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ONTOLOGY REPORT - ANNOTATIONS

Term:cell-cell signaling involved in cardiac conduction
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Accession:GO:0086019 term browser browse the term
Definition:Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.
Synonyms:exact_synonym: cell-cell signalling involved in cardiac conduction


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cell-cell signaling involved in cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TBX5 T-box transcription factor 5 acts_upstream_of_positive_effect ISO (MGI:5449667|PMID:22728936) BHF-UCL PMID:22728936 MGI:5449667 NCBI chr26:11,462,541...11,549,699
Ensembl chr26:11,463,653...11,506,446 		JBrowse link
atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:32,484,196...33,143,295
Ensembl chr32:32,671,281...33,141,036 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in ISO (PMID:19343045), (PMID:23264583) BHF-UCL PMID:19343045 PMID:23264583 NCBI chr27:39,808,987...39,810,789
Ensembl chr27:39,756,363...39,811,035 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in IEA Ensembl GO_REF:0000107
G KCNE5 potassium voltage-gated channel subfamily E regulatory subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:82,844,188...82,845,641
Ensembl chr  X:82,845,064...82,846,083 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:46,554,390...46,830,533
Ensembl chr18:46,518,908...46,830,043 		JBrowse link
G NUP155 nucleoporin 155 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19070573) Ensembl
MGI		 PMID:19070573 GO_REF:0000107 NCBI chr 4:71,340,109...71,409,286
Ensembl chr 4:71,340,168...71,408,038 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,783,235...10,808,342
Ensembl chr 5:10,783,325...10,804,242 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,420,468...8,527,414
Ensembl chr23:8,420,472...8,527,383 		JBrowse link
G SCN4B sodium voltage-gated channel beta subunit 4 involved_in ISO (PMID:17592081) BHF-UCL PMID:17592081 NCBI chr 5:15,552,347...15,564,085
Ensembl chr 5:15,543,632...15,563,486 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
AV node cell to bundle of His cell signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845 		JBrowse link
bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,420,468...8,527,414
Ensembl chr23:8,420,472...8,527,383 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:17224476) BHF-UCL PMID:17224476 NCBI chr27:44,007,363...44,748,251
Ensembl chr27:44,008,020...44,746,429 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:18,537,100...18,787,728
Ensembl chr 2:18,538,620...18,902,286 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:26253506) BHF-UCL PMID:26253506 NCBI chr27:44,007,363...44,748,251
Ensembl chr27:44,008,020...44,746,429 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:18,537,100...18,787,728
Ensembl chr 2:18,538,620...18,902,286 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,261,760...107,304,157
Ensembl chr 1:107,261,756...107,303,346 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:21,561,091...21,949,970
Ensembl chr18:21,564,676...21,949,544 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,261,760...107,304,157
Ensembl chr 1:107,261,756...107,303,346 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:117,504,428...117,510,666
Ensembl chr 1:117,503,828...117,511,727 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,261,760...107,304,157
Ensembl chr 1:107,261,756...107,303,346 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12700358) Ensembl
MGI		 PMID:12700358 GO_REF:0000107 NCBI chr20:36,189,986...36,488,460
Ensembl chr20:36,191,810...36,613,686 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:36,637,492...36,656,194
Ensembl chr30:36,639,908...36,656,406 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
membrane repolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in ISO (PMID:19343045), (PMID:23264583) BHF-UCL PMID:19343045 PMID:23264583 NCBI chr27:39,808,987...39,810,789
Ensembl chr27:39,756,363...39,811,035 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in IEA Ensembl GO_REF:0000107
G KCNJ5 potassium inwardly rectifying channel subfamily J member 5 involved_in ISO (PMID:20560207) BHF-UCL PMID:20560207 NCBI chr 5:5,736,544...5,760,705
Ensembl chr 5:5,740,176...5,760,866 		JBrowse link
G KCNN2 potassium calcium-activated channel subfamily N member 2 involved_in ISO (MGI:5292192|PMID:19139040)
(PMID:19139040)		 BHF-UCL PMID:19139040 MGI:5292192 NCBI chr11:4,279,362...4,423,080
Ensembl chr11:4,154,746...4,423,078 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:46,554,390...46,830,533
Ensembl chr18:46,518,908...46,830,043 		JBrowse link
membrane repolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in ISO (PMID:23264583) BHF-UCL PMID:23264583 NCBI chr27:39,808,987...39,810,789
Ensembl chr27:39,756,363...39,811,035 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in IEA Ensembl GO_REF:0000107
membrane repolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in ISO (PMID:19343045) BHF-UCL PMID:19343045 NCBI chr27:39,808,987...39,810,789
Ensembl chr27:39,756,363...39,811,035 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in IEA Ensembl GO_REF:0000107
positive regulation of atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPM4 transient receptor potential cation channel subfamily M member 4 ISO RGD PMID:23954346 RGD:10003031 NCBI chr 1:107,261,760...107,304,157
Ensembl chr 1:107,261,756...107,303,346 		JBrowse link
Purkinje myocyte to ventricular cardiac muscle cell signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR2 ryanodine receptor 2 involved_in ISO (MGI:3820489|PMID:17872467)
(PMID:17872467)		 BHF-UCL PMID:17872467 MGI:3820489 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875 		JBrowse link
regulation of atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:32,484,196...33,143,295
Ensembl chr32:32,671,281...33,141,036 		JBrowse link
G GJA5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G RYR2 ryanodine receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875 		JBrowse link
regulation of AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in ISO (MGI:2449848|PMID:12571597) BHF-UCL PMID:12571597 MGI:2449848 NCBI chr32:32,484,196...33,143,295
Ensembl chr32:32,671,281...33,141,036 		JBrowse link
G CXADR CXADR Ig-like cell adhesion molecule involved_in ISO (MGI:3814765|PMID:18636119)
(PMID:18636119)		 BHF-UCL PMID:18636119 MGI:3814765 NCBI chr31:14,021,292...14,079,049
Ensembl chr31:14,021,303...14,078,847 		JBrowse link
G GJA5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G RYR2 ryanodine receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875 		JBrowse link
regulation of bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G RANGRF RAN guanine nucleotide release factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:33,084,355...33,085,810
Ensembl chr 5:33,084,397...33,085,812 		JBrowse link
regulation of Purkinje myocyte action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
regulation of SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:32,484,196...33,143,295
Ensembl chr32:32,671,281...33,141,036 		JBrowse link
G RYR2 ryanodine receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875 		JBrowse link
G TBX18 T-box transcription factor 18 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:23242162) BHF-UCL
Ensembl		 PMID:23242162 GO_REF:0000107 NCBI chr12:44,901,076...44,929,730
Ensembl chr12:44,873,119...44,929,205 		JBrowse link
SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in ISO (MGI:5430886|PMID:18832177)
(PMID:18832177)		 BHF-UCL PMID:18832177 MGI:5430886 NCBI chr32:32,484,196...33,143,295
Ensembl chr32:32,671,281...33,141,036 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:11046183) MGI PMID:11046183 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:36,637,492...36,656,194
Ensembl chr30:36,639,908...36,656,406 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,783,235...10,808,342
Ensembl chr 5:10,783,325...10,804,242 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
SA node cell to atrial cardiac muscle cell signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17088
    cellular process 16614
      cell communication 6567
        cell communication involved in cardiac conduction 42
          cell-cell signaling involved in cardiac conduction 26
            AV node cell to bundle of His cell signaling + 11
            Purkinje myocyte to ventricular cardiac muscle cell signaling + 5
            SA node cell to atrial cardiac muscle cell signaling + 11
            atrial cardiac muscle cell to AV node cell signaling + 15
            bundle of His cell to Purkinje myocyte signaling + 8
Path 2
Term Annotations click to browse term
  biological_process 17088
    multicellular organismal process 7871
      system process 2867
        circulatory system process 587
          blood circulation 559
            heart contraction 246
              regulation of heart contraction 210
                cardiac conduction 70
                  cell communication involved in cardiac conduction 42
                    cell-cell signaling involved in cardiac conduction 26
                      AV node cell to bundle of His cell signaling + 11
                      Purkinje myocyte to ventricular cardiac muscle cell signaling + 5
                      SA node cell to atrial cardiac muscle cell signaling + 11
                      atrial cardiac muscle cell to AV node cell signaling + 15
                      bundle of His cell to Purkinje myocyte signaling + 8
paths to the root