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ONTOLOGY REPORT - ANNOTATIONS


Term:mature conventional dendritic cell differentiation
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Accession:GO:0097029 term browser browse the term
Definition:The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells.
Comment:Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.



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mature conventional dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO
ISS
(PMID:16478888)
(MGI:4839888|PMID:19845798)
GO_REF:0000024
RGD
UniProt
PMID:16478888 PMID:19845798 GO_REF:0000024 MGI:4839888 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (PMID:25754930) RGD PMID:25754930 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Prtn3 proteinase 3 involved_in ISO (PMID:16478888) RGD PMID:16478888 NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    developmental process 6778
      cellular developmental process 4482
        cell differentiation 4387
          myeloid cell differentiation 435
            myeloid leukocyte differentiation 235
              mature conventional dendritic cell differentiation 5
Path 2
Term Annotations click to browse term
  biological_process 19390
    developmental process 6778
      anatomical structure development 6203
        multicellular organism development 5641
          system development 5310
            immune system development 1096
              hematopoietic or lymphoid organ development 1029
                hemopoiesis 977
                  leukocyte differentiation 611
                    mononuclear cell differentiation 476
                      dendritic cell differentiation 50
                        mature conventional dendritic cell differentiation 5
paths to the root