negative regulation of sphingolipid biosynthetic process - Ontology Report

ONTOLOGY REPORT - ANNOTATIONS

Term:	negative regulation of sphingolipid biosynthetic process	go back to main search page
Accession:	GO:0090155	browse the term
Definition:	Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:	related_synonym:	negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis
	alt_id:	GO:0090157

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Rat (6) Mouse (6) Human (6) Chinchilla (6) Bonobo (6) Dog (4) Squirrel (6) Pig (4) All
Genes (6)

negative regulation of sphingolipid biosynthetic process

Symbol

Object Name

JBrowse

Chr

Start

Stop

Reference

Abca2

ATP binding cassette subfamily A member 2

2,648,787

2,668,770

RGD:1624291
RGD:14697729
RGD:1600115

Atg7

autophagy related 7

146,570,113

146,777,093

RGD:1624291

negative regulation of ceramide biosynthetic process

Symbol

Object Name

JBrowse

Chr

Start

Stop

Reference

Ormdl1

ORMDL sphingolipid biosynthesis regulator 1

53,110,628

53,120,454

RGD:1624291
RGD:13792537

Ormdl2

ORMDL sphingolipid biosynthesis regulator 2

3,242,991

3,246,085

RGD:1624291
RGD:13792537

Ormdl3

ORMDL sphingolipid biosynthesis regulator 3

86,545,910

86,554,478

RGD:1624291
RGD:13792537
RGD:1600115

Sphk1

sphingosine kinase 1

105,498,728

105,504,401

RGD:1600115
RGD:1624291

Term paths to the root

Path 1
Term	Annotations
biological_process	19576
metabolic process	11899
nitrogen compound metabolic process	10025
negative regulation of nitrogen compound metabolic process	2507
negative regulation of sphingolipid biosynthetic process	6
negative regulation of ceramide biosynthetic process +	4
Path 2
Term	Annotations
biological_process	19576
metabolic process	11899
primary metabolic process	10563
lipid metabolic process	1343
cellular lipid metabolic process	1025
membrane lipid metabolic process	186
sphingolipid metabolic process	136
sphingolipid biosynthetic process	85
regulation of sphingolipid biosynthetic process	14
negative regulation of sphingolipid biosynthetic process	6
negative regulation of ceramide biosynthetic process +	4

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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