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ONTOLOGY REPORT - ANNOTATIONS

Term:lytic vacuole organization
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Accession:GO:0080171 term browser browse the term
Definition:A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole.
Synonyms:exact_synonym: lytic vacuole organisation
 narrow_synonym: lytic vacuolar assembly
 related_synonym: lytic vacuole biogenesis;   lytic vacuole organization and biogenesis

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lysosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP6AP2 ATPase H+ transporting accessory protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:37,742,550...37,769,022
Ensembl chr  X:37,742,545...37,769,062 		JBrowse link
G CCDC115 coiled-coil domain containing 115 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chr10:66,264...70,711
Ensembl chr10:66,429...70,877 		JBrowse link
G CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:26,320,132...26,343,009
Ensembl chr 5:26,320,061...26,337,402 		JBrowse link
G CLN5 CLN5 intracellular trafficking protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:56,074,701...56,086,433
Ensembl chr 3:56,076,226...56,086,963 		JBrowse link
G CLN6 CLN6 transmembrane ER protein involved_in ISO (PMID:11722572) UniProt PMID:11722572 NCBI chr26:15,259,186...15,278,249 JBrowse link
G CLN6 CLN6 transmembrane ER protein involved_in IEA Ensembl GO_REF:0000107 Ensembl chr26:15,266,732...15,278,418 JBrowse link
G CREG1 cellular repressor of E1A stimulated genes 1 acts_upstream_of_or_within ISO (PMID:33966596) MGI PMID:33966596 NCBI chr25:61,472,601...61,485,568
Ensembl chr25:61,472,617...61,488,999 		JBrowse link
G GRN granulin precursor involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:62,037,344...62,045,765
Ensembl chr16:62,036,412...62,045,614 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in ISO (PMID:37390818) UniProt PMID:37390818 NCBI chr 3:91,295,758...91,319,881
Ensembl chr 3:91,295,681...91,321,333 		JBrowse link
G LAMP2 lysosomal associated membrane protein 2 involved_in IEA Ensembl GO_REF:0000107
G PPT1 palmitoyl-protein thioesterase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:92,809,373...92,833,048
Ensembl chr20:92,809,552...92,833,244 		JBrowse link
G SNAPIN SNAP associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20920792) Ensembl
MGI		 PMID:20920792 GO_REF:0000107 NCBI chr20:10,147,577...10,150,721
Ensembl chr20:10,148,099...10,150,641 		JBrowse link
G TMEM106B transmembrane protein 106B acts_upstream_of_or_within ISO (PMID:28728022) MGI PMID:28728022 NCBI chr21:45,899,428...45,921,500
Ensembl chr21:45,900,531...45,920,569 		JBrowse link
G TMEM199 transmembrane protein 199 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:22,124,413...22,130,922 JBrowse link
G TMEM9 transmembrane protein 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:28,230,915...28,266,835
Ensembl chr25:28,246,845...28,267,421 		JBrowse link
lysosomal lumen pH elevation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (PMID:10924275) UniProt PMID:10924275 NCBI chr 5:26,320,132...26,343,009
Ensembl chr 5:26,320,061...26,337,402 		JBrowse link
G LOC103246503 endosomal/lysosomal potassium channel TMEM175 involved_in ISO (PMID:35333573), (PMID:35750034), (PMID:37390818) UniProt PMID:35333573 PMID:35750034 PMID:37390818 NCBI chr27:47,819,512...47,852,455
Ensembl chr27:47,816,482...47,852,472 		JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein involved_in ISO (PMID:25513726), (PMID:32966160) UniProt PMID:25513726 PMID:32966160 NCBI chr26:54,022,346...54,429,991
Ensembl chr26:54,039,197...54,352,774 		JBrowse link
G SLC45A2 solute carrier family 45 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:33,178,614...33,219,664
Ensembl chr 4:33,179,349...33,219,028 		JBrowse link
lysosomal membrane organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARF1 ADP ribosylation factor 1 ISO RGD PMID:9538255 RGD:9684948 NCBI chr25:1,628,836...1,644,502
Ensembl chr25:1,628,751...1,644,499 		JBrowse link
G ATP10B ATPase phospholipid transporting 10B (putative) involved_in ISO (PMID:32172343) UniProt PMID:32172343 NCBI chr23:62,931,458...63,143,624
Ensembl chr23:62,931,078...63,051,383 		JBrowse link
lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 involved_in ISO (PMID:15163665) BHF-UCL PMID:15163665 NCBI chr12:34,587,123...34,734,936
Ensembl chr12:34,587,118...34,731,642 		JBrowse link
G ACP2 acid phosphatase 2, lysosomal acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15604265)
(PMID:9228031)		 MGI
TreeGrafter		 PMID:9228031 PMID:15604265 GO_REF:0000118 NCBI chr 1:18,061,094...18,070,929
Ensembl chr 1:18,060,994...18,072,208 		JBrowse link
G ACP3 acid phosphatase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:57,887,528...57,934,851
Ensembl chr15:57,887,365...57,934,707 		JBrowse link
G ACP4 acid phosphatase 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:43,838,103...43,843,715
Ensembl chr 6:43,838,321...43,843,654 		JBrowse link
G AKTIP AKT interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:39,283,607...39,295,320
Ensembl chr 5:39,284,308...39,295,284 		JBrowse link
G AP3B1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO (PMID:30786955), (PMID:9931340) MGI PMID:9931340 PMID:30786955 NCBI chr 4:72,225,658...72,524,971
Ensembl chr 4:72,225,599...72,524,933 		JBrowse link
G AP5Z1 adaptor related protein complex 5 subunit zeta 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:37871017) MGI
Ensembl		 PMID:37871017 GO_REF:0000107 NCBI chr28:16,852,314...16,868,408
Ensembl chr28:16,851,998...16,868,395 		JBrowse link
G ARSG arylsulfatase G acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:26975023) MGI
Ensembl		 PMID:26975023 GO_REF:0000107 NCBI chr16:53,133,829...53,273,844
Ensembl chr16:53,134,634...53,272,434 		JBrowse link
G BECN1 beclin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18497889) Ensembl
MGI		 PMID:18497889 GO_REF:0000107 NCBI chr16:63,469,187...63,482,627
Ensembl chr16:63,469,192...63,485,322 		JBrowse link
G CHMP5 charged multivesicular body protein 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16567502) Ensembl
MGI		 PMID:16567502 GO_REF:0000107 NCBI chr12:46,989,349...47,006,035
Ensembl chr12:46,988,340...47,006,742 		JBrowse link
G CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15588329)
(PMID:10191119), (PMID:10527801)
(PMID:10440905)		 MGI
TreeGrafter		 PMID:10191119 PMID:10440905 PMID:10527801 PMID:15588329 GO_REF:0000118 NCBI chr 5:26,320,132...26,343,009
Ensembl chr 5:26,320,061...26,337,402 		JBrowse link
G CLN5 CLN5 intracellular trafficking protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15459177) Ensembl
TreeGrafter
MGI		 PMID:15459177 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:56,074,701...56,086,433
Ensembl chr 3:56,076,226...56,086,963 		JBrowse link
G CLN6 CLN6 transmembrane ER protein acts_upstream_of_or_within ISO (PMID:26681805), (PMID:9600738) MGI PMID:9600738 PMID:26681805 NCBI chr26:15,259,186...15,278,249 JBrowse link
G CLN6 CLN6 transmembrane ER protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr26:15,266,732...15,278,418 JBrowse link
G CLN8 CLN8 transmembrane ER and ERGIC protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10087069), (PMID:7613514), (PMID:8144516), (PMID:8160780) Ensembl
MGI		 PMID:7613514 PMID:8144516 PMID:8160780 PMID:10087069 GO_REF:0000107 NCBI chr 8:1,424,402...1,445,505
Ensembl chr 8:1,433,953...1,445,021 		JBrowse link
G CLVS1 clavesin 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:57,174,083...57,378,424
Ensembl chr 8:57,174,291...57,380,412 		JBrowse link
G CLVS2 clavesin 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:50,743,405...50,816,387
Ensembl chr13:50,749,014...50,815,951 		JBrowse link
G CREG1 cellular repressor of E1A stimulated genes 1 acts_upstream_of_or_within ISO (PMID:33966596) MGI PMID:33966596 NCBI chr25:61,472,601...61,485,568
Ensembl chr25:61,472,617...61,488,999 		JBrowse link
G FHIP1B FHF complex subunit HOOK interacting protein 1B involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:58,592,828...58,625,732
Ensembl chr 1:58,592,886...58,626,272 		JBrowse link
G GAA alpha glucosidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15169761), (PMID:9668092)
(PMID:10547605), (PMID:11328962), (PMID:12115977), (PMID:9384603)		 Ensembl
TreeGrafter
MGI		 PMID:9384603 PMID:9668092 PMID:10547605 PMID:11328962 PMID:12115977 More... GO_REF:0000107 GO_REF:0000118 NCBI chr16:72,064,315...72,083,293
Ensembl chr16:72,067,267...72,083,349 		JBrowse link
G GBA1 glucosylceramidase beta 1 involved_in ISO (PMID:27378698)
(MGI:5817293|PMID:27378698)		 UniProt PMID:27378698 MGI:5817293 NCBI chr20:8,598,110...8,631,517
Ensembl chr20:8,598,628...8,630,990 		JBrowse link
G GNPTAB N-acetylglucosamine-1-phosphate transferase subunits alpha and beta involved_in ISO (PMID:21719679) UniProt PMID:21719679 NCBI chr11:96,998,671...97,084,333
Ensembl chr11:96,999,646...97,084,225 		JBrowse link
G GRN granulin precursor involved_in ISO (MGI:6274951|PMID:27789271) UniProt PMID:27789271 MGI:6274951 NCBI chr16:62,037,344...62,045,765
Ensembl chr16:62,036,412...62,045,614 		JBrowse link
G HEXA hexosaminidase subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8747922)
(PMID:10591619), (PMID:14972652), (PMID:9302266), (PMID:9645704)
(PMID:8896570), (PMID:9184660)
(PMID:7937929), (PMID:9103204)		 Ensembl
MGI		 PMID:7937929 PMID:8747922 PMID:8896570 PMID:9103204 PMID:9184660 More... GO_REF:0000107 NCBI chr26:11,081,985...11,130,366
Ensembl chr26:11,082,468...11,116,075 		JBrowse link
G HEXB hexosaminidase subunit beta acts_upstream_of_or_within ISO (PMID:8789434), (PMID:9645704)
(PMID:8896570), (PMID:9184660)		 MGI PMID:8789434 PMID:8896570 PMID:9184660 PMID:9645704 NCBI chr 4:69,037,532...69,065,925
Ensembl chr 4:69,037,583...69,065,814 		JBrowse link
G HOOK1 hook microtubule tethering protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:73,137,181...73,198,389
Ensembl chr20:73,133,522...73,198,205 		JBrowse link
G HOOK2 hook microtubule tethering protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:11,452,154...11,464,718
Ensembl chr 6:11,449,026...11,464,622 		JBrowse link
G HOOK3 hook microtubule tethering protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:40,897,108...41,023,068
Ensembl chr 8:40,897,209...41,021,808 		JBrowse link
G HPS1 HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 acts_upstream_of_or_within ISO (PMID:30786955) MGI PMID:30786955 NCBI chr 9:91,575,408...91,606,514
Ensembl chr 9:91,576,600...91,604,972 		JBrowse link
G HPS4 HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:9,356,868...9,387,847
Ensembl chr19:9,356,145...9,386,254 		JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29180785) Ensembl
MGI		 PMID:29180785 GO_REF:0000107 NCBI chr16:63,730,303...63,733,974
Ensembl chr16:63,728,777...63,732,411 		JBrowse link
G IDUA alpha-L-iduronidase acts_upstream_of_or_within ISO (PMID:19751987)
(PMID:9097952)		 MGI PMID:9097952 PMID:19751987 NCBI chr27:47,778,220...47,794,435
Ensembl chr27:47,778,335...47,794,352 		JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:63,301,354...63,307,716
Ensembl chr 1:63,301,885...63,307,553 		JBrowse link
G LIPA lipase A, lysosomal acid type involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25807535)
(PMID:29374543)		 Ensembl
MGI		 PMID:25807535 PMID:29374543 GO_REF:0000107 NCBI chr 9:82,639,220...82,677,479
Ensembl chr 9:82,638,621...82,677,488 		JBrowse link
G LOC119623630 lysosomal acid glucosylceramidase involved_in IEA Ensembl GO_REF:0000107
G LRRK2 leucine rich repeat kinase 2 involved_in ISO (PMID:25416817) ParkinsonsUK-UCL PMID:25416817 NCBI chr11:36,490,775...36,634,215
Ensembl chr11:36,492,011...36,634,216 		JBrowse link
G LYSET lysosomal enzyme trafficking factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:70,921,807...70,923,947
Ensembl chr24:70,922,060...70,924,183 		JBrowse link
G LYST lysosomal trafficking regulator acts_upstream_of_or_within ISO (PMID:1113502), (PMID:4031470), (PMID:4697831), (PMID:6170520)
(PMID:9368050)		 MGI PMID:1113502 PMID:4031470 PMID:4697831 PMID:6170520 PMID:9368050 NCBI chr25:72,827,997...73,048,645
Ensembl chr25:72,828,006...72,991,970 		JBrowse link
G MBTPS1 membrane bound transcription factor peptidase, site 1 involved_in ISO (PMID:21719679) UniProt PMID:21719679 NCBI chr 5:69,464,064...69,527,588
Ensembl chr 5:69,463,920...69,527,541 		JBrowse link
G MFSD8 major facilitator superfamily domain containing 8 acts_upstream_of_or_within ISO (PMID:26681805)
(PMID:24423645), (PMID:35025759)
(PMID:35025759)		 MGI PMID:24423645 PMID:26681805 PMID:35025759 NCBI chr 7:75,043,740...75,096,894
Ensembl chr 7:75,046,545...75,072,258 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020 		JBrowse link
G MYO7A myosin VIIA involved_in ISO (PMID:16001398) UniProt PMID:16001398 NCBI chr 1:68,334,781...68,423,215
Ensembl chr 1:68,350,598...68,425,625 		JBrowse link
G NAGLU N-acetyl-alpha-glucosaminidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17712420), (PMID:19632871), (PMID:25524704), (PMID:26607664) Ensembl
MGI		 PMID:17712420 PMID:19632871 PMID:25524704 PMID:26607664 GO_REF:0000107 NCBI chr16:63,735,411...63,744,365 JBrowse link
G PI4KB phosphatidylinositol 4-kinase beta acts_upstream_of_or_within ISO (PMID:25365221) MGI PMID:25365221 NCBI chr20:12,358,758...12,395,372
Ensembl chr20:12,358,762...12,394,661 		JBrowse link
G PPT1 palmitoyl-protein thioesterase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16542649)
(PMID:16368712)		 Ensembl
MGI		 PMID:16368712 PMID:16542649 GO_REF:0000107 NCBI chr20:92,809,373...92,833,048
Ensembl chr20:92,809,552...92,833,244 		JBrowse link
G SNAPIN SNAP associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20920792) Ensembl
TreeGrafter
MGI		 PMID:20920792 GO_REF:0000107 GO_REF:0000118 NCBI chr20:10,147,577...10,150,721
Ensembl chr20:10,148,099...10,150,641 		JBrowse link
G SPG11 SPG11 vesicle trafficking associated, spatacsin acts_upstream_of_or_within ISO (PMID:25365221)
(PMID:37871017)
(PMID:26284655)
(PMID:28237315), (PMID:31637311)		 MGI PMID:25365221 PMID:26284655 PMID:28237315 PMID:31637311 PMID:37871017 NCBI chr26:38,386,000...38,482,236 JBrowse link
G TFE3 transcription factor binding to IGHM enhancer 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:46,141,377...46,155,445
Ensembl chr  X:46,140,543...46,155,372 		JBrowse link
G TFEB transcription factor EB involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:31637311) Ensembl
MGI		 PMID:31637311 GO_REF:0000107 NCBI chr17:30,425,893...30,478,954
Ensembl chr17:30,426,260...30,479,124 		JBrowse link
G TMEM106B transmembrane protein 106B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25066864) MGI
TreeGrafter		 PMID:25066864 GO_REF:0000118 NCBI chr21:45,899,428...45,921,500
Ensembl chr21:45,900,531...45,920,569 		JBrowse link
G TPCN2 two pore segment channel 2 involved_in ISO (PMID:25416817) ParkinsonsUK-UCL PMID:25416817 NCBI chr 1:5,491,476...5,529,015
Ensembl chr 1:5,490,910...5,528,718 		JBrowse link
G TPP1 tripeptidyl peptidase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15483130) Ensembl
MGI		 PMID:15483130 GO_REF:0000107 NCBI chr 1:58,205,999...58,211,743
Ensembl chr 1:58,206,072...58,210,945 		JBrowse link
G VPS18 VPS18 core subunit of CORVET and HOPS complexes involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr26:42,091,348...42,100,264
Ensembl chr26:42,088,938...42,100,243 		JBrowse link
G VPS35 VPS35 retromer complex component involved_in ISO (MGI:5694519|PMID:26203154) ParkinsonsUK-UCL PMID:26203154 MGI:5694519 NCBI chr 5:32,509,037...32,539,371
Ensembl chr 5:32,508,580...32,539,343 		JBrowse link
G WASHC5 WASH complex subunit 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30061306) Ensembl
MGI		 PMID:30061306 GO_REF:0000107 NCBI chr 8:119,612,921...119,679,058
Ensembl chr 8:119,611,210...119,668,885 		JBrowse link
G ZFYVE26 zinc finger FYVE-type containing 26 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25365221)
(PMID:37871017)		 MGI
Ensembl		 PMID:25365221 PMID:37871017 GO_REF:0000107 NCBI chr24:44,986,610...45,053,801
Ensembl chr24:44,986,609...45,053,134 		JBrowse link
G ZKSCAN3 zinc finger with KRAB and SCAN domains 3 involved_in ISO (PMID:23434374) UniProt PMID:23434374 NCBI chr17:44,199,513...44,216,456
Ensembl chr17:44,200,164...44,216,706 		JBrowse link
multivesicular body-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHMP3 charged multivesicular body protein 3 involved_in ISO (PMID:16554368) ParkinsonsUK-UCL PMID:16554368 NCBI chr14:20,536,490...20,654,761
Ensembl chr14:20,594,817...20,654,404 		JBrowse link
negative regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN1 beclin 1 ISO RGD PMID:25561470 RGD:11561937 NCBI chr16:63,469,187...63,482,627
Ensembl chr16:63,469,192...63,485,322 		JBrowse link
G FLCN folliculin involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:16,245,840...16,271,465
Ensembl chr16:16,245,715...16,267,698 		JBrowse link
G FNIP1 folliculin interacting protein 1 involved_in ISO (PMID:37079666) UniProt PMID:37079666 NCBI chr23:34,443,171...34,637,797
Ensembl chr23:34,480,901...34,637,662 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020 		JBrowse link
phagolysosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CORO1A coronin 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:26,482,269...26,488,537
Ensembl chr 5:26,480,753...26,487,929 		JBrowse link
G LOC103247472 sushi repeat containing protein X-linked acts_upstream_of_or_within ISO (PMID:19368996) MGI PMID:19368996
G MYO7A myosin VIIA acts_upstream_of_or_within ISO (PMID:12743369) MGI PMID:12743369 NCBI chr 1:68,334,781...68,423,215
Ensembl chr 1:68,350,598...68,425,625 		JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:11544318) MGI PMID:11544318 NCBI chr11:116,505,975...116,560,151
Ensembl chr11:116,529,346...116,563,059 		JBrowse link
G SRPX sushi repeat containing protein X-linked involved_in IEA TreeGrafter GO_REF:0000118
phagosome-lysosome docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (MGI:5698740|PMID:26450516) UniProt PMID:26450516 MGI:5698740 NCBI chr 5:26,320,132...26,343,009
Ensembl chr 5:26,320,061...26,337,402 		JBrowse link
phagosome-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARL8B ADP ribosylation factor like GTPase 8B involved_in ISO (PMID:21802320) UniProt PMID:21802320 NCBI chr22:41,192,458...41,247,048
Ensembl chr22:41,192,484...41,244,822 		JBrowse link
G CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (MGI:5698740|PMID:26450516) UniProt PMID:26450516 MGI:5698740 NCBI chr 5:26,320,132...26,343,009
Ensembl chr 5:26,320,061...26,337,402 		JBrowse link
G DNAJC27 DnaJ heat shock protein family (Hsp40) member C27 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:82,695,889...82,725,142
Ensembl chr14:82,695,850...82,720,956 		JBrowse link
G LOC103246503 endosomal/lysosomal potassium channel TMEM175 involved_in ISO (MGI:5693670|PMID:26317472) UniProt PMID:26317472 MGI:5693670 NCBI chr27:47,819,512...47,852,455
Ensembl chr27:47,816,482...47,852,472 		JBrowse link
G PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:94,051,096...94,144,968
Ensembl chr10:94,056,923...94,145,268 		JBrowse link
G PLA2G5 phospholipase A2 group V involved_in ISO (MGI:3841317|PMID:19342668) UniProt PMID:19342668 MGI:3841317 NCBI chr20:112,465,341...112,487,082
Ensembl chr20:112,464,033...112,487,089 		JBrowse link
G RAB20 RAB20, member RAS oncogene family involved_in ISO (PMID:21255211) UniProt PMID:21255211 NCBI chr 3:88,769,676...88,803,384
Ensembl chr 3:88,770,271...88,803,177 		JBrowse link
G RAB29 RAB29, member RAS oncogene family involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr25:23,572,001...23,579,881
Ensembl chr25:23,572,542...23,577,695 		JBrowse link
G RAB32 RAB32, member RAS oncogene family involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:25,265,831...25,281,106 JBrowse link
G RAB34 RAB34, member RAS oncogene family involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:22,482,012...22,486,159
Ensembl chr16:22,481,747...22,485,186 		JBrowse link
G RAB38 RAB38, member RAS oncogene family involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:79,256,996...79,316,967
Ensembl chr 1:79,256,835...79,316,789 		JBrowse link
G RAB39A RAB39A, member RAS oncogene family involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:99,353,125...99,388,429
Ensembl chr 1:99,353,210...99,387,262 		JBrowse link
G RAB7A RAB7A, member RAS oncogene family involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:52,231,481...52,309,276
Ensembl chr22:52,230,835...52,309,306 		JBrowse link
G RAB7B RAB7B, member RAS oncogene family involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr25:23,341,090...23,367,414
Ensembl chr25:23,341,490...23,367,398 		JBrowse link
G SYT7 synaptotagmin 7 involved_in ISO (MGI:3690533|PMID:16982801) UniProt PMID:16982801 MGI:3690533 NCBI chr 1:12,267,591...12,333,181
Ensembl chr 1:12,267,685...12,333,185 		JBrowse link
phagosome-lysosome fusion involved in apoptotic cell clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPG11 SPG11 vesicle trafficking associated, spatacsin acts_upstream_of_or_within ISO (PMID:26284655) MGI PMID:26284655 NCBI chr26:38,386,000...38,482,236 JBrowse link
positive regulation of lysosomal membrane permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO RGD PMID:9038169 RGD:10059368 NCBI chr 1:114,447,348...114,452,693
Ensembl chr 1:114,446,544...114,451,562 		JBrowse link
G LAPTM5 lysosomal protein transmembrane 5 involved_in ISO (PMID:19787053) ARUK-UCL PMID:19787053 NCBI chr20:102,080,500...102,106,649
Ensembl chr20:102,080,508...102,106,729 		JBrowse link
positive regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRN granulin precursor involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:62,037,344...62,045,765
Ensembl chr16:62,036,412...62,045,614 		JBrowse link
G IRGM immunity related GTPase M involved_in ISO (PMID:32753672) UniProt PMID:32753672 NCBI chr23:53,449,576...53,451,373 JBrowse link
G MCOLN1 mucolipin TRP cation channel 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:7,019,132...7,030,675
Ensembl chr 6:7,019,277...7,030,474 		JBrowse link
G PPP3CB protein phosphatase 3 catalytic subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:57,782,256...57,841,307
Ensembl chr 9:57,782,304...57,844,573 		JBrowse link
regulation of lysosomal lumen pH term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103246503 endosomal/lysosomal potassium channel TMEM175 involved_in ISO (PMID:35750034)
(MGI:5693670|PMID:26317472)		 UniProt PMID:26317472 PMID:35750034 MGI:5693670 NCBI chr27:47,819,512...47,852,455
Ensembl chr27:47,816,482...47,852,472 		JBrowse link
G LRRK2 leucine rich repeat kinase 2 involved_in ISO (PMID:22012985) ParkinsonsUK-UCL PMID:22012985 NCBI chr11:36,490,775...36,634,215
Ensembl chr11:36,492,011...36,634,216 		JBrowse link
G SPNS1 SPNS lysolipid transporter 1, lysophospholipid acts_upstream_of_or_within ISO (PMID:36161949) MGI PMID:36161949 NCBI chr 5:26,085,461...26,095,585
Ensembl chr 5:26,085,918...26,095,309 		JBrowse link
G TASL TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:28,953,805...28,973,055
Ensembl chr  X:28,954,266...28,955,171 		JBrowse link
G TMEM165 transmembrane protein 165 involved_in ISO (PMID:23569283) UniProt PMID:23569283 NCBI chr 7:13,136,414...13,167,521
Ensembl chr 7:13,135,845...13,167,499 		JBrowse link
G VPS33A VPS33A core subunit of CORVET and HOPS complexes involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:117,585,325...117,618,713
Ensembl chr11:117,582,781...117,615,743 		JBrowse link
regulation of lysosomal membrane permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LAPTM4B lysosomal protein transmembrane 4 beta involved_in ISO (PMID:26280656) UniProt PMID:26280656 NCBI chr 8:92,695,445...92,771,935 JBrowse link
G LAPTM4B lysosomal protein transmembrane 4 beta involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 8:92,696,195...92,772,076 JBrowse link
regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRN granulin precursor acts_upstream_of_or_within ISO (PMID:28728022) MGI PMID:28728022 NCBI chr16:62,037,344...62,045,765
Ensembl chr16:62,036,412...62,045,614 		JBrowse link
G LAPTM4B lysosomal protein transmembrane 4 beta involved_in ISO (PMID:26280656) UniProt PMID:26280656 NCBI chr 8:92,695,445...92,771,935 JBrowse link
G LAPTM4B lysosomal protein transmembrane 4 beta involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 8:92,696,195...92,772,076 JBrowse link
G TMEM106B transmembrane protein 106B acts_upstream_of_or_within ISO (PMID:28728022) MGI PMID:28728022 NCBI chr21:45,899,428...45,921,500
Ensembl chr21:45,900,531...45,920,569 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO (PMID:23160154) MGI PMID:23160154 NCBI chr22:9,869,502...9,871,659 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17080
    cellular process 15997
      cellular component organization or biogenesis 6843
        cellular component organization 6618
          organelle organization 3704
            vacuole organization 221
              lytic vacuole organization 100
                lysosome organization + 100
paths to the root