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ONTOLOGY REPORT - ANNOTATIONS

Term:Cul4-RING E3 ubiquitin ligase complex
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Accession:GO:0080008 term browser browse the term
Definition:A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.


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Cul4-RING E3 ubiquitin ligase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBRA1 autophagy and beclin 1 regulator 1 part_of IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:15,935,354...16,119,082
Ensembl chr 2:15,935,375...16,119,079 		JBrowse link
G CUL4A cullin 4A part_of IEA Ensembl GO_REF:0000107 NCBI chr11:78,557,030...78,588,964
Ensembl chr11:78,557,013...78,589,193 		JBrowse link
G CUL4B cullin 4B part_of IEA Ensembl GO_REF:0000107 NCBI chr  X:98,668,945...98,730,582
Ensembl chr  X:98,668,953...98,730,565 		JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr13:33,670,976...33,750,872
Ensembl chr13:33,670,977...33,750,772 		JBrowse link
G DCAF10 DDB1 and CUL4 associated factor 10 part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:238,567,612...238,633,471
Ensembl chr 1:238,567,611...238,633,462 		JBrowse link
G DCAF11 DDB1 and CUL4 associated factor 11 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:75,169,701...75,181,137
Ensembl chr 7:75,168,992...75,180,953 		JBrowse link
G DCAF12 DDB1 and CUL4 associated factor 12 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr10:32,673,982...32,714,940
Ensembl chr10:32,674,045...32,714,940 		JBrowse link
G DCAF13 DDB1 and CUL4 associated factor 13 part_of IEA Ensembl GO_REF:0000107 NCBI chr 4:33,672,867...33,704,888
Ensembl chr 4:33,672,869...33,704,573 		JBrowse link
G DCAF15 DDB1 and CUL4 associated factor 15 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:65,205,657...65,213,514
Ensembl chr 2:65,205,659...65,213,518 		JBrowse link
G DCAF16 DDB1 and CUL4 associated factor 16 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:12,751,199...12,763,777
Ensembl chr 8:12,750,694...12,751,963 		JBrowse link
G DCAF17 DDB1 and CUL4 associated factor 17 part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:77,564,629...77,603,913
Ensembl chr15:77,564,646...77,603,620 		JBrowse link
G DCAF4 DDB1 and CUL4 associated factor 4 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 7:96,288,760...96,319,279 JBrowse link
G DCAF5 DDB1 and CUL4 associated factor 5 part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:92,717,544...92,813,297
Ensembl chr 7:92,715,384...92,812,979 		JBrowse link
G DCAF6 DDB1 and CUL4 associated factor 6 part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:82,911,576...83,069,718
Ensembl chr 4:82,911,577...83,069,699 		JBrowse link
G DCAF7 DDB1 and CUL4 associated factor 7 part_of IEA Ensembl GO_REF:0000107 NCBI chr12:15,319,578...15,350,996
Ensembl chr12:15,319,593...15,350,976 		JBrowse link
G DCAF8 DDB1 and CUL4 associated factor 8 part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:90,214,916...90,263,259
Ensembl chr 4:90,214,973...90,261,737 		JBrowse link
G DDA1 DET1 and DDB1 associated 1 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:60,367,168...60,376,986
Ensembl chr 2:60,367,166...60,376,958 		JBrowse link
G DDB1 damage specific DNA binding protein 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr 2:10,171,554...10,201,602
Ensembl chr 2:10,171,502...10,201,598 		JBrowse link
G DDB2 damage specific DNA binding protein 2 part_of IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 2:15,342,614...15,370,623
Ensembl chr 2:15,337,743...15,383,120 		JBrowse link
G DET1 DET1 partner of COP1 E3 ubiquitin ligase part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:191,263,449...191,284,973
Ensembl chr 1:191,263,448...191,284,967 		JBrowse link
G DTL denticleless E3 ubiquitin protein ligase homolog part_of IEA Ensembl GO_REF:0000107 NCBI chr 9:131,225,840...131,275,426
Ensembl chr 9:131,227,705...131,275,451 		JBrowse link
G ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit part_of IEA Ensembl GO_REF:0000107 NCBI chr16:39,704,602...39,770,330
Ensembl chr16:39,701,702...39,770,315 		JBrowse link
G FBXW5 F-box and WD repeat domain containing 5 part_of IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107
G LOC100515809 DDB1- and CUL4-associated factor 8 pseudogene part_of IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:23,567,816...23,570,915 JBrowse link
G LOC100521308 DDB1- and CUL4-associated factor 12-like protein 2 part_of IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:103,322,468...103,327,458
Ensembl chr  X:103,325,989...103,327,383 		JBrowse link
G PSME1 proteasome activator subunit 1 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 7:75,161,830...75,164,531
Ensembl chr 7:75,160,766...75,164,810 		JBrowse link
G TRPC4AP transient receptor potential cation channel subfamily C member 4 associated protein is_active_in
part_of		 ISO
IEA		 (PMID:29779948) UniProt
Ensembl		 PMID:29779948 GO_REF:0000107 NCBI chr17:38,385,650...38,468,290
Ensembl chr17:38,385,653...38,468,295 		JBrowse link
G WDTC1 WD and tetratricopeptide repeats 1 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 6:84,467,532...84,537,069
Ensembl chr 6:84,467,735...84,536,584 		JBrowse link
Cul4A-RING E3 ubiquitin ligase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 part_of
located_in		 IEA
ISO		 (PMID:24076655) Ensembl
UniProt		 PMID:24076655 GO_REF:0000107 NCBI chr 7:60,707,483...60,824,117
Ensembl chr 7:60,710,051...60,824,101 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B part_of IEA Ensembl GO_REF:0000107 NCBI chr 5:59,731,224...59,735,831
Ensembl chr 5:59,731,206...59,735,831 		JBrowse link
G COP1 COP1 E3 ubiquitin ligase part_of IEA Ensembl GO_REF:0000107 NCBI chr 9:117,913,504...118,114,268
Ensembl chr 9:117,915,443...118,114,259 		JBrowse link
G CRBN cereblon part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:59,733,503...59,757,776
Ensembl chr13:59,730,639...59,757,860 		JBrowse link
G CUL4A cullin 4A part_of
located_in		 IEA
IBA
ISO		 (PMID:22118460) Ensembl
TreeGrafter
GO_Central
ComplexPortal		 PMID:22118460 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr11:78,557,030...78,588,964
Ensembl chr11:78,557,013...78,589,193 		JBrowse link
G CUL4B cullin 4B located_in
part_of		 ISO (PMID:22118460)
(MGI:6867266|PMID:22118460)		 ComplexPortal PMID:22118460 MGI:6867266 NCBI chr  X:98,668,945...98,730,582
Ensembl chr  X:98,668,953...98,730,565 		JBrowse link
G DDB1 damage specific DNA binding protein 1 part_of
located_in		 IEA
ISO		 (PMID:22118460) Ensembl
ComplexPortal		 PMID:22118460 GO_REF:0000107 NCBI chr 2:10,171,554...10,201,602
Ensembl chr 2:10,171,502...10,201,598 		JBrowse link
G DDB2 damage specific DNA binding protein 2 located_in
part_of		 ISO (PMID:22118460)
(MGI:6867266|PMID:22118460)		 ComplexPortal PMID:22118460 MGI:6867266 NCBI chr 2:15,342,614...15,370,623
Ensembl chr 2:15,337,743...15,383,120 		JBrowse link
G DET1 DET1 partner of COP1 E3 ubiquitin ligase part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:191,263,449...191,284,973
Ensembl chr 1:191,263,448...191,284,967 		JBrowse link
G DTL denticleless E3 ubiquitin protein ligase homolog part_of IEA Ensembl GO_REF:0000107 NCBI chr 9:131,225,840...131,275,426
Ensembl chr 9:131,227,705...131,275,451 		JBrowse link
G ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr16:39,704,602...39,770,330
Ensembl chr16:39,701,702...39,770,315 		JBrowse link
G GLMN glomulin, FKBP associated protein part_of IEA Ensembl GO_REF:0000107 NCBI chr 4:124,773,957...124,813,336
Ensembl chr 4:124,773,980...124,813,335 		JBrowse link
G RBX1 ring-box 1 located_in
part_of		 ISO
IEA		 (PMID:22118460) ComplexPortal
Ensembl		 PMID:22118460 GO_REF:0000107 NCBI chr 5:7,500,492...7,515,388
Ensembl chr 5:7,500,490...7,515,370 		JBrowse link
G TRPC4AP transient receptor potential cation channel subfamily C member 4 associated protein part_of IEA
IBA		 InterPro
GO_Central
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:38,385,650...38,468,290
Ensembl chr17:38,385,653...38,468,295 		JBrowse link
Cul4B-RING E3 ubiquitin ligase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CUL4B cullin 4B part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:98,668,945...98,730,582
Ensembl chr  X:98,668,953...98,730,565 		JBrowse link
G DDB1 damage specific DNA binding protein 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr 2:10,171,554...10,201,602
Ensembl chr 2:10,171,502...10,201,598 		JBrowse link
G DDB2 damage specific DNA binding protein 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr 2:15,342,614...15,370,623
Ensembl chr 2:15,337,743...15,383,120 		JBrowse link
G DTL denticleless E3 ubiquitin protein ligase homolog part_of IEA Ensembl GO_REF:0000107 NCBI chr 9:131,225,840...131,275,426
Ensembl chr 9:131,227,705...131,275,451 		JBrowse link
G LOC102159347 cullin-4B-like part_of IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr  Y:40,605,592...40,753,014 JBrowse link
G RBX1 ring-box 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr 5:7,500,492...7,515,388
Ensembl chr 5:7,500,490...7,515,370 		JBrowse link
G WDR77 WD repeat domain 77 part_of IEA Ensembl GO_REF:0000107 NCBI chr 4:108,907,192...108,915,594
Ensembl chr 4:108,907,200...108,922,144 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18700
    protein-containing complex 6005
      intracellular protein-containing complex 907
        ubiquitin ligase complex 319
          cullin-RING ubiquitin ligase complex 186
            Cul4-RING E3 ubiquitin ligase complex 36
              CLRC complex 0
              Cul4A-RING E3 ubiquitin ligase complex 14
              Cul4B-RING E3 ubiquitin ligase complex 7
Path 2
Term Annotations click to browse term
  cellular_component 18700
    protein-containing complex 6005
      catalytic complex 1712
        transferase complex 838
          ubiquitin ligase complex 319
            cullin-RING ubiquitin ligase complex 186
              Cul4-RING E3 ubiquitin ligase complex 36
                CLRC complex 0
                Cul4A-RING E3 ubiquitin ligase complex 14
                Cul4B-RING E3 ubiquitin ligase complex 7
paths to the root