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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of sphingolipid biosynthetic process
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Accession:GO:0090153 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

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regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO MGI:1913862 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr 9:53,110,628...53,120,454
Ensembl chr 9:53,111,371...53,118,613 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO MGI:2137691|MGI:2181669|MGI:2445707|MGI:6343506|MGI:6382064 (MGI:5926671|PMID:28275141), (MGI:6393026|PMID:31880535) RGD PMID:28275141 PMID:31880535 MGI:5926671 MGI:6393026 NCBI chr10:86,545,910...86,554,478
Ensembl chr10:86,547,339...86,554,478 		JBrowse link
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 involved_in IBA
ISO		 PMID:21873635
(PMID:25691431)		 RGD PMID:25691431, PMID:21873635 RGD:13792537 NCBI chr 9:53,110,628...53,120,454
Ensembl chr 9:53,111,371...53,118,613 		JBrowse link
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 involved_in ISO
IBA		 (PMID:25691431)
PMID:21873635		 RGD PMID:25691431, PMID:21873635 RGD:13792537 NCBI chr 7:3,242,991...3,246,085
Ensembl chr 7:3,242,991...3,246,071 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
(MGI:5638294|PMID:25691431)
PMID:21873635
(PMID:25691431)		 Ensembl
RGD		 PMID:25691431, PMID:21873635 GO_REF:0000107 MGI:5638294, RGD:13792537 NCBI chr10:86,545,910...86,554,478
Ensembl chr10:86,547,339...86,554,478 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:6294167|PMID:16118219)
(PMID:16118219)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16118219 GO_REF:0000024 GO_REF:0000107 MGI:6294167 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393 		JBrowse link
negative regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO
IMP		 (PMID:24201375) RGD PMID:24201375, PMID:24201375 RGD:14697729 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809 		JBrowse link
G Atg7 autophagy related 7 acts_upstream_of_or_within ISO MGI:2176073|MGI:3587769 (MGI:5613260|PMID:25332431) RGD PMID:25332431 MGI:5613260 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124 		JBrowse link
positive regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn1 cellular communication network factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3849354|PMID:19364818)		 Ensembl
RGD		 PMID:19364818 GO_REF:0000107 MGI:3849354 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4947032|PMID:21177474)		 UniProt
RGD		 PMID:21177474 GO_REF:0000024 MGI:4947032 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483 		JBrowse link
G Pla2g6 phospholipase A2 group VI IDA RGD PMID:18936091 RGD:6482750 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
IEA		 (PMID:19279011)
GO_REF:0000107		 RGD
Ensembl		 PMID:19279011 GO_REF:0000107 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
G Sirt3 sirtuin 3 involved_in ISO (MGI:5755322|PMID:26620563) RGD PMID:26620563 MGI:5755322 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IMP RGD PMID:20096352 RGD:10041064 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528 		JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (PMID:16118219)
(MGI:6294167|PMID:16118219)		 RGD PMID:16118219 MGI:6294167 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277 		JBrowse link
regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO MGI:1913862 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr 9:53,110,628...53,120,454
Ensembl chr 9:53,111,371...53,118,613 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO MGI:2137691|MGI:2181669|MGI:6382064 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr10:86,545,910...86,554,478
Ensembl chr10:86,547,339...86,554,478 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
ISS		 (PMID:17303575)
GO_REF:0000024		 RGD
UniProt		 PMID:17303575 GO_REF:0000024 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
G Samd8 sterile alpha motif domain containing 8 involved_in ISO (PMID:19506037) RGD PMID:19506037 NCBI chr15:2,685,504...2,731,062
Ensembl chr15:2,685,511...2,731,462 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    cellular process 18481
      regulation of cellular process 12359
        regulation of cellular component biogenesis 1045
          regulation of sphingolipid biosynthetic process 14
            negative regulation of sphingolipid biosynthetic process + 6
            positive regulation of sphingolipid biosynthetic process + 7
            regulation of ceramide biosynthetic process + 12
Path 2
Term Annotations click to browse term
  biological_process 19634
    metabolic process 11911
      primary metabolic process 10648
        lipid metabolic process 1364
          cellular lipid metabolic process 1013
            membrane lipid metabolic process 189
              sphingolipid metabolic process 143
                sphingolipid biosynthetic process 90
                  regulation of sphingolipid biosynthetic process 14
                    negative regulation of sphingolipid biosynthetic process + 6
                    positive regulation of sphingolipid biosynthetic process + 7
                    regulation of ceramide biosynthetic process + 12
paths to the root