Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:membrane depolarization during action potential
go back to main search page
Accession:GO:0086010 term browser browse the term
Definition:The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


show annotations for term's descendants           Sort by:
membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 involved_in IDA (PMID:7604285) BHF-UCL PMID:7604285 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IMP (PMID:23115331) UniProt PMID:23115331 NCBI chr 3:38,696,807...38,816,217
Ensembl chr 3:38,696,802...38,816,286 		JBrowse link
G SCN11A sodium voltage-gated channel alpha subunit 11 involved_in IDA
IMP
IEA		 (PMID:12384689)
(PMID:24036948), (PMID:24776970)		 UniProt
Ensembl		 PMID:12384689 PMID:24036948 PMID:24776970 GO_REF:0000107 NCBI chr 3:38,845,764...39,051,944
Ensembl chr 3:38,845,764...39,052,157 		JBrowse link
G SCN1A sodium voltage-gated channel alpha subunit 1 involved_in ISS
IEA
IMP		 (PMID:14672992) UniProt
Ensembl		 PMID:14672992 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:165,984,641...166,149,161
Ensembl chr 2:165,984,641...166,182,806 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IDA (PMID:35277491) UniProt PMID:35277491 NCBI chr19:35,030,470...35,040,449
Ensembl chr19:35,030,470...35,040,449 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IDA (PMID:35277491) UniProt PMID:35277491 NCBI chr11:118,162,806...118,176,639
Ensembl chr11:118,162,806...118,176,639 		JBrowse link
G SCN3A sodium voltage-gated channel alpha subunit 3 involved_in IDA (PMID:35277491) UniProt PMID:35277491 NCBI chr 2:165,087,526...165,204,050
Ensembl chr 2:165,087,526...165,204,050 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IMP
IDA		 (PMID:21051419)
(PMID:20042427), (PMID:20226894)		 BHF-UCL PMID:20042427 PMID:20226894 PMID:21051419 NCBI chr11:123,629,188...123,654,624
Ensembl chr11:123,629,187...123,655,244 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IDA (PMID:14500339), (PMID:18065446), (PMID:22529811) BHF-UCL PMID:14500339 PMID:18065446 PMID:22529811 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743 		JBrowse link
G SCN7A sodium voltage-gated channel alpha subunit 7 NOT|involved_in ISO PMID:9001394 UniProt PMID:9001394 RGD:61747 NCBI chr 2:166,403,573...166,494,249
Ensembl chr 2:166,403,573...166,611,482 		JBrowse link
G YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta involved_in IDA (PMID:16728661) BHF-UCL PMID:16728661 NCBI chr22:31,944,535...31,957,603
Ensembl chr22:31,944,522...31,957,603 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IMP (PMID:17224476) BHF-UCL PMID:17224476 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IMP (PMID:17224476) BHF-UCL PMID:17224476 NCBI chr10:18,140,424...18,543,557
Ensembl chr10:18,140,424...18,543,557 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IMP (PMID:18065446) BHF-UCL PMID:18065446 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IMP (PMID:26253506) BHF-UCL PMID:26253506 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr17:50,560,715...50,627,474
Ensembl chr17:50,560,715...50,627,474 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IMP (PMID:17224476) BHF-UCL PMID:17224476 NCBI chr10:18,140,424...18,543,557
Ensembl chr10:18,140,424...18,543,557 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IMP (PMID:18616619) BHF-UCL PMID:18616619 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IMP (PMID:27207958) BHF-UCL PMID:27207958 NCBI chr19:49,157,792...49,211,836
Ensembl chr19:49,157,741...49,211,836 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in IMP (PMID:21383000) BHF-UCL PMID:21383000 NCBI chr 7:81,946,444...82,443,956
Ensembl chr 7:81,946,444...82,443,956 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IMP (PMID:18065446) BHF-UCL PMID:18065446 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IMP (PMID:27207958) BHF-UCL PMID:27207958 NCBI chr19:49,157,792...49,211,836
Ensembl chr19:49,157,741...49,211,836 		JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 involved_in TAS (PMID:23608603) BHF-UCL PMID:23608603 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IMP (PMID:15454078) BHF-UCL PMID:15454078 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in IC (PMID:21859974) BHF-UCL PMID:21859974 NCBI chr 3:53,494,611...53,813,733
Ensembl chr 3:53,328,963...53,813,733 		JBrowse link
G HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 involved_in IC (PMID:10228147) BHF-UCL PMID:10228147 NCBI chr19:589,881...617,159
Ensembl chr19:589,881...617,159 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IC (PMID:10228147) BHF-UCL PMID:10228147 NCBI chr15:73,319,859...73,368,958
Ensembl chr15:73,319,859...73,368,958 		JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 involved_in TAS (PMID:20086079) BHF-UCL PMID:20086079 NCBI chr17:70,169,532...70,180,044
Ensembl chr17:70,168,673...70,180,044 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in ISS
IMP
IEA		 (PMID:17884088)
(PMID:19808477)		 BHF-UCL
Ensembl		 PMID:17884088 PMID:19808477 GO_REF:0000107 NCBI chr19:35,030,470...35,040,449
Ensembl chr19:35,030,470...35,040,449 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IMP
IEA
IBA		 (PMID:19808477) BHF-UCL
GOC
GO_Central		 PMID:19808477 GO_REF:0000033 GO_REF:0000108 NCBI chr11:118,162,806...118,176,639
Ensembl chr11:118,162,806...118,176,639 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IMP (PMID:21051419) BHF-UCL PMID:21051419 NCBI chr11:123,629,188...123,654,624
Ensembl chr11:123,629,187...123,655,244 		JBrowse link
G SCN4B sodium voltage-gated channel beta subunit 4 involved_in IMP (PMID:17592081) BHF-UCL PMID:17592081 NCBI chr11:118,133,377...118,152,823
Ensembl chr11:118,133,377...118,152,888 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IMP (PMID:21895525) BHF-UCL PMID:21895525 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 involved_in TAS (PMID:23608603) BHF-UCL PMID:23608603 NCBI chr 2:40,097,270...40,512,435
Ensembl chr 2:40,097,270...40,611,053 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IMP (PMID:18464934) BHF-UCL PMID:18464934 NCBI chr19:35,030,470...35,040,449
Ensembl chr19:35,030,470...35,040,449 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IMP (PMID:22766342) BHF-UCL PMID:22766342 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IMP (PMID:27207958) BHF-UCL PMID:27207958 NCBI chr19:49,157,792...49,211,836
Ensembl chr19:49,157,741...49,211,836 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in TAS (PMID:19098452) BHF-UCL PMID:19098452 NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 IMP
ISO		 (PMID:21131953)
(PMID:12700358)		 BHF-UCL
MGI		 PMID:12700358 PMID:21131953 NCBI chr 3:53,494,611...53,813,733
Ensembl chr 3:53,328,963...53,813,733 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr17:50,560,715...50,627,474
Ensembl chr17:50,560,715...50,627,474 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IMP (PMID:16407510) BHF-UCL PMID:16407510 NCBI chr15:73,319,859...73,368,958
Ensembl chr15:73,319,859...73,368,958 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IMP (PMID:18616619) BHF-UCL PMID:18616619 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743 		JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:8,733,802...8,746,758
Ensembl chr 3:8,733,802...8,841,808 		JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 involved_in ISS (PMID:18180363) BHF-UCL PMID:18180363 NCBI chr10:60,026,298...60,733,528
Ensembl chr10:60,026,298...60,733,490 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:184,346,185...184,361,605
Ensembl chr 3:184,346,185...184,361,650 		JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 involved_in IDA (PMID:16930557) BHF-UCL PMID:16930557 NCBI chr 9:109,375,694...109,538,420
Ensembl chr 9:109,375,466...109,498,313 		JBrowse link
regulation of membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR208A microRNA 208a involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr14:23,388,596...23,388,666
Ensembl chr14:23,388,596...23,388,666 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in IMP (PMID:17275750) BHF-UCL PMID:17275750 NCBI chr 3:8,733,802...8,746,758
Ensembl chr 3:8,733,802...8,841,808 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:9501070) MGI PMID:9501070 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G RANGRF RAN guanine nucleotide release factor involved_in TAS
IMP		 (PMID:21621375) BHF-UCL PMID:21621375 NCBI chr17:8,288,670...8,290,087
Ensembl chr17:8,288,654...8,290,092 		JBrowse link
G SLMAP sarcolemma associated protein involved_in IMP
IBA		 (PMID:23064965) BHF-UCL
GO_Central		 PMID:23064965 GO_REF:0000033 NCBI chr 3:57,756,309...57,930,013
Ensembl chr 3:57,755,450...57,930,003 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19787
    biological regulation 13526
      regulation of biological quality 3572
        regulation of membrane potential 568
          membrane depolarization 120
            membrane depolarization during action potential 32
              membrane depolarization during cardiac muscle cell action potential + 23
              regulation of membrane depolarization during action potential + 8
paths to the root