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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of sphingolipid biosynthetic process
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Accession:GO:0090153 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


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regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO MGI:1913862 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO MGI:2137691|MGI:2181669|MGI:2445707|MGI:6343506|MGI:6382064 (MGI:5926671|PMID:28275141), (MGI:6393026|PMID:31880535) RGD PMID:28275141 PMID:31880535 MGI:5926671 MGI:6393026 NCBI chr10:83,590,052...83,598,620
Ensembl chr10:83,590,071...83,598,620 		JBrowse link
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of_or_within ISO (PMID:25691431) RGD PMID:25691431 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211 		JBrowse link
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 acts_upstream_of_or_within ISO (PMID:25691431) RGD PMID:25691431 NCBI chr 7:1,247,869...1,250,999
Ensembl chr 7:1,246,479...1,250,907 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:5638294|PMID:25691431)
(PMID:25691431)		 Ensembl
RGD		 PMID:25691431 GO_REF:0000107 MGI:5638294 NCBI chr10:83,590,052...83,598,620
Ensembl chr10:83,590,071...83,598,620 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO
ISS
IEA		 (MGI:6294167|PMID:16118219)
(PMID:16118219)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:16118219 GO_REF:0000024 GO_REF:0000107 MGI:6294167 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
negative regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in IEA
ISO
IMP		 GO_REF:0000107
(PMID:24201375)		 Ensembl
RGD		 PMID:24201375 PMID:24201375 GO_REF:0000107, RGD:14697729 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Atg7 autophagy related 7 acts_upstream_of_or_within ISO MGI:2176073|MGI:3587769 (MGI:5613260|PMID:25332431) RGD PMID:25332431 MGI:5613260 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
positive regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn1 cellular communication network factor 1 acts_upstream_of_or_within ISO (MGI:3849354|PMID:19364818) RGD PMID:19364818 MGI:3849354 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISO
ISS		 (MGI:4947032|PMID:21177474)
GO_REF:0000024		 RGD
UniProt		 PMID:21177474 GO_REF:0000024 MGI:4947032 NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589 		JBrowse link
G Pla2g6 phospholipase A2 group VI involved_in IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:18936091 PMID:21873635 RGD:6482750, RGD:13792537 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISO (PMID:19279011) RGD PMID:19279011 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Sirt3 sirtuin 3 involved_in ISO (MGI:5755322|PMID:26620563) RGD PMID:26620563 MGI:5755322 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IMP RGD PMID:20096352 RGD:10041064 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (PMID:16118219)
(MGI:6294167|PMID:16118219)		 RGD PMID:16118219 MGI:6294167 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391 		JBrowse link
regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000068509 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 Ensembl chr17:11,942,344...11,942,538 JBrowse link
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO MGI:1913862 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO MGI:2137691|MGI:2181669|MGI:6382064 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr10:83,590,052...83,598,620
Ensembl chr10:83,590,071...83,598,620 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISS
ISO		 GO_REF:0000024
(PMID:17303575)		 UniProt
RGD		 PMID:17303575 GO_REF:0000024 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Samd8 sterile alpha motif domain containing 8 involved_in ISO (PMID:19506037) RGD PMID:19506037 NCBI chr15:2,512,104...2,562,368
Ensembl chr15:2,512,105...2,515,379
Ensembl chr15:2,512,105...2,515,379 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    cellular process 18159
      regulation of cellular process 12250
        regulation of cellular component biogenesis 1082
          regulation of sphingolipid biosynthetic process 15
            negative regulation of sphingolipid biosynthetic process + 6
            positive regulation of sphingolipid biosynthetic process + 7
            regulation of ceramide biosynthetic process + 13
Path 2
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      primary metabolic process 10824
        lipid metabolic process 1451
          cellular lipid metabolic process 1050
            membrane lipid metabolic process 202
              sphingolipid metabolic process 153
                sphingolipid biosynthetic process 102
                  regulation of sphingolipid biosynthetic process 15
                    negative regulation of sphingolipid biosynthetic process + 6
                    positive regulation of sphingolipid biosynthetic process + 7
                    regulation of ceramide biosynthetic process + 13
paths to the root