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ONTOLOGY REPORT - ANNOTATIONS


Term:foam cell differentiation
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Accession:GO:0090077 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


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macrophage derived foam cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ep300 E1A binding protein p300 ISO (PMID:26504087) RGD PMID:26504087 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO
ISS
(PMID:26504087)
GO_REF:0000024
RGD
UniProt
PMID:26504087 GO_REF:0000024 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Selenok selenoprotein K ISO
IEA
MGI:MGI:4941878 (MGI:MGI:5509276|PMID:23444136)
GO_REF:0000107
RGD
Ensembl
PMID:23444136 GO_REF:0000107, MGI:MGI:5509276 NCBI chr16:6,035,926...6,044,240
Ensembl chr16:6,035,926...6,044,239
JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO
IEA
(PMID:15353128)
GO_REF:0000107
RGD
Ensembl
PMID:15353128 GO_REF:0000107 NCBI chr13:74,035,258...74,077,759
Ensembl chr13:74,035,080...74,077,783
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO (PMID:26504087) RGD PMID:26504087 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
negative regulation of macrophage derived foam cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 ISO
IEA
(MGI:MGI:4454250|PMID:20382126)
GO_REF:0000107
RGD
Ensembl
PMID:20382126 GO_REF:0000107, MGI:MGI:4454250 NCBI chr10:98,573,226...98,645,028
Ensembl chr10:98,576,039...98,644,938
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO
ISS
(PMID:11222466)
GO_REF:0000024
RGD
UniProt
PMID:11222466 GO_REF:0000024 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Crp C-reactive protein ISO (PMID:18322245) RGD PMID:18322245 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Itgav integrin subunit alpha V ISO (PMID:15215180) RGD PMID:15215180 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb3 integrin subunit beta 3 ISO (PMID:15215180) RGD PMID:15215180 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Nfkbia NFKB inhibitor alpha ISO (PMID:16938301) RGD PMID:16938301 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO (PMID:19114110) RGD PMID:19114110 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO (PMID:19114110) RGD PMID:19114110 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
positive regulation of macrophage derived foam cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15b arachidonate 15-lipoxygenase, type B IEA
ISO
GO_REF:0000107
(PMID:22912809)
Ensembl
RGD
PMID:22912809 GO_REF:0000107 NCBI chr10:55,773,748...55,783,489
Ensembl chr10:55,774,006...55,783,489
JBrowse link
G Apob apolipoprotein B ISO (PMID:17244792), (PMID:18322245), (PMID:19114110) RGD PMID:17244792, PMID:18322245, PMID:19114110 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Cd36 CD36 molecule ISO (PMID:10772654)
(MGI:MGI:2447499|PMID:12376530), (MGI:MGI:3836139|PMID:10772654)
RGD PMID:10772654, PMID:12376530 MGI:MGI:2447499, MGI:MGI:3836139 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Csf1 colony stimulating factor 1 ISO
IEA
(PMID:17244792)
GO_REF:0000107
RGD
Ensembl
PMID:17244792 GO_REF:0000107 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf2 colony stimulating factor 2 ISO (PMID:19032770) RGD PMID:19032770 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Il18 interleukin 18 ISO
IEA
(MGI:MGI:3608083|PMID:12829194)
GO_REF:0000107
RGD
Ensembl
PMID:12829194 GO_REF:0000107, MGI:MGI:3608083 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Lpl lipoprotein lipase ISO UniProtKB:P35951 (MGI:MGI:1888585|PMID:10858435) RGD PMID:10858435 MGI:MGI:1888585 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO
IEA
(PMID:18262097)
GO_REF:0000107
RGD
Ensembl
PMID:18262097 GO_REF:0000107 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Msr1 macrophage scavenger receptor 1 ISO UniProtKB:Q08857 (MGI:MGI:2447499|PMID:12376530) RGD PMID:12376530 MGI:MGI:2447499 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Pf4 platelet factor 4 ISO (PMID:17244792) RGD PMID:17244792 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Pla2g3 phospholipase A2, group III ISO (PMID:18801741) RGD PMID:18801741 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Pla2g5 phospholipase A2, group V ISS
ISO
GO_REF:0000024
(MGI:MGI:6393145|PMID:14962950)
UniProt
RGD
PMID:14962950 GO_REF:0000024, MGI:MGI:6393145 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Prkch protein kinase C, eta ISO
ISS
(MGI:MGI:5306557|PMID:20558593)
GO_REF:0000024
RGD
UniProt
PMID:20558593 GO_REF:0000024, MGI:MGI:5306557 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      cellular developmental process 4459
        cell differentiation 4363
          foam cell differentiation 25
            macrophage derived foam cell differentiation + 25
            smooth muscle derived foam cell differentiation 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.