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Term:positive regulation of release of cytochrome c from mitochondria
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Accession:GO:0090200 term browser browse the term
Definition:Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
Comment:The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and positively regulate this process.

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positive regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1624291
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:2317097
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:13792537
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:1624291
G Bik BCL2-interacting killer JBrowse link 7 124,390,924 124,410,449 RGD:1624291
G Bmf Bcl2 modifying factor JBrowse link 3 110,303,515 110,324,125 RGD:1624291
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:1624291
G Cideb cell death-inducing DFFA-like effector b JBrowse link 15 34,439,844 34,444,244 RGD:1624291
G Coa8 cytochrome c oxidase assembly factor 8 JBrowse link 6
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:1624291
G Fam162a family with sequence similarity 162, member A JBrowse link 11 67,618,683 67,646,253 RGD:1624291
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:8553942
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:1624291
G Mff mitochondrial fission factor JBrowse link 9 88,490,280 88,518,517 RGD:1624291
G Mllt11 MLLT11, transcription factor 7 cofactor JBrowse link 2 196,392,936 196,402,106 RGD:1624291
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:1624291
G Moap1 modulator of apoptosis 1 JBrowse link 6 126,620,597 126,622,532 RGD:1624291
G Pdcd5 programmed cell death 5 JBrowse link 1 91,173,473 91,178,801 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6482750
G Plaur plasminogen activator, urokinase receptor JBrowse link 1 81,328,171 81,344,954 RGD:1624291
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
G Ppif peptidylprolyl isomerase F JBrowse link 16 1,979,191 1,985,912 RGD:1624291
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Wdr35 WD repeat domain 35 JBrowse link 6 34,094,291 34,152,048 RGD:11553920

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19332
    cellular process 17237
      signal transduction 6871
        apoptotic signaling pathway 627
          release of cytochrome c from mitochondria 61
            positive regulation of release of cytochrome c from mitochondria 29
Path 2
Term Annotations click to browse term
  biological_process 19332
    biological regulation 13335
      regulation of biological process 12650
        regulation of cellular process 11989
          regulation of cell death 1771
            regulation of programmed cell death 1603
              regulation of apoptotic process 1576
                regulation of apoptotic signaling pathway 424
                  regulation of release of cytochrome c from mitochondria 48
                    positive regulation of release of cytochrome c from mitochondria 29
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.