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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of sphingolipid biosynthetic process
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Accession:GO:0090153 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


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regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO MGI:1913862 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr 9:53,110,628...53,120,454
Ensembl chr 9:53,111,371...53,118,613
JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO MGI:2137691|MGI:2181669|MGI:2445707|MGI:6343506|MGI:6382064 (MGI:5926671|PMID:28275141), (MGI:6393026|PMID:31880535) RGD PMID:28275141 PMID:31880535 MGI:5926671 MGI:6393026 NCBI chr10:86,545,910...86,554,478
Ensembl chr10:86,547,339...86,554,478
JBrowse link
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 involved_in IBA
ISO
PMID:21873635
(PMID:25691431)
RGD PMID:25691431, PMID:21873635 RGD:13792537 NCBI chr 9:53,110,628...53,120,454
Ensembl chr 9:53,111,371...53,118,613
JBrowse link
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 involved_in ISO
IBA
(PMID:25691431)
PMID:21873635
RGD PMID:25691431, PMID:21873635 RGD:13792537 NCBI chr 7:3,242,991...3,246,085
Ensembl chr 7:3,242,991...3,246,071
JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
(MGI:5638294|PMID:25691431)
PMID:21873635
(PMID:25691431)
Ensembl
RGD
PMID:25691431, PMID:21873635 GO_REF:0000107 MGI:5638294, RGD:13792537 NCBI chr10:86,545,910...86,554,478
Ensembl chr10:86,547,339...86,554,478
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6294167|PMID:16118219)
(PMID:16118219)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:16118219 GO_REF:0000024 GO_REF:0000107 MGI:6294167 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
negative regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO
IMP
(PMID:24201375) RGD PMID:24201375, PMID:24201375 RGD:14697729 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Atg7 autophagy related 7 acts_upstream_of_or_within ISO MGI:2176073|MGI:3587769 (MGI:5613260|PMID:25332431) RGD PMID:25332431 MGI:5613260 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
positive regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn1 cellular communication network factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3849354|PMID:19364818)
Ensembl
RGD
PMID:19364818 GO_REF:0000107 MGI:3849354 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:4947032|PMID:21177474)
UniProt
RGD
PMID:21177474 GO_REF:0000024 MGI:4947032 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Pla2g6 phospholipase A2 group VI IDA RGD PMID:18936091 RGD:6482750 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
IEA
(PMID:19279011)
GO_REF:0000107
RGD
Ensembl
PMID:19279011 GO_REF:0000107 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Sirt3 sirtuin 3 involved_in ISO (MGI:5755322|PMID:26620563) RGD PMID:26620563 MGI:5755322 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IMP RGD PMID:20096352 RGD:10041064 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (PMID:16118219)
(MGI:6294167|PMID:16118219)
RGD PMID:16118219 MGI:6294167 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO MGI:1913862 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr 9:53,110,628...53,120,454
Ensembl chr 9:53,111,371...53,118,613
JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO MGI:2137691|MGI:2181669|MGI:6382064 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr10:86,545,910...86,554,478
Ensembl chr10:86,547,339...86,554,478
JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
ISS
(PMID:17303575)
GO_REF:0000024
RGD
UniProt
PMID:17303575 GO_REF:0000024 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Samd8 sterile alpha motif domain containing 8 involved_in ISO (PMID:19506037) RGD PMID:19506037 NCBI chr15:2,685,504...2,731,062
Ensembl chr15:2,685,511...2,731,462
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    cellular process 18481
      regulation of cellular process 12359
        regulation of cellular component biogenesis 1045
          regulation of sphingolipid biosynthetic process 14
            negative regulation of sphingolipid biosynthetic process + 6
            positive regulation of sphingolipid biosynthetic process + 7
            regulation of ceramide biosynthetic process + 12
Path 2
Term Annotations click to browse term
  biological_process 19634
    metabolic process 11911
      primary metabolic process 10648
        lipid metabolic process 1364
          cellular lipid metabolic process 1013
            membrane lipid metabolic process 189
              sphingolipid metabolic process 143
                sphingolipid biosynthetic process 90
                  regulation of sphingolipid biosynthetic process 14
                    negative regulation of sphingolipid biosynthetic process + 6
                    positive regulation of sphingolipid biosynthetic process + 7
                    regulation of ceramide biosynthetic process + 12
paths to the root