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ONTOLOGY REPORT - ANNOTATIONS

Term:obsolete adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate
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Accession:GO:0086024 term browser browse the term
Status:
This term is obsolete. We suggest searching for the text of the ontology term or for a keyword rather than searching for the ontology ID. For more information, please contact us.
Definition:OBSOLETE. An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate.
Comment:This term was obsoleted because it represents a GO-CAM pathway.
Synonyms:exact_synonym: Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate;   adrenergic receptor signaling pathway involved in positive regulation of heart rate;   adrenergic receptor signalling pathway involved in positive regulation of heart rate
 narrow_synonym: beta adrenergic receptor signaling pathway involved in positive regulation of heart rate
 related_synonym: If activation by beta-adrenergic receptor signaling pathway;   activation of funny current by beta-adrenergic receptor signaling pathway;   adenylate cyclase-activating cardiac adrenergic receptor signaling pathway
 replaced_by: GO:0071880


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