Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:t-circle formation
go back to main search page
Accession:GO:0090656 term browser browse the term
Definition:A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD).
Synonyms:exact_synonym: telomeric circle formation


GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
 
t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chrNW_004955555:2,393,510...2,430,180
Ensembl chrNW_004955555:2,393,278...2,406,582
JBrowse link
G Nbn nibrin involved_in ISO (PMID:27918544) BHF-UCL PMID:27918544 NCBI chrNW_004955417:6,840,916...6,880,479
Ensembl chrNW_004955417:6,839,312...6,880,133
JBrowse link
G Slx1a SLX1 homolog A, structure-specific endonuclease subunit involved_in ISO (PMID:24012755)
(MGI:5645200|PMID:22579284)
BHF-UCL PMID:22579284 PMID:24012755 MGI:5645200 NCBI chrNW_004955493:6,797,913...6,800,555 JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit involved_in ISO (PMID:24012755)
(MGI:5645200|PMID:22579284)
BHF-UCL PMID:22579284 PMID:24012755 MGI:5645200 NCBI chrNW_004955442:13,765,660...13,792,106
Ensembl chrNW_004955442:13,770,340...13,791,314
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:21903669) BHF-UCL PMID:21903669 NCBI chrNW_004955538:2,499,297...2,511,898
Ensembl chrNW_004955538:2,501,607...2,509,778
JBrowse link
negative regulation of t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO (PMID:25620558)
(MGI:5522574|PMID:24115439), (MGI:5645200|PMID:22579284)
BHF-UCL PMID:22579284 PMID:24115439 PMID:25620558 MGI:5522574 MGI:5645200 NCBI chrNW_004955528:531,680...578,003 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:15507207) BHF-UCL PMID:15507207 NCBI chrNW_004955484:7,318,813...7,344,221
Ensembl chrNW_004955484:7,318,860...7,347,430
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 involved_in ISO (PMID:19581589) BHF-UCL PMID:19581589 NCBI chrNW_004955453:16,967,453...17,054,634
Ensembl chrNW_004955453:16,967,453...17,054,634
JBrowse link
positive regulation of t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chrNW_004955555:2,393,510...2,430,180
Ensembl chrNW_004955555:2,393,278...2,406,582
JBrowse link
G Slx1a SLX1 homolog A, structure-specific endonuclease subunit involved_in ISO (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chrNW_004955493:6,797,913...6,800,555 JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit involved_in ISO (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chrNW_004955442:13,765,660...13,792,106
Ensembl chrNW_004955442:13,770,340...13,791,314
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12099
    metabolic process 7720
      cellular metabolic process 7078
        cellular macromolecule metabolic process 5475
          DNA metabolic process 712
            formation of extrachromosomal circular DNA 8
              t-circle formation 8
                negative regulation of t-circle formation 3
                positive regulation of t-circle formation 3
                regulation of t-circle formation + 6
Path 2
Term Annotations click to browse term
  biological_process 12099
    metabolic process 7720
      cellular metabolic process 7078
        cellular aromatic compound metabolic process 3855
          nucleobase-containing compound metabolic process 3677
            nucleic acid metabolic process 3377
              DNA metabolic process 712
                telomere maintenance 129
                  telomere maintenance via telomere trimming 8
                    t-circle formation 8
                      negative regulation of t-circle formation 3
                      positive regulation of t-circle formation 3
                      regulation of t-circle formation + 6
paths to the root