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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation
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Accession:GO:0086030 term browser browse the term
Definition:An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation.
Synonyms:exact_synonym: Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation;   adrenergic receptor signaling pathway involved in cardiac muscle relaxation
 related_synonym: adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC;   adrenergic receptor-induced cardiac relaxation


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adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chga chromogranin A involved_in IDA
IEA
IBA		 PMID:22459152
GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 PMID:22459152 GO_REF:0000033 GO_REF:0000118, RGD:6906968 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      signal transduction 7163
        G protein-coupled receptor signaling pathway 2419
          G protein-coupled receptor signaling pathway involved in heart process 9
            adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process 3
              adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation 1
Path 2
Term Annotations click to browse term
  biological_process 20292
    biological regulation 13633
      regulation of biological process 13220
        signaling 7729
          signal transduction 7163
            G protein-coupled receptor signaling pathway 2419
              adenylate cyclase-modulating G protein-coupled receptor signaling pathway 255
                adenylate cyclase-activating G protein-coupled receptor signaling pathway 180
                  adenylate cyclase-activating adrenergic receptor signaling pathway 31
                    adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process 3
                      adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation 1
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