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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane depolarization during action potential
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Accession:GO:0086010 term browser browse the term
Definition:The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


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membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 involved_in ISO (PMID:7604285) RGD PMID:7604285 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in ISO
IBA
ISS		 (PMID:23115331)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:23115331 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in ISO
IBA
IEA
IDA		 (PMID:12384689), (PMID:24036948), (PMID:24776970)
(PMID:24036948)
GO_REF:0000033
(MGI:5553040|PMID:24036948)
GO_REF:0000107
PMID:10196578		 RGD
GO_Central
Ensembl		 PMID:12384689 PMID:24036948 PMID:24776970 PMID:10196578 GO_REF:0000033 GO_REF:0000107 MGI:5553040, RGD:69980 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044 		JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 involved_in ISO
IBA
IEA
ISS		 (PMID:14672992)
(PMID:27281198)
GO_REF:0000033
GO_REF:0000107
(MGI:5796061|PMID:27281198)
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:14672992 PMID:27281198 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:5796061 NCBI chr 3:50,952,790...51,071,804
Ensembl chr 3:50,952,791...51,071,699 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (PMID:35277491) RGD PMID:35277491 NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO (PMID:35277491) RGD PMID:35277491 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765 		JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 involved_in IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:35277491)		 GO_Central
Ensembl
RGD		 PMID:35277491 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:20042427), (PMID:20226894), (PMID:21051419) RGD PMID:20042427 PMID:20226894 PMID:21051419 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868 		JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:91,246,936...91,296,670
Ensembl chr10:91,246,936...91,296,545 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:14500339), (PMID:18065446), (PMID:22529811)		 BHF-UCL
GO_Central
RGD		 PMID:14500339 PMID:18065446 PMID:22529811 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 NOT|involved_in IDA PMID:9001394 UniProt PMID:9001394 RGD:61747 NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256 		JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516 		JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:16728661)		 BHF-UCL
Ensembl
RGD		 PMID:16728661 GO_REF:0000024 GO_REF:0000107 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO
ISS		 (PMID:17224476)
GO_REF:0000024		 RGD
BHF-UCL		 PMID:17224476 GO_REF:0000024 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17224476)		 BHF-UCL
Ensembl
RGD		 PMID:17224476 GO_REF:0000024 GO_REF:0000107 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA		 (PMID:18065446)
GO_REF:0000107		 RGD
Ensembl		 PMID:18065446 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISS
ISO		 GO_REF:0000024
(PMID:26253506)		 BHF-UCL
RGD		 PMID:26253506 GO_REF:0000024 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISS
ISO		 GO_REF:0000024
(MGI:3714901|PMID:16690884)		 BHF-UCL
RGD		 PMID:16690884 GO_REF:0000024 MGI:3714901 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISO
IEA
ISS		 (PMID:17224476)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
BHF-UCL		 PMID:17224476 GO_REF:0000024 GO_REF:0000107 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
ISS		 (PMID:18616619)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
BHF-UCL		 PMID:18616619 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO
IEA		 (PMID:27207958)
GO_REF:0000107		 RGD
Ensembl		 PMID:27207958 GO_REF:0000107 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in ISO
IEA		 (PMID:21383000)
GO_REF:0000107		 RGD
Ensembl		 PMID:21383000 GO_REF:0000107 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
ISS		 (PMID:18065446)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
BHF-UCL		 PMID:18065446 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO
IEA		 (PMID:27207958)
GO_REF:0000107		 RGD
Ensembl		 PMID:27207958 GO_REF:0000107 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO
ISS		 (PMID:15454078)
GO_REF:0000024		 RGD
BHF-UCL		 PMID:15454078 GO_REF:0000024 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in IC PMID:21859974 BHF-UCL PMID:21859974 RGD:6767284 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (MGI:3763979|PMID:17884088)
(PMID:17884088)
(PMID:19808477)		 RGD PMID:17884088 PMID:19808477 MGI:3763979 NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO
IBA		 (PMID:19808477)
GO_REF:0000033		 RGD
GO_Central		 PMID:19808477 GO_REF:0000033 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:21051419) RGD PMID:21051419 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868 		JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 involved_in ISO (PMID:17592081) RGD PMID:17592081 NCBI chr 8:45,446,580...45,462,294
Ensembl chr 8:45,446,215...45,462,292 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
ISS
IMP		 (PMID:21895525)
GO_REF:0000024
PMID:29457789		 RGD
BHF-UCL		 PMID:21895525 PMID:29457789 GO_REF:0000024, RGD:126781740 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO
IEA		 (PMID:18464934)
GO_REF:0000107		 RGD
Ensembl		 PMID:18464934 GO_REF:0000107 NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:22766342)		 BHF-UCL
Ensembl
RGD		 PMID:22766342 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO
IEA		 (PMID:27207958)
GO_REF:0000107		 RGD
Ensembl		 PMID:27207958 GO_REF:0000107 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:21131953)
MGI:2180141 (PMID:12700358)
GO_REF:0000107		 RGD
Ensembl		 PMID:12700358 PMID:21131953 GO_REF:0000107 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISS
ISO		 GO_REF:0000024
(MGI:3714901|PMID:16690884)		 BHF-UCL
RGD		 PMID:16690884 GO_REF:0000024 MGI:3714901 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 involved_in ISO
IEA		 (PMID:16407510)
GO_REF:0000107		 RGD
Ensembl		 PMID:16407510 GO_REF:0000107 NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18616619)		 BHF-UCL
Ensembl
RGD		 PMID:18616619 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (MGI:5613732|PMID:25257915)
(PMID:25257915)		 RGD PMID:25257915 MGI:5613732 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in IMP PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in IMP PMID:8816717 UniProt PMID:8816717 RGD:405650388 NCBI chr11:80,197,741...80,211,657
Ensembl chr11:80,198,153...80,211,657 		JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 involved_in ISO (PMID:16930557) RGD PMID:16930557 NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (PMID:17275750) RGD PMID:17275750 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within ISO MGI:2445238 (PMID:9501070) RGD PMID:9501070 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO (PMID:21621375) RGD PMID:21621375 NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840 		JBrowse link
G Slmap sarcolemma associated protein involved_in ISO
IBA		 (PMID:23064965)
GO_REF:0000033		 RGD
GO_Central		 PMID:23064965 GO_REF:0000033 NCBI chr16:1,667,205...1,785,200
Ensembl chr16:1,667,208...1,785,149 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  biological_process 20134
    biological regulation 13566
      regulation of biological quality 3390
        regulation of membrane potential 548
          membrane depolarization 115
            membrane depolarization during action potential 32
              membrane depolarization during cardiac muscle cell action potential + 18
              regulation of membrane depolarization during action potential + 7
paths to the root