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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of sphingolipid biosynthetic process
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Accession:GO:0090155 term browser browse the term
Definition:Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:related_synonym: negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis
 alt_id: GO:0090157


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negative regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO
IEA
IMP		 (PMID:24201375)
GO_REF:0000107		 RGD
Ensembl		 PMID:24201375 PMID:24201375 GO_REF:0000107, RGD:14697729 NCBI chr 3:28,642,660...28,662,689
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Atg7 autophagy related 7 acts_upstream_of_or_within ISO MGI:2176073|MGI:3587769 (PMID:25332431) RGD PMID:25332431 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of_or_within ISO (PMID:25691431) RGD PMID:25691431 NCBI chr 9:55,735,081...55,745,287
Ensembl chr 9:48,237,572...48,253,211 		JBrowse link
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 acts_upstream_of_or_within ISO (PMID:25691431) RGD PMID:25691431 NCBI chr 7:1,832,368...1,835,501
Ensembl chr 7:1,246,479...1,250,907 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:25691431)		 Ensembl
RGD		 PMID:25691431 GO_REF:0000107 NCBI chr10:84,086,317...84,092,673
Ensembl chr10:83,590,071...83,598,620 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:16118219)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16118219 GO_REF:0000024 GO_REF:0000107 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    regulation of biological process 13389
      regulation of cellular process 13025
        regulation of cellular component biogenesis 1157
          regulation of sphingolipid biosynthetic process 17
            negative regulation of sphingolipid biosynthetic process 6
              negative regulation of ceramide biosynthetic process + 4
Path 2
Term Annotations click to browse term
  biological_process 20546
    biological regulation 13834
      regulation of biological process 13389
        regulation of cellular process 13025
          regulation of metabolic process 6832
            regulation of primary metabolic process 5683
              regulation of lipid metabolic process 392
                negative regulation of lipid metabolic process 125
                  negative regulation of lipid biosynthetic process 74
                    negative regulation of sphingolipid biosynthetic process 6
                      negative regulation of ceramide biosynthetic process + 4
paths to the root