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ONTOLOGY REPORT - ANNOTATIONS

Term:Bcl-2 family protein complex
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Accession:GO:0097136 term browser browse the term
Definition:A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed.


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Bcl-2 family protein complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 part_of
located_in		 ISO (PMID:21041309)
(PMID:22515821)		 RGD PMID:21041309 PMID:22515821 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator part_of ISS
ISO		 GO_REF:0000024
(PMID:21199865)		 UniProt
RGD		 PMID:21199865 GO_REF:0000024 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 part_of
located_in		 ISO (PMID:21199865)
(PMID:21856303), (PMID:22515821)		 RGD PMID:21199865 PMID:21856303 PMID:22515821 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 part_of
located_in		 ISO (MGI:3775548|PMID:16645638)
(PMID:20066663)		 RGD PMID:16645638 PMID:20066663 MGI:3775548 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 part_of
located_in		 ISO (PMID:16645638)
(PMID:15694340)		 RGD PMID:15694340 PMID:16645638 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bik BCL2-interacting killer located_in ISO (PMID:15694340) RGD PMID:15694340 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member part_of
located_in		 ISO (PMID:21199865)
(PMID:21132008)
(PMID:20066663)		 RGD PMID:20066663 PMID:21132008 PMID:21199865 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 located_in ISO (PMID:21132008) RGD PMID:21132008 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
BAK complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 part_of
located_in		 ISO (PMID:10950869), (PMID:17024184), (PMID:23028632)
(PMID:32929280)
(MGI:6225541|PMID:27488021)
(MGI:5009197|PMID:10950869)		 RGD PMID:10950869 PMID:17024184 PMID:23028632 PMID:27488021 PMID:32929280 MGI:5009197 MGI:6225541 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator part_of ISO (PMID:16113678) RGD PMID:16113678 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
BAX complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator part_of ISS
ISO		 GO_REF:0000024
UniProtKB:Q07817 (MGI:2180577|PMID:11060313)
(PMID:14522999), (PMID:17024184), (PMID:19074440), (PMID:19767770), (PMID:20541605), (PMID:20850011)		 UniProt
RGD		 PMID:11060313 PMID:14522999 PMID:17024184 PMID:19074440 PMID:19767770 More... GO_REF:0000024 MGI:2180577 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
BIM-BCL-2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 Bcl2-like 11 part_of ISO (PMID:21671007) RGD PMID:21671007 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
BIM-BCL-xl complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 Bcl2-like 11 part_of ISO (PMID:21671007) RGD PMID:21671007 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
PUMA-BCL-xl complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 located_in ISO (PMID:16697956) RGD PMID:16697956 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2l1 Bcl2-like 1 located_in ISO (PMID:16697956) RGD PMID:16697956 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19189
    protein-containing complex 5927
      Bcl-2 family protein complex 9
        BAD-BCL-2 complex 0
        BAD-BCL-xl complex 0
        BAK complex 2
        BAX complex 1
        BCL-2 complex 0
        BID-BCL-2 complex 0
        BIM-BCL-2 complex 1
        BIM-BCL-xl complex 1
        NOXA-BCL-2 complex 0
        NOXA-BCL-xl complex 0
        PUMA-BCL-2 complex 0
        PUMA-BCL-xl complex 2
paths to the root