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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of peptide hormone secretion
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Accession:GO:0090278 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.



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negative regulation of peptide hormone secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma involved_in ISO (MGI:5486574|PMID:11387233) BHF-UCL PMID:11387233 MGI:5486574 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060
JBrowse link
negative regulation of corticotropin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRHBP corticotropin releasing hormone binding protein involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 5:38,327,305...38,343,901
Ensembl chr 5:38,845,925...38,869,549
JBrowse link
negative regulation of glucagon secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARTPT CART prepropeptide ISO RGD PMID:16443761 RGD:2313632 NCBI chr 5:43,591,683...43,593,586
Ensembl chr 5:44,236,114...44,238,229
JBrowse link
G CRH corticotropin releasing hormone involved_in ISO
IEA
RGD
TreeGrafter
PMID:12606499 GO_REF:0000118 RGD:704397 NCBI chr 8:62,714,721...62,716,979
Ensembl chr 8:64,383,419...64,384,009
JBrowse link
G LEP leptin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
JBrowse link
G NUCB2 nucleobindin 2 ISO RGD PMID:21828181 RGD:9831189 NCBI chr11:17,331,742...17,404,682
Ensembl chr11:17,036,038...17,072,447
JBrowse link
negative regulation of growth hormone secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KALRN kalirin RhoGEF kinase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5551307|PMID:23116210) MGI
Ensembl
PMID:23116210 GO_REF:0000107 MGI:5551307 NCBI chr 3:121,138,136...121,828,723
Ensembl chr 3:128,225,413...128,720,441
JBrowse link
G MADD MAP kinase activating death domain ISO RGD PMID:16473592 RGD:9588640 NCBI chr11:47,216,006...47,276,422
Ensembl chr11:47,773,733...47,828,360
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 acts_upstream_of_or_within ISO (MGI:3513751|PMID:15520383) MGI PMID:15520383 MGI:3513751 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762
JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:23292070 RGD:9585999 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link
G SSTR1 somatostatin receptor 1 involved_in ISO (PMID:16543371) AgBase PMID:16543371 NCBI chr14:18,968,969...18,973,560
Ensembl chr14:37,329,309...37,330,484
JBrowse link
G SSTR2 somatostatin receptor 2 involved_in ISO (PMID:16543371) AgBase PMID:16543371 NCBI chr17:67,093,013...67,099,086
Ensembl chr17:72,553,506...72,554,615
JBrowse link
G SSTR3 somatostatin receptor 3 involved_in ISO (PMID:16543371) AgBase PMID:16543371 NCBI chr22:18,116,993...18,125,170
Ensembl chr22:35,954,232...35,955,488
JBrowse link
negative regulation of insulin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 involved_in ISO
IEA
RGD
Ensembl
PMID:15163199 GO_REF:0000107 RGD:1598646 NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870
JBrowse link
G ACVR1C activin A receptor type 1C acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3796011|PMID:18480258) MGI
Ensembl
PMID:18480258 GO_REF:0000107 MGI:3796011 NCBI chr2B:44,785,808...44,883,977
Ensembl chr2B:162,034,161...162,124,151
JBrowse link
G ADRA2A adrenoceptor alpha 2A involved_in ISO (PMID:10952463)
(MGI:3772319|PMID:17992256), (MGI:7343840|PMID:1898674)
(MGI:7343840|PMID:1898674)
BHF-UCL
MGI
PMID:1898674 PMID:10952463 PMID:17992256 MGI:3772319 MGI:7343840 NCBI chr10:107,669,860...107,673,685 JBrowse link
G CCN3 cellular communication network factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:116,105,935...116,114,241
Ensembl chr 8:118,855,445...118,865,039
JBrowse link
G CHGA chromogranin A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:73,555,834...73,568,547
Ensembl chr14:92,895,450...92,908,159
JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:18216393 RGD:2311570 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935
JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107
G FAM3D FAM3 metabolism regulating signaling molecule D involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:58,564,083...58,685,370
Ensembl chr 3:59,973,612...59,993,727
JBrowse link
G FBN1 fibrillin 1 involved_in ISO (MGI:6442875|PMID:30997682) UniProt PMID:30997682 MGI:6442875 NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111
JBrowse link
G FFAR2 free fatty acid receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:32,394,401...32,398,730
Ensembl chr19:41,132,599...41,133,591
JBrowse link
G FFAR3 free fatty acid receptor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:32,305,112...32,307,223 JBrowse link
G FOXO1 forkhead box O1 involved_in ISO (MGI:2388494|PMID:12219087), (MGI:6101624|PMID:27457971) UniProt PMID:12219087 PMID:27457971 MGI:2388494 MGI:6101624 NCBI chr13:21,763,729...21,874,279 JBrowse link
G GHRL ghrelin and obestatin prepropeptide acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3709118|PMID:17130496) MGI
Ensembl
PMID:17130496 GO_REF:0000107 MGI:3709118 RGD:8553721 NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723
JBrowse link
G GHSR growth hormone secretagogue receptor acts_upstream_of_or_within ISO PMID:17130496 MGI PMID:17130496 RGD:8553721 NCBI chr 3:169,448,217...169,458,602
Ensembl chr 3:177,633,039...177,638,202
JBrowse link
G GNAO1 G protein subunit alpha o1 involved_in ISO (MGI:4941424|PMID:20622165)
(MGI:4887503|PMID:21220323)
MGI PMID:20622165 PMID:21220323 MGI:4887503 MGI:4941424 NCBI chr16:36,473,852...36,643,789
Ensembl chr16:55,606,920...55,776,619
JBrowse link
G GNAZ G protein subunit alpha z involved_in IEA Ensembl GO_REF:0000107 Ensembl chr22:21,719,169...21,746,851 JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase ISO RGD PMID:17491019 RGD:2302227 NCBI chr 4:100,495,205...100,540,589
Ensembl chr 4:111,067,336...111,113,868
JBrowse link
G HDAC1 histone deacetylase 1 ISO RGD PMID:22772764 RGD:9590127 NCBI chr 1:31,578,373...31,619,970
Ensembl chr 1:32,585,791...32,626,410
JBrowse link
G INHBB inhibin subunit beta B acts_upstream_of_or_within ISO (MGI:3796011|PMID:18480258) MGI PMID:18480258 MGI:3796011 NCBI chr2B:7,278,944...7,284,632 JBrowse link
G IRS1 insulin receptor substrate 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967
JBrowse link
G KCNB1 potassium voltage-gated channel subfamily B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:45,636,371...45,821,536
Ensembl chr20:46,776,274...46,885,521
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:17,440,522...17,444,075
Ensembl chr11:17,127,557...17,128,729
JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 ISO RGD PMID:16133261 RGD:1581603 NCBI chr11:2,469,750...2,874,467 JBrowse link
G LOC100984543 bone morphogenetic protein 8A involved_in ISO (PMID:22579288) UniProt PMID:22579288 NCBI chr 1:38,776,557...38,815,210 JBrowse link
G MIDN midnolin acts_upstream_of_or_within ISO PMID:24187134 MGI PMID:24187134 RGD:8655525
G MTNR1A melatonin receptor 1A ISO RGD PMID:22288848 RGD:9686057 NCBI chr 4:178,693,869...178,720,351
Ensembl chr 4:190,897,192...190,921,677
JBrowse link
G MTNR1B melatonin receptor 1B ISO RGD PMID:18363673 RGD:9588673 NCBI chr11:87,996,805...88,009,865
Ensembl chr11:91,491,822...91,504,652
JBrowse link
G NOS1 nitric oxide synthase 1 ISO RGD PMID:17130471 RGD:1642149 NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005
JBrowse link
G NPFF neuropeptide FF-amide peptide precursor ISO RGD PMID:1704109 RGD:2316580 NCBI chr12:35,245,172...35,246,710
Ensembl chr12:36,030,805...36,031,591
JBrowse link
G PDE8B phosphodiesterase 8B ISO RGD PMID:17991719 RGD:2312519 NCBI chr 5:37,874,089...38,121,322
Ensembl chr 5:38,402,790...38,617,743
JBrowse link
G PFKL phosphofructokinase, liver type acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1096000|PMID:9287040) MGI
Ensembl
PMID:9287040 GO_REF:0000107 MGI:1096000 NCBI chr21:30,557,576...30,584,231
Ensembl chr21:43,857,052...43,878,380
JBrowse link
G PPP3CA protein phosphatase 3 catalytic subunit alpha involved_in ISO PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chr 4:93,447,095...93,770,339
Ensembl chr 4:104,113,520...104,435,394
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:24187134) MGI
Ensembl
PMID:24187134 GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770
JBrowse link
G PSMD9 proteasome 26S subunit, non-ATPase 9 involved_in ISO PMID:16099819 BHF-UCL PMID:16099819 RGD:8554418 NCBI chr12:119,490,380...119,519,318
Ensembl chr12:122,859,940...122,887,703
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:10531320 RGD:10043332 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 acts_upstream_of_or_within ISO (MGI:3513751|PMID:15520383) MGI PMID:15520383 MGI:3513751 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762
JBrowse link
G REST RE1 silencing transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:66,984,466...67,012,301
Ensembl chr 4:73,526,085...73,582,242
JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 involved_in ISO (MGI:5619445|PMID:23092880) CACAO PMID:23092880 MGI:5619445 NCBI chr17:74,973,420...75,389,339
Ensembl chr17:80,705,544...81,118,708
JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in ISO (PMID:17994217) UniProt PMID:17994217 NCBI chr 8:40,507,027...40,555,053 JBrowse link
G SIRT4 sirtuin 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3769241|PMID:16959573) MGI
Ensembl
PMID:16959573 GO_REF:0000107 MGI:3769241 NCBI chr12:117,867,453...117,887,968
Ensembl chr12:121,241,112...121,261,777
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3770077|PMID:16890542) MGI
Ensembl
PMID:16890542 GO_REF:0000107 MGI:3770077 NCBI chr17:33,458,196...33,484,643
Ensembl chr17:38,405,794...38,432,045
JBrowse link
G STXBP5L syntaxin binding protein 5L acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5296997|PMID:21998599) MGI
Ensembl
PMID:21998599 GO_REF:0000107 MGI:5296997 NCBI chr 3:118,022,061...118,529,311
Ensembl chr 3:124,932,110...125,434,515
JBrowse link
G SYTL4 synaptotagmin like 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3770077|PMID:16890542) MGI
Ensembl
PMID:16890542 GO_REF:0000107 MGI:3770077 NCBI chr  X:89,885,478...89,941,381
Ensembl chr  X:100,024,434...100,051,663
JBrowse link
G UTS2 urotensin 2 ISO RGD PMID:17931748 RGD:2306798 NCBI chr 1:6,609,104...6,616,966
Ensembl chr 1:7,854,687...7,864,688
JBrowse link
G VSNL1 visinin like 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3694336|PMID:16731532) MGI
Ensembl
PMID:16731532 GO_REF:0000107 MGI:3694336 NCBI chr2A:17,525,561...17,641,277
Ensembl chr2A:17,703,086...17,767,274
JBrowse link
negative regulation of insulin secretion involved in cellular response to glucose stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A involved_in ISO (PMID:19965390) BHF-UCL PMID:19965390 RGD:2316628 NCBI chr10:107,669,860...107,673,685 JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:17360501 RGD:2306172 NCBI chr 7:31,265,619...31,313,902
Ensembl chr 7:31,386,026...31,434,220
JBrowse link
G ENY2 ENY2 transcription and export complex 2 subunit ISO RGD PMID:22649445 RGD:9590329 NCBI chr 8:105,985,043...105,996,686
Ensembl chr 8:108,129,883...108,141,478
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4421103|PMID:19805579) MGI
Ensembl
PMID:19805579 GO_REF:0000107 MGI:4421103 NCBI chr2A:24,047,287...24,065,765
Ensembl chr2A:24,145,893...24,159,082
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:20610886 RGD:5508687 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785
JBrowse link
G JAGN1 jagunal homolog 1 ISO RGD PMID:26882284 RGD:11520872 NCBI chr 3:9,835,123...9,838,398
Ensembl chr 3:10,183,760...10,187,064
JBrowse link
G KLF7 KLF transcription factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:94,307,334...94,399,553
Ensembl chr2B:212,448,337...212,525,403
JBrowse link
G MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 ISO RGD PMID:19690174 RGD:7495848 Ensembl chr2A:102,750,221...102,945,263 JBrowse link
G NDUFAF2 NADH:ubiquinone oxidoreductase complex assembly factor 2 acts_upstream_of_or_within ISO (MGI:5467193|PMID:22587331) MGI PMID:22587331 MGI:5467193 NCBI chr 5:52,843,931...53,053,671 JBrowse link
G PDE1C phosphodiesterase 1C ISO RGD PMID:18706893 RGD:2302857 NCBI chr 7:32,225,293...33,037,627
Ensembl chr 7:32,343,701...33,029,405
JBrowse link
G PDE3B phosphodiesterase 3B ISO RGD PMID:18706893 RGD:2302857 NCBI chr11:14,746,301...14,961,316
Ensembl chr11:14,437,060...14,648,616
JBrowse link
G PDE4C phosphodiesterase 4C ISO RGD PMID:18706893 RGD:2302857 NCBI chr19:17,683,455...17,709,936
Ensembl chr19:18,663,378...18,686,194
JBrowse link
G PDE8B phosphodiesterase 8B ISO RGD PMID:18706893 RGD:2302857 NCBI chr 5:37,874,089...38,121,322
Ensembl chr 5:38,402,790...38,617,743
JBrowse link
G PIM3 Pim-3 proto-oncogene, serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:30,186,716...30,190,270 JBrowse link
G PTPMT1 protein tyrosine phosphatase mitochondrial 1 ISO RGD PMID:20167843 RGD:12904047 NCBI chr11:47,515,304...47,521,529
Ensembl chr11:48,064,931...48,073,474
JBrowse link
G TBC1D1 TBC1 domain family member 1 ISO RGD PMID:28177704 RGD:150521607 NCBI chr 4:32,217,463...32,466,020
Ensembl chr 4:38,084,075...38,319,842
JBrowse link
G UCP2 uncoupling protein 2 ISO RGD PMID:21172424 RGD:7204422 NCBI chr11:69,047,397...69,056,056
Ensembl chr11:72,354,529...72,363,185
JBrowse link
negative regulation of prolactin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA5 annexin A5 ISO RGD PMID:15256781 RGD:10053690 NCBI chr 4:113,868,218...113,897,243
Ensembl chr 4:125,006,038...125,034,972
JBrowse link
negative regulation of somatostatin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FFAR4 free fatty acid receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:90,312,647...90,336,115
Ensembl chr10:93,823,004...93,860,262
JBrowse link
G GAL galanin and GMAP prepropeptide involved_in ISO (PMID:8837218) AgBase PMID:8837218 NCBI chr11:63,770,758...63,777,421
Ensembl chr11:67,075,547...67,081,696
JBrowse link
G IRS1 insulin receptor substrate 1 involved_in ISO PMID:12435589 BHF-UCL PMID:12435589 RGD:729325 NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967
JBrowse link
G NPY neuropeptide Y involved_in ISO (PMID:8837218) AgBase PMID:8837218 NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16309
    negative regulation of biological process 5473
      negative regulation of signaling 1495
        negative regulation of hormone secretion 106
          negative regulation of peptide hormone secretion 76
            negative regulation of calcitonin secretion 0
            negative regulation of corticotropin secretion 1
            negative regulation of corticotropin-releasing hormone secretion 0
            negative regulation of glucagon secretion 4
            negative regulation of growth hormone secretion 7
            negative regulation of insulin secretion + 60
            negative regulation of prolactin secretion 1
            negative regulation of somatostatin secretion 4
            negative regulation of substance P secretion + 0
            negative regulation of thyroid-stimulating hormone secretion 0
Path 2
Term Annotations click to browse term
  biological_process 16309
    localization 5233
      establishment of localization 4524
        transport 4214
          nitrogen compound transport 1800
            amide transport 399
              peptide transport 360
                peptide secretion 337
                  peptide hormone secretion 329
                    regulation of peptide hormone secretion 277
                      negative regulation of peptide hormone secretion 76
                        negative regulation of calcitonin secretion 0
                        negative regulation of corticotropin secretion 1
                        negative regulation of corticotropin-releasing hormone secretion 0
                        negative regulation of glucagon secretion 4
                        negative regulation of growth hormone secretion 7
                        negative regulation of insulin secretion + 60
                        negative regulation of prolactin secretion 1
                        negative regulation of somatostatin secretion 4
                        negative regulation of substance P secretion + 0
                        negative regulation of thyroid-stimulating hormone secretion 0
paths to the root