298...37,003,720
JBrowse link
G SELENOS selenoprotein S involved_in ISO (PMID:17210132) BHF-UCL PMID:17210132 NCBI chr 3:39,796,711...39,805,654
Ensembl chr 3:39,796,711...39,805,591
JBrowse link
G SYVN1 synoviolin 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3575050|PMID:15611074) MGI
Ensembl
PMID:15611074 GO_REF:0000107 MGI:3575050 NCBI chr18:52,061,284...52,068,672
Ensembl chr18:52,060,347...52,067,582
JBrowse link
G TMBIM6 transmembrane BAX inhibitor motif containing 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5525071|PMID:22240901) Ensembl
MGI
PMID:22240901 GO_REF:0000107 MGI:5525071 NCBI chr27:4,921,606...4,944,830
Ensembl chr27:4,921,606...4,944,783
JBrowse link
G TXNDC12 thioredoxin domain containing 12 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:18628206) MGI
Ensembl
PMID:18628206 GO_REF:0000107 NCBI chr15:9,261,493...9,292,097
Ensembl chr15:9,262,004...9,291,553
JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in ISO (MGI:3629256|PMID:16571599) BHF-UCL PMID:16571599 MGI:3629256 NCBI chr13:38,451,722...38,466,481
Ensembl chr13:38,451,710...38,475,827
JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO PMID:20625543
(PMID:19135031)
ParkinsonsUK-UCL PMID:19135031 PMID:20625543 RGD:10047191 NCBI chr26:22,162,675...22,168,149
Ensembl chr26:22,163,222...22,168,105
JBrowse link
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HYOU1 hypoxia up-regulated 1 involved_in ISO (MGI:3697528|PMID:17116640) ParkinsonsUK-UCL PMID:17116640 MGI:3697528 NCBI chr 5:14,795,750...14,808,203
Ensembl chr 5:14,795,750...14,807,262
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:49,886,887...51,201,930
Ensembl chr 1:49,889,005...51,201,764
JBrowse link
negative regulation of extrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr36:3,743,257...3,818,659
Ensembl chr36:3,744,163...3,818,652
JBrowse link
G AR androgen receptor involved_in ISS
IEA
BHF-UCL
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912
JBrowse link
G BIRC6 baculoviral IAP repeat containing 6 involved_in ISO (PMID:14765125) UniProt PMID:14765125 NCBI chr17:25,618,262...25,847,920
Ensembl chr17:25,617,892...25,847,202
JBrowse link
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator involved_in
acts_upstream_of_or_within
ISO (PMID:9208847)
(MGI:5486419|PMID:22675671)
(PMID:22266862)
UniProt
MGI
PMID:9208847 PMID:22266862 PMID:22675671 MGI:5486419 NCBI chr37:10,268,407...10,307,803
Ensembl chr37:10,268,582...10,345,095
JBrowse link
G CTTN cortactin acts_upstream_of_or_within ISO (MGI:5437589|PMID:22660580) MGI PMID:22660580 MGI:5437589 NCBI chr18:47,932,367...47,960,732
Ensembl chr18:47,916,632...47,960,674
JBrowse link
G DAB2 DAB adaptor protein 2 acts_upstream_of_or_within ISO (MGI:5442513|PMID:15734730) MGI PMID:15734730 MGI:5442513 NCBI chr 4:69,625,874...69,648,349
Ensembl chr 4:69,625,527...69,648,321
JBrowse link
G ERICH6 glutamate rich 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:45,290,021...45,321,238
Ensembl chr23:45,290,028...45,320,774
JBrowse link
G FCMR Fc mu receptor acts_upstream_of_or_within ISO (MGI:3576402|PMID:15632112) MGI PMID:15632112 MGI:3576402 NCBI chr 7:6,046,270...6,064,063
Ensembl chr 7:6,048,814...6,064,013
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3047441|PMID:15288121) Ensembl
MGI
PMID:15288121 GO_REF:0000107 MGI:3047441 NCBI chr12:20,999,815...21,047,779
Ensembl chr12:21,000,792...21,047,779
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit acts_upstream_of_or_within ISO (MGI:3047441|PMID:15288121) MGI PMID:15288121 MGI:3047441 NCBI chr 6:55,204,602...55,244,217 JBrowse link
G GSTP1 glutathione S-transferase pi 1 involved_in ISO (PMID:16636664) BHF-UCL PMID:16636664 NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182
JBrowse link
G HSF4 heat shock transcription factor 4 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 5:82,190,996...82,201,224
Ensembl chr 5:82,196,500...82,201,151
Ensembl chr 5:82,196,500...82,201,151
JBrowse link
G HTT huntingtin involved_in ISO (PMID:19240112) UniProt PMID:19240112 NCBI chr 3:61,076,934...61,221,462
Ensembl chr 3:61,079,904...61,330,290
JBrowse link
G IGF1 insulin like growth factor 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794
JBrowse link
G IL19 interleukin 19 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5491082|PMID:23468852) Ensembl
Ensembl
MGI
PMID:23468852 GO_REF:0000107 MGI:5491082 NCBI chr 7:6,000,994...6,006,959
Ensembl chr 7:6,000,907...6,006,870
JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1340173|PMID:10429671)
GO_Central
GO_Central
MGI
PMID:10429671 PMID:21873635 MGI:1340173 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
JBrowse link
G IL7 interleukin 7 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1340173|PMID:10429671) MGI
Ensembl
PMID:10429671 GO_REF:0000107 MGI:1340173 NCBI chr29:26,384,493...26,422,586
Ensembl chr29:26,384,493...26,422,737
JBrowse link
G ITGA6 integrin subunit alpha 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:16,777,363...16,858,725
Ensembl chr36:16,776,863...16,855,449
JBrowse link
G ITGAV integrin subunit alpha V involved_in ISO (PMID:10708943) BHF-UCL PMID:10708943 NCBI chr36:28,815,215...28,890,569
Ensembl chr36:28,804,013...28,887,430
JBrowse link
G LGALS3 galectin 3 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 8:30,977,438...30,994,711
Ensembl chr 8:30,983,633...30,994,705
JBrowse link
G LMNA lamin A/C involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4879057|PMID:21151901) Ensembl
Ensembl
MGI
PMID:21151901 GO_REF:0000107 MGI:4879057 NCBI chr 7:41,702,491...41,719,870
Ensembl chr 7:41,508,450...41,746,931
JBrowse link
G NRP1 neuropilin 1 involved_in ISO (MGI:5287519|PMID:21828096) BHF-UCL PMID:21828096 MGI:5287519 NCBI chr 2:3,416,062...3,553,929
Ensembl chr 2:3,413,821...3,552,483
JBrowse link
G PAK5 p21 (RAC1) activated kinase 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2673247|PMID:12897128) Ensembl
Ensembl
MGI
PMID:12897128 GO_REF:0000107 MGI:2673247 NCBI chr24:12,391,739...12,671,483
Ensembl chr24:12,391,471...12,669,404
JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in ISO (PMID:21785459) UniProt PMID:21785459 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303
JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (MGI:5546581|PMID:23950925)
(PMID:24113711)
MGI PMID:23950925 PMID:24113711 MGI:5546581 NCBI chr18:50,870,483...50,881,089
Ensembl chr18:50,872,426...50,879,826
JBrowse link
G PHIP pleckstrin homology domain interacting protein acts_upstream_of_or_within ISO (PMID:17636024) MGI PMID:17636024 NCBI chr12:39,899,738...40,015,795
Ensembl chr12:39,904,603...40,032,194
JBrowse link
G PRDX2 peroxiredoxin 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3050700|PMID:15259009) MGI
Ensembl
PMID:15259009 GO_REF:0000107 MGI:3050700 NCBI chr20:49,352,271...49,356,755
Ensembl chr20:49,352,266...49,356,682
JBrowse link
G PSME3 proteasome activator subunit 3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:20,185,997...20,193,320
Ensembl chr 9:20,188,167...20,222,743
JBrowse link
G RB1CC1 RB1 inducible coiled-coil 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3689241|PMID:17015619) Ensembl
Ensembl
MGI
PMID:17015619 GO_REF:0000107 MGI:3689241 NCBI chr29:4,445,668...4,544,223
Ensembl chr29:4,375,785...4,517,168
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5304595|PMID:22244329) Ensembl
Ensembl
MGI
PMID:22244329 GO_REF:0000107 MGI:5304595 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 acts_upstream_of_or_within
involved_in
ISO (MGI:5521568|PMID:22089168)
(PMID:21525013)
MGI
UniProt
PMID:21525013 PMID:22089168 MGI:5521568 NCBI chr35:3,367,796...3,407,631
Ensembl chr35:3,263,226...3,405,883
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4456959|PMID:11493700) Ensembl
MGI
PMID:11493700 GO_REF:0000107 MGI:4456959 NCBI chr 9:34,387,084...34,590,603
Ensembl chr 9:34,387,091...34,425,292
JBrowse link
G SCG2 secretogranin II involved_in ISO (PMID:14970115) BHF-UCL PMID:14970115 NCBI chr37:29,435,038...29,440,615
Ensembl chr37:29,435,041...29,437,333
JBrowse link
G SGMS1 sphingomyelin synthase 1 acts_upstream_of_or_within ISO (MGI:3609513|PMID:16226406) MGI PMID:16226406 MGI:3609513 NCBI chr26:37,243,388...37,472,806
Ensembl chr26:37,244,900...37,348,802
JBrowse link
G SH3RF1 SH3 domain containing ring finger 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr25:20,025,920...20,208,470
Ensembl chr25:20,015,915...20,205,946
JBrowse link
G SIAH2 siah E3 ubiquitin protein ligase 2 involved_in ISO (PMID:21586138) UniProt PMID:21586138 NCBI chr23:45,366,343...45,418,960
Ensembl chr23:45,341,199...45,385,546
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA
IBA
(PMID:21873635) Ensembl
Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077
JBrowse link
G TCF7L2 transcription factor 7 like 2 involved_in ISO PMID:21965303 BHF-UCL PMID:21965303 RGD:14974246 NCBI chr28:23,966,079...24,162,775
Ensembl chr28:23,966,073...24,163,737
JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:56,191,383...56,223,042
Ensembl chr11:56,161,772...56,218,594
JBrowse link
G TNFRSF4 TNF receptor superfamily member 4 involved_in ISO (MGI:2150820|PMID:11567634) BHF-UCL PMID:11567634 MGI:2150820 NCBI chr 5:56,401,410...56,404,410
Ensembl chr 5:56,401,384...56,404,761
JBrowse link
G VEGFA vascular endothelial growth factor A involved_in ISO (MGI:5287519|PMID:21828096) BHF-UCL PMID:21828096 MGI:5287519 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965
JBrowse link
G YAP1 Yes1 associated transcriptional regulator acts_upstream_of_or_within ISO (MGI:3818355|PMID:17980593) MGI PMID:17980593 MGI:3818355 NCBI chr 5:29,394,760...29,495,977
Ensembl chr 5:29,394,541...29,496,251
JBrowse link
G ZMYND11 zinc finger MYND-type containing 11 involved_in ISO (PMID:20732415) UniProt PMID:20732415 NCBI chr 2:34,492,283...34,614,152
Ensembl chr 2:34,493,994...34,570,523
JBrowse link
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 involved_in ISO PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr10:1,791,273...1,807,710
Ensembl chr10:1,792,733...1,807,610
JBrowse link
G BCL2 BCL2 apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:8358790) MGI
Ensembl
PMID:8358790 GO_REF:0000107 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G COL2A1 collagen type II alpha 1 chain acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1097047|PMID:9299161) MGI
Ensembl
PMID:9299161 GO_REF:0000107 MGI:1097047 NCBI chr27:6,756,994...6,787,733
Ensembl chr27:6,756,994...6,787,733
JBrowse link
G CSF2 colony stimulating factor 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959
JBrowse link
G CTNNA1 catenin alpha 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5315030|PMID:22411810) Ensembl
Ensembl
MGI
PMID:22411810 GO_REF:0000107 MGI:5315030 NCBI chr11:26,273,322...26,459,497
Ensembl chr11:26,143,013...26,459,091
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3777228|PMID:18322241), (MGI:3833195|PMID:18971423) MGI
Ensembl
Ensembl
PMID:18322241 PMID:18971423 GO_REF:0000107 MGI:3777228 MGI:3833195 NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 acts_upstream_of_or_within ISO (MGI:3833195|PMID:18971423) MGI PMID:18971423 MGI:3833195 NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808
JBrowse link
G EYA1 EYA transcriptional coactivator and phosphatase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3577160|PMID:15817220)
GO_Central
MGI
PMID:15817220 PMID:21873635 MGI:3577160 NCBI chr29:20,176,306...20,595,131
Ensembl chr29:20,177,014...20,525,653
JBrowse link
G EYA2 EYA transcriptional coactivator and phosphatase 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr24:34,126,086...34,308,412
Ensembl chr24:34,082,197...34,308,423
JBrowse link
G EYA3 EYA transcriptional coactivator and phosphatase 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:72,313,412...72,417,729
Ensembl chr 2:72,328,362...72,414,058
JBrowse link
G EYA4 EYA transcriptional coactivator and phosphatase 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:26,208,514...26,514,601
Ensembl chr 1:26,272,448...26,514,201
JBrowse link
G FGF10 fibroblast growth factor 10 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3690587|PMID:16956603) Ensembl
Ensembl
MGI
PMID:16956603 GO_REF:0000107 MGI:3690587 NCBI chr 4:65,851,130...65,930,944
Ensembl chr 4:65,851,069...65,928,192
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in ISO PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr12:68,105,060...68,316,630
Ensembl chr12:68,075,184...68,316,541
JBrowse link
G GAS1 growth arrest specific 1 acts_upstream_of_or_within ISO (MGI:5306314|PMID:15070677) MGI PMID:15070677 MGI:5306314 NCBI chr 1:72,927,346...72,930,119
Ensembl chr 1:72,927,670...72,928,827
JBrowse link
G GATA1 GATA binding protein 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr  X:41,991,321...41,998,319
Ensembl chr  X:41,971,582...41,998,303
JBrowse link
G GDNF glial cell derived neurotrophic factor involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 4:70,966,694...70,991,860
Ensembl chr 4:70,971,432...70,989,714
JBrowse link
G GFRAL GDNF family receptor alpha like acts_upstream_of_or_within ISO (MGI:3610244|PMID:16086688) MGI PMID:16086688 MGI:3610244 NCBI chr12:22,646,015...22,702,428
Ensembl chr12:22,646,374...22,702,545
JBrowse link
G HSP70 heat shock protein 70 involved_in ISO (PMID:17167422) BHF-UCL PMID:17167422 NCBI chr12:1,285,282...1,287,670 JBrowse link
G IFI6 interferon alpha inducible protein 6 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:72,638,657...72,642,648
Ensembl chr 2:72,638,705...72,642,648
JBrowse link
G IL1B interleukin 1 beta involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
JBrowse link
G IL7 interleukin 7 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:84869|PMID:8950980) MGI
Ensembl
PMID:8950980 GO_REF:0000107 MGI:84869 NCBI chr29:26,384,493...26,422,586
Ensembl chr29:26,384,493...26,422,737
JBrowse link
G MAP2K5 mitogen-activated protein kinase kinase 5 involved_in ISO PMID:20551324 BHF-UCL PMID:20551324 RGD:8553940 NCBI chr30:31,665,032...31,920,792
Ensembl chr30:31,664,564...31,920,751
JBrowse link
G MAPK7 mitogen-activated protein kinase 7 involved_in ISO (PMID:20551324) BHF-UCL PMID:20551324 NCBI chr 5:40,831,949...40,836,990
Ensembl chr 5:40,831,947...40,836,505
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr17:59,759,605...59,763,111
Ensembl chr17:59,759,605...59,763,111
JBrowse link
G NRG1 neuregulin 1 involved_in ISO (PMID:9553078) BHF-UCL PMID:9553078 NCBI chr16:31,697,958...32,771,888
Ensembl chr16:31,706,851...32,771,932
JBrowse link
G PRDX2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:86755|PMID:9115640) Ensembl
Ensembl
MGI
PMID:9115640 GO_REF:0000107 MGI:86755 NCBI chr20:49,352,271...49,356,755
Ensembl chr20:49,352,266...49,356,682
JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in ISO (MGI:5306563|PMID:20125124) UniProt PMID:20125124 MGI:5306563 NCBI chr35:3,367,796...3,407,631
Ensembl chr35:3,263,226...3,405,883
JBrowse link
G SGK3 serum/glucocorticoid regulated kinase family, member 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2178763|PMID:11050396) MGI
Ensembl
Ensembl
PMID:11050396 GO_REF:0000107 MGI:2178763 NCBI chr29:16,236,197...16,418,225
Ensembl chr29:16,274,352...16,415,598
JBrowse link
G SNAI2 snail family transcriptional repressor 2 acts_upstream_of_or_within ISO (MGI:5142392|PMID:10518215) MGI PMID:10518215 MGI:5142392 NCBI chr29:1,154,132...1,156,653
Ensembl chr29:1,154,036...1,156,653
JBrowse link
G STRADB STE20 related adaptor beta involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2656105|PMID:12574163) Ensembl
Ensembl
MGI
PMID:12574163 GO_REF:0000107 MGI:2656105 NCBI chr37:10,521,643...10,557,611
Ensembl chr37:10,521,574...10,557,231
JBrowse link
G TERT telomerase reverse transcriptase involved_in ISO (PMID:10449030) BHF-UCL PMID:10449030 NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951
JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G UNC5B unc-5 netrin receptor B involved_in ISO (PMID:18469807) UniProt PMID:18469807 NCBI chr 4:22,003,131...22,084,107
Ensembl chr 4:22,003,131...22,081,744
JBrowse link
G ZC3HC1 zinc finger C3HC-type containing 1 acts_upstream_of_or_within ISO (MGI:2670822|PMID:12748172) MGI PMID:12748172 MGI:2670822 NCBI chr14:6,831,017...6,852,852 JBrowse link
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 involved_in IMP (PMID:22711822) BHF-UCL
BHF-UCL
PMID:22711822 NCBI chr 7:41,835,322...41,850,488
Ensembl chr 7:41,812,353...41,850,488
JBrowse link
G BCL2L1 BCL2 like 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:26582200) MGI
Ensembl
Ensembl
PMID:26582200 GO_REF:0000107 NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355
JBrowse link
G BRCA1 BRCA1 DNA repair associated involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:19,958,941...20,025,494
Ensembl chr 9:19,958,391...20,025,494
JBrowse link
G CAPS calcyphosine acts_upstream_of_or_within ISO (MGI:2450205|PMID:12466268) MGI PMID:12466268 MGI:2450205 NCBI chr20:54,175,986...54,177,889
Ensembl chr20:54,175,986...54,177,889
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IBA
(PMID:26582200)
(PMID:21873635)
MGI
GO_Central
PMID:21873635 PMID:26582200 NCBI chr37:10,268,407...10,307,803
Ensembl chr37:10,268,582...10,345,095
JBrowse link
G DAPK1 death associated protein kinase 1 acts_upstream_of_or_within ISO (MGI:2152512|PMID:11485996) MGI PMID:11485996 MGI:2152512 NCBI chr 1:72,278,939...72,448,907
Ensembl chr 1:72,280,103...72,447,822
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in ISO (PMID:18846110) UniProt PMID:18846110 NCBI chr  X:35,759,367...35,789,759
Ensembl chr  X:35,759,416...35,789,774
JBrowse link
G FAIM Fas apoptotic inhibitory molecule involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1332875|PMID:10075978)
GO_Central
MGI
PMID:10075978 PMID:21873635 MGI:1332875 NCBI chr23:34,807,093...34,822,577
Ensembl chr23:34,807,249...34,822,244
JBrowse link
G FAIM2 Fas apoptotic inhibitory molecule 2 acts_upstream_of_or_within ISO (PMID:26582200) MGI PMID:26582200 NCBI chr27:4,802,711...4,831,230
Ensembl chr27:4,798,235...4,827,917
JBrowse link
G FGA fibrinogen alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,238,305...52,247,017
Ensembl chr15:52,236,198...52,246,975
JBrowse link
G FGB fibrinogen beta chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,220,690...52,228,526
Ensembl chr15:52,220,611...52,228,250
JBrowse link
G FGG fibrinogen gamma chain involved_in ISO (PMID:10903502) BHF-UCL PMID:10903502 NCBI chr15:52,261,215...52,270,077
Ensembl chr15:52,261,217...52,269,964
JBrowse link
G GPX1 glutathione peroxidase 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr20:39,889,165...39,890,253
Ensembl chr20:39,889,174...39,890,260
JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in ISO (PMID:18846110) UniProt PMID:18846110 NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666
JBrowse link
G HGF hepatocyte growth factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3054501|PMID:15314156) Ensembl
Ensembl
MGI
PMID:15314156 GO_REF:0000107 MGI:3054501 NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263
JBrowse link
G HMGB2 high mobility group box 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3831045|PMID:19139395) Ensembl
Ensembl
MGI
PMID:19139395 GO_REF:0000107 MGI:3831045 NCBI chr25:23,939,024...23,941,720
Ensembl chr25:23,939,027...23,941,606
JBrowse link
G HMOX1 heme oxygenase 1 involved_in ISO (PMID:18202225) BHF-UCL PMID:18202225 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773
JBrowse link
G ICAM1 intercellular adhesion molecule 1 involved_in ISO (PMID:10903502) BHF-UCL PMID:10903502 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914
JBrowse link
G ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein acts_upstream_of_or_within ISO (MGI:4431305|PMID:20053891) MGI PMID:20053891 MGI:4431305 NCBI chr28:16,613,934...16,638,058 JBrowse link
G NLE1 notchless homolog 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:38,222,083...38,230,819
Ensembl chr 9:38,222,051...38,365,621
JBrowse link
G PEA15 proliferation and apoptosis adaptor protein 15 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:3687663|PMID:10588860)
(PMID:21873635)
MGI
GO_Central
PMID:10588860 PMID:21873635 MGI:3687663 NCBI chr38:22,001,702...22,004,728
Ensembl chr38:22,003,143...22,198,158
JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (MGI:1099227|PMID:9353287) MGI PMID:9353287 MGI:1099227 NCBI chr 7:38,147,157...38,163,023
Ensembl chr 7:38,147,173...38,166,722
JBrowse link
G RAD51D RAD51 paralog D involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:38,242,178...38,259,788
Ensembl chr 9:38,222,051...38,365,621
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3612236|PMID:16365167) Ensembl
Ensembl
MGI
PMID:16365167 GO_REF:0000107 MGI:3612236 NCBI chr20:5,892,839...5,972,672
Ensembl chr20:5,892,834...5,972,090
JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:38,271,419...38,346,103
Ensembl chr 9:38,222,051...38,365,621
JBrowse link
G RNF34 ring finger protein 34 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr26:7,746,460...7,767,967
Ensembl chr26:7,744,924...7,767,892
JBrowse link
G SERPINE1 serpin family E member 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301
JBrowse link
G SFRP2 secreted frizzled related protein 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr15:51,541,197...51,548,765
Ensembl chr15:51,540,500...51,548,765
JBrowse link
G TMBIM1 transmembrane BAX inhibitor motif containing 1 involved_in ISO (PMID:21107705) UniProt PMID:21107705 NCBI chr37:24,952,145...24,983,477
Ensembl chr37:24,952,902...24,958,137
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:30,247,432...30,262,992
Ensembl chr 1:30,251,059...30,261,001
JBrowse link
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase involved_in ISO (PMID:14652021)
(MGI:5613479|PMID:14652021)
ParkinsonsUK-UCL PMID:14652021 MGI:5613479 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303
JBrowse link
G PINK1 PTEN induced kinase 1 involved_in ISO (PMID:23261939)
(PMID:21177249)
ParkinsonsUK-UCL PMID:21177249 PMID:23261939 NCBI chr 2:78,276,091...78,293,761
Ensembl chr 2:78,277,077...78,294,123
JBrowse link
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENO1 enolase 1 involved_in ISO (PMID:15459207) CAFA PMID:15459207 NCBI chr 5:62,300,805...62,314,508
Ensembl chr 5:62,300,808...62,304,093
JBrowse link
G HYOU1 hypoxia up-regulated 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:14,795,750...14,808,203
Ensembl chr 5:14,795,750...14,807,262
JBrowse link
G KDM6A lysine demethylase 6A ISO RGD PMID:30887465 RGD:151665136 NCBI chr  X:38,745,854...38,964,029
Ensembl chr  X:38,745,854...38,959,842
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 involved_in ISO PMID:15459207 CAFA PMID:15459207 RGD:12793039 NCBI chr30:30,683,192...30,760,479
Ensembl chr30:30,683,107...30,760,479
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta involved_in ISO (MGI:6444553|PMID:30496354) BHF-UCL PMID:30496354 MGI:6444553 NCBI chr23:34,832,661...34,955,410
Ensembl chr23:34,836,540...34,993,939
JBrowse link
G PINK1 PTEN induced kinase 1 involved_in ISO (MGI:5558956|PMID:24553947) ParkinsonsUK-UCL PMID:24553947 MGI:5558956 NCBI chr 2:78,276,091...78,293,761
Ensembl chr 2:78,277,077...78,294,123
JBrowse link
G TMBIM6 transmembrane BAX inhibitor motif containing 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:4,921,606...4,944,830
Ensembl chr27:4,921,606...4,944,783
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193
JBrowse link
G BCL2 BCL2 apoptosis regulator involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G BCL2L1 BCL2 like 1 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355
JBrowse link
G BCL2L2 BCL2 like 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 8:3,569,335...3,573,922
Ensembl chr 8:3,569,399...3,586,070
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in ISO (PMID:21883093) UniProt PMID:21883093 NCBI chr  X:35,759,367...35,789,759
Ensembl chr  X:35,759,416...35,789,774
JBrowse link
G FIGNL1 fidgetin like 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4944122|PMID:20886204) Ensembl
Ensembl
MGI
PMID:20886204 GO_REF:0000107 MGI:4944122 NCBI chr18:1,788,063...1,792,900
Ensembl chr18:1,788,801...1,790,831
JBrowse link
G G2E3 G2/M-phase specific E3 ubiquitin protein ligase acts_upstream_of_or_within ISO (MGI:3807157|PMID:18511420) MGI PMID:18511420 MGI:3807157 NCBI chr 8:9,914,276...9,968,798
Ensembl chr 8:9,914,008...9,965,623
JBrowse link
G GCG glucagon involved_in ISO (MGI:4453294|PMID:19915011) UniProt PMID:19915011 MGI:4453294 NCBI chr36:7,544,637...7,554,171
Ensembl chr36:7,544,637...7,554,021
JBrowse link
G HDAC1