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ONTOLOGY REPORT - ANNOTATIONS


Term:membrane depolarization during action potential
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Accession:GO:0086010 term browser browse the term
Definition:The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.



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membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 involved_in ISO (PMID:7604285) RGD PMID:7604285 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044
JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:50,952,790...51,071,804
Ensembl chr 3:50,952,791...51,071,699
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:20042427), (PMID:20226894), (PMID:21051419) RGD PMID:20042427 PMID:20226894 PMID:21051419 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868
JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:91,246,936...91,296,670
Ensembl chr10:91,246,936...91,296,545
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:14500339), (PMID:18065446), (PMID:22529811)
BHF-UCL
RGD
PMID:14500339 PMID:18065446 PMID:22529811 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:16728661)
BHF-UCL
Ensembl
RGD
PMID:16728661 GO_REF:0000024 GO_REF:0000107 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO
ISS
(PMID:17224476)
GO_REF:0000024
RGD
BHF-UCL
PMID:17224476 GO_REF:0000024 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:17224476)
BHF-UCL
RGD
PMID:17224476 GO_REF:0000024 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
(PMID:18065446)
GO_REF:0000107
RGD
Ensembl
PMID:18065446 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISS
ISO
GO_REF:0000024
(PMID:26253506)
BHF-UCL
RGD
PMID:26253506 GO_REF:0000024 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISS
ISO
GO_REF:0000024
(MGI:3714901|PMID:16690884)
BHF-UCL
RGD
PMID:16690884 GO_REF:0000024 MGI:3714901 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISO
ISS
(PMID:17224476)
GO_REF:0000024
RGD
BHF-UCL
PMID:17224476 GO_REF:0000024 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
ISS
(PMID:18616619)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18616619 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO (PMID:27207958) RGD PMID:27207958 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in ISO (PMID:21383000) RGD PMID:21383000 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
ISS
(PMID:18065446)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18065446 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO (PMID:27207958) RGD PMID:27207958 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO
ISS
(PMID:15454078)
GO_REF:0000024
RGD
BHF-UCL
PMID:15454078 GO_REF:0000024 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in IC PMID:21859974 BHF-UCL PMID:21859974 RGD:6767284 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (MGI:3763979|PMID:17884088) RGD PMID:17884088 MGI:3763979 NCBI chr 1:86,353,917...86,363,836
Ensembl chr 1:86,353,917...86,363,739
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO
IBA
(PMID:19808477)
PMID:21873635
RGD PMID:19808477 PMID:21873635 RGD:13792537 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in
acts_upstream_of_or_within
ISO (PMID:21051419)
MGI:5294639 (MGI:5294649|PMID:19351516)
RGD PMID:19351516 PMID:21051419 MGI:5294649 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868
JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 involved_in ISO (PMID:17592081) RGD PMID:17592081 NCBI chr 8:45,446,580...45,462,294
Ensembl chr 8:45,446,215...45,462,292
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
ISS
IMP
(PMID:21895525)
GO_REF:0000024
PMID:29457789
RGD
BHF-UCL
PMID:21895525 PMID:29457789 GO_REF:0000024, RGD:126781740 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO
IEA
(PMID:18464934)
GO_REF:0000107
RGD
Ensembl
PMID:18464934 GO_REF:0000107 NCBI chr 1:86,353,917...86,363,836
Ensembl chr 1:86,353,917...86,363,739
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:22766342)
BHF-UCL
Ensembl
RGD
PMID:22766342 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO (PMID:27207958) RGD PMID:27207958 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:21131953)
MGI:2180141 (MGI:3583874|PMID:12700358), (MGI:4354492|PMID:15932895)
GO_REF:0000107
RGD
Ensembl
PMID:12700358 PMID:15932895 PMID:21131953 GO_REF:0000107 MGI:3583874 MGI:4354492 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISS
ISO
GO_REF:0000024
(MGI:3714901|PMID:16690884)
BHF-UCL
RGD
PMID:16690884 GO_REF:0000024 MGI:3714901 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 involved_in ISO (PMID:16407510) RGD PMID:16407510 NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:18616619)
BHF-UCL
Ensembl
RGD
PMID:18616619 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (MGI:5613732|PMID:25257915) RGD PMID:25257915 MGI:5613732 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in IMP PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 involved_in ISO (PMID:16930557) RGD PMID:16930557 NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443
JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO
IBA
(PMID:17275750)
PMID:21873635
RGD PMID:17275750 PMID:21873635 RGD:13792537 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within ISO MGI:2445238 (MGI:1197846|PMID:9501070) RGD PMID:9501070 MGI:1197846 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO (PMID:21621375) RGD PMID:21621375 NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840
JBrowse link
G Slmap sarcolemma associated protein involved_in ISO
IBA
(PMID:23064965)
PMID:21873635
RGD PMID:23064965 PMID:21873635 RGD:13792537 NCBI chr16:1,667,205...1,785,200
Ensembl chr16:1,667,208...1,785,149
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    biological regulation 13314
      regulation of biological quality 4232
        regulation of membrane potential 499
          membrane depolarization 98
            membrane depolarization during action potential 31
              membrane depolarization during cardiac muscle cell action potential + 17
              regulation of membrane depolarization during action potential + 6
paths to the root