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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of sphingolipid biosynthetic process
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Accession:GO:0090153 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).



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regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO MGI:1913862 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211
JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO MGI:2137691|MGI:2181669|MGI:2445707|MGI:6343506|MGI:6382064 (MGI:5926671|PMID:28275141), (MGI:6393026|PMID:31880535) RGD PMID:28275141 PMID:31880535 MGI:5926671 MGI:6393026 NCBI chr10:83,590,052...83,598,620
Ensembl chr10:83,590,071...83,598,620
JBrowse link
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:25691431)
RGD PMID:25691431 PMID:21873635 RGD:13792537 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211
JBrowse link
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:25691431)
RGD PMID:25691431 PMID:21873635 RGD:13792537 NCBI chr 7:1,247,869...1,250,999
Ensembl chr 7:1,246,479...1,250,907
JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:25691431)
(MGI:5638294|PMID:25691431)
Ensembl
RGD
PMID:25691431 PMID:21873635 GO_REF:0000107 MGI:5638294, RGD:13792537 NCBI chr10:83,590,052...83,598,620
Ensembl chr10:83,590,071...83,598,620
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:6294167|PMID:16118219)
(PMID:16118219)
UniProt
Ensembl
RGD
PMID:16118219 GO_REF:0000024 GO_REF:0000107 MGI:6294167 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
negative regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO
IEA
IMP
(PMID:24201375)
GO_REF:0000107
RGD
Ensembl
PMID:24201375 PMID:24201375 GO_REF:0000107, RGD:14697729 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Atg7 autophagy related 7 acts_upstream_of_or_within ISO MGI:2176073|MGI:3587769 (MGI:5613260|PMID:25332431) RGD PMID:25332431 MGI:5613260 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
positive regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn1 cellular communication network factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3849354|PMID:19364818)
Ensembl
RGD
PMID:19364818 GO_REF:0000107 MGI:3849354 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:4947032|PMID:21177474)
UniProt
RGD
PMID:21177474 GO_REF:0000024 MGI:4947032 NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589
JBrowse link
G Pla2g6 phospholipase A2 group VI involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:18936091 PMID:21873635 RGD:6482750, RGD:13792537 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
IEA
(PMID:19279011)
GO_REF:0000107
RGD
Ensembl
PMID:19279011 GO_REF:0000107 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Sirt3 sirtuin 3 involved_in ISO (MGI:5755322|PMID:26620563) RGD PMID:26620563 MGI:5755322 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IMP RGD PMID:20096352 RGD:10041064 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (PMID:16118219)
(MGI:6294167|PMID:16118219)
RGD PMID:16118219 MGI:6294167 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO MGI:1913862 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211
JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO MGI:2137691|MGI:2181669|MGI:6382064 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr10:83,590,052...83,598,620
Ensembl chr10:83,590,071...83,598,620
JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
ISS
(PMID:17303575)
GO_REF:0000024
RGD
UniProt
PMID:17303575 GO_REF:0000024 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Samd8 sterile alpha motif domain containing 8 involved_in ISO (PMID:19506037) RGD PMID:19506037 NCBI chr15:2,512,104...2,562,368
Ensembl chr15:2,512,105...2,515,379
Ensembl chr15:2,512,105...2,515,379
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      regulation of cellular process 12336
        regulation of cellular component biogenesis 1046
          regulation of sphingolipid biosynthetic process 14
            negative regulation of sphingolipid biosynthetic process + 6
            positive regulation of sphingolipid biosynthetic process + 7
            regulation of ceramide biosynthetic process + 12
Path 2
Term Annotations click to browse term
  biological_process 19497
    metabolic process 11824
      primary metabolic process 10535
        lipid metabolic process 1388
          cellular lipid metabolic process 1035
            membrane lipid metabolic process 193
              sphingolipid metabolic process 147
                sphingolipid biosynthetic process 97
                  regulation of sphingolipid biosynthetic process 14
                    negative regulation of sphingolipid biosynthetic process + 6
                    positive regulation of sphingolipid biosynthetic process + 7
                    regulation of ceramide biosynthetic process + 12
paths to the root