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ONTOLOGY REPORT - ANNOTATIONS

Term:lytic vacuole organization
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Accession:GO:0080171 term browser browse the term
Definition:A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole.
Synonyms:exact_synonym: lytic vacuole organisation
 narrow_synonym: lytic vacuolar assembly
 related_synonym: lytic vacuole biogenesis;   lytic vacuole organization and biogenesis


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lysosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:12,453,998...12,483,290
Ensembl chr  X:12,454,040...12,483,288 		JBrowse link
G Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C acts_upstream_of_or_within TAS (PMID:11441017) MGI PMID:11441017 NCBI chr17:24,382,839...24,388,652
Ensembl chr17:24,382,840...24,388,676 		JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:34,475,751...34,478,753
Ensembl chr 1:34,475,751...34,478,753 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:126,170,571...126,184,991
Ensembl chr 7:126,170,379...126,184,989 		JBrowse link
G Cln5 ceroid-lipofuscinosis, neuronal 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr14:103,307,679...103,315,064
Ensembl chr14:103,307,652...103,315,064 		JBrowse link
G Cln6 ceroid-lipofuscinosis, neuronal 6 involved_in ISS
ISO		 (MGI:2157193|PMID:11727201) UniProt
MGI		 PMID:11727201 GO_REF:0000119 MGI:2157193 MGI:4834177 NCBI chr 9:62,746,067...62,759,288
Ensembl chr 9:62,746,067...62,759,288 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 acts_upstream_of_or_within IMP (PMID:33966596) MGI PMID:33966596 NCBI chr 1:165,591,327...165,602,878
Ensembl chr 1:165,591,315...165,602,877 		JBrowse link
G Grn granulin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:37,488,524...37,545,337
Ensembl chr  X:37,490,234...37,545,331 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:122,729,879...122,752,968
Ensembl chr 4:122,730,035...122,752,968 		JBrowse link
G Snapin SNAP-associated protein acts_upstream_of_or_within IMP (PMID:20920792) MGI PMID:20920792 NCBI chr 3:90,395,333...90,398,320
Ensembl chr 3:90,395,333...90,398,340 		JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within IMP (PMID:28728022) MGI PMID:28728022 NCBI chr 6:13,069,758...13,089,268
Ensembl chr 6:13,069,758...13,089,268 		JBrowse link
G Tmem199 transmembrane protein 199 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:78,397,881...78,402,994
Ensembl chr11:78,397,881...78,402,998 		JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:135,935,957...135,962,768
Ensembl chr 1:135,935,888...135,963,080 		JBrowse link
lysosomal lumen pH elevation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:126,170,571...126,184,991
Ensembl chr 7:126,170,379...126,184,989 		JBrowse link
G Oca2 oculocutaneous albinism II involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:55,889,341...56,186,266
Ensembl chr 7:55,889,508...56,186,266 		JBrowse link
G Slc45a2 solute carrier family 45, member 2 involved_in IMP
ISO		 (MGI:7338895|PMID:35469906) UniProt
MGI		 PMID:35469906 GO_REF:0000119 MGI:4834177 MGI:7338895 NCBI chr15:11,000,807...11,029,319
Ensembl chr15:11,000,807...11,029,319 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:108,777,649...108,795,636
Ensembl chr 5:108,777,636...108,796,648 		JBrowse link
lysosomal membrane organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf1 ADP-ribosylation factor 1 involved_in ISO RGD
MGI		 PMID:9538255 GO_REF:0000096 MGI:4417868 RGD:9684948 NCBI chr11:59,102,237...59,119,042
Ensembl chr11:59,102,238...59,119,096 		JBrowse link
G Atp10b ATPase, class V, type 10B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:42,902,991...43,153,112
Ensembl chr11:43,040,704...43,153,112 		JBrowse link
lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Acp2 acid phosphatase 2, lysosomal acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:9228031)
(PMID:15604265)		 MGI
GO_Central		 PMID:9228031 PMID:15604265 GO_REF:0000033 NCBI chr 2:91,033,157...91,044,443
Ensembl chr 2:91,033,230...91,044,443 		JBrowse link
G Acp3 acid phosphatase 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:104,165,439...104,214,921
Ensembl chr 9:104,165,450...104,214,947 		JBrowse link
G Acp4 acid phosphatase 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:43,901,427...43,910,814
Ensembl chr 7:43,901,572...43,906,802 		JBrowse link
G Aktip AKT interacting protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:91,834,267...91,862,122
Ensembl chr 8:91,838,412...91,926,604 		JBrowse link
G Ap3b1 adaptor-related protein complex 3, beta 1 subunit acts_upstream_of_or_within IMP (PMID:30786955), (PMID:9931340) MGI PMID:9931340 PMID:30786955 NCBI chr13:94,492,332...94,702,838
Ensembl chr13:94,495,468...94,702,825 		JBrowse link
G Ap5z1 adaptor-related protein complex 5, zeta 1 subunit acts_upstream_of_or_within IMP (PMID:37871017) MGI PMID:37871017 NCBI chr 5:142,448,960...142,464,471
Ensembl chr 5:142,449,699...142,464,465 		JBrowse link
G Arsg arylsulfatase G acts_upstream_of_or_within IMP (PMID:26975023) MGI PMID:26975023 NCBI chr11:109,364,159...109,464,156
Ensembl chr11:109,364,200...109,464,156 		JBrowse link
G Becn1 beclin 1, autophagy related acts_upstream_of_or_within IMP (PMID:18497889) MGI PMID:18497889 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Chmp5 charged multivesicular body protein 5 acts_upstream_of_or_within IMP (PMID:16567502) MGI PMID:16567502 NCBI chr 4:40,948,553...40,965,302
Ensembl chr 4:40,948,407...40,965,303 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:10440905)
(PMID:15588329)
(PMID:10191119), (PMID:10527801)		 MGI
GO_Central		 PMID:10191119 PMID:10440905 PMID:10527801 PMID:15588329 GO_REF:0000033 NCBI chr 7:126,170,571...126,184,991
Ensembl chr 7:126,170,379...126,184,989 		JBrowse link
G Cln5 ceroid-lipofuscinosis, neuronal 5 acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:15459177) MGI
GO_Central		 PMID:15459177 GO_REF:0000033 NCBI chr14:103,307,679...103,315,064
Ensembl chr14:103,307,652...103,315,064 		JBrowse link
G Cln6 ceroid-lipofuscinosis, neuronal 6 acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:26681805), (PMID:9600738) MGI
GO_Central		 PMID:9600738 PMID:26681805 GO_REF:0000033 NCBI chr 9:62,746,067...62,759,288
Ensembl chr 9:62,746,067...62,759,288 		JBrowse link
G Cln8 CLN8 transmembrane ER and ERGIC protein acts_upstream_of_or_within IMP (PMID:10087069), (PMID:7613514), (PMID:8144516), (PMID:8160780) MGI PMID:7613514 PMID:8144516 PMID:8160780 PMID:10087069 NCBI chr 8:14,931,335...14,951,720
Ensembl chr 8:14,931,335...14,951,720 		JBrowse link
G Clvs1 clavesin 1 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000096 MGI:4417868 NCBI chr 4:9,144,753...9,451,691
Ensembl chr 4:9,269,293...9,451,691 		JBrowse link
G Clvs2 clavesin 2 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000096 MGI:4417868 NCBI chr10:33,388,282...33,500,680
Ensembl chr10:33,388,282...33,500,765 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 acts_upstream_of_or_within IMP (PMID:33966596) MGI PMID:33966596 NCBI chr 1:165,591,327...165,602,878
Ensembl chr 1:165,591,315...165,602,877 		JBrowse link
G Fhip1b FHF complex subunit HOOK interacting protein 1B involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:105,020,418...105,049,349
Ensembl chr 7:105,020,418...105,049,261 		JBrowse link
G Gaa glucosidase, alpha, acid involved_in
acts_upstream_of_or_within		 ISO
IBA
IMP		 (PMID:15169761), (PMID:9668092)
(PMID:10547605), (PMID:11328962), (PMID:12115977), (PMID:9384603)		 MGI
GO_Central		 PMID:9384603 PMID:9668092 PMID:10547605 PMID:11328962 PMID:12115977 More... GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:119,158,789...119,176,284
Ensembl chr11:119,158,713...119,176,280 		JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in IMP
ISO		 (MGI:5817293|PMID:27378698) UniProt
MGI		 PMID:27378698 GO_REF:0000119 MGI:4834177 MGI:5817293 NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273 		JBrowse link
G Gnptab N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:88,215,130...88,283,186
Ensembl chr10:88,214,994...88,283,191 		JBrowse link
G Grn granulin involved_in IMP (MGI:6274951|PMID:27789271) UniProt PMID:27789271 MGI:6274951 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Hexa hexosaminidase A acts_upstream_of_or_within IMP
IGI		 (PMID:7937929), (PMID:9103204)
(PMID:10591619), (PMID:14972652), (PMID:9302266), (PMID:9645704)
(PMID:8747922)
(PMID:8896570), (PMID:9184660)		 MGI PMID:7937929 PMID:8747922 PMID:8896570 PMID:9103204 PMID:9184660 More... NCBI chr 9:59,446,966...59,472,392
Ensembl chr 9:59,446,823...59,472,392 		JBrowse link
G Hexb hexosaminidase B acts_upstream_of_or_within IGI
IMP		 (PMID:8896570), (PMID:9184660)
(PMID:8789434), (PMID:9645704)		 MGI PMID:8789434 PMID:8896570 PMID:9184660 PMID:9645704 NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865 		JBrowse link
G Hook1 hook microtubule tethering protein 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:95,855,418...95,913,649
Ensembl chr 4:95,855,477...95,913,650 		JBrowse link
G Hook2 hook microtubule tethering protein 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:85,715,402...85,729,981
Ensembl chr 8:85,717,232...85,729,978 		JBrowse link
G Hook3 hook microtubule tethering protein 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:26,511,449...26,609,646
Ensembl chr 8:26,511,449...26,609,252 		JBrowse link
G Hps1 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 acts_upstream_of_or_within IMP (PMID:30786955) MGI PMID:30786955 NCBI chr19:42,743,629...42,770,013
Ensembl chr19:42,743,544...42,768,417 		JBrowse link
G Hps4 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 involved_in ISS
ISO		 (MGI:3687925|PMID:12663659) UniProt
MGI		 PMID:12663659 GO_REF:0000119 MGI:3687925 MGI:4834177 NCBI chr 5:112,490,849...112,526,290
Ensembl chr 5:112,490,949...112,526,280 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 acts_upstream_of_or_within IMP (PMID:29180785) MGI PMID:29180785 NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353 		JBrowse link
G Idua iduronidase, alpha-L acts_upstream_of_or_within IMP (PMID:9097952)
(PMID:19751987)		 MGI PMID:9097952 PMID:19751987 NCBI chr 5:108,808,197...108,833,312
Ensembl chr 5:108,808,197...108,832,423 		JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in IMP (MGI:4887551|PMID:19177150) UniProt PMID:19177150 MGI:4887551 NCBI chr 7:101,555,044...101,561,110
Ensembl chr 7:101,555,111...101,575,882 		JBrowse link
G Lipa lysosomal acid lipase A acts_upstream_of_or_within IMP (PMID:25807535)
(PMID:29374543)		 MGI PMID:25807535 PMID:29374543 NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323 		JBrowse link
G Lyset lysosomal enzyme trafficking factor involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:102,709,978...102,714,551
Ensembl chr12:102,710,021...102,713,820 		JBrowse link
G Lyst lysosomal trafficking regulator acts_upstream_of_or_within IMP (PMID:1113502), (PMID:4031470), (PMID:4697831), (PMID:6170520)
(PMID:9368050)		 MGI PMID:1113502 PMID:4031470 PMID:4697831 PMID:6170520 PMID:9368050 NCBI chr13:13,764,896...13,953,388
Ensembl chr13:13,764,982...13,953,388 		JBrowse link
G Mbtps1 membrane-bound transcription factor peptidase, site 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:120,234,890...120,285,603
Ensembl chr 8:120,234,895...120,285,474 		JBrowse link
G Mfsd8 major facilitator superfamily domain containing 8 acts_upstream_of_or_within IMP
ISS
IDA		 (PMID:26681805)
(PMID:35025759)
(PMID:24423645), (PMID:35025759)		 MGI PMID:24423645 PMID:26681805 PMID:35025759 NCBI chr 3:40,772,500...40,801,322
Ensembl chr 3:40,772,538...40,801,321 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myo7a myosin VIIA involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:97,700,261...97,768,730
Ensembl chr 7:97,700,267...97,768,731 		JBrowse link
G Naglu alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) acts_upstream_of_or_within IMP (PMID:17712420), (PMID:19632871), (PMID:25524704), (PMID:26607664) MGI PMID:17712420 PMID:19632871 PMID:25524704 PMID:26607664 NCBI chr11:100,960,918...100,968,483
Ensembl chr11:100,960,838...100,968,498 		JBrowse link
G Pi4kb phosphatidylinositol 4-kinase beta acts_upstream_of_or_within ISO (PMID:25365221) MGI PMID:25365221 NCBI chr 3:94,882,042...94,914,248
Ensembl chr 3:94,882,042...94,914,154 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 acts_upstream_of_or_within IMP (PMID:16542649)
(PMID:16368712)		 MGI PMID:16368712 PMID:16542649 NCBI chr 4:122,729,879...122,752,968
Ensembl chr 4:122,730,035...122,752,968 		JBrowse link
G Snapin SNAP-associated protein involved_in
acts_upstream_of_or_within		 IBA
IMP		 (PMID:20920792) GO_Central
MGI		 PMID:20920792 GO_REF:0000033 NCBI chr 3:90,395,333...90,398,320
Ensembl chr 3:90,395,333...90,398,340 		JBrowse link
G Spg11 SPG11, spatacsin vesicle trafficking associated acts_upstream_of_or_within IMP
ISO		 (PMID:28237315), (PMID:31637311)
(PMID:37871017)
(PMID:25365221)
(PMID:26284655)		 MGI PMID:25365221 PMID:26284655 PMID:28237315 PMID:31637311 PMID:37871017 NCBI chr 2:121,884,001...121,949,915
Ensembl chr 2:121,884,001...121,948,867 		JBrowse link
G Tfe3 transcription factor E3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:7,628,769...7,641,441
Ensembl chr  X:7,628,799...7,641,441 		JBrowse link
G Tfeb transcription factor EB involved_in
acts_upstream_of_or_within		 ISO
IMP		 (PMID:31637311) MGI PMID:31637311 GO_REF:0000119 MGI:4834177 NCBI chr17:48,047,962...48,103,341
Ensembl chr17:48,047,955...48,103,344 		JBrowse link
G Tmem106b transmembrane protein 106B involved_in
acts_upstream_of_or_within		 IBA
IMP		 (PMID:25066864) GO_Central
MGI		 PMID:25066864 GO_REF:0000033 NCBI chr 6:13,069,758...13,089,268
Ensembl chr 6:13,069,758...13,089,268 		JBrowse link
G Tpcn2 two pore segment channel 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:144,735,370...144,837,743
Ensembl chr 7:144,740,261...144,837,748 		JBrowse link
G Tpp1 tripeptidyl peptidase I acts_upstream_of_or_within IMP (PMID:15483130) MGI PMID:15483130 NCBI chr 7:105,394,018...105,401,489
Ensembl chr 7:105,394,018...105,401,442 		JBrowse link
G Vps18 VPS18 CORVET/HOPS core subunit involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:119,119,220...119,128,934
Ensembl chr 2:119,119,221...119,128,934 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in IMP (MGI:5694519|PMID:26203154) ParkinsonsUK-UCL PMID:26203154 MGI:5694519 NCBI chr 8:85,987,014...86,026,146
Ensembl chr 8:85,987,021...86,026,431 		JBrowse link
G Washc5 WASH complex subunit 5 acts_upstream_of_or_within ISO
IMP		 (PMID:30061306) MGI PMID:30061306 NCBI chr15:59,203,712...59,246,043
Ensembl chr15:59,203,846...59,246,016 		JBrowse link
G Zfyve26 zinc finger, FYVE domain containing 26 acts_upstream_of_or_within ISO
IMP		 (PMID:25365221)
(PMID:37871017)		 MGI PMID:25365221 PMID:37871017 NCBI chr12:79,279,120...79,343,102
Ensembl chr12:79,279,120...79,343,078 		JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 involved_in ISO (PMID:23434374) UniProt PMID:23434374 NCBI chr13:21,571,174...21,586,942
Ensembl chr13:21,571,173...21,586,925 		JBrowse link
multivesicular body-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp1a charged multivesicular body protein 1A involved_in NAS (MGI:6881720|PMID:16505166) ComplexPortal PMID:16505166 MGI:6881720 NCBI chr 8:123,931,000...123,939,527
Ensembl chr 8:123,931,003...123,939,502 		JBrowse link
G Chmp1b charged multivesicular body protein 1B involved_in NAS (MGI:6881720|PMID:16505166) ComplexPortal PMID:16505166 MGI:6881720 NCBI chr18:67,338,430...67,340,958
Ensembl chr18:67,338,437...67,340,960 		JBrowse link
G Chmp1b2 charged multivesicular body protein 1B2 involved_in NAS (MGI:6881720|PMID:16505166) ComplexPortal PMID:16505166 MGI:6881720 NCBI chr  X:106,826,357...106,859,940
Ensembl chr  X:106,826,357...106,859,940 		JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in NAS (MGI:6881720|PMID:16505166) ComplexPortal PMID:16505166 MGI:6881720 NCBI chr 7:12,765,933...12,768,704
Ensembl chr 7:12,765,937...12,768,734 		JBrowse link
G Chmp2b charged multivesicular body protein 2B involved_in NAS (MGI:6881720|PMID:16505166) ComplexPortal PMID:16505166 MGI:6881720 NCBI chr16:65,336,014...65,359,648
Ensembl chr16:65,336,014...65,359,612 		JBrowse link
G Chmp3 charged multivesicular body protein 3 involved_in NAS (MGI:6881720|PMID:16505166) ComplexPortal PMID:16505166 MGI:6881720 NCBI chr 6:71,520,820...71,559,593
Ensembl chr 6:71,520,781...71,559,593 		JBrowse link
G Chmp4b charged multivesicular body protein 4B involved_in NAS (MGI:6881720|PMID:16505166) ComplexPortal PMID:16505166 MGI:6881720 NCBI chr 2:154,498,949...154,536,703
Ensembl chr 2:154,493,625...154,536,705 		JBrowse link
G Chmp4c charged multivesicular body protein 4C involved_in NAS (MGI:6881720|PMID:16505166) ComplexPortal PMID:16505166 MGI:6881720 NCBI chr 3:10,432,033...10,456,065
Ensembl chr 3:10,431,967...10,493,916 		JBrowse link
G Chmp5 charged multivesicular body protein 5 involved_in TAS
NAS		 (MGI:5706912|PMID:21118109)
(MGI:6881720|PMID:16505166)		 ParkinsonsUK-UCL
ComplexPortal		 PMID:16505166 PMID:21118109 MGI:5706912 MGI:6881720 NCBI chr 4:40,948,553...40,965,302
Ensembl chr 4:40,948,407...40,965,303 		JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in NAS (MGI:6881720|PMID:16505166) ComplexPortal PMID:16505166 MGI:6881720 NCBI chr11:119,803,874...119,810,378
Ensembl chr11:119,804,267...119,810,374 		JBrowse link
G Chmp7 charged multivesicular body protein 7 involved_in NAS (MGI:6881720|PMID:16505166) ComplexPortal PMID:16505166 MGI:6881720 NCBI chr14:69,954,428...69,970,019
Ensembl chr14:69,954,449...69,969,990 		JBrowse link
negative regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1, autophagy related involved_in ISO RGD
MGI		 PMID:25561470 GO_REF:0000096 MGI:4417868 RGD:11561937 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Flcn folliculin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:59,682,234...59,706,138
Ensembl chr11:59,682,234...59,700,842 		JBrowse link
G Fnip1 folliculin interacting protein 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:54,328,071...54,409,067
Ensembl chr11:54,329,025...54,409,061 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
phagolysosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1a coronin, actin binding protein 1A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:126,298,946...126,303,925
Ensembl chr 7:126,298,945...126,306,959 		JBrowse link
G Myo7a myosin VIIA acts_upstream_of_or_within IMP (PMID:12743369) MGI PMID:12743369 NCBI chr 7:97,700,261...97,768,730
Ensembl chr 7:97,700,267...97,768,731 		JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 acts_upstream_of_or_within IMP (PMID:11544318) MGI PMID:11544318 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495 		JBrowse link
G Srpx sushi-repeat-containing protein involved_in
acts_upstream_of_or_within		 IBA
IMP		 (PMID:19368996) GO_Central
MGI		 PMID:19368996 GO_REF:0000033 NCBI chr  X:9,904,216...9,983,879
Ensembl chr  X:9,904,216...9,983,948 		JBrowse link
phagolysosome assembly involved in apoptotic cell clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab14 RAB14, member RAS oncogene family involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:35,070,217...35,091,132
Ensembl chr 2:35,070,217...35,091,132 		JBrowse link
phagosome-lysosome docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in IMP (MGI:5698740|PMID:26450516) UniProt PMID:26450516 MGI:5698740 NCBI chr 7:126,170,571...126,184,991
Ensembl chr 7:126,170,379...126,184,989 		JBrowse link
phagosome-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl8b ADP-ribosylation factor-like 8B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:108,760,020...108,800,684
Ensembl chr 6:108,760,060...108,802,239 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in IMP (MGI:5698740|PMID:26450516) UniProt PMID:26450516 MGI:5698740 NCBI chr 7:126,170,571...126,184,991
Ensembl chr 7:126,170,379...126,184,989 		JBrowse link
G Pikfyve phosphoinositide kinase, FYVE type zinc finger containing involved_in IDA
IBA
ISO		 (MGI:6103777|PMID:28779020) UniProt
GO_Central
MGI		 PMID:28779020 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6103777 NCBI chr 1:65,225,796...65,317,855
Ensembl chr 1:65,225,842...65,317,854 		JBrowse link
G Pla2g5 phospholipase A2, group V involved_in IMP (MGI:3841317|PMID:19342668) UniProt PMID:19342668 MGI:3841317 NCBI chr 4:138,526,558...138,590,784
Ensembl chr 4:138,526,555...138,590,793 		JBrowse link
G Rab20 RAB20, member RAS oncogene family involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:11,503,390...11,528,640
Ensembl chr 8:11,503,518...11,528,710 		JBrowse link
G Rab34 RAB34, member RAS oncogene family involved_in IMP
IBA
ISO		 (MGI:5467668|PMID:23197834) ParkinsonsUK-UCL
GO_Central
MGI		 PMID:23197834 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5467668 NCBI chr11:78,079,253...78,083,019
Ensembl chr11:78,079,256...78,083,019 		JBrowse link
G Rab39 RAB39, member RAS oncogene family involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 9:53,595,410...53,617,532
Ensembl chr 9:53,595,410...53,617,532 		JBrowse link
G Rab7 RAB7, member RAS oncogene family involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 6:87,976,088...88,022,252
Ensembl chr 6:87,976,088...88,022,252 		JBrowse link
G Rab7b RAB7B, member RAS oncogene family involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:131,616,412...131,646,288
Ensembl chr 1:131,616,433...131,643,177 		JBrowse link
G Syt7 synaptotagmin VII involved_in IMP (MGI:3690533|PMID:16982801) UniProt PMID:16982801 MGI:3690533 NCBI chr19:10,366,142...10,430,545
Ensembl chr19:10,366,454...10,430,544 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in IMP (MGI:5693670|PMID:26317472) UniProt PMID:26317472 MGI:5693670 NCBI chr 5:108,777,649...108,795,636
Ensembl chr 5:108,777,636...108,796,648 		JBrowse link
phagosome-lysosome fusion involved in apoptotic cell clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spg11 SPG11, spatacsin vesicle trafficking associated acts_upstream_of_or_within IMP (PMID:26284655) MGI PMID:26284655 NCBI chr 2:121,884,001...121,949,915
Ensembl chr 2:121,884,001...121,948,867 		JBrowse link
positive regulation of lysosomal membrane permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspa8 heat shock protein 8 ISO RGD PMID:9038169 RGD:10059368 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Laptm5 lysosomal-associated protein transmembrane 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:130,640,627...130,663,459
Ensembl chr 4:130,640,436...130,663,452 		JBrowse link
positive regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grn granulin involved_in IDA
ISO		 (MGI:5905514|PMID:28073925) UniProt
MGI		 PMID:28073925 GO_REF:0000119 MGI:4834177 MGI:5905514 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Igtp interferon gamma induced GTPase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:58,090,382...58,098,418
Ensembl chr11:58,090,382...58,098,417 		JBrowse link
G Irgm1 immunity-related GTPase family M member 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:48,756,072...48,762,247
Ensembl chr11:48,752,795...48,762,510 		JBrowse link
G Irgm2 immunity-related GTPase family M member 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:58,105,803...58,113,609
Ensembl chr11:58,090,444...58,113,608 		JBrowse link
G Mcoln1 mucolipin 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:3,550,458...3,565,232
Ensembl chr 8:3,550,457...3,565,232 		JBrowse link
G Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr14:20,549,432...20,596,641
Ensembl chr14:20,549,432...20,596,641 		JBrowse link
regulation of lysosomal lumen pH term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gm6377 predicted gene 6377 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:108,240,362...108,244,051
Ensembl chr  X:108,240,362...108,244,045 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323 		JBrowse link
G Spns1 SPNS lysolipid transporter 1, lysophospholipid acts_upstream_of_or_within IMP (PMID:36161949) MGI PMID:36161949 NCBI chr 7:125,969,232...125,977,179
Ensembl chr 7:125,969,232...125,976,622 		JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr  X:84,820,445...84,935,105
Ensembl chr  X:84,913,960...84,935,105 		JBrowse link
G Tmem165 transmembrane protein 165 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:76,331,727...76,357,091
Ensembl chr 5:76,331,727...76,357,092 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in IMP
ISO		 (MGI:5693670|PMID:26317472) UniProt
MGI		 PMID:26317472 GO_REF:0000119 MGI:4834177 MGI:5693670 NCBI chr 5:108,777,649...108,795,636
Ensembl chr 5:108,777,636...108,796,648 		JBrowse link
G Vps33a VPS33A CORVET/HOPS core subunit involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:123,666,820...123,711,104
Ensembl chr 5:123,666,722...123,711,101 		JBrowse link
regulation of lysosomal membrane permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Laptm4b lysosomal-associated protein transmembrane 4B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:34,238,279...34,284,448
Ensembl chr15:34,238,174...34,284,448 		JBrowse link
regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grn granulin acts_upstream_of_or_within IMP (PMID:28728022) MGI PMID:28728022 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Laptm4b lysosomal-associated protein transmembrane 4B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:34,238,279...34,284,448
Ensembl chr15:34,238,174...34,284,448 		JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within IMP (PMID:28728022) MGI PMID:28728022 NCBI chr 6:13,069,758...13,089,268
Ensembl chr 6:13,069,758...13,089,268 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within IMP (PMID:23160154) MGI PMID:23160154 NCBI chr 9:108,887,000...108,888,791
Ensembl chr 9:108,887,001...108,888,802 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28694
    cellular process 17623
      cellular component organization or biogenesis 6975
        cellular component organization 6763
          organelle organization 3703
            vacuole organization 240
              lytic vacuole organization 106
                lysosome organization + 106
paths to the root