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ONTOLOGY REPORT - ANNOTATIONS


Term:CAAX-box protein maturation
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Accession:GO:0080120 term browser browse the term
Definition:A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
Synonyms:related_synonym: CAAX-box protein processing;   farnesylated protein maturation


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CAAX-box protein processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like involved_in ISO (PMID:19188362) RGD PMID:19188362 NCBI chr 1:169,720,247...169,721,788
Ensembl chr 1:169,720,253...169,721,758
JBrowse link
G Rce1 Ras converting CAAX endopeptidase 1 involved_in IBA
IEA
ISO
ISS
PMID:21873635
GO_REF:0000107
(PMID:10085068), (PMID:19188362)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:10085068 PMID:19188362, PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 1:219,860,826...219,863,933
Ensembl chr 1:219,860,827...219,863,926
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:139,982,404...140,015,541
Ensembl chr 5:139,983,680...140,015,541
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        cellular macromolecule metabolic process 8243
          cellular protein metabolic process 5230
            CAAX-box protein maturation 3
              CAAX-box protein modification 0
              CAAX-box protein processing 3
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      nitrogen compound metabolic process 10017
        organonitrogen compound metabolic process 6803
          protein metabolic process 5893
            protein maturation 312
              CAAX-box protein maturation 3
                CAAX-box protein modification 0
                CAAX-box protein processing 3
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