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ONTOLOGY REPORT - ANNOTATIONS


Term:t-circle formation
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Accession:GO:0090656 term browser browse the term
Definition:A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD).
Synonyms:exact_synonym: telomeric circle formation



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t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chr 6:51,783,537...51,808,898 JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:46,787,664...46,854,331
Ensembl chr 4:46,787,659...46,903,999
JBrowse link
G SLX1A SLX1 homolog A, structure-specific endonuclease subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:18,346,501...18,349,509 JBrowse link
G SLX4 SLX4 structure-specific endonuclease subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,646,904...38,670,173
Ensembl chr 3:38,646,938...38,670,166
JBrowse link
G XRCC3 X-ray repair cross complementing 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635
negative regulation of t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RTEL1 regulator of telomere elongation helicase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:62,611,844...62,636,628 JBrowse link
G TERF2 telomeric repeat binding factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,605,748...17,631,795
Ensembl chr 6:17,605,346...17,631,793
JBrowse link
G TMEM169 transmembrane protein 169 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:118,335,915...118,352,713
Ensembl chr15:118,335,925...118,452,296
JBrowse link
G XRCC5 X-ray repair cross complementing 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:118,354,943...118,451,974
Ensembl chr15:118,335,925...118,452,296
JBrowse link
positive regulation of t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chr 6:51,783,537...51,808,898 JBrowse link
G SLX1A SLX1 homolog A, structure-specific endonuclease subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:18,346,501...18,349,509 JBrowse link
G SLX4 SLX4 structure-specific endonuclease subunit involved_in ISO (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chr 3:38,646,904...38,670,173
Ensembl chr 3:38,646,938...38,670,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16675
    metabolic process 10521
      cellular metabolic process 9547
        cellular macromolecule metabolic process 7345
          DNA metabolic process 852
            formation of extrachromosomal circular DNA 9
              t-circle formation 9
                negative regulation of t-circle formation 4
                positive regulation of t-circle formation 3
                regulation of t-circle formation + 7
Path 2
Term Annotations click to browse term
  biological_process 16675
    metabolic process 10521
      cellular metabolic process 9547
        cellular aromatic compound metabolic process 5167
          nucleobase-containing compound metabolic process 4966
            nucleic acid metabolic process 4550
              DNA metabolic process 852
                telomere maintenance 139
                  telomere maintenance via telomere trimming 9
                    t-circle formation 9
                      negative regulation of t-circle formation 4
                      positive regulation of t-circle formation 3
                      regulation of t-circle formation + 7
paths to the root