ONTOLOGY REPORT - ANNOTATIONS
Term: positive regulation of release of cytochrome c from mitochondria
Accession: GO:0090200
browse the term
Definition: Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
Comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and positively regulate this process.
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Bad
BCL2-associated agonist of cell death
involved_in
ISO
(PMID:17289999)
RGD
PMID:17289999
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
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Bak1
BCL2-antagonist/killer 1
IMP
RGD
PMID:12485416
RGD:2317097
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
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Bax
BCL2 associated X, apoptosis regulator
involved_in
ISO ISS IEA
(PMID:14963330), (PMID:21262771) GO_REF:0000024 GO_REF:0000107
RGD UniProt Ensembl
PMID:14963330 PMID:21262771
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bbc3
Bcl-2 binding component 3
involved_in
ISO IBA IEA
UniProtKB:P70444 (PMID:21041309) GO_REF:0000033 GO_REF:0000002
RGD GO_Central InterPro
PMID:21041309
GO_REF:0000002 GO_REF:0000033
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666
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Bcl2l11
Bcl2-like 11
involved_in
ISO
UniProtKB:P70444 (PMID:17289999), (PMID:21041309)
RGD
PMID:17289999 PMID:21041309
NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695
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Bid
BH3 interacting domain death agonist
involved_in
ISS ISO IEA IMP IBA
GO_REF:0000024 UniProtKB:P70444 (PMID:17289999), (PMID:21041309), (PMID:21262771) (PMID:32029622) GO_REF:0000107 UniProtKB:O08734|UniProtKB:P70444 (PMID:10950869), (PMID:21041309) GO_REF:0000033 GO_REF:0000117 (PMID:9727491) (PMID:10480954), (PMID:9727491), (PMID:9727492)
UniProt RGD Ensembl GO_Central
PMID:9727491 PMID:9727492 PMID:10480954 PMID:10950869 PMID:17289999 PMID:21041309 PMID:21262771 PMID:32029622 PMID:25623406 More...
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:408345233
NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275
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Bik
BCL2-interacting killer
involved_in
ISO
(PMID:21041309)
RGD
PMID:21041309
NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317
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Bmf
Bcl2 modifying factor
involved_in
ISO
UniProtKB:P70444 (PMID:21041309)
RGD
PMID:21041309
NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258
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Bnip3
BCL2 interacting protein 3
involved_in
ISO IEA
(PMID:20436456) GO_REF:0000107
RGD Ensembl
PMID:20436456
GO_REF:0000107
NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962
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Casp6
caspase 6
acts_upstream_of_or_within
ISO
(PMID:32029622)
RGD
PMID:32029622
NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726
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Fam162a
family with sequence similarity 162, member A
involved_in
ISS ISO IBA
GO_REF:0000024 (PMID:15082785) GO_REF:0000033
UniProt RGD GO_Central
PMID:15082785
GO_REF:0000024 GO_REF:0000033
NCBI chr11:78,186,260...78,215,186
Ensembl chr11:78,185,852...78,216,560
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Gper1
G protein-coupled estrogen receptor 1
involved_in
IDA
PMID:23907461
UniProt
PMID:23907461
RGD:8553942
NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144
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Gzmk
granzyme K
involved_in
ISS ISO
GO_REF:0000024 (PMID:17308307)
UniProt RGD
PMID:17308307
GO_REF:0000024
NCBI chr 2:46,573,997...46,582,015
Ensembl chr 2:46,573,997...46,582,015
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Hrk
harakiri, BCL2 interacting protein
involved_in
ISO IEA
(PMID:21041309) GO_REF:0000107
RGD Ensembl
PMID:21041309
GO_REF:0000107
NCBI chr12:38,387,484...38,409,652
Ensembl chr12:44,048,402...44,070,561
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LOC120095320
protein FAM162A-like
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:36,389,447...36,391,357
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Mllt11
MLLT11, transcription factor 7 cofactor
involved_in
ISS ISO IBA IEA
GO_REF:0000024 (PMID:18852119) GO_REF:0000033 GO_REF:0000107
UniProt RGD GO_Central Ensembl
PMID:18852119
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr 2:185,484,791...185,493,961
Ensembl chr 2:185,484,793...185,493,961
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Mmp9
matrix metallopeptidase 9
involved_in
ISO IEA
(PMID:22984561) GO_REF:0000107
RGD Ensembl
PMID:22984561
GO_REF:0000107
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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Moap1
modulator of apoptosis 1
involved_in
ISO
(PMID:16199525)
RGD
PMID:16199525
NCBI chr 6:127,647,389...127,649,324
Ensembl chr 6:127,613,488...127,669,324
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Pink1
PTEN induced kinase 1
involved_in
ISO IEA
(PMID:19880420) GO_REF:0000107
RGD Ensembl
PMID:19880420
GO_REF:0000107
NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950
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Pla2g6
phospholipase A2 group VI
IDA
RGD
PMID:18936091
RGD:6482750
NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609
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Plaur
plasminogen activator, urokinase receptor
involved_in
ISO IEA
(PMID:22984561) GO_REF:0000107
RGD Ensembl
PMID:22984561
GO_REF:0000107
NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
involved_in
ISO
(PMID:14500711), (PMID:14699081), (PMID:15705586), (PMID:17289999)
RGD
PMID:14500711 PMID:14699081 PMID:15705586 PMID:17289999
NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
acts_upstream_of_or_within
ISO
(PMID:32029622)
RGD
PMID:32029622
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
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Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
acts_upstream_of_or_within
ISO
(PMID:32029622)
RGD
PMID:32029622
NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324
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Pycard
PYD and CARD domain containing
involved_in
ISO IEA
(PMID:14730312) GO_REF:0000107
RGD Ensembl
PMID:14730312
GO_REF:0000107
NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
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Tnfsf10
TNF superfamily member 10
involved_in
ISO
(PMID:22266862)
RGD
PMID:22266862
NCBI chr 2:112,136,550...112,155,903
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Tp53
tumor protein p53
involved_in
ISO IEA
(PMID:14963330) GO_REF:0000107
RGD Ensembl
PMID:14963330
GO_REF:0000107
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
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Wdr35
WD repeat domain 35
IMP
RGD
PMID:23289926
RGD:11553920
NCBI chr 6:37,490,557...37,550,391
Ensembl chr 6:37,490,545...37,550,664
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