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ONTOLOGY REPORT - ANNOTATIONS

Term:dendritic cell differentiation
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Accession:GO:0097028 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
Comment:Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.


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dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AXL AXL receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:112,699,679...112,727,434
Ensembl chr 1:112,700,365...112,726,960 		JBrowse link
G AZI2 5-azacytidine induced 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23610142) Ensembl
MGI		 PMID:23610142 GO_REF:0000107 NCBI chr23:15,911,663...15,947,713
Ensembl chr23:15,911,942...15,946,265 		JBrowse link
G BATF3 basic leucine zipper ATF-like transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:10,843,859...10,854,269
Ensembl chr 7:10,843,850...10,857,847 		JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:18384807 RGD:2313415 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006 		JBrowse link
G CSF2 colony stimulating factor 2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:8535150 PMID:20628067 GO_REF:0000107 RGD:5131511 RGD:5131521 NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959 		JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 involved_in ISO (MGI:3795633|PMID:18469816) UniProt PMID:18469816 MGI:3795633 NCBI chr25:11,551,372...11,670,891
Ensembl chr25:11,581,206...11,692,284 		JBrowse link
G GAS6 growth arrest specific 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:60,975,196...61,005,869
Ensembl chr22:60,974,849...61,005,875 		JBrowse link
G GATA1 GATA binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17505015) Ensembl
MGI		 PMID:17505015 GO_REF:0000107 NCBI chr  X:41,991,321...41,998,319
Ensembl chr  X:41,971,582...41,998,303 		JBrowse link
G IL4 interleukin 4 involved_in ISO (PMID:21149635) DFLAT PMID:21149635 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G IRF8 interferon regulatory factor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:66,789,264...66,812,477
Ensembl chr 5:66,791,350...66,842,179 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr29:7,367,617...7,448,862
Ensembl chr29:7,332,684...7,448,507 		JBrowse link
G TMEM176B transmembrane protein 176B acts_upstream_of ISO (PMID:20501748) MGI PMID:20501748 NCBI chr16:14,918,491...14,926,673
Ensembl chr16:14,919,126...14,926,583 		JBrowse link
G TREML1 triggering receptor expressed on myeloid cells like 1 involved_in ISO (PMID:11602640) BHF-UCL PMID:11602640 NCBI chr12:9,915,692...9,928,322
Ensembl chr12:9,915,677...9,928,174 		JBrowse link
G TRPM2 transient receptor potential cation channel subfamily M member 2 involved_in ISO (MGI:5298324|PMID:21753080) UniProt PMID:21753080 MGI:5298324 NCBI chr31:38,201,075...38,224,076 JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:22615127) Ensembl
MGI		 PMID:22615127 GO_REF:0000107 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570 		JBrowse link
Langerhans cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 acts_upstream_of_or_within ISO (PMID:17938236) MGI PMID:17938236 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G ITGB6 integrin subunit beta 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19118215) Ensembl
MGI		 PMID:19118215 GO_REF:0000107 NCBI chr36:5,833,206...5,962,699
Ensembl chr36:5,834,638...5,962,633 		JBrowse link
G ITGB8 integrin subunit beta 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19118215) Ensembl
MGI		 PMID:19118215 GO_REF:0000107 NCBI chr14:34,370,957...34,449,091
Ensembl chr14:34,349,232...34,444,235 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:112,629,476...112,643,885
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17938236) Ensembl
MGI		 PMID:17938236 GO_REF:0000107 NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636 		JBrowse link
mature conventional dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:3576832 NCBI chr11:51,357,706...51,359,207
Ensembl chr11:51,340,530...51,359,365 		JBrowse link
G CCR7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:29,801,119...29,810,006
Ensembl chr 3:29,800,211...29,810,180 		JBrowse link
G LGALS9 galectin 9 NOT|involved_in ISO (PMID:25754930) UniProt PMID:25754930 NCBI chr 9:42,154,613...42,170,423
Ensembl chr 9:42,154,702...42,170,391 		JBrowse link
myeloid dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,537,036...48,561,154 JBrowse link
G BATF2 basic leucine zipper ATF-like transcription factor 2 involved_in ISO (MGI:5441724|PMID:22992524) UniProt PMID:22992524 MGI:5441724 NCBI chr18:52,176,681...52,196,365
Ensembl chr18:52,175,549...52,195,404 		JBrowse link
G BATF3 basic leucine zipper ATF-like transcription factor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23913046) Ensembl
MGI		 PMID:23913046 GO_REF:0000107 NCBI chr 7:10,843,859...10,854,269
Ensembl chr 7:10,843,850...10,857,847 		JBrowse link
G CAMK4 calcium/calmodulin dependent protein kinase IV involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:1,174,975...1,369,640
Ensembl chr 3:1,180,401...1,369,803 		JBrowse link
G CD86 CD86 molecule ISO RGD PMID:21039614 RGD:4892198 NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087 		JBrowse link
G CSF2 colony stimulating factor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12021780) Ensembl
MGI		 PMID:12021780 GO_REF:0000107 NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959 		JBrowse link
G DCSTAMP dendrocyte expressed seven transmembrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:5,542,474...5,559,433
Ensembl chr13:5,542,425...5,571,968 		JBrowse link
G DHRS2 dehydrogenase/reductase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:3,820,269...3,847,217
Ensembl chr 8:3,836,476...3,845,916 		JBrowse link
G IL4 interleukin 4 involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G IRF4 interferon regulatory factor 4 involved_in
acts_upstream_of_or_within		 ISO (MGI:5441724|PMID:22992524)
(PMID:15184678)		 UniProt
MGI		 PMID:15184678 PMID:22992524 MGI:5441724 NCBI chr35:760,367...782,314
Ensembl chr35:767,011...781,339 		JBrowse link
G LOC100687459 GTPase IMAP family member 5 ISO RGD PMID:15922563 RGD:2303773 NCBI chr16:14,887,308...14,895,522 JBrowse link
G LOC611446 leukocyte immunoglobulin-like receptor subfamily A member 6 acts_upstream_of_or_within ISO (PMID:12021780) MGI PMID:12021780 NCBI chr 1:102,955,916...102,978,669 JBrowse link
G LTBR lymphotoxin beta receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23913046) Ensembl
MGI		 PMID:23913046 GO_REF:0000107 NCBI chr27:38,598,725...38,605,829
Ensembl chr27:38,599,268...38,605,780 		JBrowse link
G NOTCH2 notch receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23913046) Ensembl
MGI		 PMID:23913046 GO_REF:0000107 NCBI chr17:56,854,825...57,020,157
Ensembl chr17:56,860,429...57,020,857 		JBrowse link
G PSEN1 presenilin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23913046) Ensembl
MGI		 PMID:23913046 GO_REF:0000107 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532 		JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23913046) Ensembl
MGI		 PMID:23913046 GO_REF:0000107 NCBI chr 3:84,060,417...84,286,008
Ensembl chr 3:84,064,440...84,286,360 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14499111), (PMID:7845467) Ensembl
MGI		 PMID:7845467 PMID:14499111 GO_REF:0000107 NCBI chr 1:110,436,677...110,466,709
Ensembl chr 1:110,436,662...110,466,809 		JBrowse link
G SPI1 Spi-1 proto-oncogene acts_upstream_of_or_within ISO (PMID:10648399) MGI PMID:10648399 NCBI chr18:42,253,849...42,269,497
Ensembl chr18:42,253,811...42,269,727 		JBrowse link
G TNFSF9 TNF superfamily member 9 ISO RGD PMID:18687212 RGD:2317345 NCBI chr20:53,680,882...53,682,521
Ensembl chr20:53,679,880...53,682,706 		JBrowse link
G TRAF6 TNF receptor associated factor 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14499111) Ensembl
MGI		 PMID:14499111 GO_REF:0000107 NCBI chr18:31,674,242...31,689,160
Ensembl chr18:31,675,391...31,688,641 		JBrowse link
G UBD ubiquitin D involved_in ISO (PMID:19028597) UniProt PMID:19028597 NCBI chr35:26,426,919...26,436,189 JBrowse link
negative regulation of dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TMEM176A transmembrane protein 176A acts_upstream_of_or_within ISO (PMID:20501748) MGI PMID:20501748 NCBI chr16:14,927,031...14,931,350
Ensembl chr16:14,926,805...14,931,238 		JBrowse link
G TMEM176B transmembrane protein 176B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20501748) TreeGrafter
MGI		 PMID:20501748 GO_REF:0000118 NCBI chr16:14,918,491...14,926,673
Ensembl chr16:14,919,126...14,926,583 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22615127) Ensembl
MGI		 PMID:22615127 GO_REF:0000107 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570 		JBrowse link
plasmacytoid dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF8 interferon regulatory factor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:66,789,264...66,812,477
Ensembl chr 5:66,791,350...66,842,179 		JBrowse link
G SLAMF9 SLAM family member 9 acts_upstream_of_or_within ISO (PMID:31346085) MGI PMID:31346085 NCBI chr38:22,199,752...22,202,299
Ensembl chr38:22,199,494...22,202,299 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:22615127) Ensembl
MGI		 PMID:22615127 GO_REF:0000107 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570 		JBrowse link
positive regulation of dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129 		JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:18384807 RGD:2313415 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:15944249) UniProt PMID:15944249 NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165 		JBrowse link
G LGALS1 galectin 1 NOT|involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr10:26,932,351...26,935,580
Ensembl chr10:26,932,301...26,935,646 		JBrowse link
G LGALS3 galectin 3 NOT|involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr 8:30,977,438...30,994,711
Ensembl chr 8:30,983,633...30,994,705 		JBrowse link
G LGALS9 galectin 9 involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr 9:42,154,613...42,170,423
Ensembl chr 9:42,154,702...42,170,391 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22615127) Ensembl
MGI		 PMID:22615127 GO_REF:0000107 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570 		JBrowse link
regulation of dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEBPB CCAAT enhancer binding protein beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:36,661,294...36,663,162
Ensembl chr24:36,661,616...36,662,656 		JBrowse link
G DLA88 MHC class I DLA-88 involved_in ISO (PMID:20008523) BHF-UCL PMID:20008523 NCBI chr12:892,442...895,691
Ensembl chr12:892,388...1,021,690 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    cellular process 16926
      cellular developmental process 4594
        cell differentiation 4593
          leukocyte differentiation 673
            mononuclear cell differentiation 551
              dendritic cell differentiation 50
                mature conventional dendritic cell differentiation 4
                myeloid dendritic cell differentiation + 26
                negative regulation of dendritic cell differentiation 3
                plasmacytoid dendritic cell differentiation + 3
                positive regulation of dendritic cell differentiation 7
                regulation of dendritic cell differentiation + 11
Path 2
Term Annotations click to browse term
  biological_process 17917
    cellular process 16926
      cellular developmental process 4594
        cell differentiation 4593
          cell development 3258
            hemopoiesis 1053
              leukocyte differentiation 673
                mononuclear cell differentiation 551
                  dendritic cell differentiation 50
                    mature conventional dendritic cell differentiation 4
                    myeloid dendritic cell differentiation + 26
                    negative regulation of dendritic cell differentiation 3
                    plasmacytoid dendritic cell differentiation + 3
                    positive regulation of dendritic cell differentiation 7
                    regulation of dendritic cell differentiation + 11
paths to the root