ONTOLOGY REPORT - ANNOTATIONS |
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Term: | replicative senescence |
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Accession: | GO:0090399
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browse the term
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Definition: | A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. |
Synonyms: | only_in_taxon: | NCBITaxon:33208 ! Metazoa |
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Atm |
ATM serine/threonine kinase |
involved_in |
ISO |
(PMID:15149599) |
RGD |
PMID:15149599 |
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NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Atr |
ATR serine/threonine kinase |
involved_in |
ISO |
(PMID:15149599) |
RGD |
PMID:15149599 |
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NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
involved_in |
IEA |
GO_REF:0000107 |
Ensembl |
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GO_REF:0000107 |
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
involved_in |
ISO |
(PMID:14720514) |
RGD |
PMID:14720514 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Ctc1 |
CST telomere replication complex component 1 |
acts_upstream_of_or_within |
ISO |
MGI:5427642 (PMID:22531781) |
RGD |
PMID:22531781 |
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NCBI chr10:53,714,614...53,735,298
Ensembl chr10:53,714,644...53,735,298
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Ercc1 |
ERCC excision repair 1, endonuclease non-catalytic subunit |
acts_upstream_of_or_within |
ISO |
MGI:2183944|MGI:2183945 (PMID:17173483), (PMID:9197240) |
RGD |
PMID:9197240 PMID:17173483 |
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NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
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Mme |
membrane metallo-endopeptidase |
involved_in |
ISO ISS IEA |
(PMID:20876573) GO_REF:0000024 GO_REF:0000107 |
RGD UniProt Ensembl |
PMID:20876573 |
GO_REF:0000024 GO_REF:0000107 |
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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Pla2r1 |
phospholipase A2 receptor 1 |
involved_in |
ISO ISS |
(PMID:19197340) GO_REF:0000024 |
RGD UniProt |
PMID:19197340 |
GO_REF:0000024 |
NCBI chr 3:44,883,943...45,013,793
Ensembl chr 3:44,883,943...45,013,660
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Romo1 |
reactive oxygen species modulator 1 |
involved_in |
ISO |
(PMID:18836179) |
RGD |
PMID:18836179 |
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NCBI chr 3:144,659,709...144,661,310
Ensembl chr 3:144,659,826...144,661,310
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Serpine1 |
serpin family E member 1 |
involved_in |
IEA ISO ISS |
GO_REF:0000107 (PMID:16862142) GO_REF:0000024 |
Ensembl RGD UniProt |
PMID:16862142 |
GO_REF:0000024 GO_REF:0000107 |
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Tert |
telomerase reverse transcriptase |
involved_in |
ISO |
(PMID:9454332) |
RGD |
PMID:9454332 |
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NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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Tp53 |
tumor protein p53 |
involved_in |
ISO IEA |
(PMID:19951988) GO_REF:0000107 |
RGD Ensembl |
PMID:19951988 |
GO_REF:0000107 |
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Wnt16 |
Wnt family member 16 |
involved_in |
ISO |
(PMID:19951988) |
RGD |
PMID:19951988 |
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NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380
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Wrn |
WRN RecQ like helicase |
acts_upstream_of_or_within |
ISO |
MGI:2386438 (PMID:10757812) |
RGD |
PMID:10757812 |
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NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450
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Mir21 |
microRNA 21 |
involved_in |
ISO |
(PMID:23496142) |
RGD |
PMID:23496142 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Term paths to the root
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