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ONTOLOGY REPORT - ANNOTATIONS

Term:CAAX-box protein maturation
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Accession:GO:0080120 term browser browse the term
Definition:A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
Synonyms:related_synonym: CAAX-box protein processing;   farnesylated protein maturation


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CAAX-box protein maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icmt isoprenylcysteine carboxyl methyltransferase involved_in ISO MGI:2680650 (PMID:10747846) RGD PMID:10747846 NCBI chr 5:168,084,487...168,097,519 JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 involved_in ISO (PMID:20709748) RGD PMID:20709748 NCBI chr 2:227,500,366...227,645,213 JBrowse link
G Rce1 Ras converting CAAX endopeptidase 1 involved_in ISO MGI:1857763 (PMID:10085069) RGD PMID:10085069 NCBI chr 1:201,899,358...201,902,593 JBrowse link
CAAX-box protein processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rce1 Ras converting CAAX endopeptidase 1 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
(PMID:10085068), (PMID:19188362)		 UniProt
GO_Central
Ensembl
InterPro
RGD		 PMID:10085068 PMID:19188362 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:201,899,358...201,902,593 JBrowse link
G Usp17la2 ubiquitin specific peptidase 17-like a2 involved_in ISO (PMID:19188362) RGD PMID:19188362 NCBI chr 1:159,151,417...159,155,192 JBrowse link
G Zmpste24 zinc metallopeptidase STE24 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:139,912,395...139,945,532 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      metabolic process 12157
        macromolecule metabolic process 9981
          protein metabolic process 5231
            protein maturation 625
              CAAX-box protein maturation 5
                CAAX-box protein processing 3
Path 2
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      metabolic process 12157
        biosynthetic process 8641
          macromolecule biosynthetic process 7653
            gene expression 7211
              protein maturation 625
                CAAX-box protein maturation 5
                  CAAX-box protein processing 3
paths to the root