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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular senescence
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Accession:GO:0090398 term browser browse the term
Definition:A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.



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cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of
involved_in
ISO
IEA
MGI:104738 (MGI:5449665|PMID:22729085)
GO_REF:0000107
RGD
Ensembl
PMID:22729085 GO_REF:0000107 MGI:5449665 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Brca2 BRCA2, DNA repair associated acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:2653913|MGI:2653914 (MGI:1277623|PMID:9699678)
GO_REF:0000107
RGD
Ensembl
PMID:9699678 GO_REF:0000107 MGI:1277623 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Calr calreticulin involved_in ISO ENSEMBL_GeneID:ENSG00000124762 (PMID:14726956)
(MGI:3813434|PMID:14726956)
RGD PMID:14726956 MGI:3813434 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Cav1 caveolin 1 IMP RGD PMID:23941874 RGD:9588563 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:15149599), (PMID:17553787) RGD PMID:15149599 PMID:17553787 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in
acts_upstream_of_or_within
ISO (PMID:16243918)
(MGI:2159048|PMID:11748239), (MGI:5299398|PMID:21911473), (MGI:5449665|PMID:22729085)
(PMID:14966292), (PMID:16243918)
(MGI:5299398|PMID:21911473), (MGI:5449665|PMID:22729085)
RGD PMID:11748239 PMID:14966292 PMID:16243918 PMID:21911473 PMID:22729085 MGI:2159048 MGI:5299398 MGI:5449665 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B involved_in ISO (PMID:17553787) RGD PMID:17553787 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 IEP RGD PMID:20569237 RGD:5147849 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 acts_upstream_of_or_within ISO (MGI:3525039|PMID:15572682) RGD PMID:15572682 MGI:3525039 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161
JBrowse link
G Ecrg4 ECRG4 augurin precursor involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:4454240|PMID:20404145)
RGD PMID:20404145 PMID:21873635 MGI:4454240, RGD:13792537 NCBI chr 9:45,992,954...46,012,605
Ensembl chr 9:45,992,954...46,012,595
JBrowse link
G H2ax H2A.X variant histone IEP RGD PMID:19946210 RGD:8693719 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hras HRas proto-oncogene, GTPase involved_in
acts_upstream_of_or_within
IEP
IBA
ISO
PMID:21873635
(MGI:2670239|PMID:12878730), (MGI:3525039|PMID:15572682)
(PMID:9054499)
RGD PMID:9054499 PMID:12878730 PMID:15572682 PMID:17706954 PMID:21873635 MGI:2670239 MGI:3525039, RGD:11060281, RGD:13792537 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Htt huntingtin acts_upstream_of_or_within ISO MGI:3603606 (MGI:3619488|PMID:16403806) RGD PMID:16403806 MGI:3619488 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070
JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP vascular smooth muscle cells RGD PMID:20421514 RGD:4145420 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id2 inhibitor of DNA binding 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:4412240|PMID:18474814)
UniProt
RGD
PMID:18474814 GO_REF:0000024 MGI:4412240 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEP RGD PMID:19862643 RGD:10045872 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Kat6a lysine acetyltransferase 6A involved_in ISO
IEA
ISS
(PMID:23431171)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23431171 GO_REF:0000024 GO_REF:0000107 NCBI chr16:69,084,914...69,165,923
Ensembl chr16:69,084,914...69,163,606
JBrowse link
G Lmna lamin A/C involved_in
acts_upstream_of_or_within_positive_effect
IEP
IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:20458013)
Ensembl
UniProt
RGD
PMID:20458013 PMID:20362703 GO_REF:0000024 GO_REF:0000107, RGD:12791030 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 involved_in ISO
IEA
(PMID:9765203)
GO_REF:0000107
RGD
Ensembl
PMID:9765203 GO_REF:0000107 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Mif macrophage migration inhibitory factor acts_upstream_of_or_within ISO MGI:2673280 (MGI:2670239|PMID:12878730) RGD PMID:12878730 MGI:2670239 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mir125a microRNA 125a acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710
JBrowse link
G Mir125b1 microRNA 125b-1 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052
JBrowse link
G Mir125b2 microRNA 125b-2 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir128-1 microRNA 128-1 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr13:39,699,449...39,699,530
Ensembl chr13:39,699,449...39,699,530
JBrowse link
G Mir128-2 microRNA 128-2 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 8:112,085,467...112,085,550
Ensembl chr 8:112,085,467...112,085,550
JBrowse link
G Mir130a microRNA 130a acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629
JBrowse link
G Mir132 microRNA 132 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
JBrowse link
G Mir134 microRNA 134 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 6:128,748,908...128,748,980 JBrowse link
G Mir140 microRNA 140 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
JBrowse link
G Mir15b microRNA 15b acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
JBrowse link
G Mir16 microRNA 16 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443
JBrowse link
G Mir183 microRNA 183 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723
JBrowse link
G Mir188 microRNA 188 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr  X:15,247,715...15,247,794
Ensembl chr  X:15,247,715...15,247,794
JBrowse link
G Mir191 microRNA 191 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 8:109,264,098...109,264,188 JBrowse link
G Mir193b microRNA 193b acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr10:1,317,742...1,317,824
Ensembl chr10:1,317,742...1,317,824
JBrowse link
G Mir199a2 microRNA 199a-2 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063
JBrowse link
G Mir19b1 microRNA 19b-1 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr15:92,181,214...92,181,300
Ensembl chr15:92,181,214...92,181,300
JBrowse link
G Mir19b2 microRNA 19b-2 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr  X:132,422,072...132,422,167
Ensembl chr  X:132,422,072...132,422,167
JBrowse link
G Mir20a microRNA 20a acts_upstream_of_or_within ISO (MGI:5705446|PMID:25959411)
(MGI:5643971|PMID:25751060), (MGI:5705446|PMID:25959411)
RGD PMID:25751060 PMID:25959411 MGI:5643971 MGI:5705446 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
JBrowse link
G Mir211 microRNA 211 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644
JBrowse link
G Mir22 microRNA 22 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Mir23a microRNA 23a acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071
JBrowse link
G Mir23b microRNA 23b acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763
JBrowse link
G Mir24-2 microRNA 24-2 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790
JBrowse link
G Mir25 microRNA 25 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015
JBrowse link
G Mir27a microRNA 27a acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917
JBrowse link
G Mir296 microRNA 296 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 3:163,051,838...163,051,915
Ensembl chr 3:163,051,838...163,051,915
JBrowse link
G Mir30a microRNA 30a acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670
JBrowse link
G Mir31 microRNA 31 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mir342 microRNA 342 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367
JBrowse link
G Mir34a microRNA 34a acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
JBrowse link
G Mir34b microRNA 34b acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 8:51,410,244...51,410,327
Ensembl chr 8:51,410,244...51,410,327
JBrowse link
G Mir34c microRNA 34c acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802
JBrowse link
G Mir370 microRNA 370 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 6:128,572,257...128,572,335
Ensembl chr 6:128,572,257...128,572,335
JBrowse link
G Mir671 microRNA 671 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 4:10,580,747...10,580,827
Ensembl chr 4:10,580,738...10,580,835
JBrowse link
G Mir877 microRNA 877 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr20:2,811,476...2,811,560
Ensembl chr20:2,811,476...2,811,560
JBrowse link
G Mir99a microRNA 99a acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523
JBrowse link
G Mirlet7b microRNA let-7b acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
JBrowse link
G Mirlet7d microRNA let-7d acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990
JBrowse link
G Mirlet7f-1 microRNA let7f-1 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr17:16,114,130...16,114,226
Ensembl chr17:16,114,130...16,114,226
JBrowse link
G Mirlet7f2 microRNA let-7f-2 acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr  X:20,980,632...20,980,714
Ensembl chr  X:20,980,632...20,980,714
JBrowse link
G Mirlet7g microRNA let-7g acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 8:106,822,293...106,822,380
Ensembl chr 8:106,822,280...106,822,388
JBrowse link
G Mirlet7i microRNA let-7i acts_upstream_of_or_within ISO (MGI:5643971|PMID:25751060) RGD PMID:25751060 MGI:5643971 NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571
JBrowse link
G Mnt MAX network transcriptional repressor acts_upstream_of_or_within ISO MGI:2678322 (MGI:2675510|PMID:12970171) RGD PMID:12970171 MGI:2675510 NCBI chr10:59,699,208...59,714,848
Ensembl chr10:59,699,585...59,714,835
JBrowse link
G Npm1 nucleophosmin 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:12080348)
UniProt
RGD
PMID:12080348 GO_REF:0000024 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
JBrowse link
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase involved_in ISO
ISS
(PMID:17589526)
GO_REF:0000024
RGD
UniProt
PMID:17589526 GO_REF:0000024 NCBI chr 7:90,936,112...91,173,435
Ensembl chr 7:90,936,112...91,164,899
JBrowse link
G Nup62 nucleoporin 62 acts_upstream_of_or_within ISO (MGI:3525039|PMID:15572682) RGD PMID:15572682 MGI:3525039 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
ISO
GO_REF:0000024
(PMID:17545159)
ParkinsonsUK-UCL
RGD
PMID:17545159 GO_REF:0000024 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (PMID:22002537), (PMID:22117195), (PMID:23431171) RGD PMID:22002537 PMID:22117195 PMID:23431171 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Pot1b protection of telomeres 1B involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 9:9,670,355...9,728,624
Ensembl chr 9:9,670,362...9,728,532
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein acts_upstream_of_or_within ISO (MGI:3525039|PMID:15572682) RGD PMID:15572682 MGI:3525039 NCBI chr13:45,368,407...45,391,480
Ensembl chr13:45,370,533...45,380,270
JBrowse link
G Prkcd protein kinase C, delta involved_in ISO (PMID:15282327) RGD PMID:15282327 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prmt6 protein arginine methyltransferase 6 acts_upstream_of_or_within ISO (MGI:5504576|PMID:22904064) RGD PMID:22904064 MGI:5504576 NCBI chr 2:197,927,750...197,932,980
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
G Smc5 structural maintenance of chromosomes 5 involved_in ISO (PMID:17589526) RGD PMID:17589526 NCBI chr 1:220,769,366...220,839,138
Ensembl chr 1:220,769,366...220,839,096
JBrowse link
G Smc6 structural maintenance of chromosomes 6 involved_in ISO (PMID:17589526) RGD PMID:17589526 NCBI chr 6:33,978,730...34,033,201
Ensembl chr 6:33,978,716...34,031,746
JBrowse link
G Srf serum response factor involved_in ISO (PMID:15282327) RGD PMID:15282327 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
G Tbx2 T-box transcription factor 2 involved_in
acts_upstream_of_or_within
ISO (PMID:22002537)
(PMID:11748239), (PMID:22002537)
(MGI:2159048|PMID:11748239)
RGD PMID:11748239 PMID:22002537 MGI:2159048 NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529
JBrowse link
G Tbx3 T-box transcription factor 3 involved_in
acts_upstream_of_or_within
ISO
ISS
(PMID:22002537)
(PMID:11748239), (PMID:22002537)
(MGI:2159048|PMID:11748239)
GO_REF:0000024
RGD
UniProt
PMID:11748239 PMID:22002537 GO_REF:0000024 MGI:2159048 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
JBrowse link
G Top2b DNA topoisomerase II beta IEP RGD PMID:20708677 RGD:13432149 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
JBrowse link
G Tp53 tumor protein p53 involved_in ISO
ISS
(PMID:12080348)
GO_REF:0000024
RGD
UniProt
PMID:12080348 GO_REF:0000024 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp63 tumor protein p63 acts_upstream_of_or_within ISO MGI:2385473 (MGI:3588617|PMID:16107615) RGD PMID:16107615 MGI:3588617 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Wrn WRN RecQ like helicase involved_in ISO (PMID:18212065) RGD PMID:18212065 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450
JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 acts_upstream_of_or_within ISO (MGI:3525039|PMID:15572682) RGD PMID:15572682 MGI:3525039 NCBI chr16:1,027,083...1,232,616
Ensembl chr16:1,027,325...1,232,597
JBrowse link
negative regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:104738 (MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:5449665 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Akt3 AKT serine/threonine kinase 3 involved_in ISO
IEA
(PMID:25323119)
GO_REF:0000107
RGD
Ensembl
PMID:25323119 GO_REF:0000107 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
JBrowse link
G Bcl2l12 Bcl2-like 12 acts_upstream_of_or_within ISO (MGI:4834958|PMID:20837658) RGD PMID:20837658 MGI:4834958 NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991
JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158436 (MGI:5469797|PMID:23209284) RGD PMID:23209284 MGI:5469797 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Cdk6 cyclin-dependent kinase 6 involved_in ISO (PMID:17420273) RGD PMID:17420273 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Fbxo5 F-box protein 5 involved_in ISO (PMID:17875940) RGD PMID:17875940 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in ISO
IEA
(MGI:5009768|PMID:21241890)
GO_REF:0000107
RGD
Ensembl
PMID:21241890 GO_REF:0000107 MGI:5009768 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952
JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO (MGI:5582375|PMID:23072816) RGD PMID:23072816 MGI:5582375 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G LOC100912427 nuclease-sensitive element-binding protein 1-like involved_in ISO (MGI:6158172|PMID:29712925) RGD PMID:29712925 MGI:6158172 NCBI chr 1:171,304,587...171,306,092
Ensembl chr 1:171,304,774...171,306,097
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 involved_in ISO (PMID:28640956) RGD PMID:28640956 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848
JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:10562313) RGD PMID:10562313 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase IDA RGD PMID:28125705 RGD:13781884 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Plk2 polo-like kinase 2 involved_in ISO (MGI:6120300|PMID:27908889) RGD PMID:27908889 MGI:6120300 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (MGI:5009768|PMID:21241890) RGD PMID:21241890 MGI:5009768 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 involved_in ISO
IEA
(PMID:28595801)
GO_REF:0000107
RGD
Ensembl
PMID:28595801 GO_REF:0000107 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:20203304), (PMID:20424141) RGD PMID:20203304 PMID:20424141 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (PMID:22753495), (PMID:27043296), (PMID:29474172) RGD PMID:22753495 PMID:27043296 PMID:29474172 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
JBrowse link
G Slc30a10 solute carrier family 30, member 10 involved_in ISO (PMID:22427991) RGD PMID:22427991 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
JBrowse link
G Tbx2 T-box transcription factor 2 involved_in ISO (PMID:11062467), (PMID:12000749) RGD PMID:11062467 PMID:12000749 NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529
JBrowse link
G Terc telomerase RNA component involved_in ISO (PMID:11313459) RGD PMID:11313459 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:11927518) RGD PMID:11927518 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819
JBrowse link
G Tert telomerase reverse transcriptase involved_in ISO (PMID:11313459), (PMID:11927518) RGD PMID:11313459 PMID:11927518 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tp63 tumor protein p63 involved_in ISO (PMID:19451233) RGD PMID:19451233 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO
IEA
(PMID:16501043)
GO_REF:0000107
RGD
Ensembl
PMID:16501043 GO_REF:0000107 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
G Ybx1 Y box binding protein 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:6158172|PMID:29712925)
UniProt
Ensembl
RGD
PMID:29712925 GO_REF:0000024 GO_REF:0000107 MGI:6158172 NCBI chr 5:132,882,137...132,899,108
Ensembl chr 5:132,882,145...132,898,862
JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 involved_in ISO (PMID:23434374) RGD PMID:23434374 NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827
JBrowse link
oncogene-induced cell senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmga1 high mobility group AT-hook 1 involved_in ISO
ISS
(PMID:16901784)
GO_REF:0000024
RGD
UniProt
PMID:16901784 GO_REF:0000024 NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752
JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:16901784)
UniProt
RGD
PMID:16901784 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (MGI:3717518|PMID:10910364) RGD PMID:10910364 MGI:3717518 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (MGI:6478061|PMID:28912174) RGD PMID:28912174 MGI:6478061 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
JBrowse link
oxidative stress-induced premature senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arntl aryl hydrocarbon receptor nuclear translocator-like involved_in ISS
ISO
GO_REF:0000024
(MGI:5554364|PMID:22101268)
UniProt
RGD
PMID:22101268 GO_REF:0000024 MGI:5554364 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Pla2r1 phospholipase A2 receptor 1 involved_in ISO
ISS
(PMID:19197340)
GO_REF:0000024
RGD
UniProt
PMID:19197340 GO_REF:0000024 NCBI chr 3:44,883,943...45,013,793
Ensembl chr 3:44,883,943...45,013,660
JBrowse link
G Tp53 tumor protein p53 involved_in ISO (PMID:19951988) RGD PMID:19951988 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Wnt16 Wnt family member 16 involved_in ISO (PMID:19951988) RGD PMID:19951988 NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380
JBrowse link
positive regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3 ABI family, member 3 involved_in ISO (PMID:21223585) RGD PMID:21223585 NCBI chr10:80,769,819...80,780,816
Ensembl chr10:80,769,822...80,780,816
JBrowse link
G Abi3bp ABI family member 3 binding protein involved_in ISS GO_REF:0000024 ARUK-UCL GO_REF:0000024 NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929
JBrowse link
G Arg2 arginase 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:22928666)
Ensembl
RGD
PMID:22928666 GO_REF:0000107 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G B2m beta-2 microglobulin involved_in ISO (PMID:28213472) RGD PMID:28213472 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO (MGI:5909142|PMID:28759028) RGD PMID:28759028 MGI:5909142 NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 involved_in ISO (PMID:25465621) RGD PMID:25465621 NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720
JBrowse link
G Ilk integrin-linked kinase IMP RGD PMID:17234816 RGD:2301768 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Kras KRAS proto-oncogene, GTPase IMP RGD PMID:17706954 RGD:11060281 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mir188 microRNA 188 involved_in ISO (PMID:28640956) RGD PMID:28640956 NCBI chr  X:15,247,715...15,247,794
Ensembl chr  X:15,247,715...15,247,794
JBrowse link
G Mir20b microRNA 20b involved_in ISO (PMID:28595801) RGD PMID:28595801 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282
JBrowse link
G Mir217 microRNA 217 involved_in ISO (PMID:19786632) RGD PMID:19786632 NCBI chr14:102,531,505...102,531,609
Ensembl chr14:102,531,505...102,531,609
JBrowse link
G Mir22 microRNA 22 involved_in ISO (PMID:25323119) RGD PMID:25323119 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Mir34a microRNA 34a involved_in ISO (PMID:20424141) RGD PMID:20424141 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
JBrowse link
G Morc3 MORC family CW-type zinc finger 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17332504)
GO_REF:0000107
RGD
Ensembl
PMID:17332504 GO_REF:0000107 NCBI chr11:33,151,906...33,194,646
Ensembl chr11:33,152,025...33,194,646
JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:19698731 RGD:10003167 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in ISO (MGI:5648604|PMID:25472717) RGD PMID:25472717 MGI:5648604 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:23184984) RGD PMID:23184984 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:18687677) RGD PMID:18687677 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO (PMID:20203304) RGD PMID:20203304 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in
ISO MGI:1920086 (MGI:3692019|PMID:17053789)
(MGI:5142390|PMID:10562313)
RGD PMID:10562313 PMID:17053789 MGI:3692019 MGI:5142390 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ypel3 yippee-like 3 involved_in ISO (PMID:20388804) RGD PMID:20388804 NCBI chr 1:181,384,385...181,387,706
Ensembl chr 1:181,384,357...181,387,705
JBrowse link
regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:1338938 (MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:5449665 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like involved_in ISS
ISO
GO_REF:0000024
(MGI:5554364|PMID:22101268)
UniProt
RGD
PMID:22101268 GO_REF:0000024 MGI:5554364 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO MGI:87859 (MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:5449665 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase acts_upstream_of_or_within ISO MGI:1890508 (MGI:5500993|PMID:23686339) RGD PMID:23686339 MGI:5500993 NCBI chr 5:162,804,368...162,811,129
Ensembl chr 5:162,804,368...162,811,128
JBrowse link
G Ing2 inhibitor of growth family, member 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482
JBrowse link
G Nek4 NIMA-related kinase 4 involved_in ISO (PMID:22851694) RGD PMID:22851694 NCBI chr16:6,144,900...6,185,376
Ensembl chr16:6,144,959...6,188,932
JBrowse link
G Nuak1 NUAK family kinase 1 involved_in ISO (PMID:19927127) RGD PMID:19927127 NCBI chr 7:19,330,034...19,401,918
Ensembl chr 7:19,329,933...19,401,913
JBrowse link
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 involved_in ISO (PMID:16055741) RGD PMID:16055741 NCBI chr14:102,877,553...102,908,696
Ensembl chr14:102,877,553...102,908,696
JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 involved_in ISO (PMID:18678645) RGD PMID:18678645 NCBI chr10:4,424,868...4,436,753
Ensembl chr10:4,397,821...4,439,593
JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase acts_upstream_of_or_within ISO MGI:2445449 (MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:5913114 NCBI chr  X:14,421,028...14,434,216
Ensembl chr  X:14,421,109...14,433,982
JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 acts_upstream_of_or_within ISO MGI:2445449 (MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:5913114 NCBI chr  X:141,793,695...141,795,558 JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:2139971 (MGI:5504576|PMID:22904064) RGD PMID:22904064 MGI:5504576 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vash1 vasohibin 1 acts_upstream_of_or_within ISO (PMID:23056314) RGD PMID:23056314 NCBI chr 6:106,330,374...106,345,740
Ensembl chr 6:106,329,123...106,345,726
JBrowse link
G Zfp277 zinc finger protein 277 acts_upstream_of_or_within ISO MGI:5496522 (MGI:5496352|PMID:20808772) RGD PMID:20808772 MGI:5496352 NCBI chr 6:57,383,944...57,512,785
Ensembl chr 6:57,383,951...57,512,765
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO MGI:1888594|MGI:2180033 (MGI:3789238|PMID:16079796), (MGI:5139938|PMID:21746928), (MGI:5500993|PMID:23686339) RGD PMID:16079796 PMID:21746928 PMID:23686339 MGI:3789238 MGI:5139938 MGI:5500993 NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110
JBrowse link
stress-induced premature senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk14 mitogen activated protein kinase 14 involved_in ISO
IEA
(PMID:20160708)
GO_REF:0000107
RGD
Ensembl
PMID:20160708 GO_REF:0000107 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 involved_in ISO (PMID:17254968)
(MGI:3697960|PMID:17254968)
RGD PMID:17254968 MGI:3697960 NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:17916362) RGD PMID:17916362 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    metabolic process 11458
      cellular metabolic process 9697
        cellular senescence 142
          negative regulation of cellular senescence 28
          oncogene-induced cell senescence 4
          positive regulation of cellular senescence 21
          regulation of cellular senescence + 61
          stress-induced premature senescence + 7
Path 2
Term Annotations click to browse term
  biological_process 18734
    response to stimulus 10209
      response to stress 4154
        cellular response to stress 2090
          cellular senescence 142
            negative regulation of cellular senescence 28
            oncogene-induced cell senescence 4
            positive regulation of cellular senescence 21
            regulation of cellular senescence + 61
            stress-induced premature senescence + 7
paths to the root