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ONTOLOGY REPORT - ANNOTATIONS


Term:t-circle formation
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Accession:GO:0090656 term browser browse the term
Definition:A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD).
Synonyms:exact_synonym: telomeric circle formation



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t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLM BLM RecQ like helicase involved_in TAS (PMID:27918544) BHF-UCL PMID:27918544 NCBI chr15:90,717,346...90,816,166
Ensembl chr15:90,717,346...90,816,166
JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in TAS (PMID:27918544) BHF-UCL PMID:27918544 NCBI chr10:68,414,064...68,472,521
Ensembl chr10:68,414,064...68,472,121
JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828
JBrowse link
G EXO1 exonuclease 1 involved_in TAS (PMID:27918544) BHF-UCL PMID:27918544 NCBI chr 1:241,847,967...241,889,939
Ensembl chr 1:241,847,967...241,895,148
JBrowse link
G NBN nibrin involved_in IMP (PMID:27918544) BHF-UCL PMID:27918544 NCBI chr 8:89,933,331...89,984,698
Ensembl chr 8:89,933,331...90,003,228
JBrowse link
G SLX1A SLX1 homolog A, structure-specific endonuclease subunit involved_in IMP
ISS
(PMID:24012755) BHF-UCL PMID:24012755 GO_REF:0000024 NCBI chr16:30,193,843...30,197,566
Ensembl chr16:30,193,875...30,197,561
JBrowse link
G SLX1B SLX1 homolog B, structure-specific endonuclease subunit involved_in IMP
ISS
(PMID:24012755) BHF-UCL PMID:24012755 GO_REF:0000024 NCBI chr16:29,454,501...29,458,219
Ensembl chr16:29,454,501...29,458,219
JBrowse link
G SLX4 SLX4 structure-specific endonuclease subunit involved_in IMP
ISS
(PMID:24012755) BHF-UCL PMID:24012755 GO_REF:0000024 NCBI chr16:3,579,653...3,611,639
Ensembl chr16:3,581,181...3,611,606
JBrowse link
G SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 involved_in TAS (PMID:27918544) BHF-UCL PMID:27918544 NCBI chr 2:216,412,484...216,483,053
Ensembl chr 2:216,412,414...216,483,053
JBrowse link
G TERF1 telomeric repeat binding factor 1 involved_in TAS (PMID:27918544) BHF-UCL PMID:27918544 NCBI chr 8:73,008,856...73,048,123
Ensembl chr 8:73,008,856...73,048,123
JBrowse link
G WRN WRN RecQ like helicase involved_in TAS (PMID:27918544) BHF-UCL PMID:27918544 NCBI chr 8:31,033,749...31,176,138
Ensembl chr 8:31,033,788...31,176,138
JBrowse link
G XRCC3 X-ray repair cross complementing 3 involved_in IBA
IMP
IC
(PMID:21873635)
(PMID:21903669)
(PMID:15507207)
GO_Central
BHF-UCL
PMID:15507207 PMID:21873635 PMID:21903669 NCBI chr14:103,697,611...103,715,486
Ensembl chr14:103,697,609...103,715,504
JBrowse link
negative regulation of t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RTEL1 regulator of telomere elongation helicase 1 involved_in IBA
TAS
IMP
ISS
(PMID:21873635)
(PMID:24115439)
(PMID:25620558)
GO_Central
BHF-UCL
PMID:21873635 PMID:24115439 PMID:25620558 GO_REF:0000024 NCBI chr20:63,657,810...63,696,253
Ensembl chr20:63,657,810...63,696,253
JBrowse link
G TERF2 telomeric repeat binding factor 2 involved_in IMP
TAS
(PMID:15507207)
(PMID:19581589)
BHF-UCL PMID:15507207 PMID:19581589 NCBI chr16:69,355,567...69,386,007
Ensembl chr16:69,355,567...69,408,571
JBrowse link
G XRCC5 X-ray repair cross complementing 5 involved_in IMP (PMID:19581589) BHF-UCL PMID:19581589 NCBI chr 2:216,109,348...216,206,293
Ensembl chr 2:216,107,464...216,206,303
JBrowse link
positive regulation of t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828
JBrowse link
G SLX1A SLX1 homolog A, structure-specific endonuclease subunit involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr16:30,193,843...30,197,566
Ensembl chr16:30,193,875...30,197,561
JBrowse link
G SLX1B SLX1 homolog B, structure-specific endonuclease subunit involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr16:29,454,501...29,458,219
Ensembl chr16:29,454,501...29,458,219
JBrowse link
G SLX4 SLX4 structure-specific endonuclease subunit involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr16:3,579,653...3,611,639
Ensembl chr16:3,581,181...3,611,606
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18607
    metabolic process 11952
      cellular metabolic process 10866
        cellular macromolecule metabolic process 8304
          DNA metabolic process 989
            formation of extrachromosomal circular DNA 15
              t-circle formation 15
                negative regulation of t-circle formation 3
                positive regulation of t-circle formation 4
                regulation of t-circle formation + 7
Path 2
Term Annotations click to browse term
  biological_process 18607
    metabolic process 11952
      cellular metabolic process 10866
        cellular aromatic compound metabolic process 6064
          nucleobase-containing compound metabolic process 5818
            nucleic acid metabolic process 5315
              DNA metabolic process 989
                telomere maintenance 154
                  telomere maintenance via telomere trimming 15
                    t-circle formation 15
                      negative regulation of t-circle formation 3
                      positive regulation of t-circle formation 4
                      regulation of t-circle formation + 7
paths to the root