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Term:centralspindlin complex
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Accession:GO:0097149 term browser browse the term
Definition:A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).

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centralspindlin complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ect2 epithelial cell transforming 2 ISO (PMID:16236794) RGD PMID:16236794 NCBI chr 2:112,769,385...112,831,476
Ensembl chr 2:112,769,385...112,831,476
JBrowse link
G Kif23 kinesin family member 23 ISO (PMID:11782313), (PMID:16236794) RGD PMID:11782313, PMID:16236794 NCBI chr 8:66,866,043...66,893,241
Ensembl chr 8:66,866,082...66,893,196
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 ISO (PMID:11782313), (PMID:16236794) RGD PMID:11782313, PMID:16236794 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6093
      centralspindlin complex 3
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13258
        intracellular organelle 12912
          intracellular non-membrane-bounded organelle 5172
            cytoskeleton 2174
              microtubule cytoskeleton 1269
                spindle 351
                  mitotic spindle 137
                    centralspindlin complex 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.