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ONTOLOGY REPORT - ANNOTATIONS

Term:voltage-gated sodium channel activity involved in cardiac muscle cell action potential
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Accession:GO:0086006 term browser browse the term
Definition:Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


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voltage-gated sodium channel activity involved in cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn10a sodium voltage-gated channel alpha subunit 10 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 enables ISO (PMID:19808477)
(MGI:3763979|PMID:17884088)		 RGD PMID:17884088 PMID:19808477 MGI:3763979 NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 enables ISO (PMID:19808477)
MGI:2451362 (PMID:27932425)		 RGD PMID:19808477 PMID:27932425 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 enables ISO (PMID:20042427), (PMID:21051419)
MGI:5294639 (PMID:19351516)		 RGD PMID:19351516 PMID:20042427 PMID:21051419 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868 		JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 enables ISO (PMID:17592081) RGD PMID:17592081 NCBI chr 8:45,446,580...45,462,294
Ensembl chr 8:45,446,215...45,462,292 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISO
IBA
IEA
IMP
ISS		 (PMID:18065446), (PMID:18616619), (PMID:21895525), (PMID:22529811)
MGI:2179753 (PMID:11972032)
GO_REF:0000033
GO_REF:0000118
PMID:29457789
GO_REF:0000024		 RGD
GO_Central
TreeGrafter
BHF-UCL		 PMID:11972032 PMID:18065446 PMID:18616619 PMID:21895525 PMID:22529811 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000118, RGD:126781740 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
voltage-gated sodium channel activity involved in AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18616619)		 BHF-UCL
Ensembl
RGD		 PMID:18616619 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
voltage-gated sodium channel activity involved in bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISO
IEA
ISS		 (PMID:18065446)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
BHF-UCL		 PMID:18065446 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
voltage-gated sodium channel activity involved in Purkinje myocyte action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 enables ISO
IEA		 (PMID:18464934)
GO_REF:0000107		 RGD
Ensembl		 PMID:18464934 GO_REF:0000107 NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISO
IEA
ISS		 (PMID:22766342)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
BHF-UCL		 PMID:22766342 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
voltage-gated sodium channel activity involved in SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISO
ISS
IEA		 (PMID:18616619)
GO_REF:0000024
GO_REF:0000107
MGI:2179753 (PMID:15932895)		 RGD
BHF-UCL
Ensembl		 PMID:15932895 PMID:18616619 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20890
    transporter activity 1252
      transmembrane transporter activity 1157
        monoatomic ion transmembrane transporter activity 750
          monoatomic ion channel activity 456
            monoatomic cation channel activity 345
              sodium channel activity 44
                voltage-gated sodium channel activity 26
                  voltage-gated sodium channel activity involved in cardiac muscle cell action potential 6
                    voltage-gated sodium channel activity involved in AV node cell action potential 1
                    voltage-gated sodium channel activity involved in Purkinje myocyte action potential 2
                    voltage-gated sodium channel activity involved in SA node cell action potential 1
                    voltage-gated sodium channel activity involved in bundle of His cell action potential 1
Path 2
Term Annotations click to browse term
  molecular_function 20890
    transporter activity 1252
      transmembrane transporter activity 1157
        monoatomic ion transmembrane transporter activity 750
          monoatomic cation transmembrane transporter activity 628
            metal ion transmembrane transporter activity 456
              sodium ion transmembrane transporter activity 166
                sodium channel activity 44
                  voltage-gated sodium channel activity 26
                    voltage-gated sodium channel activity involved in cardiac muscle cell action potential 6
                      voltage-gated sodium channel activity involved in AV node cell action potential 1
                      voltage-gated sodium channel activity involved in Purkinje myocyte action potential 2
                      voltage-gated sodium channel activity involved in SA node cell action potential 1
                      voltage-gated sodium channel activity involved in bundle of His cell action potential 1
paths to the root