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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of release of cytochrome c from mitochondria
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Accession:GO:0090200 term browser browse the term
Definition:Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
Comment:The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and positively regulate this process.


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positive regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death involved_in ISO (PMID:17289999) RGD PMID:17289999 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 IMP RGD PMID:12485416 RGD:2317097 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO
ISS
IEA 		(PMID:14963330), (PMID:21262771)
GO_REF:0000024
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:14963330 PMID:21262771 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in ISO
IBA
IEA 		UniProtKB:P70444 (PMID:21041309)
GO_REF:0000033
GO_REF:0000002 		RGD
GO_Central
InterPro		 PMID:21041309 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Bcl2l11 Bcl2-like 11 involved_in ISO UniProtKB:P70444 (PMID:17289999), (PMID:21041309) RGD PMID:17289999 PMID:21041309 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in ISS
ISO
IEA
IMP
IBA 		GO_REF:0000024
UniProtKB:P70444 (PMID:17289999), (PMID:21041309), (PMID:21262771)
(PMID:32029622)
GO_REF:0000107
UniProtKB:O08734|UniProtKB:P70444 (PMID:10950869), (PMID:21041309)
GO_REF:0000033
GO_REF:0000117
(PMID:9727491)
(PMID:10480954), (PMID:9727491), (PMID:9727492) 		UniProt
RGD
Ensembl
GO_Central		 PMID:9727491 PMID:9727492 PMID:10480954 PMID:10950869 PMID:17289999 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:408345233 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Bik BCL2-interacting killer involved_in ISO (PMID:21041309) RGD PMID:21041309 NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317 		JBrowse link
G Bmf Bcl2 modifying factor involved_in ISO UniProtKB:P70444 (PMID:21041309) RGD PMID:21041309 NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO
IEA 		(PMID:20436456)
GO_REF:0000107 		RGD
Ensembl		 PMID:20436456 GO_REF:0000107 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962 		JBrowse link
G Casp6 caspase 6 acts_upstream_of_or_within ISO (PMID:32029622) RGD PMID:32029622 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726 		JBrowse link
G Fam162a family with sequence similarity 162, member A involved_in ISS
ISO
IBA 		GO_REF:0000024
(PMID:15082785)
GO_REF:0000033 		UniProt
RGD
GO_Central		 PMID:15082785 GO_REF:0000024 GO_REF:0000033 NCBI chr11:78,186,260...78,215,186
Ensembl chr11:78,185,852...78,216,560 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in IDA PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144 		JBrowse link
G Gzmk granzyme K involved_in ISS
ISO 		GO_REF:0000024
(PMID:17308307) 		UniProt
RGD		 PMID:17308307 GO_REF:0000024 NCBI chr 2:46,573,997...46,582,015
Ensembl chr 2:46,573,997...46,582,015 		JBrowse link
G Hrk harakiri, BCL2 interacting protein involved_in ISO
IEA 		(PMID:21041309)
GO_REF:0000107 		RGD
Ensembl		 PMID:21041309 GO_REF:0000107 NCBI chr12:38,387,484...38,409,652
Ensembl chr12:44,048,402...44,070,561 		JBrowse link
G LOC120095320 protein FAM162A-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:36,389,447...36,391,357 JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor involved_in ISS
ISO
IBA
IEA 		GO_REF:0000024
(PMID:18852119)
GO_REF:0000033
GO_REF:0000107 		UniProt
RGD
GO_Central
Ensembl		 PMID:18852119 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:185,484,791...185,493,961
Ensembl chr 2:185,484,793...185,493,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO
IEA 		(PMID:22984561)
GO_REF:0000107 		RGD
Ensembl		 PMID:22984561 GO_REF:0000107 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:127,647,389...127,649,324
Ensembl chr 6:127,613,488...127,669,324 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO
IEA 		(PMID:19880420)
GO_REF:0000107 		RGD
Ensembl		 PMID:19880420 GO_REF:0000107 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950 		JBrowse link
G Pla2g6 phospholipase A2 group VI IDA RGD PMID:18936091 RGD:6482750 NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609 		JBrowse link
G Plaur plasminogen activator, urokinase receptor involved_in ISO
IEA 		(PMID:22984561)
GO_REF:0000107 		RGD
Ensembl		 PMID:22984561 GO_REF:0000107 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:14500711), (PMID:14699081), (PMID:15705586), (PMID:17289999) RGD PMID:14500711 PMID:14699081 PMID:15705586 PMID:17289999 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 acts_upstream_of_or_within ISO (PMID:32029622) RGD PMID:32029622 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 acts_upstream_of_or_within ISO (PMID:32029622) RGD PMID:32029622 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO
IEA 		(PMID:14730312)
GO_REF:0000107 		RGD
Ensembl		 PMID:14730312 GO_REF:0000107 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419 		JBrowse link
G Tnfsf10 TNF superfamily member 10 involved_in ISO (PMID:22266862) RGD PMID:22266862 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tp53 tumor protein p53 involved_in ISO
IEA 		(PMID:14963330)
GO_REF:0000107 		RGD
Ensembl		 PMID:14963330 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Wdr35 WD repeat domain 35 IMP RGD PMID:23289926 RGD:11553920 NCBI chr 6:37,490,557...37,550,391
Ensembl chr 6:37,490,545...37,550,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    positive regulation of biological process 6855
      positive regulation of cellular process 6468
        positive regulation of cellular component organization 1337
          positive regulation of organelle organization 556
            positive regulation of release of cytochrome c from mitochondria 28
Path 2
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      cellular component organization or biogenesis 7219
        cellular component organization 6928
          organelle organization 3741
            mitochondrion organization 470
              apoptotic mitochondrial changes 135
                release of cytochrome c from mitochondria 70
                  regulation of release of cytochrome c from mitochondria 55
                    positive regulation of release of cytochrome c from mitochondria 28
paths to the root