ONTOLOGY REPORT - ANNOTATIONS
Term: Bcl-2 family protein complex
Accession: GO:0097136
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Definition: A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed.
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Bak1
BCL2-antagonist/killer 1
part_of located_in
ISO
(PMID:21041309) (PMID:22515821)
RGD
PMID:21041309 PMID:22515821
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
part_of
ISS ISO
GO_REF:0000024 (PMID:21199865)
UniProt RGD
PMID:21199865
GO_REF:0000024
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1
Bcl2-like 1
part_of located_in
ISO
(PMID:21199865) (PMID:21856303), (PMID:22515821)
RGD
PMID:21199865 PMID:21856303 PMID:22515821
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bcl2l11
Bcl2-like 11
part_of located_in
ISO
(MGI:3775548|PMID:16645638) (PMID:20066663)
RGD
PMID:16645638 PMID:20066663
MGI:3775548
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Bcl2l2
Bcl2-like 2
part_of located_in
ISO
(PMID:16645638) (PMID:15694340)
RGD
PMID:15694340 PMID:16645638
NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
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Bik
BCL2-interacting killer
located_in
ISO
(PMID:15694340)
RGD
PMID:15694340
NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
part_of located_in
ISO
(PMID:21199865) (PMID:21132008) (PMID:20066663)
RGD
PMID:20066663 PMID:21132008 PMID:21199865
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
located_in
ISO
(PMID:21132008)
RGD
PMID:21132008
NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
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Bak1
BCL2-antagonist/killer 1
part_of located_in
ISO
(PMID:10950869), (PMID:17024184), (PMID:23028632) (PMID:32929280) (MGI:6225541|PMID:27488021) (MGI:5009197|PMID:10950869)
RGD
PMID:10950869 PMID:17024184 PMID:23028632 PMID:27488021 PMID:32929280
MGI:5009197 MGI:6225541
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
G
Bax
BCL2 associated X, apoptosis regulator
part_of
ISO
(PMID:16113678)
RGD
PMID:16113678
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bax
BCL2 associated X, apoptosis regulator
part_of
ISS ISO
GO_REF:0000024 UniProtKB:Q07817 (MGI:2180577|PMID:11060313) (PMID:14522999), (PMID:17024184), (PMID:19074440), (PMID:19767770), (PMID:20541605), (PMID:20850011)
UniProt RGD
PMID:11060313 PMID:14522999 PMID:17024184 PMID:19074440 PMID:19767770 PMID:20541605 PMID:20850011 More...
GO_REF:0000024 MGI:2180577
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l11
Bcl2-like 11
part_of
ISO
(PMID:21671007)
RGD
PMID:21671007
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Bcl2l11
Bcl2-like 11
part_of
ISO
(PMID:21671007)
RGD
PMID:21671007
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Bbc3
Bcl-2 binding component 3
located_in
ISO
(PMID:16697956)
RGD
PMID:16697956
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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Bcl2l1
Bcl2-like 1
located_in
ISO
(PMID:16697956)
RGD
PMID:16697956
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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