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ONTOLOGY REPORT - ANNOTATIONS

Term:siRNA-mediated gene silencing by mRNA destabilization
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Accession:GO:0090625 term browser browse the term
Definition:An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.
Synonyms:exact_synonym: mRNA cleavage involved in gene silencing by siRNA
 broad_synonym: gene silencing by mRNA cleavage


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siRNA-mediated gene silencing by mRNA destabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGO1 argonaute RISC component 1 NOT|involved_in ISO (PMID:15260970) BHF-UCL PMID:15260970 NCBI chr 6:92,038,104...92,076,477
Ensembl chr 6:91,984,303...92,215,149 		JBrowse link
G AGO2 argonaute RISC catalytic component 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:2,966,794...3,012,388
Ensembl chr 4:2,919,511...3,015,334 		JBrowse link
G AGO4 argonaute RISC component 4 NOT|involved_in ISO (PMID:15260970) BHF-UCL PMID:15260970 NCBI chr 6:91,967,499...92,013,030
Ensembl chr 6:91,973,119...92,012,990 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17799
    biological regulation 12896
      regulation of biological quality 3225
        regulation of RNA stability 246
          regulation of mRNA stability 233
            mRNA destabilization 160
              siRNA-mediated gene silencing by mRNA destabilization 3
                siRNA-mediated long-distance post-transcriptional gene silencing 0
Path 2
Term Annotations click to browse term
  biological_process 17799
    biological regulation 12896
      regulation of biological process 12533
        regulation of metabolic process 6217
          regulation of biosynthetic process 5090
            regulation of cellular biosynthetic process 5003
              regulation of macromolecule biosynthetic process 4906
                regulation of gene expression 4791
                  negative regulation of gene expression 1354
                    mRNA catabolic process 314
                      regulation of mRNA catabolic process 249
                        regulation of mRNA stability 233
                          mRNA destabilization 160
                            siRNA-mediated gene silencing by mRNA destabilization 3
                              siRNA-mediated long-distance post-transcriptional gene silencing 0
paths to the root