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ONTOLOGY REPORT - ANNOTATIONS


Term:gene silencing by RNA-directed DNA methylation
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Accession:GO:0080188 term browser browse the term
Definition:A small RNA-based epigenetic gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism.
Comment:This process has been shown in plants and in yeasts, but so far has not been detected in vertebrates, organisms that lack RNA-dependent RNA polymerase.
Synonyms:exact_synonym: RdDM
 related_synonym: RNA-directed DNA methylation



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  biological_process 19834
    metabolic process 12042
      negative regulation of metabolic process 3270
        negative regulation of macromolecule metabolic process 3040
          negative regulation of gene expression 1185
            gene silencing by RNA 159
              pre-transcriptional gene silencing by RNA 0
                gene silencing by RNA-directed DNA methylation 0
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  biological_process 19834
    cellular process 18637
      cellular component organization or biogenesis 6736
        cellular component organization 6486
          organelle organization 3987
            chromosome organization 1036
              chromatin organization 594
                regulation of gene expression, epigenetic 220
                  negative regulation of gene expression, epigenetic 147
                    heterochromatin assembly 141
                      facultative heterochromatin assembly 39
                        DNA methylation-dependent heterochromatin assembly 28
                          gene silencing by RNA-directed DNA methylation 0
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