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ONTOLOGY REPORT - ANNOTATIONS

Term:Bcl-2 family protein complex
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Accession:GO:0097136 term browser browse the term
Definition:A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed.

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Bcl-2 family protein complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 part_of ISO (PMID:21041309) RGD PMID:21041309 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator part_of ISS
ISO		 GO_REF:0000024
(PMID:21199865)		 UniProt
RGD		 PMID:21199865 GO_REF:0000024 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2l1 Bcl2-like 1 part_of ISO (PMID:21199865) RGD PMID:21199865 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bcl2l11 BCL2 like 11 part_of ISO (MGI:3775548|PMID:16645638) RGD PMID:16645638 MGI:3775548 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bcl2l2 Bcl2-like 2 part_of ISO (PMID:16645638) RGD PMID:16645638 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member part_of ISO (PMID:21199865) RGD PMID:21199865 NCBI chr 2:197,786,212...197,788,992 JBrowse link
BAK complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 part_of ISO (PMID:10950869), (PMID:17024184), (PMID:23028632)
(MGI:5009197|PMID:10950869)		 RGD PMID:10950869 PMID:17024184 PMID:23028632 MGI:5009197 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator part_of ISO
IEA		 (PMID:16113678)
GO_REF:0000107		 RGD
Ensembl		 PMID:16113678 GO_REF:0000107 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
BAX complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator part_of ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
UniProtKB:Q07817 (MGI:2180577|PMID:11060313)
(PMID:14522999), (PMID:17024184), (PMID:19074440), (PMID:19767770), (PMID:20541605), (PMID:20850011)		 UniProt
Ensembl
RGD		 PMID:11060313 PMID:14522999 PMID:17024184 PMID:19074440 PMID:19767770 PMID:20541605 PMID:20850011 GO_REF:0000024 GO_REF:0000107 MGI:2180577 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
BIM-BCL-2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 BCL2 like 11 part_of ISO (PMID:21671007) RGD PMID:21671007 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
BIM-BCL-xl complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 BCL2 like 11 part_of ISO (PMID:21671007) RGD PMID:21671007 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20142
    protein-containing complex 6031
      Bcl-2 family protein complex 6
        BAD-BCL-2 complex 0
        BAD-BCL-xl complex 0
        BAK complex 2
        BAX complex 1
        BCL-2 complex 0
        BID-BCL-2 complex 0
        BIM-BCL-2 complex 1
        BIM-BCL-xl complex 1
        NOXA-BCL-2 complex 0
        NOXA-BCL-xl complex 0
        PUMA-BCL-2 complex 0
        PUMA-BCL-xl complex 0
paths to the root