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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane depolarization during action potential
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Accession:GO:0086010 term browser browse the term
Definition:The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


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membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:94,299,217...94,365,226
Ensembl chr11:94,299,217...94,365,024 		JBrowse link
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759 		JBrowse link
G Cacna1i calcium channel, voltage-dependent, alpha 1I subunit involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:80,171,439...80,282,493
Ensembl chr15:80,171,439...80,282,480 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Scn10a sodium channel, voltage-gated, type X, alpha involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 9:119,437,522...119,548,388
Ensembl chr 9:119,437,522...119,548,388 		JBrowse link
G Scn11a sodium channel, voltage-gated, type XI, alpha involved_in IMP
ISO
IBA		 (MGI:5553040|PMID:24036948)
(PMID:24036948)		 UniProt
GO_Central
MGI		 PMID:24036948 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 MGI:5553040 NCBI chr 9:119,582,829...119,654,522
Ensembl chr 9:119,582,825...119,654,522 		JBrowse link
G Scn1a sodium channel, voltage-gated, type I, alpha involved_in IDA
ISO
IBA		 (MGI:5796061|PMID:27281198) UniProt
GO_Central
MGI		 PMID:27281198 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5796061 NCBI chr 2:66,101,125...66,271,181
Ensembl chr 2:66,101,122...66,271,184 		JBrowse link
G Scn1b sodium channel, voltage-gated, type I, beta involved_in ISO (PMID:35277491) UniProt PMID:35277491 NCBI chr 7:30,815,949...30,826,436
Ensembl chr 7:30,815,949...30,826,428 		JBrowse link
G Scn2a sodium channel, voltage-gated, type II, alpha involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:65,451,108...65,597,791
Ensembl chr 2:65,451,115...65,597,791 		JBrowse link
G Scn2b sodium channel, voltage-gated, type II, beta involved_in ISO (PMID:35277491) UniProt PMID:35277491 NCBI chr 9:45,029,174...45,041,368
Ensembl chr 9:45,029,080...45,041,368 		JBrowse link
G Scn3a sodium channel, voltage-gated, type III, alpha involved_in IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:65,287,462...65,397,935
Ensembl chr 2:65,288,607...65,397,971 		JBrowse link
G Scn3b sodium channel, voltage-gated, type III, beta involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr 9:40,180,512...40,202,914
Ensembl chr 9:40,180,513...40,202,914 		JBrowse link
G Scn4a sodium channel, voltage-gated, type IV, alpha involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:106,208,374...106,256,385
Ensembl chr11:106,209,418...106,244,114 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
G Scn7a sodium channel, voltage-gated, type VII, alpha NOT|involved_in ISO PMID:9001394 UniProt PMID:9001394 RGD:61747 NCBI chr 2:66,503,770...66,615,254
Ensembl chr 2:66,503,769...66,615,258 		JBrowse link
G Scn8a sodium channel, voltage-gated, type VIII, alpha involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:100,766,600...100,943,819
Ensembl chr15:100,767,739...100,943,819 		JBrowse link
G Scn9a sodium channel, voltage-gated, type IX, alpha involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:66,310,424...66,465,456
Ensembl chr 2:66,310,424...66,465,306 		JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide involved_in ISS
ISO		 (MGI:3714891|PMID:16728661)
(PMID:16728661)		 BHF-UCL
GO_Central
MGI		 PMID:16728661 GO_REF:0000119 MGI:3714891 MGI:4834177 NCBI chr 5:33,176,160...33,185,310
Ensembl chr 5:33,176,160...33,185,310 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit involved_in ISO
ISS		 MGI
BHF-UCL		 GO_REF:0000024 GO_REF:0000119 MGI:4834177 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851 		JBrowse link
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit involved_in ISO
ISS		 MGI
BHF-UCL
GO_Central		 GO_REF:0000024 GO_REF:0000119 MGI:4834177 NCBI chr 2:14,608,672...14,993,622
Ensembl chr 2:14,607,899...14,992,719 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851 		JBrowse link
G Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit involved_in IMP (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr11:94,299,217...94,365,226
Ensembl chr11:94,299,217...94,365,024 		JBrowse link
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:14,608,672...14,993,622
Ensembl chr 2:14,607,899...14,992,719 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO
IEA		 MGI
Ensembl		 GO_REF:0000107 GO_REF:0000119 MGI:4834177 NCBI chr 7:44,952,579...44,983,495
Ensembl chr 7:44,952,056...44,983,204 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 involved_in ISO
IEA		 MGI
Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 MGI:4834177 NCBI chr 5:16,139,390...16,579,509
Ensembl chr 5:16,139,786...16,579,502 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO
IEA		 MGI
Ensembl		 GO_REF:0000107 GO_REF:0000119 MGI:4834177 NCBI chr 7:44,952,579...44,983,495
Ensembl chr 7:44,952,056...44,983,204 		JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851 		JBrowse link
G Scn1b sodium channel, voltage-gated, type I, beta involved_in IMP (MGI:3763979|PMID:17884088) BHF-UCL PMID:17884088 MGI:3763979 NCBI chr 7:30,815,949...30,826,436
Ensembl chr 7:30,815,949...30,826,428 		JBrowse link
G Scn2b sodium channel, voltage-gated, type II, beta involved_in ISO
IEA
IBA		 MGI
Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 MGI:4834177 NCBI chr 9:45,029,174...45,041,368
Ensembl chr 9:45,029,080...45,041,368 		JBrowse link
G Scn3b sodium channel, voltage-gated, type III, beta involved_in ISO
IEA		 MGI
Ensembl		 GO_REF:0000107 GO_REF:0000119 MGI:4834177 NCBI chr 9:40,180,512...40,202,914
Ensembl chr 9:40,180,513...40,202,914 		JBrowse link
G Scn4b sodium channel, type IV, beta involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 9:45,049,922...45,065,453
Ensembl chr 9:45,049,693...45,065,450 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha involved_in ISO
IEA		 MGI
GOC
GO_Central		 GO_REF:0000096 GO_REF:0000108 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium channel, voltage-gated, type I, beta involved_in ISO
IEA		 MGI
Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 MGI:4834177 NCBI chr 7:30,815,949...30,826,436
Ensembl chr 7:30,815,949...30,826,428 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:44,952,579...44,983,495
Ensembl chr 7:44,952,056...44,983,204 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit involved_in
acts_upstream_of_or_within		 ISO
IMP		 (PMID:12700358) MGI
GO_Central		 PMID:12700358 GO_REF:0000119 MGI:4834177 NCBI chr14:29,761,898...30,213,113
Ensembl chr14:29,761,896...30,213,412 		JBrowse link
G Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit involved_in IMP (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr11:94,299,217...94,365,226
Ensembl chr11:94,299,217...94,365,024 		JBrowse link
G Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr 9:58,730,232...58,770,458
Ensembl chr 9:58,730,695...58,770,458 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in IMP (MGI:5613732|PMID:25257915)
(PMID:25257915)		 BHF-UCL PMID:25257915 MGI:5613732 NCBI chr 6:112,436,466...112,449,833
Ensembl chr 6:112,436,466...112,449,833 		JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3, epithelial involved_in ISO
ISS		 MGI
BHF-UCL		 GO_REF:0000024 GO_REF:0000096 MGI:4417868 NCBI chr10:69,234,608...69,863,266
Ensembl chr10:69,234,603...69,863,268 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride channel, voltage-sensitive 2 involved_in ISO PMID:8816717 UniProt PMID:8816717 RGD:405650388 NCBI chr16:20,521,185...20,536,496
Ensembl chr16:20,521,714...20,536,496 		JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 involved_in ISO
IEA		 MGI
Ensembl		 GO_REF:0000107 GO_REF:0000119 MGI:4834177 NCBI chr 4:57,190,841...57,339,036
Ensembl chr 4:57,190,841...57,301,837 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr 6:112,436,466...112,449,833
Ensembl chr 6:112,436,466...112,449,833 		JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within IMP (PMID:9501070) MGI PMID:9501070 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr11:68,863,310...68,866,011
Ensembl chr11:68,863,310...68,866,011 		JBrowse link
G Slmap sarcolemma associated protein involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr14:26,134,323...26,256,103
Ensembl chr14:26,134,323...26,256,086 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  biological_process 28753
    biological regulation 13498
      regulation of biological quality 3535
        regulation of membrane potential 551
          membrane depolarization 115
            membrane depolarization during action potential 32
              membrane depolarization during cardiac muscle cell action potential + 17
              regulation of membrane depolarization during action potential + 7
paths to the root