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Term:centralspindlin complex
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Accession:GO:0097149 term browser browse the term
Definition:A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).

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centralspindlin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ect2 epithelial cell transforming 2 part_of ISO (PMID:16236794) RGD PMID:16236794 NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
JBrowse link
G Kif23 kinesin family member 23 part_of ISO (PMID:11782313), (PMID:16236794) RGD PMID:11782313 PMID:16236794 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 part_of ISO (PMID:11782313), (PMID:16236794) RGD PMID:11782313 PMID:16236794 NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  cellular_component 19895
    protein-containing complex 5947
      centralspindlin complex 3
Path 2
Term Annotations click to browse term
  cellular_component 19895
    cellular anatomical entity 19598
      organelle 13016
        intracellular organelle 12665
          intracellular non-membrane-bounded organelle 4845
            cytoskeleton 2190
              microtubule cytoskeleton 1298
                spindle 371
                  mitotic spindle 160
                    centralspindlin complex 3
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