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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
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Accession:GO:0090100 term browser browse the term
Definition:Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.
Synonyms:exact_synonym: positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway


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positive regulation of activin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1b activin A receptor type 1B involved_in ISO (PMID:16720724) RGD PMID:16720724 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572
JBrowse link
G Acvr2a activin A receptor type 2A involved_in IEA
ISO
GO_REF:0000107
(PMID:12665502)
Ensembl
RGD
PMID:12665502 GO_REF:0000107 NCBI chr 3:32,947,901...33,034,598
Ensembl chr 3:32,947,378...33,034,282
JBrowse link
G Acvr2b activin A receptor type 2B involved_in IEA
ISO
GO_REF:0000107
(PMID:8622651)
Ensembl
RGD
PMID:8622651 GO_REF:0000107 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746
JBrowse link
G Csnk2b casein kinase 2 beta involved_in ISO (PMID:19592636) RGD PMID:19592636 NCBI chr20:5,108,692...5,113,675
Ensembl chr20:5,106,890...5,113,112
JBrowse link
G Fgf9 fibroblast growth factor 9 acts_upstream_of_or_within ISO (MGI:5444317|PMID:23034635) RGD PMID:23034635 MGI:5444317 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Nodal nodal growth differentiation factor involved_in ISO UniProtKB:Q8NER5 (PMID:15150278) RGD PMID:15150278 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
G Synj2bp synaptojanin 2 binding protein involved_in ISO (MGI:3623710|PMID:16648306) RGD PMID:16648306 MGI:3623710 NCBI chr 6:105,224,166...105,261,549
Ensembl chr 6:105,224,166...105,261,549
JBrowse link
G Zc3h3 zinc finger CCCH type containing 3 acts_upstream_of_or_within ISO MGI:1338944 (MGI:3619747|PMID:16115198) RGD PMID:16115198 MGI:3619747 NCBI chr 7:116,787,762...116,872,536
Ensembl chr 7:116,787,766...116,872,511
JBrowse link
positive regulation of BMP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (PMID:17068149)
(MGI:4830635|PMID:20406889)
RGD PMID:17068149 PMID:20406889 MGI:4830635 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:4418577|PMID:20059955)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:20059955 GO_REF:0000024 GO_REF:0000107 MGI:4418577 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:17992660) RGD PMID:17992660 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
JBrowse link
G Ccn1 cellular communication network factor 1 involved_in ISO
IEA
UniProtKB:P21274 (PMID:20675382)
GO_REF:0000107
RGD
Ensembl
PMID:20675382 GO_REF:0000107 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Cdh5 cadherin 5 involved_in ISO (PMID:26598555) RGD PMID:26598555 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Crb2 crumbs cell polarity complex component 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5296388|PMID:22072575)
UniProt
RGD
PMID:22072575 GO_REF:0000024 MGI:5296388 NCBI chr 3:22,037,812...22,061,247
Ensembl chr 3:22,038,357...22,058,871
JBrowse link
G Elapor2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 involved_in IBA
ISO
PMID:21873635
(MGI:6393099|PMID:21177533)
RGD PMID:21177533, PMID:21873635 MGI:6393099, RGD:13792537 NCBI chr 4:21,563,848...21,757,668
Ensembl chr 4:21,584,369...21,668,570
JBrowse link
G Eng endoglin involved_in ISO (PMID:17068149) RGD PMID:17068149 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Fbxl15 F-box and leucine-rich repeat protein 15 involved_in ISO
ISS
(PMID:21572392)
GO_REF:0000024
RGD
UniProt
PMID:21572392 GO_REF:0000024 NCBI chr 1:266,075,782...266,078,023
Ensembl chr 1:266,075,782...266,078,023
JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 acts_upstream_of_or_within ISO MGI:3042750 (MGI:3806189|PMID:18590716) RGD PMID:18590716 MGI:3806189 NCBI chr16:20,645,956...20,652,890
Ensembl chr16:20,645,957...20,652,889
JBrowse link
G Foxd1 forkhead box D1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3525902|PMID:15634693)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:15634693 GO_REF:0000024 GO_REF:0000107 MGI:3525902 NCBI chr 2:28,460,068...28,462,488
Ensembl chr 2:28,460,068...28,462,488
JBrowse link
G Gata4 GATA binding protein 4 involved_in IDA PMID:12606287 BHF-UCL PMID:12606287 RGD:8554170 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gata6 GATA binding protein 6 involved_in IDA PMID:12606287 BHF-UCL PMID:12606287 RGD:8554170 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Gdf2 growth differentiation factor 2 involved_in ISO (MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:4830635 NCBI chr16:10,267,510...10,293,545
Ensembl chr16:10,267,482...10,273,239
JBrowse link
G Gdf5 growth differentiation factor 5 involved_in ISO (PMID:21976273), (PMID:24098149) RGD PMID:21976273 PMID:24098149 NCBI chr 3:151,482,672...151,487,129
Ensembl chr 3:151,483,249...151,486,693
JBrowse link
G Gpc3 glypican 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2159356 (MGI:3583399|PMID:15925496)
Ensembl
RGD
PMID:15925496 GO_REF:0000107 MGI:3583399 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104876 (MGI:3807421|PMID:18579678)
Ensembl
RGD
PMID:18579678 GO_REF:0000107 MGI:3807421 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hes5 hes family bHLH transcription factor 5 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:104853 (MGI:3807421|PMID:18579678)
UniProt
RGD
PMID:18579678 GO_REF:0000024 MGI:3807421 NCBI chr 5:172,364,421...172,365,188
Ensembl chr 5:172,364,421...172,365,188
JBrowse link
G Ilk integrin-linked kinase involved_in ISO (MGI:5009350|PMID:20675382) RGD PMID:20675382 MGI:5009350 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Kcp kielin cysteine rich BMP regulator acts_upstream_of_or_within ISO (MGI:3575605|PMID:15793581) RGD PMID:15793581 MGI:3575605 NCBI chr 4:56,750,782...56,796,878
Ensembl chr 4:56,760,220...56,786,754
JBrowse link
G Kdr kinase insert domain receptor involved_in ISO (MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:4830635 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Msx1 msh homeobox 1 acts_upstream_of_or_within ISO MGI:97169 (MGI:3810851|PMID:18667074) RGD PMID:18667074 MGI:3810851 NCBI chr14:77,712,262...77,716,061
Ensembl chr14:77,712,240...77,716,059
JBrowse link
G Msx2 msh homeobox 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97168 (MGI:3810851|PMID:18667074)
Ensembl
RGD
PMID:18667074 GO_REF:0000107 MGI:3810851 NCBI chr17:11,683,862...11,689,527
Ensembl chr17:11,683,862...11,689,527
JBrowse link
G Neo1 neogenin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000002
MGI:88177 (MGI:4455113|PMID:20065295)
InterPro
RGD
PMID:20065295 GO_REF:0000002 MGI:4455113 NCBI chr 8:63,649,871...63,756,394
Ensembl chr 8:63,653,266...63,750,531
JBrowse link
G Notch1 notch receptor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4844232|PMID:20547764)
UniProt
RGD
PMID:20547764 GO_REF:0000024 MGI:4844232 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch2 notch receptor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3617328 (MGI:5492288|PMID:23676271)
Ensembl
RGD
PMID:23676271 GO_REF:0000107 MGI:5492288 NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215
JBrowse link
G Numa1 nuclear mitotic apparatus protein 1 involved_in ISO (MGI:5754878|PMID:26765568) RGD PMID:26765568 MGI:5754878 NCBI chr 1:167,044,544...167,091,453
Ensembl chr 1:167,051,209...167,091,453
JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor acts_upstream_of_or_within ISO MGI:2450933 (MGI:5705244|PMID:24835669) RGD PMID:24835669 MGI:5705244 NCBI chr 2:47,266,758...47,268,526
Ensembl chr 2:47,266,738...47,268,625
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:3701380|PMID:17336907) RGD PMID:17336907 MGI:3701380 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Rnf165 ring finger protein 165 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5516581 (MGI:5499270|PMID:23610558)
RGD PMID:23610558, PMID:21873635 MGI:5499270, RGD:13792537 NCBI chr18:73,831,289...73,873,246
Ensembl chr18:73,831,326...73,873,280
JBrowse link
G Smad2 SMAD family member 2 involved_in ISO (PMID:19366699) RGD PMID:19366699 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad4 SMAD family member 4 involved_in ISO
IEA
(PMID:19366699)
GO_REF:0000107
RGD
Ensembl
PMID:19366699 GO_REF:0000107 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Sox11 SRY-box transcription factor 11 involved_in ISS
ISO
GO_REF:0000024
(MGI:3797299|PMID:18423449)
UniProt
RGD
PMID:18423449 GO_REF:0000024 MGI:3797299 NCBI chr 6:46,629,967...46,631,988
Ensembl chr 6:46,629,974...46,631,983
JBrowse link
G Sulf1 sulfatase 1 involved_in ISO
IEA
ISS
(PMID:20479257)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20479257 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:5,999,520...6,186,901
Ensembl chr 5:5,999,475...6,186,329
JBrowse link
G Tbx20 T-box transcription factor 20 acts_upstream_of ISO (MGI:5299248|PMID:21983003) RGD PMID:21983003 MGI:5299248 NCBI chr 8:25,849,394...25,904,570
Ensembl chr 8:25,850,962...25,904,570
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 acts_upstream_of_or_within ISO (MGI:5617089|PMID:25382630) RGD PMID:25382630 MGI:5617089 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 acts_upstream_of_or_within ISO MGI:2655736 (MGI:2654977|PMID:12665593) RGD PMID:12665593 MGI:2654977 NCBI chr 9:113,699,151...113,732,601
Ensembl chr 9:113,699,170...113,732,622
JBrowse link
G Ube2o ubiquitin-conjugating enzyme E2O involved_in ISO (PMID:23455153) RGD PMID:23455153 NCBI chr10:105,505,721...105,553,167
Ensembl chr10:105,506,955...105,552,986
JBrowse link
G Vsir V-set immunoregulatory receptor acts_upstream_of_or_within ISO MGI:1338938 (MGI:5468994|PMID:20042595) RGD PMID:20042595 MGI:5468994 NCBI chr20:29,897,543...29,923,381
Ensembl chr20:29,897,594...29,919,998
JBrowse link
G Zfp423 zinc finger protein 423 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:4844232|PMID:20547764)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:20547764 GO_REF:0000024 GO_REF:0000107 MGI:4844232 NCBI chr19:20,147,201...20,405,999
Ensembl chr19:20,147,037...20,406,003
JBrowse link
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 involved_in ISO (PMID:17239842) RGD PMID:17239842 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Zic2 Zic family member 2 acts_upstream_of_or_within ISO MGI:1862004 (MGI:5584215|PMID:24585447) RGD PMID:24585447 MGI:5584215 NCBI chr15:108,908,366...108,913,812
Ensembl chr15:108,908,607...108,912,737
JBrowse link
positive regulation of pathway-restricted SMAD protein phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:3610266|PMID:16140292)
(PMID:19506109)
Ensembl
RGD
PMID:16140292 PMID:19506109 GO_REF:0000107 MGI:3610266 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
G Acvr1b activin A receptor type 1B IMP RGD PMID:17040568 RGD:2315948 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572
JBrowse link
G Acvr2a activin A receptor type 2A involved_in IEA
ISO
GO_REF:0000107
(PMID:19366699)
Ensembl
RGD
PMID:19366699 GO_REF:0000107 NCBI chr 3:32,947,901...33,034,598
Ensembl chr 3:32,947,378...33,034,282
JBrowse link
G Acvrl1 activin A receptor like type 1 involved_in ISO (PMID:19366699) RGD PMID:19366699 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in IEA
ISO
IBA
GO_REF:0000107
(MGI:3695247|PMID:16798733)
(PMID:16049014), (PMID:17068149), (PMID:19903896)
PMID:21873635
Ensembl
RGD
PMID:16049014 PMID:16798733 PMID:17068149 PMID:19903896, PMID:21873635 GO_REF:0000107 MGI:3695247, RGD:13792537 NCBI chr 4:119,224,906...119,230,534
Ensembl chr 4:119,225,040...119,230,728
JBrowse link
G Bmp15 bone morphogenetic protein 15 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:17,016,831...17,021,894
Ensembl chr  X:17,016,778...17,023,418
JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in ISO
ISS
IBA
(PMID:16049014), (PMID:17244894), (PMID:17992660), (PMID:19664780)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:16049014 PMID:17244894 PMID:17992660 PMID:19664780, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp3 bone morphogenetic protein 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:12,362,912...12,387,572
Ensembl chr14:12,359,363...12,387,102
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:16816361), (PMID:17244894), (PMID:17992660), (PMID:20559569), (PMID:9389648)
Ensembl
UniProt
RGD
PMID:9389648 PMID:16816361 PMID:17244894 PMID:17992660 PMID:20559569, PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in IBA
ISO
PMID:21873635
(PMID:11580864)
RGD PMID:11580864, PMID:21873635 RGD:13792537 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273
JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:4352622|PMID:19252488)
GO_REF:0000024
(PMID:17244894), (PMID:19366699)
RGD
UniProt
PMID:17244894 PMID:19252488 PMID:19366699, PMID:21873635 GO_REF:0000024 MGI:4352622, RGD:13792537 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in ISO
IBA
(PMID:16049014), (PMID:17244894), (PMID:19736306), (PMID:9311995)
PMID:21873635
RGD PMID:9311995 PMID:16049014 PMID:17244894 PMID:19736306, PMID:21873635 RGD:13792537 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Bmp8a bone morphogenetic protein 8a involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:141,007,462...141,033,511
Ensembl chr 5:141,007,462...141,033,511
JBrowse link
G Bmp8b bone morphogenetic protein 8b involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:140,803,387...140,821,104
Ensembl chr 5:140,803,638...140,820,628
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:24904118), (PMID:9389648) RGD PMID:9389648 PMID:24904118 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:17992660), (PMID:19366699) RGD PMID:17992660 PMID:19366699 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
JBrowse link
G Cers1 ceramide synthase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:20,845,580...20,860,789
Ensembl chr16:20,845,576...20,860,789
JBrowse link
G Csnk2b casein kinase 2 beta involved_in ISO (PMID:19592636) RGD PMID:19592636 NCBI chr20:5,108,692...5,113,675
Ensembl chr20:5,106,890...5,113,112
JBrowse link
G Dab2 DAB adaptor protein 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:5317100|PMID:20881059)
Ensembl
RGD
PMID:20881059 GO_REF:0000107 MGI:5317100 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Eng endoglin involved_in ISO (PMID:18974388)
(PMID:12015308)
RGD PMID:12015308 PMID:18974388 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Gdf1 growth differentiation factor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:20,845,580...20,860,789
Ensembl chr16:20,845,576...20,860,767
JBrowse link
G Gdf10 growth differentiation factor 10 involved_in ISS
ISO
IBA
IEA
GO_REF:0000024
(MGI:5545973|PMID:21712809)
PMID:21873635
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:21712809, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5545973, RGD:13792537 NCBI chr16:10,250,508...10,262,383
Ensembl chr16:10,250,404...10,263,150
JBrowse link
G Gdf11 growth differentiation factor 11 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:3,306,863...3,315,856
Ensembl chr 7:3,306,863...3,315,856
JBrowse link
G Gdf15 growth differentiation factor 15 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gdf2 growth differentiation factor 2 involved_in IBA
ISO
PMID:21873635
(PMID:17068149), (PMID:19366699), (PMID:19903896)
RGD PMID:17068149 PMID:19366699 PMID:19903896, PMID:21873635 RGD:13792537 NCBI chr16:10,267,510...10,293,545
Ensembl chr16:10,267,482...10,273,239
JBrowse link
G Gdf3 growth differentiation factor 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:155,417,667...155,422,014
Ensembl chr 4:155,417,004...155,421,998
JBrowse link
G Gdf5 growth differentiation factor 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:151,482,672...151,487,129
Ensembl chr 3:151,483,249...151,486,693
JBrowse link
G Gdf6 growth differentiation factor 6 involved_in IBA
ISO
PMID:21873635
(PMID:16049014)
RGD PMID:16049014, PMID:21873635 RGD:13792537 NCBI chr 5:23,056,345...23,072,666
Ensembl chr 5:23,056,347...23,074,599
JBrowse link
G Gdf7 growth differentiation factor 7 involved_in ISO
IBA
(PMID:16049014)
PMID:21873635
RGD PMID:16049014, PMID:21873635 RGD:13792537 NCBI chr 6:33,496,596...33,507,626
Ensembl chr 6:33,503,217...33,507,542
JBrowse link
G Gdf9 growth differentiation factor 9 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:38,782,519...38,793,238
Ensembl chr10:38,788,992...38,792,940
JBrowse link
G Hfe homeostatic iron regulator involved_in ISO (PMID:24904118) RGD PMID:24904118 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Inha inhibin subunit alpha involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
JBrowse link
G Inhba inhibin subunit beta A involved_in IBA
ISO
PMID:21873635
(PMID:19736306)
RGD PMID:19736306, PMID:21873635 RGD:13792537 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Inhbb inhibin subunit beta B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Inhbc inhibin subunit beta C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:70,648,005...70,661,475
Ensembl chr 7:70,646,519...70,661,891
JBrowse link
G Inhbe inhibin subunit beta E involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Lefty1 left right determination factor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:99,212,778...99,217,786
Ensembl chr13:99,214,389...99,217,786
JBrowse link
G Lefty2 Left-right determination factor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:99,173,484...99,178,037
Ensembl chr13:99,173,484...99,178,037
JBrowse link
G Lgals9 galectin 9 involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Mstn myostatin involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:53,310,977...53,315,804
Ensembl chr 9:53,309,598...53,315,915
JBrowse link
G Nodal nodal growth differentiation factor involved_in IBA
ISO
PMID:21873635
(PMID:21741376)
RGD PMID:21741376, PMID:21873635 RGD:13792537 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO UniProtKB:P01137 (PMID:31023188)
UniProtKB:Q91ZX7 (MGI:6434720|PMID:31023188)
RGD PMID:31023188 MGI:6434720 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Rbpms RNA binding protein, mRNA processing factor involved_in ISO (PMID:17099224) RGD PMID:17099224 NCBI chr16:61,954,569...62,109,998
Ensembl chr16:61,954,590...62,096,497
JBrowse link
G Sdcbp syndecan binding protein involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:25893292)
UniProt
RGD
PMID:25893292, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:19,471,664...19,498,499
Ensembl chr 5:19,471,664...19,498,485
JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:2683382|PMID:14691138)
Ensembl
RGD
PMID:14691138 GO_REF:0000107 MGI:2683382 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in IBA
ISO
ISS
PMID:21873635
(PMID:19736306), (PMID:26634652), (PMID:28467929), (PMID:31023188), (PMID:9389648)
GO_REF:0000024
RGD
UniProt
PMID:9389648 PMID:19736306 PMID:26634652 PMID:28467929 PMID:31023188, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in IBA
ISO
PMID:21873635
(MGI:2683382|PMID:14691138)
RGD PMID:14691138, PMID:21873635 MGI:2683382, RGD:13792537 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO (PMID:9311995), (PMID:9389648) RGD PMID:9311995 PMID:9389648 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 involved_in ISO (PMID:17164348) RGD PMID:17164348 NCBI chr 9:113,699,151...113,732,601
Ensembl chr 9:113,699,170...113,732,622
JBrowse link
positive regulation of SMAD protein signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:18382765)
GO_REF:0000107
(MGI:3795340|PMID:18382765)
RGD
Ensembl
PMID:18382765 GO_REF:0000107 MGI:3795340 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:9389648)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9389648 GO_REF:0000024 GO_REF:0000107 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO (MGI:4352622|PMID:19252488) RGD PMID:19252488 MGI:4352622 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:9389648) RGD PMID:9389648 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 acts_upstream_of_or_within
involved_in
ISO
IEA
UniProtKB:P12643 (PMID:18382765)
GO_REF:0000107
RGD
Ensembl
PMID:18382765 GO_REF:0000107 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
JBrowse link
G Dab2 DAB adaptor protein 2 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Jak2 Janus kinase 2 acts_upstream_of_or_within ISO UniProtKB:Q5VV43 (PMID:28334068) RGD PMID:28334068 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Nodal nodal growth differentiation factor involved_in ISO (PMID:21741376) RGD PMID:21741376 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
G Nup93 nucleoporin 93 involved_in ISO
ISS
(PMID:26878725)
(MGI:5787706|PMID:26878725)
GO_REF:0000024
RGD
UniProt
PMID:26878725 GO_REF:0000024 MGI:5787706 NCBI chr19:11,159,769...11,263,980
Ensembl chr19:11,159,774...11,263,980
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in IMP PMID:22073128 BHF-UCL PMID:22073128 RGD:8554355 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO UniProtKB:P01137 (PMID:31023188)
UniProtKB:Q91ZX7 (MGI:6434720|PMID:31023188)
RGD PMID:31023188 MGI:6434720 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Rbpms RNA binding protein, mRNA processing factor involved_in ISO (PMID:17099224) RGD PMID:17099224 NCBI chr16:61,954,569...62,109,998
Ensembl chr16:61,954,590...62,096,497
JBrowse link
G RGD1307443 similar to mKIAA0319 protein acts_upstream_of_or_within ISO UniProtKB:O60674|UniProtKB:Q9NRF2 (PMID:28334068) RGD PMID:28334068 NCBI chr17:42,163,245...42,226,725
Ensembl chr17:42,165,817...42,226,377
JBrowse link
G Sh2b1 SH2B adaptor protein 1 acts_upstream_of_or_within ISO UniProtKB:Q5VV43 (PMID:28334068) RGD PMID:28334068 NCBI chr 1:197,878,839...197,888,223
Ensembl chr 1:197,878,840...197,886,759
JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:2683382|PMID:14691138)
Ensembl
RGD
PMID:14691138 GO_REF:0000107 MGI:2683382 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:19366691), (PMID:28467929), (PMID:29167509), (PMID:31023188), (PMID:9389648)
AgBase
RGD
PMID:9389648 PMID:19366691 PMID:28467929 PMID:29167509 PMID:31023188 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISO (MGI:2683382|PMID:14691138) RGD PMID:14691138 MGI:2683382 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO (PMID:9389648) RGD PMID:9389648 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
positive regulation of transforming growth factor beta receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO (MGI:3829110|PMID:18625725) RGD PMID:18625725 MGI:3829110 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Axin1 axin 1 acts_upstream_of_or_within ISO MGI:1934919 (MGI:3628833|PMID:16601693) RGD PMID:16601693 MGI:3628833
G Cdkn1c cyclin-dependent kinase inhibitor 1C involved_in ISO (PMID:16943770) RGD PMID:16943770 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B involved_in IEA
ISO
GO_REF:0000107
(PMID:16943770)
Ensembl
RGD
PMID:16943770 GO_REF:0000107 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3690196|PMID:16619037)
UniProt
RGD
PMID:16619037 GO_REF:0000024 MGI:3690196 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Crebbp CREB binding protein involved_in IEA
ISO
GO_REF:0000107
(PMID:25514493)
Ensembl
RGD
PMID:25514493 GO_REF:0000107 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Dab2 DAB adaptor protein 2 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:25514493) RGD PMID:25514493 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Fermt1 FERM domain containing kindlin 1 involved_in ISO (MGI:5571208|PMID:24681597) RGD PMID:24681597 MGI:5571208 NCBI chr 3:125,566,744...125,607,864
Ensembl chr 3:125,566,643...125,607,735
JBrowse link
G Flcn folliculin involved_in
acts_upstream_of_or_within
IBA
ISO
ISS
PMID:21873635
MGI:4348628 (MGI:5050037|PMID:21258407)
(PMID:20573232)
GO_REF:0000024
RGD
UniProt
PMID:20573232 PMID:21258407, PMID:21873635 GO_REF:0000024 MGI:5050037, RGD:13792537 NCBI chr10:46,153,185...46,172,331
Ensembl chr10:46,153,188...46,172,309
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) IMP RGD PMID:15194465 RGD:1582619 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 involved_in ISO (MGI:3807767|PMID:11546783) RGD PMID:11546783 MGI:3807767 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 IMP RGD PMID:26880260 RGD:13504840 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 involved_in ISO (PMID:14678985) RGD PMID:14678985 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 involved_in ISO
ISS
(PMID:24613385)
GO_REF:0000024
RGD
UniProt
PMID:24613385 GO_REF:0000024 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Ing2 inhibitor of growth family, member 2 involved_in ISO (PMID:18334480) RGD PMID:18334480 NCBI chr16:47,714,756...47,725,836
Ensembl chr16:47,717,951...47,725,836
JBrowse link
G Itga8 integrin subunit alpha 8 acts_upstream_of_or_within ISO MGI:107430|MGI:2181699 (MGI:3714574|PMID:17537792) RGD PMID:17537792 MGI:3714574 NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 acts_upstream_of_or_within ISO MGI:98725 (MGI:5543310|PMID:23868260) RGD PMID:23868260 MGI:5543310 NCBI chr 9:10,952,424...10,954,664
Ensembl chr 9:10,952,374...10,954,681
JBrowse link
G Men1 menin 1 involved_in ISO (PMID:11274402) RGD PMID:11274402 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Myocd myocardin involved_in IEA
ISO
GO_REF:0000107
(MGI:3696631|PMID:16224064)
Ensembl
RGD
PMID:16224064 GO_REF:0000107 MGI:3696631 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
G Npnt nephronectin acts_upstream_of_or_within ISO MGI:3715213 (MGI:3714574|PMID:17537792) RGD PMID:17537792 MGI:3714574 NCBI chr 2:238,001,767...238,068,886
Ensembl chr 2:238,002,990...238,068,694
JBrowse link
G RGD1311739 similar to RIKEN cDNA 1700037H04 involved_in ISO (PMID:32024300) RGD PMID:32024300 NCBI chr 3:123,688,633...123,702,762
Ensembl chr 3:123,688,634...123,702,732
JBrowse link
G Rnf111 ring finger protein 111 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3628833|PMID:16601693)
RGD PMID:16601693, PMID:21873635 MGI:3628833, RGD:13792537 NCBI chr 8:76,864,343...76,940,235
Ensembl chr 8:76,864,344...76,940,196
JBrowse link
G Sdcbp syndecan binding protein involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:25893292)
UniProt
RGD
PMID:25893292, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:19,471,664...19,498,499
Ensembl chr 5:19,471,664...19,498,485
JBrowse link
G Slc2a10 solute carrier family 2 member 10 acts_upstream_of_or_within ISO (PMID:26376865) RGD PMID:26376865 NCBI chr 3:162,182,156...162,194,610
Ensembl chr 3:162,181,974...162,194,804
JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:19328798)
Ensembl
RGD
PMID:19328798 GO_REF:0000107 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Snw1 SNW domain containing 1 involved_in ISO (PMID:11278756) RGD PMID:11278756 NCBI chr 6:111,483,698...111,507,782
Ensembl chr 6:111,483,703...111,507,782
JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO (PMID:18311138)
(MGI:3788958|PMID:18311138)
RGD PMID:18311138 MGI:3788958 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 involved_in ISO (PMID:18762808) RGD PMID:18762808 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 acts_upstream_of_or_within IMP
ISO
(MGI:5617089|PMID:25382630) RGD PMID:25382630, PMID:8106553 MGI:5617089, RGD:1579949 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:18555217)
(MGI:1270011|PMID:9657149)
RGD PMID:9657149 PMID:18555217 MGI:1270011 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 involved_in ISO (PMID:30592286) RGD PMID:30592286 NCBI chr 3:29,857,289...29,985,932
Ensembl chr 3:29,862,473...29,996,865
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    positive regulation of biological process 6583
      positive regulation of signaling 1930
        positive regulation of signal transduction 1597
          positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 121
            positive regulation of BMP signaling pathway + 40
            positive regulation of SMAD protein signal transduction 19
            positive regulation of activin receptor signaling pathway + 10
            positive regulation of pathway-restricted SMAD protein phosphorylation 50
            positive regulation of transforming growth factor beta receptor signaling pathway 32
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13515
      regulation of biological process 12773
        regulation of cellular process 12275
          signal transduction 6881
            cell surface receptor signaling pathway 2774
              enzyme linked receptor protein signaling pathway 978
                transmembrane receptor protein serine/threonine kinase signaling pathway 391
                  regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 259
                    positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 121
                      positive regulation of BMP signaling pathway + 40
                      positive regulation of SMAD protein signal transduction 19
                      positive regulation of activin receptor signaling pathway + 10
                      positive regulation of pathway-restricted SMAD protein phosphorylation 50
                      positive regulation of transforming growth factor beta receptor signaling pathway 32
paths to the root