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ONTOLOGY REPORT - ANNOTATIONS


Term:foam cell differentiation
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Accession:GO:0090077 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.



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foam cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Samd1 sterile alpha motif domain containing 1 acts_upstream_of_or_within ISO (PMID:34006929) RGD PMID:34006929 NCBI chr19:24,151,136...24,154,475 JBrowse link
macrophage derived foam cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ep300 E1A binding protein p300 involved_in ISO (PMID:26504087) RGD PMID:26504087 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO
ISS
(PMID:26504087)
GO_REF:0000024
RGD
UniProt
PMID:26504087 GO_REF:0000024 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Selenok selenoprotein K involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:4941878 (MGI:5509276|PMID:23444136)
Ensembl
RGD
PMID:23444136 GO_REF:0000107 MGI:5509276 NCBI chr16:5,152,066...5,160,648
Ensembl chr16:5,152,066...5,159,188
JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in ISO
IEA
(PMID:15353128)
GO_REF:0000107
RGD
Ensembl
PMID:15353128 GO_REF:0000107 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494
JBrowse link
G Stat1 signal transducer and activator of transcription 1 involved_in ISO (PMID:26504087) RGD PMID:26504087 NCBI chr 9:49,419,561...49,459,969 JBrowse link
negative regulation of macrophage derived foam cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 involved_in IEA
ISO
GO_REF:0000107
(MGI:4454250|PMID:20382126)
Ensembl
RGD
PMID:20382126 GO_REF:0000107 MGI:4454250 NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO
ISS
(PMID:11222466)
GO_REF:0000024
RGD
UniProt
PMID:11222466 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Crp C-reactive protein involved_in ISO (PMID:18322245) RGD PMID:18322245 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (PMID:15215180) RGD PMID:15215180 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb3 integrin subunit beta 3 involved_in ISO (PMID:15215180) RGD PMID:15215180 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in ISO (PMID:16938301) RGD PMID:16938301 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha involved_in ISO (PMID:19114110) RGD PMID:19114110 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (PMID:19114110) RGD PMID:19114110 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
positive regulation of macrophage derived foam cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15b arachidonate 15-lipoxygenase, type B involved_in ISO
IEA
(PMID:22912809)
GO_REF:0000107
RGD
Ensembl
PMID:22912809 GO_REF:0000107 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
JBrowse link
G Apob apolipoprotein B involved_in ISO (PMID:17244792), (PMID:18322245), (PMID:19114110) RGD PMID:17244792 PMID:18322245 PMID:19114110 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Cd36 CD36 molecule involved_in ISO
IEA
(PMID:10772654)
GO_REF:0000107
(MGI:2447499|PMID:12376530), (MGI:3836139|PMID:10772654)
RGD
Ensembl
PMID:10772654 PMID:12376530 GO_REF:0000107 MGI:2447499 MGI:3836139 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Csf1 colony stimulating factor 1 involved_in ISO
IEA
(PMID:17244792)
GO_REF:0000107
RGD
Ensembl
PMID:17244792 GO_REF:0000107 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf2 colony stimulating factor 2 involved_in ISO (PMID:19032770) RGD PMID:19032770 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Il18 interleukin 18 involved_in IEA
ISO
GO_REF:0000107
(MGI:3608083|PMID:12829194)
Ensembl
RGD
PMID:12829194 GO_REF:0000107 MGI:3608083 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Lpl lipoprotein lipase involved_in ISO UniProtKB:P35951 (MGI:1888585|PMID:10858435) RGD PMID:10858435 MGI:1888585 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 involved_in ISO
IEA
(PMID:18262097)
GO_REF:0000107
RGD
Ensembl
PMID:18262097 GO_REF:0000107 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in ISO UniProtKB:Q08857 (MGI:2447499|PMID:12376530) RGD PMID:12376530 MGI:2447499 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Pf4 platelet factor 4 involved_in ISO (PMID:17244792) RGD PMID:17244792 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:18801741) RGD PMID:18801741 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Pla2g5 phospholipase A2, group V involved_in ISS
ISO
GO_REF:0000024
(MGI:6393145|PMID:14962950)
UniProt
RGD
PMID:14962950 GO_REF:0000024 MGI:6393145 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Prkch protein kinase C, eta involved_in ISS
ISO
GO_REF:0000024
(MGI:5306557|PMID:20558593)
UniProt
RGD
PMID:20558593 GO_REF:0000024 MGI:5306557 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
JBrowse link
G RGD1565355 similar to fatty acid translocase/CD36 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:17,424,749...17,465,808
Ensembl chr 4:17,354,466...17,513,903
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      cellular developmental process 4543
        cell differentiation 4448
          foam cell differentiation 27
            macrophage derived foam cell differentiation + 26
            smooth muscle derived foam cell differentiation 0
paths to the root