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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
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Accession:GO:0090101 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.
Synonyms:exact_synonym: negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway


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negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fstl3 follistatin like 3 JBrowse link 7 12,806,031 12,810,556 RGD:1624291
negative regulation of activin receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1624291
RGD:1600115
G Cer1 cerberus 1, DAN family BMP antagonist JBrowse link 5 101,003,019 101,006,375 RGD:1624291
G Fst follistatin JBrowse link 2 46,537,589 46,544,813 RGD:1624291
RGD:13792537
G Fstl3 follistatin like 3 JBrowse link 7 12,806,031 12,810,556 RGD:1624291
RGD:13792537
G Igsf1 immunoglobulin superfamily, member 1 JBrowse link X 136,792,637 136,808,107 RGD:1624291
G Lemd3 LEM domain containing 3 JBrowse link 7 62,976,671 63,045,860 RGD:1624291
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 JBrowse link 4 10,995,241 12,472,423 RGD:1600115
RGD:1624291
G Mir210 microRNA 210 JBrowse link 1 214,208,355 214,208,464 RGD:1624291
G Ski SKI proto-oncogene JBrowse link 5 172,556,196 172,623,878 RGD:1624291
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:1624291
negative regulation of BMP signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Bmper BMP-binding endothelial regulator JBrowse link 8 24,369,916 24,615,484 RGD:1624291
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
G Cer1 cerberus 1, DAN family BMP antagonist JBrowse link 5 101,003,019 101,006,375 RGD:1624291
G Chrd chordin JBrowse link 11 83,858,503 83,867,543 RGD:1624291
RGD:1600115
G Chrdl1 chordin-like 1 JBrowse link X 114,554,359 114,658,975 RGD:1624291
RGD:1600115
G Chrdl2 chordin-like 2 JBrowse link 1 165,008,997 165,036,431 RGD:1624291
G Ctdspl2 CTD small phosphatase like 2 JBrowse link 3 113,906,803 113,957,289 RGD:1624291
RGD:1600115
G Dand5 DAN domain BMP antagonist family member 5 JBrowse link 19 25,929,704 25,937,852 RGD:1624291
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Dlx1 distal-less homeobox 1 JBrowse link 3 58,164,931 58,169,521 RGD:1600115
RGD:1624291
G Fstl3 follistatin like 3 JBrowse link 7 12,806,031 12,810,556 RGD:1624291
G Fzd1 frizzled class receptor 1 JBrowse link 4 26,470,864 26,475,262 RGD:1624291
RGD:1600115
G Gdf3 growth differentiation factor 3 JBrowse link 4 155,417,667 155,422,014 RGD:1624291
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
RGD:1600115
G Grem2 gremlin 2, DAN family BMP antagonist JBrowse link 13 92,894,431 92,988,137 RGD:1624291
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:1624291
G Hjv hemojuvelin BMP co-receptor JBrowse link 2 198,655,437 198,659,318 RGD:1624291
RGD:1600115
G Htra1 HtrA serine peptidase 1 JBrowse link 1 201,499,067 201,548,508 RGD:1624291
G Htra3 HtrA serine peptidase 3 JBrowse link 14 80,248,140 80,276,534 RGD:1624291
RGD:1600115
G Lemd2 LEM domain nuclear envelope protein 2 JBrowse link 20 5,779,742 5,786,213 RGD:13792537
G Lemd3 LEM domain containing 3 JBrowse link 7 62,976,671 63,045,860 RGD:1624291
RGD:13792537
G LOC108348120 LEM domain-containing protein 2-like JBrowse link 20 6,544,925 6,556,668 RGD:13792537
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:1600115
RGD:1624291
G Mir675 microRNA 675 JBrowse link 1 215,745,981 215,746,064 RGD:1624291
G Nanog Nanog homeobox JBrowse link 4 155,531,906 155,539,268 RGD:1624291
G Nbl1 NBL1, DAN family BMP antagonist JBrowse link 5 157,524,569 157,535,701 RGD:1624291
RGD:1600115
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1600115
RGD:13792537
RGD:1624291
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:1624291
RGD:1600115
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
G Ski SKI proto-oncogene JBrowse link 5 172,556,196 172,623,878 RGD:1624291
RGD:13792537
G Skil SKI-like proto-oncogene JBrowse link 2 115,862,932 115,891,304 RGD:13792537
G Skor1 SKI family transcriptional corepressor 1 JBrowse link 8 68,029,930 68,040,504 RGD:1624291
RGD:13792537
G Skor2 SKI family transcriptional corepressor 2 JBrowse link 18 73,145,596 73,199,395 RGD:1624291
RGD:13792537
G Smad6 SMAD family member 6 JBrowse link 8 68,897,746 68,967,221 RGD:1624291
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:1624291
RGD:1600115
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:1624291
RGD:13792537
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 JBrowse link 10 95,018,050 95,118,107 RGD:13792537
G Sorl1 sortilin related receptor 1 JBrowse link 8 46,228,077 46,287,171 RGD:1624291
G Sost sclerostin JBrowse link 10 89,897,087 89,900,131 RGD:1624291
G Sostdc1 sclerostin domain containing 1 JBrowse link 6 55,812,820 55,816,994 RGD:1624291
G Spart spartin JBrowse link 2 144,522,382 144,548,968 RGD:1624291
RGD:13792537
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:1624291
G Tmprss6 transmembrane serine protease 6 JBrowse link 7 119,659,323 119,689,953 RGD:1624291
G Tob1 transducer of ErbB-2.1 JBrowse link 10 81,913,689 81,915,727 RGD:1624291
RGD:1600115
G Trim33 tripartite motif-containing 33 JBrowse link 2 205,783,252 205,863,426 RGD:1624291
G Twsg1 twisted gastrulation BMP signaling modulator 1 JBrowse link 9 113,699,151 113,732,601 RGD:1624291
G Vwc2 von Willebrand factor C domain containing 2 JBrowse link 14 91,201,141 91,348,219 RGD:1624291
RGD:13792537
G Vwc2l von Willebrand factor C domain containing 2 like JBrowse link 9 77,833,534 78,024,670 RGD:1624291
RGD:13792537
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
negative regulation of nodal receptor complex assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lefty1 left right determination factor 1 JBrowse link 13 99,212,778 99,217,786 RGD:1624291
negative regulation of nodal signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dact2 dishevelled-binding antagonist of beta-catenin 2 JBrowse link 1 56,159,435 56,169,443 RGD:1624291
G Dand5 DAN domain BMP antagonist family member 5 JBrowse link 19 25,929,704 25,937,852 RGD:1624291
G Lefty1 left right determination factor 1 JBrowse link 13 99,212,778 99,217,786 RGD:1624291
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cer1 cerberus 1, DAN family BMP antagonist JBrowse link 5 101,003,019 101,006,375 RGD:13792537
G Dand5 DAN domain BMP antagonist family member 5 JBrowse link 19 25,929,704 25,937,852 RGD:13792537
negative regulation of pathway-restricted SMAD protein phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Emilin1 elastin microfibril interfacer 1 JBrowse link 6 26,821,249 26,829,013 RGD:1624291
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 JBrowse link 18 63,717,423 64,045,224 RGD:1624291
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Pbld1 phenazine biosynthesis-like protein domain containing 1 JBrowse link 20 27,103,300 27,118,650 RGD:1624291
G Pmepa1 prostate transmembrane protein, androgen induced 1 JBrowse link 3 171,295,630 171,342,662 RGD:1624291
G Smad6 SMAD family member 6 JBrowse link 8 68,897,746 68,967,221 RGD:1624291
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:1624291
RGD:1600115
G Snx25 sorting nexin 25 JBrowse link 16 49,328,958 49,432,415 RGD:1624291
G Strap serine/threonine kinase receptor associated protein JBrowse link 4 171,730,629 171,744,877 RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
negative regulation of SMAD protein complex assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 JBrowse link 18 63,717,423 64,045,224 RGD:1624291
G Pmepa1 prostate transmembrane protein, androgen induced 1 JBrowse link 3 171,295,630 171,342,662 RGD:1624291
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:1600115
RGD:1624291
G Smad6 SMAD family member 6 JBrowse link 8 68,897,746 68,967,221 RGD:1624291
G Tbx20 T-box transcription factor 20 JBrowse link 8 25,849,394 25,904,570 RGD:1624291
negative regulation of SMAD protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccn3 cellular communication network factor 3 JBrowse link 7 94,375,134 94,382,154 RGD:1624291
RGD:1600115
G Cilp cartilage intermediate layer protein JBrowse link 8 70,760,922 70,775,891 RGD:1624291
G Fam89b family with sequence similarity 89, member B JBrowse link 1 221,085,894 221,087,449 RGD:1624291
G Pbld1 phenazine biosynthesis-like protein domain containing 1 JBrowse link 20 27,103,300 27,118,650 RGD:1624291
G Veph1 ventricular zone expressed PH domain-containing 1 JBrowse link 2 157,869,383 158,156,266 RGD:1600115
RGD:1624291
negative regulation of transforming growth factor beta receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:1624291
RGD:1600115
G Adamtsl2 ADAMTS-like 2 JBrowse link 3 5,624,473 5,654,890 RGD:1624291
G Aspn asporin JBrowse link 17 14,655,958 14,681,355 RGD:1624291
G Bambi BMP and activin membrane-bound inhibitor JBrowse link 17 56,905,419 56,909,675 RGD:1624291
G Bcl9l BCL9 like JBrowse link 8 48,805,684 48,835,794 RGD:1624291
RGD:13792537
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1600115
RGD:1624291
G Cav2 caveolin 2 JBrowse link 4 44,573,264 44,580,640 RGD:1624291
RGD:1600115
G Cd109 CD109 molecule JBrowse link 8 85,951,420 86,065,411 RGD:1624291
G Chst11 carbohydrate sulfotransferase 11 JBrowse link 7 26,641,856 26,890,503 RGD:1624291
G Cidea cell death-inducing DFFA-like effector a JBrowse link 18 63,082,861 63,108,450 RGD:1624291
G Dand5 DAN domain BMP antagonist family member 5 JBrowse link 19 25,929,704 25,937,852 RGD:1624291
G Dnm2 dynamin 2 JBrowse link 8 22,458,869 22,540,649 RGD:9685289
G Eid2 EP300 interacting inhibitor of differentiation 2 JBrowse link 1 85,515,610 85,517,516 RGD:1624291
G Emilin1 elastin microfibril interfacer 1 JBrowse link 6 26,821,249 26,829,013 RGD:1624291
G Fam89b family with sequence similarity 89, member B JBrowse link 1 221,085,894 221,087,449 RGD:1624291
G Glg1 golgi glycoprotein 1 JBrowse link 19 42,983,879 43,088,074 RGD:1624291
RGD:1600115
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1624291
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1624291
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1624291
G Htra1 HtrA serine peptidase 1 JBrowse link 1 201,499,067 201,548,508 RGD:1624291
G Htra3 HtrA serine peptidase 3 JBrowse link 14 80,248,140 80,276,534 RGD:1624291
RGD:1600115
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 JBrowse link 18 63,717,423 64,045,224 RGD:1624291
G Lemd3 LEM domain containing 3 JBrowse link 7 62,976,671 63,045,860 RGD:1624291
G Mecom MDS1 and EVI1 complex locus JBrowse link 2 117,396,084 117,993,604 RGD:1624291
G Nepn nephrocan JBrowse link 20 33,527,932 33,543,860 RGD:1600115
G Nkx2-1 NK2 homeobox 1 JBrowse link 6 77,418,096 77,423,383 RGD:1600115
RGD:1624291
G Onecut1 one cut homeobox 1 JBrowse link 8 81,765,779 81,799,894 RGD:1624291
RGD:1600115
G Onecut2 one cut homeobox 2 JBrowse link 18 59,830,375 59,882,490 RGD:1624291
RGD:1600115
G Pbld1 phenazine biosynthesis-like protein domain containing 1 JBrowse link 20 27,103,300 27,118,650 RGD:1624291
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1624291
G Peg10 paternally expressed 10 JBrowse link 4 29,795,524 29,804,517 RGD:1624291
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 8 21,669,236 21,680,615 RGD:1624291
G Pmepa1 prostate transmembrane protein, androgen induced 1 JBrowse link 3 171,295,630 171,342,662 RGD:1624291
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:1600115
RGD:1624291
G Prdm16 PR/SET domain 16 JBrowse link 5 171,662,277 171,711,561 RGD:1624291
G Rasl11b RAS-like family 11 member B JBrowse link 14 36,550,353 36,554,574 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
G Ski SKI proto-oncogene JBrowse link 5 172,556,196 172,623,878 RGD:1624291
RGD:13792537
G Skil SKI-like proto-oncogene JBrowse link 2 115,862,932 115,891,304 RGD:1624291
RGD:13792537
G Skor2 SKI family transcriptional corepressor 2 JBrowse link 18 73,145,596 73,199,395 RGD:1624291
G Smad6 SMAD family member 6 JBrowse link 8 68,897,746 68,967,221 RGD:1624291
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:1600115
RGD:1624291
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:1624291
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 JBrowse link 10 95,018,050 95,118,107 RGD:1624291
G Snx1 sorting nexin 1 JBrowse link 8 71,745,687 71,786,182 RGD:1624291
G Snx25 sorting nexin 25 JBrowse link 16 49,328,958 49,432,415 RGD:1624291
G Snx6 sorting nexin 6 JBrowse link 6 75,626,927 75,670,172 RGD:1624291
G Strap serine/threonine kinase receptor associated protein JBrowse link 4 171,730,629 171,744,877 RGD:1624291
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:1624291
G Tdgf1 teratocarcinoma-derived growth factor 1 JBrowse link 8 119,215,266 119,220,909 RGD:1624291
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 JBrowse link 1 199,664,039 199,670,970 RGD:1624291
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:730235
G Tgfbr3 transforming growth factor beta receptor 3 JBrowse link 14 3,506,416 3,680,508 RGD:1579946
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Vasn vasorin JBrowse link 10 11,121,041 11,131,548 RGD:1624291
RGD:13792537
G Veph1 ventricular zone expressed PH domain-containing 1 JBrowse link 2 157,869,383 158,156,266 RGD:1600115
RGD:1624291
G Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 JBrowse link 10 15,243,429 15,245,757 RGD:1624291
RGD:13792537
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 JBrowse link 10 81,936,156 81,943,142 RGD:1624291
RGD:13792537
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
G Zbtb7a zinc finger and BTB domain containing 7a JBrowse link 7 11,429,266 11,446,119 RGD:1600115
RGD:1624291
G Zfp451 zinc finger protein 451 JBrowse link 9 38,395,464 38,451,585 RGD:1624291
sequestering of BMP from receptor via BMP binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grem2 gremlin 2, DAN family BMP antagonist JBrowse link 13 92,894,431 92,988,137 RGD:1624291
G Nbl1 NBL1, DAN family BMP antagonist JBrowse link 5 157,524,569 157,535,701 RGD:1624291
RGD:1600115
sequestering of BMP in extracellular matrix term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cer1 cerberus 1, DAN family BMP antagonist JBrowse link 5 101,003,019 101,006,375 RGD:1624291
RGD:13792537
G Dand5 DAN domain BMP antagonist family member 5 JBrowse link 19 25,929,704 25,937,852 RGD:13792537
G Fbn1 fibrillin 1 JBrowse link 3 117,569,708 117,766,160 RGD:1624291
G Nbl1 NBL1, DAN family BMP antagonist JBrowse link 5 157,524,569 157,535,701 RGD:1624291
RGD:1600115
sequestering of nodal from receptor via nodal binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dand5 DAN domain BMP antagonist family member 5 JBrowse link 19 25,929,704 25,937,852 RGD:1624291
sequestering of TGFbeta in extracellular matrix term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fbn1 fibrillin 1 JBrowse link 3 117,569,708 117,766,160 RGD:1624291
G Fbn2 fibrillin 2 JBrowse link 18 53,068,495 53,272,254 RGD:1624291
G Ltbp1 latent transforming growth factor beta binding protein 1 JBrowse link 6 21,203,502 21,600,441 RGD:1600115
RGD:1624291
G Nrros negative regulator of reactive oxygen species JBrowse link 11 71,872,728 71,889,897 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    negative regulation of biological process 5577
      negative regulation of signaling 1413
        negative regulation of signal transduction 1221
          negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 117
            negative regulation of BMP signaling pathway + 54
            negative regulation of SMAD protein complex assembly 5
            negative regulation of SMAD protein signal transduction 5
            negative regulation of activin receptor signaling pathway + 13
            negative regulation of pathway-restricted SMAD protein phosphorylation 13
            negative regulation of transforming growth factor beta receptor signaling pathway + 66
Path 2
Term Annotations click to browse term
  biological_process 19439
    biological regulation 13444
      regulation of biological process 12747
        regulation of cellular process 12246
          signal transduction 6902
            cell surface receptor signaling pathway 2691
              enzyme linked receptor protein signaling pathway 935
                transmembrane receptor protein serine/threonine kinase signaling pathway 367
                  regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 244
                    negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 117
                      negative regulation of BMP signaling pathway + 54
                      negative regulation of SMAD protein complex assembly 5
                      negative regulation of SMAD protein signal transduction 5
                      negative regulation of activin receptor signaling pathway + 13
                      negative regulation of pathway-restricted SMAD protein phosphorylation 13
                      negative regulation of transforming growth factor beta receptor signaling pathway + 66
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.