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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cholesterol metabolic process
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Accession:GO:0090181 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


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regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3852307|PMID:16556852) RGD PMID:16556852 MGI:3852307 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain involved_in ISO (MGI:3526480|PMID:15639194) RGD PMID:15639194 MGI:3526480 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain involved_in IEA
ISO		 GO_REF:0000107
(MGI:3526480|PMID:15639194)		 Ensembl
RGD		 PMID:15639194 GO_REF:0000107 MGI:3526480 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Apoe apolipoprotein E involved_in ISO UniProtKB:P35951 (PMID:24412220) RGD PMID:24412220 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Arv1 ARV1 homolog, fatty acid homeostasis modulator involved_in
acts_upstream_of_or_within		 ISO (PMID:20663892)
(MGI:4849624|PMID:20663892)		 RGD PMID:20663892 MGI:4849624 NCBI chr19:52,692,337...52,704,156
Ensembl chr19:52,692,337...52,704,156 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 IMP RGD PMID:17526931 RGD:10400884 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Dgkq diacylglycerol kinase, theta involved_in ISO (PMID:24369117) RGD PMID:24369117 NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131 		JBrowse link
G Ephx2 epoxide hydrolase 2 involved_in ISO (PMID:18974052)
(MGI:3829349|PMID:18974052)		 RGD PMID:18974052 MGI:3829349 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(MGI:5648738|PMID:26049045)		 Ensembl
UniProt
RGD		 PMID:26049045 GO_REF:0000024 GO_REF:0000107 MGI:5648738 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693 		JBrowse link
G Gnb3 G protein subunit beta 3 involved_in ISO UniProtKB:Q61011 (PMID:29206867) RGD PMID:29206867 NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO UniProtKB:P02649 (MGI:5575733|PMID:24412220) RGD PMID:24412220 MGI:5575733 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lmf1 lipase maturation factor 1 acts_upstream_of_or_within ISO MGI:1856820 (MGI:55554|PMID:6857276) RGD PMID:6857276 MGI:55554 NCBI chr10:14,597,726...14,684,071
Ensembl chr10:14,597,594...14,684,119 		JBrowse link
G Por cytochrome p450 oxidoreductase IMP RGD PMID:19264869 RGD:2316785 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Serpina12 serpin family A member 12 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5568548 (MGI:5563627|PMID:22837305)		 Ensembl
RGD		 PMID:22837305 GO_REF:0000107 MGI:5563627 NCBI chr 6:122,952,552...122,967,271
Ensembl chr 6:122,952,552...122,967,271 		JBrowse link
G Thrb thyroid hormone receptor beta IMP RGD PMID:17878314 RGD:2315101 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Ttc39b tetratricopeptide repeat domain 39B involved_in ISS
ISO
IBA		 GO_REF:0000024
(MGI:5800596|PMID:27383786)
PMID:21873635		 UniProt
RGD		 PMID:27383786 PMID:21873635 GO_REF:0000024 MGI:5800596, RGD:13792537 NCBI chr 5:97,603,329...97,708,103
Ensembl chr 5:97,609,392...97,736,270 		JBrowse link
G Ttc39d tetratricopeptide repeat domain 39D involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:14,802,753...14,811,516
Ensembl chr 6:14,786,089...14,811,978 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in IDA
ISO
IEA		 (PMID:1917954)
GO_REF:0000107		 RGD
Ensembl		 PMID:1917954 PMID:9225228 GO_REF:0000107, RGD:10059686 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) RGD PMID:24217618 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) RGD PMID:24217618 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671 		JBrowse link
G Idi2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within ISO (MGI:5490819|PMID:17202134) RGD PMID:17202134 MGI:5490819 NCBI chr17:61,331,669...61,334,285
Ensembl chr17:61,331,669...61,334,285 		JBrowse link
G Mir185 microRNA 185 acts_upstream_of ISO RNAcentral:URS00002367FA_9606|RNAcentral:URS00004176D4_9606 (PMID:23951060), (PMID:24296663) RGD PMID:23951060 PMID:24296663 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795 		JBrowse link
G Mir342 microRNA 342 acts_upstream_of ISO (PMID:23951060) RGD PMID:23951060 NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367 		JBrowse link
G Mir98 microRNA 98 involved_in ISO (PMID:30195495) RGD PMID:30195495 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342 		JBrowse link
G Sod1 superoxide dismutase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15473258)		 UniProt
RGD		 PMID:15473258 GO_REF:0000024 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
negative regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ch25h cholesterol 25-hydroxylase involved_in ISO (MGI:6101070|PMID:29033131) RGD PMID:29033131 MGI:6101070 NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195 		JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3768186|PMID:17916878) RGD PMID:17916878 MGI:3768186 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 involved_in ISO (MGI:3768186|PMID:17916878) RGD PMID:17916878 MGI:3768186 NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in IDA PMID:23536474 BHF-UCL PMID:23536474 RGD:13792517 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Fdps farnesyl diphosphate synthase IMP RGD PMID:18637708 RGD:2316295 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fgf1 fibroblast growth factor 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19229075)		 UniProt
RGD		 PMID:19229075 GO_REF:0000024 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Mir96 microRNA 96 involved_in ISO RNAcentral:URS00001CC379_9606 (PMID:23823476) RGD PMID:23823476 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Por cytochrome p450 oxidoreductase IMP RGD PMID:19264869 RGD:2316785 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Scap SREBF chaperone involved_in ISO (PMID:32322062) RGD PMID:32322062 NCBI chr 8:110,306,031...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Scp2 sterol carrier protein 2 IDA RGD PMID:2554812 RGD:9850260 NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 IDA RGD PMID:11226224 RGD:727312 NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:32322062)
(PMID:12177166)
(MGI:3623165|PMID:9062341), (MGI:83216|PMID:8833906)
MGI:2177958|MGI:2177959 (MGI:1098057|PMID:9329978), (MGI:3603730|PMID:16046411)
GO_REF:0000024		 RGD
UniProt		 PMID:8833906 PMID:9062341 PMID:9329978 PMID:12177166 PMID:16046411 More... GO_REF:0000024 MGI:1098057 MGI:3603730 MGI:3623165 MGI:83216 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:12177166)
GO_REF:0000107
(PMID:32322062)		 UniProt
RGD
Ensembl		 PMID:12177166 PMID:32322062 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
positive regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 involved_in ISO
IEA		 (PMID:4335615)
GO_REF:0000107		 RGD
Ensembl		 PMID:4335615 GO_REF:0000107 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA		 (PMID:15654758)
GO_REF:0000107
(MGI:3850619|PMID:15654758)		 RGD
Ensembl		 PMID:15654758 GO_REF:0000107 MGI:3850619 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Ces1d carboxylesterase 1D involved_in ISO (PMID:16971496) RGD PMID:16971496 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) RGD PMID:18403318 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024 		JBrowse link
regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 NOT|involved_in ISO (PMID:21810484) RGD PMID:21810484 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Apob apolipoprotein B acts_upstream_of_or_within ISO MGI:2183298 (MGI:3652707|PMID:16455790) RGD PMID:16455790 MGI:3652707 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Aqp8 aquaporin 8 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:30579780)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:30579780 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158 		JBrowse link
G Cyp51 cytochrome P450, family 51 TAS RGD PMID:7665087 RGD:1298863 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase IDA RGD PMID:10329655 RGD:632010 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) RGD PMID:24217618 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) RGD PMID:24217618 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6278041|PMID:29395055)		 UniProt
RGD		 PMID:29395055 GO_REF:0000024 MGI:6278041 NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880 		JBrowse link
G Mvk mevalonate kinase NAS RGD PMID:2158094 RGD:728935 NCBI chr12:42,141,391...42,158,858
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO MGI:2180128 (MGI:3027293|PMID:14673138) RGD PMID:14673138 MGI:3027293 NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404 		JBrowse link
G Scap SREBF chaperone acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:2148743|MGI:2180899 (MGI:3770209|PMID:16054043)
PMID:21873635		 RGD PMID:16054043 PMID:21873635 MGI:3770209, RGD:13792537 NCBI chr 8:110,306,031...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19738
    regulation of biological process 13021
      regulation of metabolic process 6823
        regulation of small molecule metabolic process 389
          regulation of cholesterol metabolic process 46
            negative regulation of cholesterol metabolic process + 9
            positive regulation of cholesterol metabolic process + 16
            regulation of cholesterol biosynthetic process + 28
Path 2
Term Annotations click to browse term
  biological_process 19738
    metabolic process 12010
      primary metabolic process 8886
        lipid metabolic process 1448
          steroid metabolic process 345
            sterol metabolic process 156
              cholesterol metabolic process 145
                regulation of cholesterol metabolic process 46
                  negative regulation of cholesterol metabolic process + 9
                  positive regulation of cholesterol metabolic process + 16
                  regulation of cholesterol biosynthetic process + 28
paths to the root