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ONTOLOGY REPORT - ANNOTATIONS

Term:EMC complex
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Accession:GO:0072546 term browser browse the term
Definition:A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
Comment:Note that this complex used to be thought to be involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane, but newer findings show that this was incorrect.
Synonyms:exact_synonym: ER membrane protein complex
 broad_synonym: endoplasmic reticulum membrane protein complex

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EMC complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Emc1 ER membrane protein complex subunit 1 located_in
part_of		 ISO
IEA		 (PMID:32439656) ComplexPortal
TreeGrafter
Ensembl
InterPro		 PMID:32439656 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:5,512,100...5,539,198
Ensembl chrNW_004936474:5,511,661...5,539,237 		JBrowse link
G Emc10 ER membrane protein complex subunit 10 located_in
part_of		 ISO
IEA		 (PMID:32439656) ComplexPortal
TreeGrafter
Ensembl		 PMID:32439656 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936889:288,704...296,144
Ensembl chrNW_004936889:290,605...293,718 		JBrowse link
G Emc2 ER membrane protein complex subunit 2 located_in
part_of		 ISO
IEA		 (PMID:32439656) ComplexPortal
TreeGrafter
Ensembl
UniProt		 PMID:32439656 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936470:36,354,048...36,397,977
Ensembl chrNW_004936470:36,350,969...36,398,008 		JBrowse link
G Emc3 ER membrane protein complex subunit 3 located_in
part_of		 ISO
IEA		 (PMID:32439656) ComplexPortal
TreeGrafter
Ensembl		 PMID:32439656 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936602:3,220,545...3,239,913
Ensembl chrNW_004936602:3,220,253...3,240,050 		JBrowse link
G Emc4 ER membrane protein complex subunit 4 located_in
part_of		 ISO
IEA		 (PMID:32439656) ComplexPortal
Ensembl
TreeGrafter		 PMID:32439656 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936673:2,723,563...2,732,164
Ensembl chrNW_004936673:2,723,322...2,732,305 		JBrowse link
G Emc6 ER membrane protein complex subunit 6 located_in
part_of		 ISO
IEA		 (PMID:32439656) ComplexPortal
TreeGrafter
Ensembl
InterPro		 PMID:32439656 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936677:367,364...368,268
Ensembl chrNW_004936677:367,341...368,265 		JBrowse link
G Emc7 ER membrane protein complex subunit 7 located_in
part_of		 ISO
IEA		 (PMID:32439656) ComplexPortal
TreeGrafter
Ensembl		 PMID:32439656 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936673:2,624,900...2,640,973
Ensembl chrNW_004936673:2,622,472...2,641,266 		JBrowse link
G Emc8 ER membrane protein complex subunit 8 located_in
part_of		 ISO
IEA		 (PMID:32439656) ComplexPortal
TreeGrafter
InterPro
Ensembl		 PMID:32439656 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936641:2,696,184...2,710,141
Ensembl chrNW_004936641:2,696,178...2,710,180 		JBrowse link
G Emc9 ER membrane protein complex subunit 9 part_of IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936722:403,208...405,497
Ensembl chrNW_004936722:403,112...407,517 		JBrowse link
G Mmgt1 membrane magnesium transporter 1 located_in
part_of		 ISO
IEA		 (PMID:32439656) ComplexPortal
TreeGrafter
UniProt
Ensembl		 PMID:32439656 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936513:11,229,354...11,239,152
Ensembl chrNW_004936513:11,229,506...11,239,525 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16767
    protein-containing complex 5555
      endoplasmic reticulum protein-containing complex 121
        EMC complex 10
Path 2
Term Annotations click to browse term
  cellular_component 16767
    cellular anatomical entity 16677
      organelle 11970
        intracellular organelle 11572
          intracellular membrane-bounded organelle 10429
            endoplasmic reticulum 1579
              endoplasmic reticulum subcompartment 816
                endoplasmic reticulum membrane 804
                  EMC complex 10
paths to the root