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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
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Accession:GO:0090100 term browser browse the term
Definition:Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.
Synonyms:exact_synonym: positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway


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positive regulation of activin receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1b activin A receptor type 1B JBrowse link 7 142,817,174 142,858,365 RGD:1624291
G Acvr2a activin A receptor type 2A JBrowse link 3 32,947,901 33,034,598 RGD:1624291
RGD:1600115
G Acvr2b activin A receptor type 2B JBrowse link 8 128,087,308 128,126,776 RGD:1624291
RGD:1600115
G Csnk2b casein kinase 2 beta JBrowse link 20 5,108,692 5,113,675 RGD:1624291
G Fgf9 fibroblast growth factor 9 JBrowse link 15 38,341,657 38,386,945 RGD:1624291
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:1624291
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:1624291
G Zc3h3 zinc finger CCCH type containing 3 JBrowse link 7 116,787,762 116,872,536 RGD:1624291
positive regulation of BMP signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvrl1 activin A receptor like type 1 JBrowse link 7 142,769,942 142,787,336 RGD:1624291
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1600115
RGD:1624291
G Bmpr2 bone morphogenetic protein receptor type 2 JBrowse link 9 66,568,074 66,683,019 RGD:1624291
G Ccn1 cellular communication network factor 1 JBrowse link 2 251,529,354 251,532,312 RGD:1624291
RGD:1600115
G Cdh5 cadherin 5 JBrowse link 19 1,025,122 1,074,333 RGD:1624291
G Crb2 crumbs cell polarity complex component 2 JBrowse link 3 22,037,812 22,061,247 RGD:1624291
RGD:1600115
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Fbxl15 F-box and leucine-rich repeat protein 15 JBrowse link 1 266,075,782 266,078,023 RGD:1624291
RGD:1600115
G Fkbp8 FKBP prolyl isomerase 8 JBrowse link 16 20,645,956 20,652,890 RGD:1624291
G Foxd1 forkhead box D1 JBrowse link 2 28,460,068 28,462,488 RGD:1600115
RGD:1624291
G Gata4 GATA binding protein 4 JBrowse link 15 46,386,703 46,458,679 RGD:8554170
G Gata6 GATA binding protein 6 JBrowse link 18 2,415,821 2,447,087 RGD:8554170
G Gdf2 growth differentiation factor 2 JBrowse link 16 10,267,510 10,293,545 RGD:1624291
G Gdf5 growth differentiation factor 5 JBrowse link 3 151,482,672 151,487,129 RGD:1624291
G Gpc3 glypican 3 JBrowse link X 139,579,268 139,947,093 RGD:1624291
RGD:1600115
G Hes1 hes family bHLH transcription factor 1 JBrowse link 11 74,312,837 74,315,249 RGD:1624291
RGD:1600115
G Hes5 hes family bHLH transcription factor 5 JBrowse link 5 172,364,421 172,365,188 RGD:1624291
RGD:1600115
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:1624291
G Kcp kielin cysteine rich BMP regulator JBrowse link 4 56,750,782 56,796,878 RGD:1624291
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1624291
G Msx1 msh homeobox 1 JBrowse link 14 77,712,262 77,716,061 RGD:1624291
G Msx2 msh homeobox 2 JBrowse link 17 11,683,862 11,689,527 RGD:1624291
RGD:1600115
G Neo1 neogenin 1 JBrowse link 8 63,649,871 63,756,394 RGD:1624291
RGD:1600115
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
RGD:1600115
G Notch2 notch receptor 2 JBrowse link 2 200,187,184 200,320,403 RGD:1624291
RGD:1600115
G Numa1 nuclear mitotic apparatus protein 1 JBrowse link 1 167,044,544 167,091,453 RGD:1624291
G Pelo pelota mRNA surveillance and ribosome rescue factor JBrowse link 2 47,266,758 47,268,526 RGD:1624291
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 14 59,657,738 59,865,427 RGD:1624291
G Rnf165 ring finger protein 165 JBrowse link 18 73,831,289 73,873,246 RGD:1624291
RGD:13792537
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:1624291
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1624291
RGD:1600115
G Sox11 SRY-box transcription factor 11 JBrowse link 6 46,629,967 46,631,988 RGD:1624291
RGD:1600115
G Sulf1 sulfatase 1 JBrowse link 5 5,999,520 6,186,901 RGD:1600115
RGD:1624291
G Tgfbr3 transforming growth factor beta receptor 3 JBrowse link 14 3,506,416 3,680,508 RGD:1624291
G Twsg1 twisted gastrulation BMP signaling modulator 1 JBrowse link 9 113,699,151 113,732,601 RGD:1624291
G Ube2o ubiquitin-conjugating enzyme E2O JBrowse link 10 105,505,721 105,553,167 RGD:1624291
G Vsir V-set immunoregulatory receptor JBrowse link 20 29,897,543 29,923,381 RGD:1624291
G Zfp423 zinc finger protein 423 JBrowse link 19 20,147,201 20,405,999 RGD:1600115
RGD:1624291
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:1624291
G Zic2 Zic family member 2 JBrowse link 15 108,908,366 108,913,812 RGD:1624291
positive regulation of pathway-restricted SMAD protein phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1624291
RGD:1600115
G Acvr1b activin A receptor type 1B JBrowse link 7 142,817,174 142,858,365 RGD:2315948
G Acvr2a activin A receptor type 2A JBrowse link 3 32,947,901 33,034,598 RGD:1624291
RGD:1600115
G Acvrl1 activin A receptor like type 1 JBrowse link 7 142,769,942 142,787,336 RGD:1624291
G Bmp10 bone morphogenetic protein 10 JBrowse link 4 119,224,906 119,230,534 RGD:1624291
RGD:13792537
RGD:1600115
G Bmp15 bone morphogenetic protein 15 JBrowse link X 17,016,831 17,021,894 RGD:13792537
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1600115
RGD:13792537
RGD:1624291
G Bmp3 bone morphogenetic protein 3 JBrowse link 14 12,362,912 12,387,572 RGD:13792537
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1600115
RGD:13792537
RGD:1624291
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:1624291
RGD:13792537
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:1624291
RGD:13792537
RGD:1600115
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
RGD:13792537
G Bmp8a bone morphogenetic protein 8a JBrowse link 5 141,007,462 141,033,511 RGD:13792537
G Bmp8b bone morphogenetic protein 8b JBrowse link 5 140,803,387 140,821,104 RGD:13792537
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
G Bmpr2 bone morphogenetic protein receptor type 2 JBrowse link 9 66,568,074 66,683,019 RGD:1624291
G Cers1 ceramide synthase 1 JBrowse link 16 20,845,580 20,860,789 RGD:13792537
G Csnk2b casein kinase 2 beta JBrowse link 20 5,108,692 5,113,675 RGD:1624291
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1600115
RGD:1624291
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Gdf1 growth differentiation factor 1 JBrowse link 16 20,845,580 20,860,789 RGD:13792537
G Gdf10 growth differentiation factor 10 JBrowse link 16 10,250,508 10,262,383 RGD:1600115
RGD:13792537
RGD:1624291
G Gdf11 growth differentiation factor 11 JBrowse link 7 3,306,863 3,315,856 RGD:13792537
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:13792537
G Gdf2 growth differentiation factor 2 JBrowse link 16 10,267,510 10,293,545 RGD:1624291
RGD:13792537
G Gdf3 growth differentiation factor 3 JBrowse link 4 155,417,667 155,422,014 RGD:13792537
G Gdf5 growth differentiation factor 5 JBrowse link 3 151,482,672 151,487,129 RGD:13792537
G Gdf6 growth differentiation factor 6 JBrowse link 5 23,056,345 23,072,666 RGD:1624291
RGD:13792537
G Gdf7 growth differentiation factor 7 JBrowse link 6 33,496,596 33,507,626 RGD:1624291
RGD:13792537
G Gdf9 growth differentiation factor 9 JBrowse link 10 38,782,519 38,793,238 RGD:13792537
G Hfe homeostatic iron regulator JBrowse link 17 43,661,276 43,669,327 RGD:1624291
G Inha inhibin subunit alpha JBrowse link 9 82,700,482 82,703,383 RGD:13792537
G Inhba inhibin subunit beta A JBrowse link 17 51,894,869 51,919,998 RGD:1624291
RGD:13792537
G Inhbb inhibin subunit beta B JBrowse link 13 35,436,532 35,442,222 RGD:13792537
G Inhbc inhibin subunit beta C JBrowse link 7 70,648,005 70,661,475 RGD:13792537
G Inhbe inhibin subunit beta E JBrowse link 7 70,641,423 70,642,848 RGD:13792537
G Lefty1 left right determination factor 1 JBrowse link 13 99,212,778 99,217,786 RGD:13792537
G Lefty2 Left-right determination factor 2 JBrowse link 13 99,173,484 99,178,037 RGD:13792537
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Mstn myostatin JBrowse link 9 53,310,977 53,315,804 RGD:13792537
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:1624291
RGD:13792537
G Rbpms RNA binding protein, mRNA processing factor JBrowse link 16 61,954,569 62,109,998 RGD:1624291
G Sdcbp syndecan binding protein JBrowse link 5 19,471,664 19,498,499 RGD:1624291
RGD:13792537
RGD:1600115
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1600115
RGD:13792537
RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:13792537
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:1624291
RGD:13792537
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
G Twsg1 twisted gastrulation BMP signaling modulator 1 JBrowse link 9 113,699,151 113,732,601 RGD:1624291
positive regulation of SMAD protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:1624291
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1600115
RGD:1624291
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1624291
RGD:1600115
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:1624291
G Nup93 nucleoporin 93 JBrowse link 19 11,159,769 11,263,980 RGD:1624291
RGD:1600115
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:8554355
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
G Rbpms RNA binding protein, mRNA processing factor JBrowse link 16 61,954,569 62,109,998 RGD:1624291
G RGD1307443 similar to mKIAA0319 protein JBrowse link 17 42,163,245 42,226,725 RGD:1624291
RGD:1600115
G Sh2b1 SH2B adaptor protein 1 JBrowse link 1 197,878,839 197,888,223 RGD:1624291
RGD:1600115
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1600115
RGD:1624291
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:1624291
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
positive regulation of transforming growth factor beta receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:1624291
G Axin1 axin 1 RGD:1624291
G Cdkn1c cyclin-dependent kinase inhibitor 1C JBrowse link 1 216,661,067 216,663,791 RGD:1624291
G Cdkn2b cyclin-dependent kinase inhibitor 2B JBrowse link 5 107,834,353 107,857,428 RGD:1624291
RGD:1600115
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 JBrowse link 1 12,823,363 12,825,806 RGD:1624291
RGD:1600115
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:1600115
RGD:1624291
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1600115
RGD:1624291
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:1624291
G Fermt1 fermitin family member 1 JBrowse link 3 125,566,744 125,607,864 RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1624291
RGD:13792537
RGD:1600115
G Furin furin (paired basic amino acid cleaving enzyme) JBrowse link 1 142,185,092 142,198,167 RGD:1582619
G Gipc1 GIPC PDZ domain containing family, member 1 JBrowse link 19 24,786,604 24,798,231 RGD:1624291
G Got1 glutamic-oxaloacetic transaminase 1 JBrowse link 1 263,246,248 263,269,762 RGD:13504840
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:1624291
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1624291
RGD:1600115
G Ing2 inhibitor of growth family, member 2 JBrowse link 16 47,714,756 47,725,836 RGD:1624291
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,893 79,676,927 RGD:1624291
G Lrg1 leucine-rich alpha-2-glycoprotein 1 JBrowse link 9 10,952,424 10,954,664 RGD:1624291
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:1624291
G Myocd myocardin JBrowse link 10 51,682,053 51,781,458 RGD:1624291
RGD:1600115
G Npnt nephronectin JBrowse link 2 238,001,767 238,068,886 RGD:1624291
RGD:1600115
G Rnf111 ring finger protein 111 JBrowse link 8 76,864,343 76,940,235 RGD:1624291
RGD:13792537
G Sdcbp syndecan binding protein JBrowse link 5 19,471,664 19,498,499 RGD:1624291
RGD:13792537
RGD:1600115
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1624291
RGD:1600115
G Snw1 SNW domain containing 1 JBrowse link 6 111,483,698 111,507,782 RGD:1624291
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1624291
RGD:1600115
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 JBrowse link 1 199,664,039 199,670,970 RGD:1624291
G Tgfbr3 transforming growth factor beta receptor 3 JBrowse link 14 3,506,416 3,680,508 RGD:1579949
RGD:1624291
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    positive regulation of biological process 6410
      positive regulation of signaling 2040
        positive regulation of signal transduction 1635
          positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 115
            positive regulation of BMP signaling pathway + 38
            positive regulation of SMAD protein signal transduction 16
            positive regulation of activin receptor signaling pathway + 10
            positive regulation of pathway-restricted SMAD protein phosphorylation 49
            positive regulation of transforming growth factor beta receptor signaling pathway 29
Path 2
Term Annotations click to browse term
  biological_process 19336
    biological regulation 13340
      regulation of biological process 12655
        regulation of cellular process 11994
          signal transduction 6872
            cell surface receptor signaling pathway 2674
              enzyme linked receptor protein signaling pathway 925
                transmembrane receptor protein serine/threonine kinase signaling pathway 365
                  regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 243
                    positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 115
                      positive regulation of BMP signaling pathway + 38
                      positive regulation of SMAD protein signal transduction 16
                      positive regulation of activin receptor signaling pathway + 10
                      positive regulation of pathway-restricted SMAD protein phosphorylation 49
                      positive regulation of transforming growth factor beta receptor signaling pathway 29
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.