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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of excitatory postsynaptic potential
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Accession:GO:0090394 term browser browse the term
Definition:Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
Synonyms:exact_synonym: negative regulation of excitatory post-synaptic membrane potential;   reduction of excitatory postsynaptic membrane potential
 related_synonym: negative regulation of EPSP


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negative regulation of excitatory postsynaptic potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbln1 cerebellin 1 precursor ISO (PMID:27418511) RGD PMID:27418511 NCBI chr19:20,607,507...20,611,316
Ensembl chr19:20,607,507...20,611,316
JBrowse link
G Celf4 CUGBP, Elav-like family member 4 ISO MGI:MGI:5425630 (MGI:MGI:5313512|PMID:21745337) RGD PMID:21745337 MGI:MGI:5313512 NCBI chr18:17,689,090...18,079,835
Ensembl chr18:17,698,038...17,716,880
JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 IMP RGD PMID:17632064 RGD:10044262 NCBI chr10:108,415,201...108,425,195
Ensembl chr10:108,415,202...108,425,206
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO (MGI:MGI:4941068|PMID:21307259) RGD PMID:21307259 MGI:MGI:4941068 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Mtmr2 myotubularin related protein 2 IMP PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr 8:12,283,471...12,334,014
Ensembl chr 8:12,284,528...12,333,316
JBrowse link
G Nlgn3 neuroligin 3 ISO
IEA
(MGI:MGI:5286761|PMID:21808020)
GO_REF:0000107
RGD
Ensembl
PMID:21808020 GO_REF:0000107, MGI:MGI:5286761 NCBI chr  X:71,199,390...71,227,460
Ensembl chr  X:71,199,491...71,222,732
JBrowse link
G Npy2r neuropeptide Y receptor Y2 IDA RGD PMID:12055128 RGD:1642608 NCBI chr 2:181,528,949...181,538,145
Ensembl chr 2:181,530,832...181,531,978
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:19033459 RGD:10413844 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Pten phosphatase and tensin homolog ISO (MGI:MGI:5320272|PMID:21411674) RGD PMID:21411674 MGI:MGI:5320272 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 ISO MGI:MGI:2180817 (MGI:MGI:2157237|PMID:11553273) RGD PMID:11553273 MGI:MGI:2157237 NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
JBrowse link
G Tmem25 transmembrane protein 25 ISO
IBA
(MGI:MGI:6370252|PMID:31424425)
PMID:21873635
RGD PMID:31424425, PMID:21873635 MGI:MGI:6370252, RGD:13792537 NCBI chr 8:49,100,759...49,106,258
Ensembl chr 8:49,100,759...49,106,177
JBrowse link
negative regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syne1 spectrin repeat containing nuclear envelope protein 1 IMP RGD PMID:24191017 RGD:13209020 NCBI chr 1:41,608,287...41,763,591
NCBI chr 1:41,844,840...42,086,662
Ensembl chr 1:41,608,418...42,077,535
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    multicellular organismal process 9056
      negative regulation of multicellular organismal process 1391
        negative regulation of nervous system process 34
          negative regulation of excitatory postsynaptic potential 12
            negative regulation of acetylcholine-gated cation channel activity 0
            negative regulation of mini excitatory postsynaptic potential 1
Path 2
Term Annotations click to browse term
  biological_process 20015
    cellular process 18788
      cell communication 7670
        cell-cell signaling 1754
          synaptic signaling 897
            trans-synaptic signaling 871
              anterograde trans-synaptic signaling 864
                chemical synaptic transmission 864
                  chemical synaptic transmission, postsynaptic 127
                    excitatory postsynaptic potential 118
                      modulation of excitatory postsynaptic potential 58
                        negative regulation of excitatory postsynaptic potential 12
                          negative regulation of acetylcholine-gated cation channel activity 0
                          negative regulation of mini excitatory postsynaptic potential 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.