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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of spindle checkpoint
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Accession:GO:0090231 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).



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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) RGD PMID:19010891 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mad2l1bp MAD2L1 binding protein involved_in ISO (PMID:18022368) RGD PMID:18022368 NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447
JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:24374861)
UniProt
RGD
PMID:24374861 GO_REF:0000024 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872
JBrowse link
positive regulation of meiosis I spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Knl1 kinetochore scaffold 1 involved_in ISO (MGI:7356173|PMID:35167144) RGD PMID:35167144 MGI:7356173 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19229290)
UniProt
Ensembl
RGD
PMID:19229290 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:22898774), (PMID:36322655) RGD PMID:22898774 PMID:36322655 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in ISO (MGI:4839685|PMID:20870947)
(PMID:20870947), (PMID:22898774), (PMID:8824189)
RGD PMID:8824189 PMID:20870947 PMID:22898774 MGI:4839685 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:25743205) RGD PMID:25743205 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
RGD PMID:20870947 MGI:4839685 NCBI chr16:76,423,245...76,448,712
Ensembl chr16:76,423,245...76,448,712
JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:18981471), (PMID:19273613)
UniProt
Ensembl
RGD
PMID:18981471 PMID:19273613 GO_REF:0000024 GO_REF:0000107 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
JBrowse link
regulation of meiosis I spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zwint ZW10 interacting kinetochore protein involved_in ISS
ISO
GO_REF:0000024
(MGI:6215447|PMID:26486467)
UniProt
RGD
PMID:26486467 GO_REF:0000024 MGI:6215447 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 involved_in ISO
IEA
IBA
ISS
(PMID:21926987)
GO_REF:0000118
GO_REF:0000033
GO_REF:0000002
GO_REF:0000024
RGD
TreeGrafter
GO_Central
InterPro
UniProt
PMID:21926987 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145
JBrowse link
G Ccnb1 cyclin B1 involved_in ISO
IEA
(PMID:18195732)
GO_REF:0000107
RGD
Ensembl
PMID:18195732 GO_REF:0000107 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in ISS
IBA
IEA
ISO
GO_REF:0000024
GO_REF:0000033
GO_REF:0000118
(PMID:19282672)
GO_REF:0000107
UniProt
GO_Central
TreeGrafter
RGD
Ensembl
PMID:19282672 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782
JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Knl1 kinetochore scaffold 1 involved_in ISO (PMID:19893618) RGD PMID:19893618 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17724024)
GO_REF:0000107
RGD
Ensembl
PMID:17724024 GO_REF:0000107 NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112
JBrowse link
G Prpf4b pre-mRNA processing factor 4B involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:17998396)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17998396 GO_REF:0000024 GO_REF:0000107 NCBI chr17:29,985,343...30,020,285
Ensembl chr17:29,985,343...30,019,625
JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO (MGI:5448515|PMID:21853124) RGD PMID:21853124 MGI:5448515 NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      signal transduction 7163
        intracellular signal transduction 2818
          cell cycle checkpoint signaling 186
            spindle checkpoint signaling 41
              regulation of spindle checkpoint 19
                negative regulation of spindle checkpoint + 3
                positive regulation of spindle checkpoint + 9
                regulation of meiosis I spindle assembly checkpoint + 2
                regulation of mitotic spindle checkpoint + 18
Path 2
Term Annotations click to browse term
  biological_process 20292
    biological regulation 13633
      regulation of biological process 13220
        regulation of cellular process 12685
          regulation of cell cycle 1090
            regulation of cell cycle process 768
              negative regulation of cell cycle process 316
                negative regulation of cell cycle phase transition 266
                  cell cycle checkpoint signaling 186
                    spindle checkpoint signaling 41
                      regulation of spindle checkpoint 19
                        negative regulation of spindle checkpoint + 3
                        positive regulation of spindle checkpoint + 9
                        regulation of meiosis I spindle assembly checkpoint + 2
                        regulation of mitotic spindle checkpoint + 18
paths to the root