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ONTOLOGY REPORT - ANNOTATIONS


Term:endothelial tip cell fate specification
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Accession:GO:0097102 term browser browse the term
Definition:The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels.
Synonyms:exact_synonym: angiogenic tip cell fate specification



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endothelial tip cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:5466218|PMID:22282195)
Ensembl
UniProt
RGD
PMID:22282195 GO_REF:0000024 GO_REF:0000107 MGI:5466218 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
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Path 1
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure formation involved in morphogenesis 1239
        angiogenesis 537
          sprouting angiogenesis 131
            endothelial tip cell fate specification 1
Path 2
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure development 6306
        multicellular organism development 5727
          system development 5373
            circulatory system development 1244
              vasculature development 786
                blood vessel development 749
                  blood vessel endothelial cell differentiation 8
                    blood vessel endothelial cell fate commitment 2
                      blood vessel endothelial cell fate specification 2
                        endothelial tip cell fate specification 1
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