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ONTOLOGY REPORT - ANNOTATIONS

Term:dendritic cell differentiation
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Accession:GO:0097028 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
Comment:Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.


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dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in ISO (PMID:19657094) RGD PMID:19657094 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Azi2 5-azacytidine induced 2 acts_upstream_of_or_within ISO
IEA		 MGI:5544312 (PMID:23610142)
GO_REF:0000107		 RGD
Ensembl		 PMID:23610142 GO_REF:0000107 NCBI chr 8:126,651,268...126,674,795
Ensembl chr 8:117,773,279...117,797,847 		JBrowse link
G Batf3 basic leucine zipper ATF-like transcription factor 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20351058)		 UniProt
RGD		 PMID:20351058 GO_REF:0000024 NCBI chr13:105,220,782...105,232,365
Ensembl chr13:102,689,657...102,701,139 		JBrowse link
G Cd40lg CD40 ligand IMP RGD PMID:18384807 RGD:2313415 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Csf2 colony stimulating factor 2 involved_in IDA
IEA
ISO		 GO_REF:0000107
(PMID:21149635)		 Ensembl
RGD		 PMID:21149635 PMID:20628067 PMID:8535150 GO_REF:0000107, RGD:5131511, RGD:5131521 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 involved_in ISO (PMID:18469816) RGD PMID:18469816 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand involved_in ISO
IEA		 (PMID:38701783)
GO_REF:0000107		 RGD
Ensembl		 PMID:38701783 GO_REF:0000107 NCBI chr 1:104,751,518...104,756,925
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO
IEA		 (PMID:19657094)
GO_REF:0000107		 RGD
Ensembl		 PMID:19657094 GO_REF:0000107 NCBI chr16:82,747,676...82,778,090
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gata1 GATA binding protein 1 acts_upstream_of_or_within ISO
IEA		 (PMID:17505015)
GO_REF:0000107		 RGD
Ensembl		 PMID:17505015 GO_REF:0000107 NCBI chr  X:17,193,291...17,209,462
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Il4 interleukin 4 involved_in ISO (PMID:21149635) RGD PMID:21149635 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Irf8 interferon regulatory factor 8 involved_in ISO
IEA		 (PMID:12461077)
GO_REF:0000107		 RGD
Ensembl		 PMID:12461077 GO_REF:0000107 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000107
(PMID:16034130)
GO_REF:0000033		 UniProt
Ensembl
RGD
GO_Central		 PMID:16034130 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Rpl13a ribosomal protein L13A involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:104,746,223...104,748,975
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
G Tmem176b transmembrane protein 176B acts_upstream_of ISO (PMID:20501748) RGD PMID:20501748 NCBI chr 4:79,097,808...79,105,263
Ensembl chr 4:77,766,928...77,774,384 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO
IEA		 (PMID:11602640)
GO_REF:0000107		 RGD
Ensembl		 PMID:11602640 GO_REF:0000107 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:21753080)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21753080 GO_REF:0000024 GO_REF:0000107 NCBI chr20:10,703,190...10,752,795
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of ISO
IEA		 MGI:5320483 (PMID:22615127)
GO_REF:0000107		 RGD
Ensembl		 PMID:22615127 GO_REF:0000107 NCBI chr 3:188,874,826...188,949,005
Ensembl chr 3:168,499,583...168,568,782 		JBrowse link
Langerhans cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgb6 integrin subunit beta 6 acts_upstream_of_or_within ISO
IEA		 MGI:1338035 (PMID:19118215)
GO_REF:0000107		 RGD
Ensembl		 PMID:19118215 GO_REF:0000107 NCBI chr 3:65,454,964...65,579,179
Ensembl chr 3:45,048,044...45,121,671 		JBrowse link
G Itgb8 integrin subunit beta 8 acts_upstream_of_or_within ISO MGI:96615 (PMID:19118215) RGD PMID:19118215 NCBI chr 6:146,267,982...146,351,245
Ensembl chr 6:140,127,203...140,208,476 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO
IEA		 MGI:3719583 (PMID:17938236)
GO_REF:0000107		 RGD
Ensembl		 PMID:17938236 GO_REF:0000107 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 acts_upstream_of_or_within ISO
IEA		 MGI:2384513 (PMID:17938236)
GO_REF:0000107		 RGD
Ensembl		 PMID:17938236 GO_REF:0000107 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
mature conventional dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO
IEA		 (PMID:15845453)
GO_REF:0000107		 RGD
Ensembl		 PMID:15845453 GO_REF:0000107 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO
IEA
ISS		 (PMID:16478888)
GO_REF:0000107
(PMID:19845798)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:16478888 PMID:19845798 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (PMID:25754930) RGD PMID:25754930 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Prtn3 proteinase 3 involved_in ISO (PMID:16478888) RGD PMID:16478888 NCBI chr 7:10,472,750...10,482,037
Ensembl chr 7:9,822,122...9,831,944 		JBrowse link
G Taok3 TAO kinase 3 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr12:44,973,180...45,134,439
Ensembl chr12:39,314,027...39,461,244 		JBrowse link
myeloid dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:22992524)		 UniProt
Ensembl
RGD		 PMID:22992524 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:111,084,717...111,107,052
Ensembl chr 6:105,353,715...105,376,051 		JBrowse link
G Batf2 basic leucine zipper ATF-like transcription factor 2 involved_in ISO (PMID:22992524) RGD PMID:22992524 NCBI chr 1:212,897,076...212,905,740
Ensembl chr 1:203,468,097...203,475,889 		JBrowse link
G Batf3 basic leucine zipper ATF-like transcription factor 3 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(PMID:19008445)
MGI:3817232 (PMID:23913046)		 UniProt
RGD		 PMID:19008445 PMID:23913046 GO_REF:0000024 NCBI chr13:105,220,782...105,232,365
Ensembl chr13:102,689,657...102,701,139 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV involved_in ISO
IEA
ISS		 (PMID:17909078)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17909078 GO_REF:0000024 GO_REF:0000107 NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Cd86 CD86 molecule IEP RGD PMID:21039614 RGD:4892198 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Csf2 colony stimulating factor 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:16116184)
GO_REF:0000107
(PMID:12021780)		 RGD
Ensembl		 PMID:12021780 PMID:16116184 GO_REF:0000107 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein involved_in ISO (PMID:17713547) RGD PMID:17713547 NCBI chr 7:72,692,364...72,706,983
Ensembl chr 7:70,807,581...70,822,078 		JBrowse link
G Dhrs2 dehydrogenase/reductase 2 involved_in ISO
IEA		 (PMID:11944995)
GO_REF:0000107		 RGD
Ensembl		 PMID:11944995 GO_REF:0000107 NCBI chr15:32,658,855...32,673,591
Ensembl chr15:28,688,940...28,703,644 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:15922563 RGD:2303773 NCBI chr 4:79,025,151...79,031,917
Ensembl chr 4:77,687,564...77,703,086 		JBrowse link
G Il4 interleukin 4 involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Irf4 interferon regulatory factor 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:2387941 (PMID:15184678)
GO_REF:0000107
(PMID:22992524)		 RGD
Ensembl		 PMID:15184678 PMID:22992524 GO_REF:0000107 NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Ltbr lymphotoxin beta receptor acts_upstream_of_or_within ISO MGI:2384140 (PMID:23913046) RGD PMID:23913046 NCBI chr 4:159,795,115...159,801,571
Ensembl chr 4:158,108,886...158,121,539 		JBrowse link
G Notch2 notch receptor 2 acts_upstream_of_or_within ISO
IEA		 MGI:3617328 (PMID:23913046)
GO_REF:0000107		 RGD
Ensembl		 PMID:23913046 GO_REF:0000107 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088 		JBrowse link
G Pirb paired Ig-like receptor B acts_upstream_of_or_within ISO MGI:2180757 (PMID:12021780) RGD PMID:12021780 NCBI chr 1:74,414,556...74,433,015
Ensembl chr 1:65,499,195...65,506,666 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within ISO
IEA		 MGI:2449306 (PMID:23913046)
GO_REF:0000107		 RGD
Ensembl		 PMID:23913046 GO_REF:0000107 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within ISO MGI:3583755 (PMID:23913046) RGD PMID:23913046 NCBI chr14:61,551,366...61,736,220
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO
IEA		 MGI:2179544 (PMID:14499111), (PMID:7845467)
GO_REF:0000107		 RGD
Ensembl		 PMID:7845467 PMID:14499111 GO_REF:0000107 NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Spi1 Spi-1 proto-oncogene acts_upstream_of_or_within ISO
IEA		 MGI:1930970 (PMID:10648399)
GO_REF:0000107		 RGD
Ensembl		 PMID:10648399 GO_REF:0000107 NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Tnfsf9 TNF superfamily member 9 IDA RGD PMID:18687212 RGD:2317345 NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Traf6 TNF receptor associated factor 6 acts_upstream_of_or_within ISO MGI:2678775 (PMID:14499111) RGD PMID:14499111 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ubd ubiquitin D involved_in ISO
ISS		 (PMID:19028597)
GO_REF:0000024		 RGD
UniProt		 PMID:19028597 GO_REF:0000024 NCBI chr20:1,390,734...1,392,685
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639 		JBrowse link
negative regulation of dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec12a C-type lectin domain family 12, member A involved_in ISO (PMID:16239426)
(PMID:30787988)		 RGD PMID:16239426 PMID:30787988 NCBI chr 4:164,484,162...164,502,793
Ensembl chr 4:162,798,125...162,816,753 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:20702625) RGD PMID:20702625 NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Tmem176a transmembrane protein 176A acts_upstream_of_or_within ISO (PMID:20501748) RGD PMID:20501748 NCBI chr 4:79,101,946...79,109,499
Ensembl chr 4:77,774,843...77,778,620 		JBrowse link
G Tmem176b transmembrane protein 176B involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:20501748)		 GO_Central
RGD		 PMID:20501748 GO_REF:0000033 NCBI chr 4:79,097,808...79,105,263
Ensembl chr 4:77,766,928...77,774,384 		JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO
IEA		 MGI:5320483 (PMID:22615127)
GO_REF:0000107		 RGD
Ensembl		 PMID:22615127 GO_REF:0000107 NCBI chr 3:188,874,826...188,949,005
Ensembl chr 3:168,499,583...168,568,782 		JBrowse link
plasmacytoid dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf8 interferon regulatory factor 8 involved_in ISO
IEA		 (PMID:12538667)
GO_REF:0000107		 RGD
Ensembl		 PMID:12538667 GO_REF:0000107 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Slamf9 SLAM family member 9 acts_upstream_of_or_within ISO MGI:6364884 (PMID:31346085) RGD PMID:31346085 NCBI chr13:87,474,290...87,477,108
Ensembl chr13:84,941,982...84,944,748 		JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of ISO
IEA		 MGI:5320483 (PMID:22615127)
GO_REF:0000107		 RGD
Ensembl		 PMID:22615127 GO_REF:0000107 NCBI chr 3:188,874,826...188,949,005
Ensembl chr 3:168,499,583...168,568,782 		JBrowse link
positive regulation of dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO
IEA		 (PMID:15944249)
GO_REF:0000107		 RGD
Ensembl		 PMID:15944249 GO_REF:0000107 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Cd40lg CD40 ligand IDA RGD PMID:18384807 RGD:2313415 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15944249) RGD PMID:15944249 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Lgals1 galectin 1 NOT|involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Lgals3 galectin 3 NOT|involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO
IEA		 MGI:5320483 (PMID:22615127)
GO_REF:0000107		 RGD
Ensembl		 PMID:22615127 GO_REF:0000107 NCBI chr 3:188,874,826...188,949,005
Ensembl chr 3:168,499,583...168,568,782 		JBrowse link
regulation of dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpb CCAAT/enhancer binding protein beta involved_in IEA
ISO		 GO_REF:0000107
RNAcentral:URS00000B7E30_10090 (PMID:26526992)		 Ensembl
RGD		 PMID:26526992 GO_REF:0000107 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      cellular developmental process 4833
        cell differentiation 4832
          leukocyte differentiation 690
            mononuclear cell differentiation 556
              dendritic cell differentiation 54
                mature conventional dendritic cell differentiation 6
                myeloid dendritic cell differentiation + 25
                negative regulation of dendritic cell differentiation 5
                plasmacytoid dendritic cell differentiation + 3
                positive regulation of dendritic cell differentiation 7
                regulation of dendritic cell differentiation + 12
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      cellular developmental process 4833
        cell differentiation 4832
          cell development 3350
            hemopoiesis 1083
              leukocyte differentiation 690
                mononuclear cell differentiation 556
                  dendritic cell differentiation 54
                    mature conventional dendritic cell differentiation 6
                    myeloid dendritic cell differentiation + 25
                    negative regulation of dendritic cell differentiation 5
                    plasmacytoid dendritic cell differentiation + 3
                    positive regulation of dendritic cell differentiation 7
                    regulation of dendritic cell differentiation + 12
paths to the root