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ONTOLOGY REPORT - ANNOTATIONS


Term:t-circle formation
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Accession:GO:0090656 term browser browse the term
Definition:A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD).
Synonyms:exact_synonym: telomeric circle formation



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t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 involved_in IMP (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chr 7:19,344,067...19,356,524
Ensembl chr 7:19,344,778...19,356,524
JBrowse link
G Nbn nibrin involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 4:15,957,587...15,992,589
Ensembl chr 4:15,957,925...15,992,589
JBrowse link
G Slx1b SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) involved_in IMP (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chr 7:126,688,927...126,695,783
Ensembl chr 7:126,689,468...126,695,784
JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) involved_in IMP
ISO
(MGI:5645200|PMID:22579284) BHF-UCL
MGI
PMID:22579284 GO_REF:0000096 MGI:4834177 MGI:5645200 NCBI chr16:3,979,105...4,003,829
Ensembl chr16:3,979,105...4,003,770
JBrowse link
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr12:111,803,192...111,813,893
Ensembl chr12:111,803,192...111,813,873
JBrowse link
negative regulation of t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtel1 regulator of telomere elongation helicase 1 involved_in IBA
IMP
ISO
(MGI:6201960|PMID:21873635)
(MGI:5522574|PMID:24115439), (MGI:5645200|PMID:22579284)
GO_Central
BHF-UCL
MGI
PMID:21873635 PMID:22579284 PMID:24115439 GO_REF:0000096 MGI:4834177 MGI:5522574 MGI:5645200 MGI:6201960 NCBI chr 2:181,319,711...181,356,616
Ensembl chr 2:181,319,739...181,356,616
JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 8:107,069,400...107,096,548
Ensembl chr 8:107,069,400...107,096,547
JBrowse link
G Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 1:72,307,417...72,394,953
Ensembl chr 1:72,307,427...72,394,952
JBrowse link
positive regulation of t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 involved_in IMP (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chr 7:19,344,067...19,356,524
Ensembl chr 7:19,344,778...19,356,524
JBrowse link
G Slx1b SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) involved_in IMP (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chr 7:126,688,927...126,695,783
Ensembl chr 7:126,689,468...126,695,784
JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) involved_in IMP (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chr16:3,979,105...4,003,829
Ensembl chr16:3,979,105...4,003,770
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28604
    metabolic process 11327
      cellular metabolic process 10160
        cellular macromolecule metabolic process 7727
          DNA metabolic process 908
            formation of extrachromosomal circular DNA 8
              t-circle formation 8
                negative regulation of t-circle formation 3
                positive regulation of t-circle formation 3
                regulation of t-circle formation + 6
Path 2
Term Annotations click to browse term
  biological_process 28604
    metabolic process 11327
      cellular metabolic process 10160
        cellular aromatic compound metabolic process 5526
          nucleobase-containing compound metabolic process 5294
            nucleic acid metabolic process 4851
              DNA metabolic process 908
                telomere maintenance 143
                  telomere maintenance via telomere trimming 8
                    t-circle formation 8
                      negative regulation of t-circle formation 3
                      positive regulation of t-circle formation 3
                      regulation of t-circle formation + 6
paths to the root