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ONTOLOGY REPORT - ANNOTATIONS


Term:CAAX-box protein maturation
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Accession:GO:0080120 term browser browse the term
Definition:A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
Synonyms:related_synonym: CAAX-box protein processing;   farnesylated protein maturation



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CAAX-box protein maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 involved_in ISO (PMID:20709748) RGD PMID:20709748 NCBI chr 2:227,500,366...227,645,243
Ensembl chr 2:227,500,367...227,645,169
JBrowse link
CAAX-box protein processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like involved_in ISO (PMID:19188362) RGD PMID:19188362 NCBI chr 1:159,151,417...159,155,192
Ensembl chr 1:159,151,432...159,155,192
JBrowse link
G Rce1 Ras converting CAAX endopeptidase 1 involved_in ISS
IEA
IBA
ISO
GO_REF:0000024
GO_REF:0000002
PMID:21873635
(PMID:10085068), (PMID:19188362)
UniProt
InterPro
RGD
PMID:10085068 PMID:19188362 PMID:21873635 GO_REF:0000002 GO_REF:0000024, RGD:13792537 NCBI chr 1:201,899,358...201,902,593
Ensembl chr 1:201,899,358...201,902,484
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19874
    metabolic process 12191
      primary metabolic process 10954
        protein metabolic process 6102
          protein maturation 365
            CAAX-box protein maturation 4
              CAAX-box protein modification 0
              CAAX-box protein processing 3
Path 2
Term Annotations click to browse term
  biological_process 19874
    metabolic process 12191
      organic substance metabolic process 11722
        macromolecule metabolic process 10080
          gene expression 6640
            protein maturation 365
              CAAX-box protein maturation 4
                CAAX-box protein modification 0
                CAAX-box protein processing 3
paths to the root