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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular senescence
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Accession:GO:0090398 term browser browse the term
Definition:A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
Synonyms:never_in_taxon: NCBITaxon:4751 ! Fungi


show annotations for term's descendants           Sort by:
cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of ISO MGI:104738 (PMID:22729085) RGD PMID:22729085 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Brca2 BRCA2, DNA repair associated involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2653913|MGI:2653914 (PMID:9699678)		 Ensembl
RGD		 PMID:9699678 GO_REF:0000107 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Calr calreticulin involved_in ISO ENSEMBL_GeneID:ENSG00000124762 (PMID:14726956) RGD PMID:14726956 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Cav1 caveolin 1 IMP RGD PMID:23941874 RGD:9588563 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A acts_upstream_of_or_within
involved_in		 ISO MGI:104738 (PMID:11551927)
(PMID:15149599)
(PMID:17553787)		 RGD PMID:11551927 PMID:15149599 PMID:17553787 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in
acts_upstream_of_or_within		 ISO (PMID:14966292), (PMID:16243918)
MGI:104556 (PMID:11551927), (PMID:11748239), (PMID:21911473), (PMID:22729085)		 RGD PMID:11551927 PMID:11748239 PMID:14966292 PMID:16243918 PMID:21911473 More... NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B acts_upstream_of ISO (PMID:17553787) RGD PMID:17553787 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 IEP RGD PMID:20569237 RGD:5147849 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Comp cartilage oligomeric matrix protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2180787 (PMID:27498005)		 Ensembl
RGD		 PMID:27498005 GO_REF:0000107 NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 acts_upstream_of_or_within ISO (PMID:15572682) RGD PMID:15572682 NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Ecrg4 ECRG4 augurin precursor involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:20404145)		 GO_Central
RGD		 PMID:20404145 GO_REF:0000033 NCBI chr 9:45,992,954...46,012,605
Ensembl chr 9:45,992,954...46,012,595 		JBrowse link
G Fbxo4 F-box protein 4 acts_upstream_of_or_within ISO MGI:5301830 (PMID:21911473) RGD PMID:21911473 NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792 		JBrowse link
G Gins3 GINS complex subunit 3 acts_upstream_of_or_within ISO (PMID:35603789) RGD PMID:35603789 NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687 		JBrowse link
G H2ax H2A.X variant histone IEP RGD PMID:19946210 RGD:8693719 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hras HRas proto-oncogene, GTPase acts_upstream_of_or_within
involved_in		 IEP
ISO
IBA		 (PMID:12878730), (PMID:15572682)
GO_REF:0000033
(PMID:9054499)		 RGD
GO_Central		 PMID:9054499 PMID:12878730 PMID:15572682 PMID:17706954 GO_REF:0000033, RGD:11060281 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Htt huntingtin acts_upstream_of_or_within ISO MGI:3603606 (PMID:16403806) RGD PMID:16403806 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP vascular smooth muscle cells RGD PMID:20421514 RGD:4145420 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id2 inhibitor of DNA binding 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18474814)		 UniProt
RGD		 PMID:18474814 GO_REF:0000024 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEP RGD PMID:19862643 RGD:10045872 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Kat6a lysine acetyltransferase 6A involved_in ISO
IEA
ISS		 (PMID:23431171)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23431171 GO_REF:0000024 GO_REF:0000107 NCBI chr16:69,084,914...69,165,923
Ensembl chr16:69,084,914...69,163,606 		JBrowse link
G Lmna lamin A/C involved_in
acts_upstream_of_or_within_positive_effect		 IEP
IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:20458013)		 Ensembl
UniProt
RGD		 PMID:20458013 PMID:20362703 GO_REF:0000024 GO_REF:0000107, RGD:12791030 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 involved_in ISO
IEA		 (PMID:9765203)
GO_REF:0000107		 RGD
Ensembl		 PMID:9765203 GO_REF:0000107 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mif macrophage migration inhibitory factor acts_upstream_of_or_within ISO MGI:2673280 (PMID:12878730) RGD PMID:12878730 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Mirlet7d microRNA let-7d acts_upstream_of_or_within ISO (PMID:25751060) RGD PMID:25751060 NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990 		JBrowse link
G Mirlet7f-1 microRNA let7f-1 acts_upstream_of_or_within ISO (PMID:25751060) RGD PMID:25751060 NCBI chr17:16,114,130...16,114,226
Ensembl chr17:16,114,130...16,114,226 		JBrowse link
G Mirlet7f2 microRNA let-7f-2 acts_upstream_of_or_within ISO (PMID:25751060) RGD PMID:25751060 NCBI chr  X:20,980,632...20,980,714
Ensembl chr  X:20,980,632...20,980,714 		JBrowse link
G Mirlet7g microRNA let-7g acts_upstream_of_or_within ISO (PMID:25751060) RGD PMID:25751060 NCBI chr 8:106,822,293...106,822,380
Ensembl chr 8:106,822,280...106,822,388 		JBrowse link
G Mnt MAX network transcriptional repressor acts_upstream_of_or_within ISO MGI:2678322 (PMID:12970171) RGD PMID:12970171 NCBI chr10:59,699,208...59,714,848
Ensembl chr10:59,699,585...59,714,835 		JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 acts_upstream_of_or_within ISO (PMID:33323934) RGD PMID:33323934 NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467 		JBrowse link
G Npm1 nucleophosmin 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:12080348)		 UniProt
RGD		 PMID:12080348 GO_REF:0000024 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
Ensembl chr  X:17,739,941...17,751,645 		JBrowse link
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase involved_in ISO
IEA
ISS		 (PMID:17589526)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17589526 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:90,936,112...91,173,435
Ensembl chr 7:90,936,112...91,164,899 		JBrowse link
G Nup62 nucleoporin 62 acts_upstream_of_or_within ISO (PMID:15572682) RGD PMID:15572682 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17545159)		 ParkinsonsUK-UCL
Ensembl
RGD		 PMID:17545159 GO_REF:0000024 GO_REF:0000107 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (PMID:22002537), (PMID:22117195), (PMID:23431171) RGD PMID:22002537 PMID:22117195 PMID:23431171 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Pot1b protection of telomeres 1B involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 9:9,670,355...9,728,624
Ensembl chr 9:9,670,362...9,728,532 		JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein acts_upstream_of_or_within ISO (PMID:15572682) RGD PMID:15572682 NCBI chr13:45,368,407...45,391,480
Ensembl chr13:45,370,533...45,380,270 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
IEA		 (PMID:15282327)
GO_REF:0000107		 RGD
Ensembl		 PMID:15282327 GO_REF:0000107 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prmt6 protein arginine methyltransferase 6 acts_upstream_of_or_within ISO (PMID:22904064) RGD PMID:22904064 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648 		JBrowse link
G Smc5 structural maintenance of chromosomes 5 involved_in ISO (PMID:17589526) RGD PMID:17589526 NCBI chr 1:220,769,366...220,839,138
Ensembl chr 1:220,769,366...220,839,096 		JBrowse link
G Smc6 structural maintenance of chromosomes 6 involved_in ISO (PMID:17589526) RGD PMID:17589526 NCBI chr 6:33,978,730...34,033,201
Ensembl chr 6:33,978,716...34,031,746 		JBrowse link
G Srf serum response factor involved_in ISO (PMID:15282327) RGD PMID:15282327 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Tbx2 T-box transcription factor 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:11748239), (PMID:22002537) RGD PMID:11748239 PMID:22002537 NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529 		JBrowse link
G Tbx3 T-box transcription factor 3 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(PMID:11748239)
(PMID:11748239), (PMID:22002537)		 UniProt
RGD		 PMID:11748239 PMID:22002537 GO_REF:0000024 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
G Top2b DNA topoisomerase II beta IEP RGD PMID:20708677 RGD:13432149 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO
ISS		 (PMID:12080348)
GO_REF:0000024		 RGD
UniProt		 PMID:12080348 GO_REF:0000024 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp63 tumor protein p63 acts_upstream_of_or_within ISO MGI:2385473 (PMID:16107615) RGD PMID:16107615 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Wrn WRN RecQ like helicase involved_in ISO (PMID:18212065) RGD PMID:18212065 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 acts_upstream_of_or_within ISO (PMID:15572682) RGD PMID:15572682 NCBI chr16:1,027,083...1,232,616
Ensembl chr16:1,027,325...1,232,597 		JBrowse link
negative regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:104738 (PMID:22729085) RGD PMID:22729085 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 involved_in ISO
IEA		 (PMID:25323119)
GO_REF:0000107		 RGD
Ensembl		 PMID:25323119 GO_REF:0000107 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Ang angiogenin involved_in ISO (PMID:33758201) RGD PMID:33758201 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Bcl2l12 Bcl2 like 12 acts_upstream_of_or_within ISO (PMID:20837658) RGD PMID:20837658 NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991 		JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158436 (PMID:23209284) RGD PMID:23209284 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 involved_in ISO (PMID:17420273) RGD PMID:17420273 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Fbxo5 F-box protein 5 involved_in ISO (PMID:17875940) RGD PMID:17875940 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in ISO (PMID:21241890) RGD PMID:21241890 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952 		JBrowse link
G Gch1 GTP cyclohydrolase 1 IMP RGD PMID:30690003 RGD:401717569 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO (PMID:23072816) RGD PMID:23072816 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:10562313) RGD PMID:10562313 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase IDA RGD PMID:28125705 RGD:13781884 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Plk2 polo-like kinase 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:27908889)		 Ensembl
RGD		 PMID:27908889 GO_REF:0000107 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:21241890) RGD PMID:21241890 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 involved_in ISO
IEA		 (PMID:28595801)
GO_REF:0000107		 RGD
Ensembl		 PMID:28595801 GO_REF:0000107 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (PMID:20203304), (PMID:20424141)
GO_REF:0000107		 RGD
Ensembl		 PMID:20203304 PMID:20424141 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (PMID:22753495), (PMID:27043296), (PMID:29474172) RGD PMID:22753495 PMID:27043296 PMID:29474172 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Tbx2 T-box transcription factor 2 involved_in ISO (PMID:11062467), (PMID:12000749) RGD PMID:11062467 PMID:12000749 NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529 		JBrowse link
G Terc telomerase RNA component involved_in ISO (PMID:11313459) RGD PMID:11313459 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:11927518) RGD PMID:11927518 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
G Tert telomerase reverse transcriptase involved_in ISO (PMID:11313459), (PMID:11927518) RGD PMID:11313459 PMID:11927518 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tp63 tumor protein p63 involved_in ISO (PMID:19451233) RGD PMID:19451233 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (PMID:16501043) RGD PMID:16501043 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
G Ybx1 Y box binding protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29712925)		 UniProt
RGD		 PMID:29712925 GO_REF:0000024 NCBI chr 5:132,882,137...132,898,885
Ensembl chr 5:132,882,145...132,898,862 		JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 involved_in ISO (PMID:23434374) RGD PMID:23434374 NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827 		JBrowse link
oncogene-induced cell senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A acts_upstream_of_or_within ISO MGI:104738|MGI:1933751 (PMID:11551927) RGD PMID:11551927 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A acts_upstream_of_or_within ISO MGI:104556|MGI:1857942 (PMID:11551927) RGD PMID:11551927 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Hmga1 high mobility group AT-hook 1 involved_in ISO
ISS		 (PMID:16901784)
GO_REF:0000024		 RGD
UniProt		 PMID:16901784 GO_REF:0000024 NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752 		JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16901784)		 UniProt
RGD		 PMID:16901784 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784 		JBrowse link
G Hras HRas proto-oncogene, GTPase acts_upstream_of_or_within ISO (PMID:11551927) RGD PMID:11551927 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (PMID:10910364) RGD PMID:10910364 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (PMID:28912174) RGD PMID:28912174 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
oxidative stress-induced premature senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmal1 basic helix-loop-helix ARNT like 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:22101268)		 UniProt
RGD		 PMID:22101268 GO_REF:0000024 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Pla2r1 phospholipase A2 receptor 1 involved_in ISO
ISS		 (PMID:19197340)
GO_REF:0000024		 RGD
UniProt		 PMID:19197340 GO_REF:0000024 NCBI chr 3:44,883,943...45,013,793
Ensembl chr 3:44,883,943...45,013,660 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO
IEA		 (PMID:19951988)
GO_REF:0000107		 RGD
Ensembl		 PMID:19951988 GO_REF:0000107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wnt16 Wnt family member 16 involved_in ISO (PMID:19951988) RGD PMID:19951988 NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380 		JBrowse link
positive regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3 ABI family, member 3 involved_in ISO (PMID:21223585) RGD PMID:21223585 NCBI chr10:80,769,819...80,780,816
Ensembl chr10:80,769,822...80,780,816 		JBrowse link
G Abi3bp ABI family member 3 binding protein involved_in ISS GO_REF:0000024 ARUK-UCL GO_REF:0000024 NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929 		JBrowse link
G Arg2 arginase 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22928666)		 Ensembl
RGD		 PMID:22928666 GO_REF:0000107 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G B2m beta-2 microglobulin involved_in ISO
IEA		 (PMID:28213472)
GO_REF:0000107		 RGD
Ensembl		 PMID:28213472 GO_REF:0000107 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Ccn1 cellular communication network factor 1 IEP RGD PMID:30371213 RGD:329845516 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO (PMID:28759028) RGD PMID:28759028 NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 involved_in ISO (PMID:25465621) RGD PMID:25465621 NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720 		JBrowse link
G Ilk integrin-linked kinase IMP RGD PMID:17234816 RGD:2301768 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Kras KRAS proto-oncogene, GTPase IMP RGD PMID:17706954 RGD:11060281 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mir20b microRNA 20b involved_in ISO (PMID:28595801) RGD PMID:28595801 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282 		JBrowse link
G Mir217 microRNA 217 involved_in ISO (PMID:19786632) RGD PMID:19786632 NCBI chr14:102,531,505...102,531,609
Ensembl chr14:102,531,505...102,531,609 		JBrowse link
G Mir22 microRNA 22 involved_in ISO (PMID:25323119) RGD PMID:25323119 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133 		JBrowse link
G Mir34a microRNA 34a involved_in ISO (PMID:20424141) RGD PMID:20424141 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Morc3 MORC family CW-type zinc finger 3 acts_upstream_of_or_within ISO (PMID:17332504) RGD PMID:17332504 NCBI chr11:33,151,906...33,194,650
Ensembl chr11:33,152,025...33,194,646 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:19698731 RGD:10003167 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in ISO (PMID:25472717) RGD PMID:25472717 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:23184984) RGD PMID:23184984 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (PMID:18687677)
GO_REF:0000107		 RGD
Ensembl		 PMID:18687677 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO (PMID:20203304) RGD PMID:20203304 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:29474172)
(PMID:10562313)
MGI:1920086 (PMID:17053789)
GO_REF:0000107		 RGD
Ensembl		 PMID:10562313 PMID:17053789 PMID:29474172 GO_REF:0000107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ypel3 yippee-like 3 involved_in ISO (PMID:20388804) RGD PMID:20388804 NCBI chr 1:181,384,385...181,387,706
Ensembl chr 1:181,384,357...181,387,705 		JBrowse link
regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:1338938 (PMID:22729085) RGD PMID:22729085 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:22101268)		 UniProt
RGD		 PMID:22101268 GO_REF:0000024 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO MGI:87859 (PMID:22729085) RGD PMID:22729085 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase acts_upstream_of_or_within ISO MGI:1890508 (PMID:23686339) RGD PMID:23686339 NCBI chr 5:162,804,368...162,811,129
Ensembl chr 5:162,804,368...162,811,128 		JBrowse link
G Nek4 NIMA-related kinase 4 involved_in ISO (PMID:22851694) RGD PMID:22851694 NCBI chr16:6,144,900...6,185,376
Ensembl chr16:6,144,959...6,188,932 		JBrowse link
G Nuak1 NUAK family kinase 1 involved_in ISO (PMID:19927127) RGD PMID:19927127 NCBI chr 7:19,330,034...19,401,918
Ensembl chr 7:19,329,933...19,401,913 		JBrowse link
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 involved_in ISO (PMID:16055741) RGD PMID:16055741 NCBI chr14:102,877,553...102,908,696
Ensembl chr14:102,877,553...102,908,696 		JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 involved_in ISO (PMID:18678645) RGD PMID:18678645 NCBI chr10:4,424,868...4,436,753
Ensembl chr10:4,397,821...4,439,593 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase acts_upstream_of_or_within ISO MGI:2445449 (PMID:23695662) RGD PMID:23695662 NCBI chr  X:14,421,028...14,433,993
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 acts_upstream_of_or_within ISO MGI:2445449 (PMID:23695662) RGD PMID:23695662 NCBI chr  X:141,792,589...141,795,257 JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:2139971 (PMID:22904064) RGD PMID:22904064 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vash1 vasohibin 1 acts_upstream_of_or_within ISO (PMID:23056314) RGD PMID:23056314 NCBI chr 6:106,330,374...106,345,740
Ensembl chr 6:106,329,123...106,345,726 		JBrowse link
G Zfp277 zinc finger protein 277 acts_upstream_of_or_within ISO MGI:5496522 (PMID:20808772) RGD PMID:20808772 NCBI chr 6:57,383,454...57,512,785
Ensembl chr 6:57,383,951...57,512,765 		JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO MGI:1888594|MGI:2180033 (PMID:16079796), (PMID:21746928), (PMID:23686339) RGD PMID:16079796 PMID:21746928 PMID:23686339 NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110 		JBrowse link
stress-induced premature senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk14 mitogen activated protein kinase 14 involved_in ISO
IEA		 (PMID:20160708)
GO_REF:0000107		 RGD
Ensembl		 PMID:20160708 GO_REF:0000107 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 involved_in ISO (PMID:17254968) RGD PMID:17254968 NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (PMID:17916362)
GO_REF:0000107		 RGD
Ensembl		 PMID:17916362 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        cellular senescence 108
          negative regulation of cellular senescence 27
          oncogene-induced cell senescence 7
          positive regulation of cellular senescence 21
          regulation of cellular senescence + 59
          stress-induced premature senescence + 7
Path 2
Term Annotations click to browse term
  biological_process 20076
    response to stimulus 10795
      response to stress 4260
        cellular response to stress 2017
          cellular senescence 108
            negative regulation of cellular senescence 27
            oncogene-induced cell senescence 7
            positive regulation of cellular senescence 21
            regulation of cellular senescence + 59
            stress-induced premature senescence + 7
paths to the root